Neanderthals vanished roughly 42,000 years ago, but a piece of their biology appears to be quietly at work in some people today, according to a new study led by scientists from the Max Planck Institute for Evolutionary Anthropology.
More than 150 years after Charles Darwin first wondered whether certain sticky-leaved Saxifraga plants might be secretly carnivorous, Kunming Institute of Botany researcher Tao Deng and colleagues say they have finally confirmed it.
New research led by the University of California, Berkeley reveals that beyond Neanderthals and Denisovans, humans interbred with two mysterious ‘ghost’ lineages: one in Africa more than 50,000 years ago, another in Eurasia over 1.7 million years ago.
New research has revealed the complex biological history preserved in DNA traces on the Shroud of Turin. Fibers taken from the Shroud of Turin nearly five decades ago still contain a complex record of biological material accumulated over centuries. In research published in Scientific Reports, scientists applied advanced genomic sequencing (rigorous PCR-free next-generation metagenomic sequencing) [...]
In recent years, advances in ancient DNA sequencing have redefined our understanding of human evolution, revealing that our species did not emerge in isolation but repeatedly interbred with close evolutionary relatives like Neanderthals and Denisovans.
Yet one of the field’s greatest mysteries has remained unanswered: What if some of our ancestors also encountered extinct human groups whose DNA has never been recovered from fossils? Now, a recent study published in Science suggests researchers may finally have found a way to detect those long-lost relatives.
Instead of relying on ancient bones or preserved genomes, researchers developed a powerful computational approach capable of identifying genetic traces of previously unknown archaic humans using only the genomes of living people.
Applying the technique to modern populations around the world, the researchers uncovered evidence that an unidentified “ghost” hominin contributedDNA to the ancestors of all living humans before the great migration out of Africa.
Researchers also found new evidence providing evidence for the existence of an even older “super-archaic”human lineage whose genetic legacy may survive today through Denisovan ancestry in Oceania.
“Admixture between modern humans and extinct hominins has shaped the genomes of present-day individuals, but reconstructing this history has been constrained by the scarcity of archaic samples and unadmixed outgroup populations,” researchers write. “We introduce TRACE, a reference- and outgroup-free approach that uses features of ancestral recombination graphs to identify archaic ancestry.”
Past research has sequenced only a handful of high-quality archaic human genomes, all from Eurasia. While those genomes have revealed that most people outside Africa carry roughly 1 to 2 percent Neanderthal DNA and that many Asian and Oceanian populations also inherited Denisovan ancestry, scientists have long suspected those known groups represented only part of humanity’s evolutionary history.
Previous genetic studies had hinted that modern humans, especially African populations, contained fragments of DNA from unidentified archaic relatives. However, because no fossil genomes exist for those populations, proving their existence has been extraordinarily difficult.
The new method, called TRACE, short for “TRacking Archaic Contributions via ARG Estimation,” takes a fundamentally different approach. Rather than comparing modern DNA against known Neanderthal or Denisovan genomes, it reconstructs ancestral recombination graphs. These enormous evolutionary family trees trace how pieces of DNA have been inherited over hundreds of thousands of years.
These ancestral graphs preserve signatures left behind when deeply divergent human lineages interbred. Such events create unusually long branches and distinctive genetic patterns that can persist in descendants for hundreds of thousands of years. By searching for those signatures, TRACE can identify archaic ancestry even when no reference genome exists.
To test the system, the researchers first ran extensive computer simulations modeling ancient human populations and known episodes of Neanderthal interbreeding. The method consistently revealed high accuracy while producing very low false-positive rates.
The team then applied TRACE to genomes from the 1000 Genomes Project, encompassing hundreds of individuals representing populations across Africa, Europe, Asia, and elsewhere.
The program successfully recovered well-established Neanderthal ancestry in Europeans and Asians, along with Denisovan ancestry concentrated primarily in Asian populations. More intriguing, however, was the discovery of an additional category of DNA that matched neither Neanderthalsnor Denisovans.
TRACE identified between roughly 0.5 and 1.1 percent “ghost” ancestry across all modern populations examined. The genetic evidence suggests these segments originated from an unknown archaic human lineage that diverged from our ancestors roughly 830,000 years ago, before later contributing DNA to the ancestors of modern humans.
Perhaps most surprising was where that ancestry appeared.
Rather than being confined to African populations, as several earlier hypotheses proposed, the researchers found remarkably similar ghost ancestry in both Africans and non-Africans.
Most of the segments detected outside Africa were shared with African populations, suggesting the interbreeding event occurred before modern humans started dispersing across the globe roughly 50,000 to 70,000 years ago.
The findings point toward a previously unrecognized chapter ofhuman evolutionin which an unidentified human population mixed with the common ancestors of everyone alive today.
The researchers also explored where these ancient genetic fragments survive in the modern genome.
They found ghost ancestry spread across more than 70 percent of the accessible human genome, although it was far from evenly distributed. Some regions contained unusually high concentrations of ghost DNA, including genes involved in immune function and metabolism.
Even more unexpectedly, ghost ancestry persisted inside genomic regions previously believed to be largely devoid of archaic DNA.
These regions, known as “Neanderthal and Denisovan ancestry deserts,” have often been interpreted as places where natural selection eliminated archaic genetic variants because uniquely modern human versions proved advantageous.
The presence of ghost ancestry inside many of those same regions suggests the story may be more complicated. Rather than rejecting all archaic DNAequally, natural selection may have acted differently depending on which ancient human lineage contributed the genes.
The study also ventured even farther back in evolutionary time.
Focusing on genomes from Papua New Guinea, Vanuatu, and the Santa Cruz Islands, the researchers searched for evidence of “super-archaic” ancestry—genetic contributions from a lineage that diverged long before Neanderthals, Denisovans, and modern humans separated.
Previous studies had suggested Denisovans themselves may have inherited DNA from such an ancient population. TRACE now provides additional support for that hypothesis.
The team identified deeply divergent genetic segments embedded explicitly within Denisovan-derived DNA in Oceanian populations. Based on their analyses, those ancient lineages may have split from the ancestors of modern humans approximately 1.77 million years ago.
While the researchers stress this represents a conservative estimate of surviving super-archaic ancestry, the findings strengthen the idea that modern humans indirectly inherited DNA from a much older human lineage through Denisovan interbreeding.
The identity of both the ghost lineage and the super-archaic population remains unknown.
The ghost population may represent Middle Pleistocene human groups or African populations of Homo heidelbergensis that encountered the ancestors of modern humans before the Out-of-Africa migration. For the older super-archaic lineage, the researchers note that Homo erectus remains one plausible candidate given its estimated divergence time and broad geographic distribution.
Although the new method cannot yet identify specific fossil species, it provides researchers with an entirely new tool for investigating chapters of human evolution that may never yield recoverable ancient DNA.
Because DNA older than roughly one million years is extraordinarily unlikely to survive outside permanently frozen environments, computational approaches like TRACE are becoming increasingly important for reconstructing humanity’s deepest evolutionary history.
“We find evidence for at least one ghost introgression predating the OOA expansion that contributed ancestry to all present-day populations,” researchers write. “These results point to multiple layers of introgression—both direct and mediated through other archaic groups—shaping modern human genomes.”
Tim McMillan is a retired law enforcement executive, investigative reporter and co-founder of The Debrief. His writing typically focuses on defense, national security, the Intelligence Community and topics related to psychology. You can follow Tim on Twitter:@LtTimMcMillan. Tim can be reached by email: tim@thedebrief.org or through encrypted email:LtTimMcMillan@protonmail.com
An international team of researchers who extracted ancient mammoth DNA from a sample of 500 bones reports that Ice Age humans selectively targeted female woolly mammoths.
The results of the team’s work show a contrast in sex ratio and mammoth remains, and found that the connection to large bones associated with ancient human activity was dominated by females.
“Whether these massive mammoth bone accumulations were formed naturally or by human hunting has been debated for decades”, says David Díez del Molino, Researcher at the Centre for Palaeogenetics and co-senior author of the study, in a statement. “By comparing the genetic sex ratios of hundreds of mammoths from natural settings with those found in these archaeological contexts, we can now infer that human activity was the primary driver behind these bone accumulations.”
The team took samples from a total of 521 woolly mammoths, including 448 individuals whose DNA was sequenced for the first time. The study, the team says, became the largest genetic analysis of mammoths ever conducted.
Archaeologists have been wondering for years if the large bone piles they found were created naturally or organized by humans. The new research pointed to a clear answer: these discoveries can be attributed directly to human hunting and organization.
Excavation in Langmannersdorf 2025. Photo: Marc Händel/Austrian Academy of Sciences (Image Credit: Marc Händel/Austrian Academy of Sciences).
The researchers determined the sex of each mammoth based on genetics and found that remains from natural settings were more likely to be male, with around 66 percent being males and 34 percent females. Scientists believe these reveal a direct connection to the behavior of mammoths, much like modern elephants, where adult males were more likely to be trapped in sinkholes or other related natural disasters, which would increase the chances of their bones being preserved, compared to females.
However, the sites connected to human organization and consumption told a different story. Around 70 percent of the mammoths found were female, suggesting that during the Ice Age, strategic hunting was being undertaken. The question remains why hunters preferred females over males, which also seems unusual since killing more female mammoths would decrease the population, and therefore decrease the overall food supply of Ice Age hunters.
“While it is tempting to assume that hunters would have targeted females because they were smaller than adult males, the reality may have been more complex. If mammoths behaved like modern elephants, females living in matriarchal herds may have had group defences that would have made encounters with herds equally or even more risky,” says Hannah M. Moots, Postdoctoral Researcher at the Centre for Palaeogenetics and lead author of the study.
Although females were generally smaller than fully grown bulls, researchers caution against assuming they were easier prey.
“Another possibility is that female-led herds moved across the landscape in more predictable ways than solitary males, meaning Upper Palaeolithic hunter-gatherers may simply have encountered them more frequently, whether for hunting or scavenging”, Moots adds. The researchers also suggest that female herds could have followed migration routes, therefore making their movements more predictable for Upper Paleolithic hunter-gatherers.
The study examined 11 major archaeological sites dating from 30,000 to 20,000 years ago, a time when mammoths were essential to human survival. Hunters during this period used nearly every part of the animal for food, clothing, shelter, tools, and even art.
By analyzing DNA from 100 mammoths found at archaeological sites and 421 from natural deposits, researchers assembled the largest dataset of its kind, revealing new insights into mammoth behavior and Ice Age hunting practices.
The analysis also uncovered the first known case of X0/XX mosaicism, a genetic condition similar to Turner syndrome in modern humans, in an extinct species. The affected mammoth, from Wrangel Island, provides a rare glimpse into the biology of these ancient giants.
Chrissy Newton is a PR professional and the founder of VOCAB Communications. She currently appears on The Discovery Channel and Max and hosts the Rebelliously Curious podcast, which can be found on YouTube and on all audio podcast streaming platforms. Follow her on X: @ChrissyNewton, Instagram: @BeingChrissyNewton, and chrissynewton.com. To contact Chrissy with a story, please email chrissy @ thedebrief.org.
A large British study spanning more than 70 years has found that people who experience chronic money struggles over their working lives show measurable declines in memory and processing speed by their 50s, along with signs of accelerated brain shrinkage decades later.
Researchers have identified and formally described a new species of the African monkey genus Colobus living in the remote interior of the Democratic Republic of Congo, marking only the fifth new monkey species found on the continent in the past 75 years.
The mystery of life's origin on Earth remains unsolved. With modern biochemistry tools scientists are no closer to synthesizing life from non-living chemicals despite advanced knowledge and technology, let alone understanding how it could have arisen abiogenetically. The rejection of the Creator has led to foolishness in the wise.
Silver nanoparticles provide a more efficient way to cut and assemble DNA, improving recovery rates and boosting DNA joining efficiency for future gene engineering applications. DNA is made of long chains that carry the instructions living things need to grow and function. In genetic engineering, researchers cut DNA at chosen locations and attach the pieces [...]
A longstanding archaeological mystery has loomed over discoveries at ancient burial sites in eastern Siberia: why were so many children and adolescents among the dead?
Now, according to a recent study in the journal Nature, DNA recovered from human remains found in burial sites at four cemeteries near Lake Baikal in eastern Siberia may finally reveal the answer.
Thousands of years ago, prior to the rise of ancient medieval cities—and their often-rat-infested streets—a disease famously associated with these rodents had already ravaged communities of prehistoric hunter-gatherers.
The research, based on reconstructions of ancient bacterial genomes preserved in the teeth of these ancient Siberians, revealed the presence of previously unknown strains of Yersinia pestis—the bacteria responsible for plague—providing fresh evidence that the lethal disease was already manifesting and killing human populations at least as far back as 5,500 years ago.
“Whether the earliest forms of plague were mild or virulent has been a matter of debate, but our findings demonstrate that these ancient strains were already highly lethal,” said senior author Eske Willerslev of the University of Copenhagen and the University of Cambridge.
New Evidence of an Ancient Siberian Plague
In their study, the team successfully located plague DNA in 18 out of 46 individuals they studied. Based on radiocarbon dating, many of the deaths were confirmed to have all happened within a short span of time, which is consistent with sudden deaths resulting from plague. Additionally, genetic evidence showed that several of these victims had been close relatives.
One key finding in the research involved the number of children and adolescents who were among the dead—a discovery mirroring earlier findings at prehistoric sites in the region, which had remained a longstanding archaeological mystery.
“The unusually high number of children and the short timespan was a real puzzle that we’ve been trying to solve since the 1990s,” said archaeologist Andrzej Weber of the University of Alberta. “Finding out that plague was the cause is extraordinary, but it makes so much sense.”
New Findings Challenge Old Assumptions
Based on the new findings, ancient strains of plague appear to have been more harmful than once thought. In the past, it was presumed that because these early strains lacked genetic adaptations that helped the bubonic plague spread so efficiently through fleas and rodents, they were relatively harmless.
The team’s research now reveals that these newly identified strains carried a specific toxin-producing genetic feature, known as a superantigen, which can trigger severe immune responses that potentially had devastating impacts on mortality rates in the ancient world.
Such deadly outbreaks may have had a far more significant impact on ancient human populations than previously realized, and during periods long before the rise of major urban centers and organized agriculture.
In terms of the origins of the disease, researchers believe that they may have finally traced it to Central or Northeast Asia, where infections may have spread from marmots, large rodents that are still recognized as plague carriers in modern times.
After years of uncertainty, the team’s research offers some of the best evidence to-date that one of the most devastating diseases in human history was already playing a role in shaping human history thousands of years earlier than once thought.
Martin Sikora, associate professor at the University of Copenhagen and the study’s senior author, says his team’s research “changes our understanding of the earliest plague outbreak,” and now confirms that such ancient strains “appear to have carried a potent combination of virulence factors that could make infection highly lethal.”
Micah Hanks is the Editor-in-Chief and Co-Founder of The Debrief. A longtime reporter on science, defense, and technology with a focus on space and astronomy, he can be reached atmicah@thedebrief.org. Follow him on X @MicahHanks, and at micahhanks.com.
A genetic study of 2,000-year-old grape seeds is shedding new light on ancient winemaking. For centuries, the vineyards of Tuscany have been associated with some of the world’s most celebrated red wines. But a cache of grape seeds buried in ancient wells is revealing a very different story about what people were growing and drinking [...]
Have you ever considered buying a DNA kit for a family member as a special gift, such as Father’s Day? On the surface, it may seem like a good idea, as it allows loved ones or friends to peer into their past and family history; however, psychologistshave recently warned against it, asit might have profound psychological implications.
In a new book titled The Psychology of Genealogy,Dr. Susan Moore, a retired Australian university researcher in social and developmental psychology, examines the complex emotions associated with DNA testing and uses real-life case studies to illustrate its psychological impact.
“Should you give DNA kits as gifts? It can be fun, [but] it can be risky,” Moore says in a statement.
Moore cautions that the psychological impact of DNA testing may be far greater than many people anticipate. These tests can reveal unexpected family secrets, uncover cases of misattributed paternity, disclose donor conception, and even link individuals to hundreds of previously unknown half-siblings or relatives they may not want to be connected with.
“Do first think carefully about how your intended recipient might cope with unexpected outcomes,” Moore says.
“Hobbyist family historians are uncovering joyful and inspiring stories of the past as well as sad and unsettling secrets of their ancestry,” Moore explains. “Records and DNA matches provide boosts, challenges, and even threats to one’s sense of self, and this is occurring at unprecedented levels.”
Unexpected DNA results can deeply impact a person’s sense of self and identity, along with family belonging and dynamics—a phenomenon psychologists call “identity disruption.” Moore’s book highlights cases involving revelations of misattributed parentage, late-discovered adoption, and donor conception uncovered through genetic testing, all of which caused more physical harm than good.
“At the personal level, these may be findings that cause you great distress, that destabilize your sense of who you are, that initially at least, you would have preferred not to know. Once known, however, they cannot be unknown,” says Moore.
DNA testing has also raised privacy concerns in recent years. A 2023 23andMe data breach exposed millions of users’ genetic information, while financial challenges that DNA companies have faced raise questions about what happens to genetic data if these companies fail.
Surprising statistics show that, presently, over 30 million people have tested their DNA through genealogical services like 23andMe and AncestryDNA.
Still, for many people, even with data breaches and larger companies buying up DNA data sets, it’s still enticing to buy, as their curiosity seems to outweigh the risks.
“How exciting it can be to discover the identity of an ancestor, solve a family mystery, prove or disprove family ‘legends’ or discover previously unknown living relatives,” Moore says.
“Indeed, genealogists regularly report elation and joy as they unearth lost relatives, discover the identity of a ‘missing’ ancestor, or otherwise break down ‘brick walls’ (genealogical puzzles that seem to resist solutions due to missing, inaccurate, or hard-to-access records).”
“Curiosity is a great motivator,” Moore adds.
Chrissy Newton is a PR professional and the founder of VOCAB Communications. She currently appears on The Discovery Channel and Max and hosts the Rebelliously Curious podcast, which can be found on YouTube and on all audio podcast streaming platforms. Follow her on X: @ChrissyNewton, Instagram: @BeingChrissyNewton, and chrissynewton.com. To contact Chrissy with a story, please email chrissy @ thedebrief.org.
Scientists found that some inherited traits can bypass the traditional rules of genetics, revealing a surprising new layer of inheritance beyond DNA. For more than a century, Gregor Mendel’s laws of inheritance have served as the foundation of genetics. But new research suggests that inheritance can be more complicated than the DNA sequences passed from [...]
DNA carries the instructions for life, but additional molecular systems help determine how those instructions are used. New research in a sea anemone reveals an unexpected role for one of these systems. DNA is often described as the blueprint of life, but a blueprint is only useful if someone knows how to read it. Across [...]
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