The global health organization Coalition for Epidemic Preparedness Innovations (CEPI) announced Monday that it will "urgently accelerate development" of three vaccine candidates against Bundibugyo ebolavirus (BDBV), pledging a little over $60 million in the effort to extinguish an outbreak currently raging out of control in the Democratic Republic of the Congo.
Under the plans, CEPI has committed up to $50 million to US-based Moderna for preclinical development and Phase 1 clinical testing of its mRNA-based BDBV vaccine candidate. The funding will simultaneously allow the company to ramp up manufacturing capabilities and ready large-scale Phase 2/3 trials in the event the vaccine makes it through early testing. The vaccine will use Moderna's mRNA vaccine platform that allowed for rapid development of a COVID-19 vaccine during the pandemic.
"[W]e believe our mRNA platform can play an important role in responding rapidly to emerging infectious disease threats," Moderna CEO Stéphane Bancel said in a statement Monday. " We will move with urgency and scientific rigor to support the response and help bring a potential vaccine closer to the communities that need it most."
The global health organization Coalition for Epidemic Preparedness Innovations (CEPI) announced Monday that it will "urgently accelerate development" of three vaccine candidates against Bundibugyo ebolavirus (BDBV), pledging a little over $60 million in the effort to extinguish an outbreak currently raging out of control in the Democratic Republic of the Congo.
Under the plans, CEPI has committed up to $50 million to US-based Moderna for preclinical development and Phase 1 clinical testing of its mRNA-based BDBV vaccine candidate. The funding will simultaneously allow the company to ramp up manufacturing capabilities and ready large-scale Phase 2/3 trials in the event the vaccine makes it through early testing. The vaccine will use Moderna's mRNA vaccine platform that allowed for rapid development of a COVID-19 vaccine during the pandemic.
"[W]e believe our mRNA platform can play an important role in responding rapidly to emerging infectious disease threats," Moderna CEO Stéphane Bancel said in a statement Monday. " We will move with urgency and scientific rigor to support the response and help bring a potential vaccine closer to the communities that need it most."
People under stress may find it harder to orient themselves in space, and researchers in Bochum have identified a possible reason why. The stress hormone cortisol appears to interfere with the brain system that helps people navigate. It weakens the activity of grid cells, which are important for spatial orientation. Researchers at Ruhr University Bochum [...]
Two new tool compounds may help scientists study TAOK proteins linked to Alzheimer’s disease and other neurological disorders. Alzheimer’s disease is the leading cause of dementia and affects more than seven million people in the United States. Some treatments can slow the disease, but most address symptoms rather than the root biology, and none can [...]
A new meta-analysis of 57 psychological studies found that essentially identical patient interviews can lead to different diagnoses for the same exact patient.
The American Medical Association came out swinging this weekend at an executive order President Trump signed Friday that reaffirms intentions to model US childhood vaccine recommendations after those of Denmark—a country with universal healthcare, less diversity, and a population about the size of Maryland's.
“There is no credible scientific evidence to support," such a change, AMA President Bobby Mukkamala said in a statement. The current vaccine schedule "is built on decades of rigorous research and real-world data, and it is designed to protect children in the US when they are most vulnerable based on our nation’s disease burden," he said.
The plan to align federal childhood vaccine recommendations with Denmark's was first revealed by anti-vaccine Health Secretary Robert F. Kennedy Jr. in January. The overhaul would see the total number of recommended immunizations drop from 17 to 11, walking back recommendations for shots against rotavirus, COVID-19, influenza, meningococcal disease, hepatitis A, and hepatitis B. It stemmed from a December executive order by Trump to align US vaccine recommendations with the "best practices from peer, developed countries."
The American Medical Association came out swinging this weekend at an executive order President Trump signed Friday that reaffirms intentions to model US childhood vaccine recommendations after those of Denmark—a country with universal healthcare, less diversity, and a population about the size of Maryland's.
“There is no credible scientific evidence to support," such a change, AMA President Bobby Mukkamala said in a statement. The current vaccine schedule "is built on decades of rigorous research and real-world data, and it is designed to protect children in the US when they are most vulnerable based on our nation’s disease burden," he said.
The plan to align federal childhood vaccine recommendations with Denmark's was first revealed by anti-vaccine Health Secretary Robert F. Kennedy Jr. in January. The overhaul would see the total number of recommended immunizations drop from 17 to 11, walking back recommendations for shots against rotavirus, COVID-19, influenza, meningococcal disease, hepatitis A, and hepatitis B. It stemmed from a December executive order by Trump to align US vaccine recommendations with the "best practices from peer, developed countries."
Scientists may have found a completely new way to treat depression by targeting inflammation instead of brain chemistry. A small clinical trial led by researchers at the University of Bristol suggests that targeting the immune system could help people with depression who do not improve with standard antidepressant medications. The findings, published May 20 in [...]
Researchers suggest that old psychoanalytic ideas and modern brain science may be describing the same mental processes from different angles. More than a century after Sigmund Freud developed his influential theories of the mind, some researchers believe modern neuroscience may be arriving at surprisingly similar conclusions. A new paper published in the neurocognitive journal Entropy [...]
Amateur male soccer players had greater changes in certain blood markers associated with neural damage the harder and more frequently they headed balls.
Amateur male soccer players had greater changes in certain blood markers associated with neural damage the harder and more frequently they headed balls.
A simple writing task may offer clues about aging brains. Researchers found that dictation, in particular, exposed subtle differences linked to cognitive impairment. Handwriting depends on both fine motor skills and complex mental processes, including selecting, organizing, and interpreting sensory information. Because writing places heavy demands on the brain, changes in handwriting may help reveal [...]
Scientists restored young gut bacteria in aging mice and saw signs of rejuvenation along with complete protection from liver cancer. Returning the gut microbiome to a more youthful state could help slow aging and lower the risk of liver cancer, according to research entitled “Restoration of a youthful gut microbiome reduces liver aging and suppresses [...]
Heart attacks and strokes are among the leading causes of death worldwide. In most cases, these serious medical emergencies happen when blood vessels become narrowed or blocked, preventing oxygen-rich blood from reaching vital organs such as the heart or brain. The underlying problem often begins many years earlier with a condition called atherosclerosis. This disease […]
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