A couple of decades after the discovery of systems that could selectively target DNA, we're starting to see the first therapies based on gene editing. One challenge these developments have faced is safety. While we can make them pretty specific to the gene we want edited, the human genome is very large, and even rare DNA sequences can appear a couple of times by chance.

As a result, all the original gene-editing systems had known rates of what are called off-target effects, in which they simply edit the wrong sequence. This may be a low-probability event, but edit enough cells—and therapies generally have to edit many—and errors become inevitable.

A lot of effort has gone into finding ways to minimize or eliminate off-target edits. In a recent issue of Nature, researchers described modifying the AI protein-folding software AlphaFold to help identify key areas of gene-editing proteins responsible for off-target effects. Those areas were then modified to reduce the problems.

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A spacecraft fitted with two flexible robotic arms is on the way to geosynchronous orbit after launching earlier this week on a SpaceX Falcon 9 rocket, kicking off a planned decade-long mission to open new frontiers in satellite servicing.

The Mission Robotic Vehicle, owned and built by Northrop Grumman, rocketed into orbit from Cape Canaveral Space Force Station in Florida on Tuesday. Three small propulsion pods, each functioning as standalone spacecraft, accompanied the MRV aboard the Falcon 9 rocket.

The Falcon 9 deployed all four payloads within about an hour of liftoff. It will take about a year for the satellites to maneuver from their initial elliptical drop-off orbit into a circular orbit more than 22,000 miles (nearly 36,000 kilometers) over the equator. At this altitude, the MRV and the three Mission Extension Pods (MEPs) will travel in lockstep with Earth's rotation, operating in the same kind of orbit as numerous civilian and military communications satellites, missile warning platforms, and a growing number of spy satellites.

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Welcome to Edition 9.04 of the Rocket Report! We've had to wait an extra week for SpaceX to get its 13th Starship test flight off the ground. A last-second abort on July 16 led engineers to roll the booster back to its hangar in South Texas to swap out engines. Starship is now back on the launch pad. Liftoff is set for Friday evening. A flawless launch and reentry will put SpaceX on the cusp of an orbital flight later this year. Ars will have a comprehensive recap story after the completion of the test flight.

As always, we welcome reader submissions. If you don't want to miss an issue, please subscribe using the box below (the form will not appear on AMP-enabled versions of the site). Each report will include information on small-, medium-, and heavy-lift rockets, as well as a quick look ahead at the next three launches on the calendar.

India's first private rocket reaches orbit. Indian space officials celebrated the debut flight of Skyroot Aerospace’s Vikram-1 rocket, India’s first fully commercial satellite launcher, as a “grand success” Saturday after an on-target climb into a 280-mile-high orbit following liftoff from an island spaceport in the Bay of Bengal, Ars reports. The Vikram-1 lifted off from India’s primary spaceport on Sriharikota Island around midday local time. The launch was delayed more than a half-hour to resolve a last-minute technical problem. The countdown resumed, culminating in the command to ignite Vikram-1’s solid-fueled first stage booster to propel the rocket off the launch pad.

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On Tuesday, the White House Office of Science and Technology Policy (OSTP) released a report entitled "Science: A New Golden Age," in which it lays out how it has viewed science, found it lacking, and believes the Trump administration is in the perfect position to fix things. It's a bit unexpected coming from an administration that has been proposing crippling funding cuts to research and trying to enable political appointees to terminate grants awarded based on scientific merit.

The report presents itself as the spiritual successor of "Science, the Endless Frontier," a policy document that laid out the case for government-funded science in the wake of World War II. The New Golden Age (SNGA) says that, while the concepts promoted by the original remain vital, the circumstances have changed such that we need major revisions to how the government is implementing things.

The result is an odd mix. It completely ignores or glosses over many things that the administration is doing to harm scientific progress. In some cases, it identifies issues that have already been discussed as problems within the scientific community, but misrepresents them. Elsewhere, it's a mixture of political grievances, ideas without a solid intellectual foundation, and an injection of Silicon Valley's perspective on innovation (Michael Kratsios, the director of the OSTP, formerly worked with Peter Thiel). As a result, it's unlikely to have anything like the impact of "Science, the Endless Frontier."

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There have been numerous accounts in recent years of orcas ramming boats—and sometimes sinking them. Scientists believe this may be a form of culturally learned behavior passed down through generations. Now we have fresh examples: orcas in the Gulf of California were filmed teaming up to ram sunfish with so much force that the carcasses exploded into small fragments. While orcas have been known to use force to remove flesh from prey, this is something different, according to a new paper published in the journal Frontiers in Ethology.

“We think this may help younger orcas feed more easily, or it could also just be for fun," said co-author Kathryn Ayres of Beneath The Waves, a nonprofit organization promoting ocean health. "Orcas are known for playing with their food.”

Orcas engage in cooperative hunting strategies that can involve striking or killing animals—sometimes eating their prey, sometimes not—so the behavior could be described as social interaction, play, or practice as a mode of social learning. Orcas have been observed ramming whale sharks as another orca held the prey steady. Other cooperative strategies include herding mobile rays, blocking an escape path while hunting white sharks, and deliberately producing waves to bump penguins off ice floes.

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A photon is a single particle of light, and under normal circumstances, it can't be divided. But a photon is also not a particle, in the sense that it does not have a specific location. Instead, it is an extended object.

So if a photon is only partway through the process of reflecting from a perfect mirror and you yank the mirror away, what happens? The answer, from a trio of Norwegian physicists, turns out (arxiv.org link) to be more complex than I expected.

A photon divided?

Let’s first talk briefly about dividing and combining photons. If this were a common experience in our lives, then shining a single color of light through a piece of glass or reflecting it from a surface might cause photons to divide or combine. This would lead to an amazing array of colors: Our universe would be the most fantastic and legal LSD trip you could imagine. But this doesn't generally happen, hence LSD.

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When Mount Vesuvius erupted in 79 CE, it spewed molten rock, pumice, and hot ash over the cities of Pompeii and Herculaneum, killing thousands of people. It's one of the most famous natural disasters in human history, so naturally there have been countless documentaries about Pompeii (and at least one popular song). But only one features actor Tom Hiddleston taking on the role of a "time detective" to bring the people of Pompeii to vivid life. That would be National Geographic's new three-part docuseries, Pompeii: Out of Time.

The Marvel connection made Out of Time happen. Executive producer Kevin Wright was also a producer on the Disney+ series Loki, which included a scene where Hiddleston's Loki travels through time to visit Pompeii. Hiddleston also studied classics at Cambridge University and had visited the Pompeii archaeological site as a teenager, which the Marvel star attributes to indirectly influencing his career path into acting.

"There is just a passion to the way Tom tells stories that's infectious," Wright told Ars. "We knew that if we could capture that and put it into [the series], it might interest people who wouldn't normally want to watch a documentary about Pompeii. "

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Naked mole rats are weird. They spend their lives almost entirely underground, are largely insensitive to some kinds of pain, can persist without oxygen for a long time, rarely develop cancer, and can live past 30 years, which is decades longer than similarly sized rodents. They are also eusocial, like ants, bees, or termites—in a colony that can hold more than a hundred animals, only one female, the queen, breeds.

We didn’t know how exactly naked mole-rat queens stop other females from breeding. For a long time, our leading hypothesis was bullying and violence, but that may be a bit impractical, given their kingdoms are vast networks of tunnels that can stretch for up to three kilometers. But now a team of Lewin Lab scientists at Max Delbrück Center for Molecular Medicine in Berlin discovered it’s actually just one part of a sophisticated olfactory signaling program.

Running on smell

"It's very clear that mole rats actually have quite big noses and smell a lot," says Gary Lewin, a neurobiologist at the Max Delbrück Center for Molecular Medicine and senior author of the study. Naked mole rats have around 1200 olfactory receptor genes, more than mice (which have roughly 1,000 of them) and way more than the few hundred in humans. They're also blind. "They have to be able to navigate and move around without vision, so smell is one of those things that’s enhanced," Lewin said.

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It seems as though $5.6 billion wasn't enough. That was the news from the US Space Force on Friday, when military officials announced they were tripling the maximum value of one of the service's National Security Space Launch contracts to $17 billion.

The expansion of the Space Force's National Security Space Launch (NSSL) Phase 3 contract comes as the Pentagon signals rising demand for military satellite launches. The NSSL program is set up to allow Space Systems Command, which oversees the Space Force's launch program, to select from a pool of launch providers for individual missions to deliver the military's satellites to orbit.

The NSSL program has two parts. Lane 1 covers the Space Force's more risk-tolerant missions, such as medium-lift launches with experimental payloads or rideshare missions carrying satellites for the Pentagon's surveillance or data relay constellations. Lane 2 includes higher-priority strategic missions, like the government's largest and most expensive spy satellites, or radiation-hardened communications satellites designed to survive a nuclear war.

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Indian space officials celebrated the debut flight of Skyroot Aerospace's Vikram-1 rocket, India's first fully commercial satellite launcher, as a "grand success" Saturday after an on-target climb into a 280-mile-high orbit following liftoff from an island spaceport in the Bay of Bengal.

The Vikram-1 lifted off from India's primary spaceport on Sriharikota Island at 1:35 am EDT (06:35 UTC) Saturday, around midday at the launch base along India's southeast coast. The launch was delayed more than a half-hour to resolve a last-minute technical problem. The countdown resumed, culminating in the command to ignite Vikram-1's solid-fueled first stage booster to propel the rocket off the launch pad.

Vikram-1 is modest in size compared to India's larger workhorse rockets. Skyroot's rocket stands about 72 feet (22 meters) tall, with the capability to place payloads of up to 770 pounds (350 kilograms) into low-Earth orbit. This makes Vikram-1 somewhat larger than the Electron launch vehicle developed by Rocket Lab, the world's most successful dedicated small satellite launcher.

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With summer heat comes pool parties, beach days, backyard cookouts, and, of course, swarms of bloodthirsty mosquitoes.

But while insect bites have always been a side effect of time spent outdoors, the species doing the biting are changing in historically temperate regions like New England. As climate change makes these areas warmer and wetter, their ranges are expanding—and any diseases they carry come with them.

In Connecticut, for example, a statewide mosquito monitoring program has detected 54 different species, including invasives like the Asian tiger mosquito, which can transmit potentially serious diseases including dengue and Zika. The mosquito’s historical territory is in hot and humid climates farther south, but it has been moving north.

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