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Humanity’s greatest challenge in becoming a multi-planet species may not be building bigger rockets or landing astronauts on Mars. Instead, it could come down to the question: Can humans safely conceive, carry pregnancies, and raise healthy children off Earth?
A new review published in Frontiers in Space Technologies argues that the answer to this question remains unclear. Drawing on decades of research on animal reproduction in space alongside emerging advances in artificial intelligence, biotechnology, synthetic biology, and cybernetic systems, the researchers suggest that future generations born off Earth may require technologies far beyond today’s medical capabilities.
In the most speculative sections of the paper, researchers even envision a scenario in which reproduction itself acts as a tool for helping humans gradually adapt to life in space.
Rather than presenting new experiments, the paper synthesizes existing evidence while outlining possible technological pathways that could someday enable permanent human settlements on the Moon, Mars, or even deeper into the solar system.
The central message is that surviving in space is only the first hurdle. Establishing self-sustaining civilizations will ultimately depend on whether human reproduction can succeed under conditions of microgravity, radiation, isolation, and other environmental stresses that evolution never prepared us to face.
“It is proposed that prenatal and early postnatal developmental stages may constitute critical biological windows for facilitating long-term adaptation to space,” researchers write. “Such interactions could ultimately transform reproduction and early development into active drivers of human evolution, contributing to the emergence of biologically distinct populations progressively adapted to diverse space environments.”
Despite more than six decades of human spaceflight, no human has ever conceived or carried a pregnancy in space. Therefore, science has little direct evidence about what would happen if astronauts attempted to start families off Earth. Nearly everything researchers know comes from studies involving animals ranging from sea urchins and fish to frogs, birds, mice, and rats.
The results are encouraging in some respects but troubling in others.
Several non-mammalian species have successfully reproduced in orbit. Medaka fish, for example, became the first vertebrates to reproduce in space, with fertilization rates comparable to those seen on Earth. Yet, even when reproduction occurs successfully, researchers have documented developmental abnormalities in some species, suggesting that space environments can slightly modify embryonic development.
Rodent studies paint an even more complicated picture. Fertilization is not impossible under microgravity, but early embryonic development frequently suffers. Experiments have shown reduced blastocyst formation, slower embryo development, lower live birth rates, and changes in gene expression. Other studies have linked space radiation to DNA damage, genomic instability, and developmental defects affecting the nervous system.
At the same time, some findings show surprising resilience. Mouse embryos cultured aboard the International Space Station have developed into apparently normal blastocysts under certain conditions. In contrast, freeze-dried mouse sperm stored in orbit for months later produced healthy offspring after returning to Earth.
These mixed findings suggest that reproduction may be biologically possible, but far from routine, under space conditions.
In their review, researchers also examined growing evidence that spaceflight affects male and female reproductive health even before conception occurs.
Microgravity and radiation appear capable of disrupting sperm production, reducing testosterone levels, altering ovarian function, impairing egg maturation, and interfering with hormone regulation.
Some studies suggest sperm can still swim under simulated microgravity, but lose their capability to navigate effectively toward an egg. Others report that radiation accelerates the depletion of ovarian follicles and increases DNA damage in reproductive cells.
More concerning is the possibility that some biological changes could be passed to future generations through epigenetic mechanisms. Experiments involving mice have suggested that spaceflight may alter gene regulation in sperm and influence gene expression in offspring, although the long-term significance is still unknown.
For women, pregnancy itself could present an even greater challenge. On Earth, pregnancy requires profound cardiovascular changes that help deliver oxygen and nutrients to a growing fetus. Microgravity, however, causes fluid redistribution, muscle loss, reduced blood volume, bone demineralization, and changes in cardiovascular function that could interfere with placental development and fetal growth. Radiation exposure, oxidative stress, circadian disruption, and limited medical support would only add to those risks.
Researchers argue that simply shielding astronauts from radiation may not be enough. Gravity itself appears to function as a biological signal that influences everything from cell organization to tissue development. That realization carries renewed interest in artificial gravity as a potential solution.
Instead of depending solely on habitats built on the Moon or Mars, future space settlements could include rotating structures that generate centrifugal force to recreate Earth-like gravity.
Such habitats have appeared in science fiction for decades, but researchers suggest they may ultimately become essential for healthy conception, pregnancy, childhood development, and multigenerational life off Earth.
Researchers propose dedicated orbital research platforms where scientists could systematically study reproduction under lunar, Martian, or custom-designed gravity levels before humans attempt permanent settlements.
Artificial intelligence also features prominently in the researchers’ vision of the future. They propose AI-powered “digital twins” capable of integrating biological, physiological, and environmental data to simulate how embryos, pregnancies, and developing children might respond to different gravitational and radiation environments. These computer simulations could help researchers examine scenarios that would be difficult, or ethically impossible, to test directly in humans.
Perhaps the paper’s most futuristic proposal is something the researchers call Synthetic Reproductive Adaptive Enhancement Technology, or SRAET. This speculative concept envisions highly automated reproductive systems combining artificial wombs, advanced reproductive biotechnology, biosensors, AI-assisted monitoring, and predictive developmental modeling into a closed-loop environment capable of supporting conception through birth under carefully controlled conditions.
The framework explores the controversial possibility that future advances in gene editing and synthetic biology could one day help humans adapt biologically to off-world environments.
Researchers emphasize that such ideas are still speculative and acknowledge the enormous ethical, biological, and safety concerns surrounding germline modification, off-target mutations, and multigenerational consequences. Rather than advocating immediate implementation, they present these possibilities as conceptual pathways that justify careful scientific and ethical discussion.
For fans of science fiction, many of these concepts may sound remarkably familiar. Yet, researchers attempt to ground their arguments in existing developmental biology, reproductive medicine, aerospace engineering, and space medicine while clearly distinguishing current evidence from future speculation.
In the end, researchers suggest that the future of human space travel may depend less on propulsion systems than on understanding how life develops under entirely new environmental conditions. If humanity hopes to establish permanent settlements off Earth, science will first need to ensure that future generations are able to begin life safely under alien skies.
“Ultimately, the greatest challenge of human expansion beyond Earth may not be transporting humans into space, but understanding how life itself can develop, adapt, and evolve under space conditions,” researchers write. “In this sense, SRAET would not merely support reproduction beyond Earth; it would represent a developmental biotechnology through which humanity may begin to actively participate in shaping its own evolutionary future.”
Study: Ferraz M, Moeharram L. “Past, present and future of human reproduction and development in space.” Frontiers in Space Technologies. 2026.
Tim McMillan is a retired law enforcement executive, investigative reporter and co-founder of The Debrief. His writing typically focuses on defense, national security, the Intelligence Community and topics related to psychology. You can follow Tim on Twitter: @LtTimMcMillan. Tim can be reached by email: tim@thedebrief.org or through encrypted email: LtTimMcMillan@protonmail.com
Converting an engineering model of a Mars rover into an actual lunar rover could cost NASA more than $1 billion, an estimate strongly rejected by the agency’s administrator.
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During future space missions, humans may finally encounter extraterrestrial life forms, settling the age-old question of whether we are alone in the cosmos. But what if alien biology is so different from that of Earthlings that its presence could become a potential global hazard?
This is the concern raised by researchers Frederick I. Moxley and Anthony Ricciardi in a new study, which argues that in an era of sample return missions and space missions that are carrying humans and our robotic probes farther into the cosmos than ever before, we need to be prepared to enact measures to protect our planet against the unforeseen consequences of any potential alien encounters the future may hold.
“The advancement of space exploration into an era of sample return missions from Mars, asteroids, and icy moons raises the potential for biological contamination either to or from Earth,” the authors write in their recent study, published in the journal Ambio. Given the potential for such contamination, Moxley and Ricciardi approach the question of alien contact from the perspective of past examples where invasive species on Earth have caused major disturbances to the environments they encounter.
“We consider the possibility that extraterrestrial organisms introduced to Earth could behave analogously to invasive species by destabilizing ecosystems or interacting unpredictably with their new environment,” the authors write, pointing to the multitude of examples known to science, many of which involve the introduction of microbial organisms into new environments—often with devastating consequences.
In many cases, such organisms not only can survive in new environments, but can often adapt with remarkable speed, even in some of the most extreme environments.
This, the authors say, challenges the idea that extraterrestrial life might not even be capable of surviving on Earth, as expressed by some past research.
“The plausibility of encountering extraterrestrial life warrants stringent planetary protection measures grounded in biosafety and biosecurity principles,” the authors warn.
So how do they suggest protecting Earth against such potentially catastrophic events involving future encounters with extraterrestrials?
According to Moxley and Ricciardi, building a quarantine facility on the Moon could serve as Earth’s last line of defense against any unintended alien invasions that could radically disrupt Earth’s fragile ecosystems.
“Due to its proximity, natural isolation, and apparent lack of a biosphere, the Moon can serve as a secure site for biocontainment of extraterrestrial samples,” the authors write. In their study, they examine historical instances where biological invasions have led to catastrophic environmental changes and argue that constructing a biocontainment facility on the Moon “should form the cornerstone of modern astrobiological risk mitigation strategies.”
What the researchers propose falls in line with current plans NASA has for a permanent lunar base, which is one of the many ambitious efforts under its Artemis Mission. Such a lunar outpost, which will serve as the official Artemis Base Camp, is planned for construction near the Moon’s South Pole.
At a cost of close to $30 billion, the effort will help to facilitate an ongoing human presence on the Moon by as soon as 2028, according to current mission timelines, and will serve as a science hub in support of future lunar exploration.
For Moxley and Ricciardi, incorporating a quarantine facility within our future lunar infrastructure that can house any extraterrestrial life forms we may encounter could prove to be vital. Ultimately, having such a facility may play the important role of shielding Earth against unintentional contamination by a potentially invasive alien species.
The team’s recent paper, “Protecting earth from extraterrestrial contamination: The case for a lunar biocontainment facility,” was published in Ambio.
Micah Hanks is the Editor-in-Chief and Co-Founder of The Debrief. A longtime reporter on science, defense, and technology with a focus on space and astronomy, he can be reached at micah@thedebrief.org. Follow him on X @MicahHanks, and at micahhanks.com.
Lunar lander developer Astrobotic decided to sell to Voyager Technologies so it could quickly scale up to meet the projected demands of NASA’s lunar base initiative.
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Astrobotic showed off the lunar lander it plans to launch later this year that will be the vanguard of NASA’s new lunar base ambitions.
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NASA officials announced contract awards for the initial elements of a lunar base on Tuesday, including two rovers that will provide mobility to astronauts.
With the series of announcements, NASA Administrator Jared Isaacman sought to maintain momentum around a Moon Base initiative revealed two months ago as part of the space agency's return to the Moon. "For those waiting patiently, the grand return is close at hand, and we will not slow down," he said.
The manager for the lunar base, Carlos Garcia-Galan, said the space agency had selected two companies, Astrolab and Lunar Outpost, to build approximately 1-ton rovers that would be ready for delivery to the Moon in 2028. Astrolab will receive $219 million for its "CLV-1" rover, and Lunar Outpost $220 million for its "Pegasus" rover, building upon initial contracts awarded two years ago. Each rover is expected to have a range of 200 km and be capable of driving autonomously, with guidance from operators on Earth, in addition to being driven by astronauts.
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