A new study reveals that an extremely small change in a non-coding region of DNA can dramatically alter how sex develops in mice. How much can a single letter of DNA matter? According to new research from Bar-Ilan University, one misplaced genetic “letter” can completely change the course of sexual development. In a study published [...]
Scientists have discovered a new spider species in Ecuador’s Amazon rainforest that uses an unprecedented form of mimicry. Deep in Ecuador’s Amazon rainforest, researchers encountered what appeared to be an ordinary mushroom clinging to the underside of a leaf. On closer inspection, however, the strange growth revealed itself to be something far more unexpected: a [...]
Scientists from ETH Zurich in Switzerland have announced a series of successful experiments involving the repair of injured spinal cords in zebrafish and mice after being injected with magnetically controlled microrobots containing pluripotent stem cells.
According to a statement announcing the ETH team’s work, both the zebrafish and mice injected with the microrobots showed improved movement and normalized exploratory behavior within just a few days after treatment.
Although the initial studies were confined to lab animals, the team hopes their magnetically controlled microrobot approach to the precision delivery of pluripotent stem cells could eventually be adapted for humans with spinal cord injuries.
Unlike some cells in the human body, nerve cells within the spinal cord rarely regenerate on their own. If the spinal cord is injured, scarring can further reduce the ability of the nerve fibers within the cord to regrow. For people living with spinal cord injuries, this scenario can offer a bleak prognosis for recovery.
In recent decades, scientists have turned to the natural regenerative properties of pluripotent stem cells. Although the use of stem cells was initially controversial due to the need to extract neonatal stem cells, scientists ultimately learned to convert ordinary stem cells into pluripotent stem cells capable of becoming any cell type in the human body.
The most promising approach involves implanting stem cells at the site of the injury and then using electrical stimulation to promote the growth of new cells. However, according to the ETH team behind the new approach, the current method has several drawbacks.
First, stimulating the cells requires the use of implanted electrodes. Second, the team notes that after transplantation, many of the stem cells “do not always survive or integrate properly into the existing tissue.”
To improve healing and increase the chance of restoring spinal cord nerve cell function, they said their new approach combines therapeutic stem cells with magnetoelectric nanoparticles and uses magnetic fields to guide them to the “precise site of an injury” and “stimulate the stem cells to accelerate repair.”
To construct their magnetically guided spinal cord repairing robot, the team built what they termed a “biohybrid microrobot.”
First, the team creates pluripotent stem cells from adult cells by genetically manipulating them in the lab. The result is what researchers call an “induced” pluripotent stem cell (iPS). According to the study authors, these newly pluripotent iPS cells are used to derive living neural progenitor cells (NPCs), meaning “they have the potential to differentiate into various types of nervous system cells.”
Next, the team creates customized magnetic nanoparticles consisting of two layers. The inner layer responds to the “commands” from the magnetic fields used to control them, and an outer layer that converts this response into an electrical signal.
According to Professor Salvador Pané i Vidal of the Multi-Scale Robotics Lab at ETH Zurich, each tiny robot has a reservoir near the center “where we trap the cells.” The professor said the best way to accomplish this is to inject the nanoparticles into a solution with the NPC, “and wait for the two components to bind.”
After 30 minutes, the process is complete, and the team is left with a batch of nanobots, each around 6 micrometers in size. Since the new robots combine a magnetic bot and a reservoir of NPCs, the team named them ‘NPCbots.’
In preparatory cellular experiments, the researchers used hundreds of thousands of NPCbots. However, several million were required for animal trials.
To test the efficacy of their new NPCbots, the ETH team injected millions of them into the spinal cord of zebrafish larvae with spinal cord injuries. To improve the chances of nerve regeneration, the NPCbots were injected directly into the site of the injury.
After injecting the microrobots, the injury site was subjected to electromagnetic fields. Although the repair was not immediately evident, the team noted that after three days, the zebrafish with the injured spinal cords “exhibited nearly normal swimming and exploratory behaviour.”
Next, the team injected millions of NPCbots into mice with completely separated spinal cords. According to the team, the results were “very promising.”
“After 28 days, the animals’ nerve cells had reconnected at the site of the injury,” they explained.
The team said further observation of the treated mice revealed “increasingly normal movement patterns,” including improvements in gait, stride length, and coordination. The ETH team also noted that the mice’s exploratory behavior “improved significantly.”
When discussing the mouse experiments, the team described the result as “particularly significant” because zebrafish spinal cords regenerate, whereas mouse spinal cords do not. They also noted that the treatment was “well tolerated by the animals,” with no reported immune reactions or adverse effects.
Unlike science fiction movies, where tiny robots repair tissue mechanically, the research team said that the stem cells carried by the NPCbots are exposed to electrical stimulation, “greatly enhancing their differentiation after transplantation.” This means the nanoparticles convert the electric signals from the EM field into electrical impulses, stimulating healing.
Unlike more complicated stem cell procedures that use implanted electrodes and cables, the team said they only needed to apply external magnetic fields around the spinal cord injury site. The team said this simplification was “crucial,” since the spinal cord is considered extremely sensitive. They also note that the ability to manipulate the frequency and field strength of magnetic fields, combined with their ability to penetrate deeply into tissue, makes the entire process safe and easy to control.
“Microrobotic guidance makes the treatment more precise and minimally invasive,” Hao explained.
After the NPC bots have delivered and stimulated the stem cells, the team said they “essentially dissolve” within the tissue. Because the bots contain a barium titanate coating, the researchers also believe that they will be “stable and minimally reactive” with surrounding tissue. Still, they concede that “further studies will determine whether and how the particles are degraded or excreted over the long term.”
Although the team described the animal trials of their NPCbots as “promising,” they noted that further research is needed before the process can be attempted on human patients with spinal cord injuries. For example, Hao noted that in addition to ‘clinical aspects’ that require more exploration, the team needs to start by determining which magnetic fields “work best in humans” and determining the “optimal stimulation duration” for human NPCs. Nevertheless, the team noted, they are “already considering further applications.”
“The reproducible and scalable production of microrobots using our lab-on-a-chip system demonstrates that the platform’s application potential extends beyond basic research,” Professor Vidal explained.
Some potential biomedical applications mentioned by the RETH team include cardiology, oncology, wound healing, “and other targeted therapies,” adding that their process could make such treatments “safer, more controllable and more effective.”
The study “Magnetoelectric Microrobots for Spinal Cord Injury Regeneration” was published in Nature Materials.
Christopher Plain is a Science Fiction and Fantasy novelist and Head Science Writer at The Debrief. Follow and connect with him on X, learn about his books at plainfiction.com, or email him directly at christopher@thedebrief.org.
Editor’s Note: Astrobites is a graduate-student-run organization that digests astrophysical literature for undergraduate students. As part of the partnership between the AAS and astrobites, we occasionally repost astrobites content here at AAS Nova. We hope you enjoy this post from astrobites; the original can be viewed at astrobites.org.
Title: Retrieving the Red Edge on Earth-Like Planets with Heterogeneous Clouds and Surfaces
Authors: Zachary Burr et al.
First Author’s Institution: Jet Propulsion Laboratory; ETH Zurich
Status: Published in ApJ
In the next 25 years, astronomers could find signs of life on other planets with the launch of the Habitable Worlds Observatory. Atmospheric signs of life, known as atmospheric biosignatures, are how astronomers currently search for life on other planets. Figure 1 shows examples of atmospheric biosignatures with pictures of each chemical’s origin on Earth. Before E.T. can phone home, though, we have to understand what chemicals make up a planet’s atmosphere. To do this, astronomers can use spectroscopy to observe a planet’s atmosphere in different wavelengths and measure the types and quantities of chemicals present.
Figure 1: Atmospheric biosignatures present in Earth’s atmosphere. More abundant biosignatures include oxygen and ozone (byproducts of photosynthesis in plants and bacteria) and nitrous oxide (byproduct of bacteria that don’t need oxygen to survive). Less abundant biosignatures include isoprene (released from the breakdown of leaves that have fallen from trees) and sulfur gases (byproducts of cyanobacteria). [Kaz Gary]
But are atmospheric biosignatures the only way to tell if life exists on other planets? Short answer: absolutely not. Let’s take Earth as an example. If we imagine Earth as a directly imaged exoplanet and take spectra of the light it reflects, you’ll find that around near-infrared wavelengths (~700 nanometers or just past the red part of the visible light spectrum), the light reflected off of Earth increases sharply. This sharp increase is called the vegetation red edge and is caused by plant and ocean life on Earth’s surface as shown in Figure 2. This is made possible because chlorophyll (the thing that makes plants green) absorbs nearly all visible light but reflects near-infrared light. The vegetation red edge is an example of a surface biosignature. In today’s article, the authors determine if the vegetation red edge will be visible in spectra of Earth-like exoplanets!
Figure 2: Spectra of different sources of the vegetation red edge on Earth. The vegetation red edge is highlighted in gray where the spectra rapidly increase and then level off beyond the visible light part of the spectrum. Each color represents a different source with pictures of each source on the right-hand side of the plot. [O’Malley-James and Kaltenegger 2019]
Planets rotate; that’s how we have morning, noon, and night in 24 hours guaranteed. This means that different parts of the surface will be visible at different times when we take spectra. Sometimes, we may see more ocean than land, other times not. To determine if the vegetation red edge would be visible at all points in Earth’s day, the authors simulated nine different spectra of modern-day Earth representing nine snapshots of Earth’s rotation. Additionally, they also simulated a time-averaged spectrum that shows an entire Earth day in one snapshot without the time variability. These spectra are shown in Figure 3.
Figure 3: Spectra of a directly imaged modern-day Earth at nine different times in its rotation. The y-axis is the ratio of the planet’s signal to the star’s signal and the x-axis is wavelength in microns. Each color represents a time in UTC and the black curve represents the time-averaged spectrum. [Burr et al. 2026]
After running the models, the authors were able to detect a sharp increase in the surface albedo value in every spectrum, including the time-averaged one. This result is shown in Figure 4. The authors take this result one step further in order to validate that the vegetation red edge is actually a result of surface variation of vegetation. They re-run models on each of their spectra but instead include a constant surface albedo instead of a time-varying one. This resulted in incorrectly measured radii, chemicals, and surface gravity in nearly all of the models. Without the vegetation red edge and surface features, the models could not accurately determine if life was present on Earth.
Figure 4: Retrieved surface albedos for the nine time-varying spectra. The surface albedo is broken down into three different values (a₁, a₂, a₃). Each of these values represents a change in the surface albedo at different wavelengths (i.e., how reflective the surface is at three different wavelengths). The nine spectra were broken down by the amount of surface that was visible at that time and color-coded for each category. The time-averaged spectrum is shown in gray. Each category of spectra was able to retrieve an increase in reflected light from the surface at vegetation red edge wavelengths. The spectra that had the majority land visible have the biggest increase in the surface albedo. This makes sense since the amount of visible vegetation is the largest with majority-land planets. [Burr et al. 2026]
Original astrobite edited by Madison VanWyngarden.
About the author, Kaz Gary:
I am a fourth-year PhD candidate at The Ohio State University with a passion for planets. My current work focuses on modeling exoplanet observations for the Habitable Worlds Observatory and understanding planetary atmospheres. Outside of research, I help develop planetarium shows and love all forms of science communication. In my free time, I enjoy playing tabletop RPGs, painting, watching terrible reality TV, and hanging out with my pet hedgehog.
The post Life on the (Red) Edge appeared first on AAS Nova.
Editor’s Note: Astrobites is a graduate-student-run organization that digests astrophysical literature for undergraduate students. As part of the partnership between the AAS and astrobites, we occasionally repost astrobites content here at AAS Nova. We hope you enjoy this post from astrobites; the original can be viewed at astrobites.org.
Title: Clouds Can Enhance Direct-Imaging Detection of O2 and O3 on Terrestrial Exoplanets
Authors: Huanzhou Yang, Michelle Hu, and Dorian S. Abbot
First Author’s Institution: University of Chicago
Status: Published in ApJ
In the hunt for life beyond Earth, studying exoplanet atmospheres is one of our most powerful tools. The atmosphere of an exoplanet acts as a window into its environment and allows astronomers to take a guess at what processes are shaping the planet’s climate, chemistry, and thus, its potential for habitability. The gases present in the planet’s atmosphere impart a unique spectral fingerprint on the light that passes through the atmosphere and allows us to identify what gases might be present and look for possible signs of life.
JWST is already hard at work looking at distant worlds and gathering spectroscopic data for us to analyse. It has already observed several exoplanets and recorded the light that passed through their atmospheres. This has not only sparked a debate over what could be interpreted as the first possible signs of biological activity, but has also given us a glimpse of worlds that are remarkably different from our own.
However, JWST is mostly limited to observing the atmospheres of transiting exoplanets. That means planets that orbit close to their host star and are more or less directly edge-on, as viewed from us, so that they transit across the face of the star. The only planets that the telescope is able to observe directly are big, young, and hot planets farther from their host star, at distances more resembling those of the outer planets in our solar system, like Saturn or Uranus. If only we had a telescope powerful enough to image a potentially habitable planet directly and analyse the light reflected from it.
This is where the Habitable Worlds Observatory (HWO) will come in. Now, I know what you are thinking. Why must astronomers always look towards greener pastures bigger telescopes when we already have perfectly functional space telescopes in orbit or practically on the launch pad? Well, it is true that the next flagship space telescope from NASA, the Nancy Grace Roman Space Telescope, is designed to directly image exoplanets and analyse their atmospheres. But space telescopes can take decades to plan and are often built on lessons learned from previous missions. Roman, with its 2.4-meter primary mirror and coronagraph, will be able to observe planets similar in size and orbital distance to Jupiter and will get us some of the way, for sure, but not all the way. At three times the mirror size, HWO, NASA’s proposed successor to Roman that is planned for the 2040s, will carry the torch even further and be able to directly image Earth-like planets in the habitable zone, where liquid water can exist on the planet’s surface.
This brings us to today’s article. If the HWO is going to potentially observe Earth analogues, we might expect it to run into the same issue that plagues everyone living in the UK for most of the year — clouds. Clouds in the atmosphere of an exoplanet can sometimes cause trouble when trying to analyse the light. Cloud particles scatter different wavelengths of light differently, and cloud variability creates dynamic changes in the observed brightness that can make it hard to know what exactly you are looking at. Clouds can also mean varying levels of opacity to look through depending on cloud composition, and they can hide underlying atmospheric properties such as water content beneath a thick cloud layer. For transmission spectroscopy, even a thin layer of clouds can disrupt the measurements as the light has to travel a long distance through the atmosphere. However, for direct imaging, the effect of clouds is perhaps more nuanced. While a thick cloud deck will block the signal from whatever gas lies beneath it, it will also increase the overall albedo of the planet and make it easier to detect the gas above. This means that cloud height and type are both critical variables in understanding atmospheric properties of exoplanets, which is what the authors of today’s article set out to investigate.
To understand how clouds affect the ability to detect signs of life on distant Earth-like planets, the authors used computer simulations. They focused on two gases, molecular oxygen (O2) and ozone (O3). Both gases are often regarded as biosignatures, although their astrobiological significance has been debated. The authors first used a tool that simulates how a telescope like the HWO might observe an Earth-like planet around a star 15 parsecs away. This tool predicts how light bounces off a planet’s surface and atmosphere, and whether the two gases would show up clearly in the reflected light. Next, they created realistic cloud conditions using a cloud microphysics model. This model calculates how clouds might form and behave depending on factors like surface pressure or how much sunlight the planet gets. With this they were able to change things like cloud height and particle size. They then combined the two tools by adding the simulated clouds into the observations model and building a mathematical model to help explain what they saw in the simulations. The sketch for their model can be seen in Figure 1.
Figure 1: Clouds can affect the amount of reflected light (albedo) from the imaged planet. Depending on the cloud height and particle size, this can have a big impact on the observability of different species of gas in the atmosphere. Here the blue arrows indicate the amount of light entering the atmosphere and being reflected. The arrows get thinner from tail to head, representing absorption in the atmosphere. Depending on the presence of clouds, a varying amount is reflected back. The red colour indicates the assumed distribution of ozone, O3, which is concentrated at a high altitude. [Yang et al. 2025]
The researchers discovered that low clouds can actually make gases like oxygen and ozone easier to detect, because these clouds reflect more light without blocking the gases above them. On the other hand, high clouds can make it harder since they can hide the gases from view. They tested different cloud types using real data from Earth as seen in Figure 2. They looked at five common cloud types, like stratus (flat and low), cirrus (high and wispy), and deep convective clouds (tall, thunderstorm-like), and compared them to their model clouds (labelled as CARMA in the figure).
Figure 2: The figure shows how different types of clouds affect our ability to detect oxygen (blue) and ozone (red) on an Earth-like planet. The dashed lines show the results without clouds, while the bars show what happens when clouds are present. Solid bars represent larger cloud droplets, and striped bars represent smaller ones, which reflect more light. The figure shows that most cloud types — especially low clouds like stratus and thick storm clouds — actually make it easier to detect these gases, particularly when droplets are small. Only high, thin clouds (cirrus) slightly reduce oxygen detection, and even then, the effect is small. This is the article’s main finding: while clouds can block light in some observation methods, for direct imaging of reflected light, they often help us see signs of life better. The cloud types are based on real Earth data while the authors’ simulated cloud model is labelled as CARMA. [Yang et al. 2025]
Original astrobite edited by Maria Vincent.
About the author, Kasper Zoellner:
I have a Master of Science in astronomy and I am currently working towards a PhD in physics and educational science. My greatest passion is the search for exoplanets and how stellar variability may influence the possibility of life. I am also interested in science outreach, education, and discussing what sci-fi novel to read next!
The post Weather Forecast for the Habitable Worlds Observatory: Cloudy with a Chance of Biosignatures appeared first on AAS Nova.
Editor’s Note: Astrobites is a graduate-student-run organization that digests astrophysical literature for undergraduate students. As part of the partnership between the AAS and astrobites, we occasionally repost astrobites content here at AAS Nova. We hope you enjoy this post from astrobites; the original can be viewed at astrobites.org.
Title: Impacts on Ocean Worlds Are Sufficiently Frequent and Energetic to Be of Astrobiological Importance
Authors: Shannon M. MacKenzie et al.
First Author’s Institution: Johns Hopkins University Applied Physics Laboratory
Status: Published in PSJ
Asteroids and meteorites are usually associated with doom and destruction (rest easy, dinosaurs), but they may have also been essential for the emergence of life on Earth. It is popularly theorized that some of the base building blocks of life, like volatiles and organics, were delivered here by meteorites and that the energy of these impacts synthesized even more, like HCN and amino acids. Expectedly, the same should be true for other planets. Today’s article explores this possibility using nearby analogies for potentially habitable exoplanets: our solar system’s ocean worlds.
The solar system formed from one massive cloud of gas and dust, so the composition everywhere is approximately the same. However, early Earth was an extremely hot ball of magma that destroyed its organic matter. Luckily, organics were able to survive in objects like meteorites in the cold outskirts of the solar system.
In the search for extraterrestrial life, we start by looking for the basic necessities — and water is a big one. Though Earth is the only planet in our solar system with liquid water, several moons of Jupiter and Saturn have it as well. These moons are beyond the balmy habitable zone, so their surfaces are covered in icy crusts, but beneath those crusts are subsurface oceans of liquid water, making these moons “ocean worlds” (see Figure 1). On their own, the presence of water makes these moons astrobiologically interesting, and they will also elucidate ocean worlds that are further away.
Figure 1: Saturn’s moon Enceladus with a liquid water ocean beneath the icy crust. Jets on the surface are strong indicators of hydrothermal vents on the ocean floor. [JPL]
To evaluate survivability, the authors modeled the maximum pressure of an impact on an ocean world’s ice crust for a range of impact velocities and angles. Around Jupiter and Saturn, most impactors are either icy or rocky objects that originate from the Kuiper Belt or Oort cloud, so the authors modeled both types of impactors. Rocky impactors create higher pressures (shown in gray in Figure 2) than icy impactors (shown in black in Figure 2). From the sizes of observed craters on the ocean world moons, previous works determined the velocities and pressures of impacts, which are shown by the colored boxes in Figure 2. Finally, a number of other works have estimated the ranges of survivable pressures for biota and biologically important molecules, which are shown by the green and black bars on the right of Figure 2. Impressively, the survivable pressure ranges are within the observed and modeled pressures of impacts! So these life building blocks can be, and likely have been, deposited on the ocean world moons.
Figure 2: The modeled impact velocities and maximum pressures for icy (black) and rocky (gray) impactors. Survivable pressures of various organics (green and gray colored bars on the y-axis) are within the range of observed velocities and pressures from craters on each ocean world moon (colored boxes). [MacKenzie et al. 2024]
When an impactor hits the icy crust, some of the ice will melt. The deposited organics will end up in a pool of liquid water in the crater, which is an ample environment for prebiotic chemistry until the pool freezes. From the observed crater sizes and modeled velocities, the authors estimated how much liquid water could remain in a crater and how long it would take to freeze. Freeze times ranged from a few Earth years for the smallest craters (<4 kilometers in diameter) to thousands of years for the largest craters (hundreds of kilometers). In labs on Earth mimicking the crater conditions, amino acids have been synthesized in as short as a few months to a few years, so synthesis is possible in the melt pools.
The pools eventually freeze, trapping any deposited or synthesized material on the icy surface. Other processes, like future impacts, are required to break through the icy crust and transport material to the subsurface oceans where theorized hydrothermal vents could allow more complex development.
In summary, survivable impacts on the ocean world moons are common, and each provides an opportunity for prebiotic chemistry to arise. Unlike most objects astronomers study, the proximity of these ocean worlds means that we can thoroughly understand them through physical samples. NASA’s Cassini detected organic compounds in the plumes that burst off the surface of Enceladus, and the Dragonfly mission is set to head for Titan in 2028 to collect and analyze samples once it arrives in 2034. In the coming decades, we may witness the discovery of more precursors to life or microbial life itself in the subsurface oceans of moons in our solar system, and gain radical insight into the ocean worlds beyond.
Original astrobite edited by Sonja Panjkov.
About the author, Annelia Anderson:
I’m an Astrophysics PhD candidate at the University of Alabama, using simulations to study the circumgalactic medium. Beyond research, I’m interested in historical astronomy, and hope to someday write astronomy children’s books. Beyond astronomy, I enjoy making music, cooking, and my cat.
The post Seeding Life in the Oceans of Moons appeared first on AAS Nova.
Scientists have uncovered the genetic secrets behind a novel energy-use strategy that allows a deep-sea “giant” to survive without food for over five years, in one of nature’s most stunning survival stories.
Supergiant bathynomids, also known as giant isopods, present a bizarre biological paradox: they exhibit pronounced body gigantism as megafaunal species yet inhabit a deep-sea habitat with extremely sparse nutrient availability.
In a recent paper in Cell, researchers from the Institute of Oceanology of the Chinese Academy of Sciences (IOCAS) revealed how these large deep-sea creatures subsist on such limited food, using a novel genetic strategy unique to bathynomids.
The IOCAS team employed a multi-omic strategy to address the problem, combining genomics with other disciplines, such as morphology, physiology, behaviorology, and metagenomics. Doing so led to a novel discovery: that supergiant bathynomids don’t have just one, but two techniques to manage their limited access to nutrients.
First, isopods have a massive stomach that can store vast amounts of nutrients for later use. Second, they have an exceptionally low basal metabolic rate (BMR), which is genetically driven.
To diversify their research, the team focused on two species that occupy different depths. At around 300 meters, the Bathynomus doederleini is the shallower of the two, while the Bathynomus jamesi is found at 898 meters. Despite the difference in depth, both are technically considered “deep-sea” inhabitants, as the boundary is defined at 200 meters.
Roughly two-thirds of a bathynomid’s body is stomach—a figure far beyond that of related intertidal and shallow water species. The contents of those enormous stomachs are also unusual, filled with a mud-like mixture of highly digested food. This finely ground nutrient sludge has a low proportion of digestive bacteria, but a high amount of lipid-storing Chlamydiae.
With a bacterial ratio leaning toward preservation rather than just digestion, this creates a food reserve that can be slowly digested and utilized as the creatures lower their BMR to endure long periods between feedings.
Another major finding was that bathynomids benefit not only from vertically transferred genes between parents and offspring, but from the horizontally transferred ND1 gene they acquired from an exogenous symbiotic bacterium. Intriguingly, the transfer defied typical horizontal transfer limitations, achieving an ultra-high level of expression in the bathynomid genome.
These isopods use epigenetic histone modifications to regulate energy-related gene expression, thereby improving efficiency, conservation, and control. An example of this is histone acetylation regulating ND1 expression at an ultra-high level, which the team investigated in a laboratory test. Researchers suspected this gene was essential to energy metabolism, as it is a component of Complex I in the electron transport chain.
Using zebrafish, nematodes, and human 293T cells, the IOCAS team tested the gene’s impact on energy usage. At normal temperatures, the team found that ND1 actually decreased starvation tolerance by increasing energy metabolism. Yet when the team lowered temperatures to reflect those found in a typical deep sea environment, they found the opposite effect, with ND1 decreasing mitochondrial activity and energy metabolism rates, to improve zebrafish starvation tolerance an astounding 37%.
The IOCAS team concluded that ND1 provides a solution to the long-standing paradox of bathynomid gigantism in the context of their nutrient-poor environment. By fine-tuning the degree of metabolic depression, the gene can adjust the mitochondrial metabolic network to preserve energy during extended periods without sustenance.
Never before has such a strategy for energy efficiency, combining horizontal gene transfer and epigenetic optimization, been identified in a deep-sea megafaunal species.
“Our work not only deciphers the mystery of ultra-long starvation tolerance in deep-sea isopods,” said lead author Yuan Jianbo, “but also provides an important paradigm for understanding how life balances growth and survival in extreme environments.”
The paper, “Deep-Sea Megafauna Co-Opts Microbial Energy Metabolism Genes to Withstand Ultra-Long Starvation,” appeared in Cell on June 5, 2026.
Ryan Whalen covers science and technology for The Debrief. He holds an MA in History and a Master of Library and Information Science with a certificate in Data Science. He can be contacted at ryan@thedebrief.org, and follow him on Twitter @mdntwvlf.
Deep in the mountains of northern Taiwan, a towering Taiwania cryptomerioides -- a large coniferous tree in the cypress family Cupressaceae whose ancestors date back 100 million years -- has been confirmed as the tallest known tree in East Asia.
The post After Decade-Long Hunt, Scientists Find East Asia’s Tallest Tree appeared first on Sci.News: Breaking Science News.
Scientists found that aging may begin with a hidden cellular remodel that could help drive disease later in life. Thanks to advances in public health, people are living longer than ever before. However, many of those extra years are accompanied by chronic illnesses rather than good health. Aging is a normal part of life, but [...]
Scientists discovered a hidden gut-brain network that can change cravings when the body needs more protein. The body has a remarkable ability to recognize when it is missing important nutrients and adjust behavior accordingly. New research shows that the gut plays a much larger role in this process than previously understood, actively detecting protein shortages [...]
It's just crazy enough to work.
A gene normally responsible for repairing DNA may have a darker side when produced in excess. Cancer treatment is increasingly moving beyond where a tumor forms and focusing instead on the genetic flaws that drive it. Now, researchers at Penn State College of Medicine have identified an unexpected DNA repair gene that could help expand [...]
I t was the dead of winter in Boston. The surface of the Charles River was frozen solid. But Zachary Kelso braved the biting cold to finally put to rest a mystery that has haunted neuroscience labs for over half a century. To do that, Kelso, a research assistant in the Harvard lab of the neuroscientist Sam Gershman, needed some worms. Specifically, planarians: arrow-headed flatworms…
New DNA evidence reveals bed bugs tracked human expansion from ancient caves to modern cities.
Scientists have uncovered evidence that tiny microbes living inside fish may be helping shape the chemistry of the world’s oceans. The new study, led by former graduate student Anthony Bonacolta at the University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science, suggests that bacteria in fish intestines may work together with their hosts [...]
Despite having tiny brains, bumblebees have demonstrated a remarkable ability to socially learn how to use tools, solve simple puzzles, and cooperate to achieve a goal. It seems they can also solve object-manipulation tasks without any previous training, according to a new paper published in the journal Science. According to the authors, it's the first time this kind of spontaneous problem-solving has been demonstrated in an insect.
In 2024, Olli Loukola of the University of Finland co-authored a study demonstrating that bumblebees could cooperate to solve complex challenges. It's the kind of cognitive task scientists had previously only observed in large-brained mammals like humans and chimpanzees. Loukola et al. trained pairs of bees to push a Lego block to the middle of a mini-arena or push against a door at the end of a tunnel to get a reward.
The team noticed that the bees were more likely to engage in the tasks if their partners also participated, compared to untrained control groups. They concluded that bees can learn to solve novel cooperative tasks outside the hive and may even be intentionally working together, although the researchers cautioned that more detailed monitoring of the behavior was needed to fully understand the partners' roles.
© Mikko Törmänen
PFDA, a PFAS “forever chemical,” can cause craniofacial birth defects by disrupting retinoic acid regulation during fetal development, revealing the first clear molecular mechanism behind the link. Researchers have long linked perfluoroalkyl and polyfluoroalkyl substances (PFAS), often called “forever chemicals,” to serious birth defects. However, scientists have struggled to explain exactly how these pollutants affect [...]
A newly identified pest is raising concerns for North Carolina’s blueberry industry. What began as a mystery beneath North Carolina’s blueberry fields has now been traced to a surprising culprit: a giant root-feeding beetle never before confirmed attacking blueberries anywhere else in the United States. Researchers at North Carolina State University have identified the insect [...]
Brown rot is a common fungal disease in the Southeastern United States that affects stone fruits like peaches, cherries, and plums. Monilinia fructicola is a tan, fuzzy fungus that grows on tree flowers, twigs, and fruit, and is the most common cause of brown rot. Once brown rot infects a tree, the damage is irreversible, causing significant crop losses in commercial orchards. Farmers try to control the spread of M. fructicola by applying chemical sprays, called fungicides, to fruit trees in the spring.
In M. fructicola, a biosynthesis gene named MfCYP51 encodes a major protein critical to the fungi’s survival. Certain fungicides, called demethylation inhibitor (DMI) fungicides, stop M. fructicola from growing by targeting this protein. Over the last 20 years, DMI fungicides have become less effective against brown rot as M. fructicola becomes more resistant.
Living microorganisms and their metabolites can control fungal diseases as an alternative to chemical fungicides, known as biofungicides. Many bacteria produce compounds like hydrogen cyanide and pyrrolnitrin that damage fungal cells. However, scientists have not found a biofungicide suitable for commercial production. A group of researchers at Clemson University in the USA and Huazhong Agricultural University in China set out to test whether the soil bacteria Pseudomonas chlororaphis and Bacillus subtilis could be effective biofungicides against brown rot.
The researchers performed an incubation experiment to analyze how the fungal cells make their critical protein from the MfCYP51 gene, a process called gene expression, under different fungicide treatments. They used 3 M. fructicola strains sensitive to traditional DMI fungicides and 3 resistant strains. They tested these with 5 different fungicide treatments: a DMI fungicide, a mixture of P. chlororaphis metabolites, a mixture of living B. subtilis cells, a DMI fungicide + P. chlororaphis metabolites, and a DMI fungicide + B. subtilis cells. They also set up a control treatment with sterile water instead of fungicide.
After 6 hours, the researchers extracted the molecule that measures gene expression, called RNA, from the fungi. They found that both the P. chlororaphis treatment and the DMI fungicide + P. chlororaphis treatment substantially reduced MfCYP51 expression in both the sensitive and resistant isolates compared to the controls. In contrast, the DMI fungicide, B. subtilis, and DMI fungicide + B. subtilis treatments increased MfCYP51 expression in the resistant isolates. The researchers concluded that P. chlororaphis has a unique ability to reduce gene expression, unlike other biofungicides.
To further investigate how the biofungicide treatments work, the team tested whether P. chlororaphis and B. subtilis produced the anti-fungal metabolite pyrrolnitrin. They added 1 milliliter of each treatment to a machine that separates and identifies liquid compounds using high pressure, called a high-performance liquid chromatograph. They found that the P. chlororaphis treatment contained pyrrolnitrin, so they hypothesized that it was responsible for reducing gene expression.
Additionally, the researchers tested their 5 treatments on brown rot in fruit. For each treatment, they took 10 Gala apples, washed and sterilized their surfaces, and sprayed them with the fungicides. After 24 hours, they poked holes in the apples with toothpicks and added 20 microliters of liquid containing M. fructicola cells to the poked holes. They placed the apples in a humid chamber for 5 days and measured the number and size of brown rot spots that developed on their surfaces.
Despite decreasing MfCYP51 expression, the researchers found that P. chlororaphis treatment alone didn’t reduce brown rot disease compared to the control, but the DMI fungicide and B. subtilis treatments did. The mixed treatments of DMI fungicide + P. chlororaphis and DMI fungicide + B. subtilis both reduced brown rot disease compared to the control, but only the DMI fungicide + P. chlororaphis treatment prevented it.
The researchers concluded that although biofungicides may not be fully effective on their own, commercializing them could allow farmers to use less DMI fungicide. They explained that scaling back the use of DMI fungicides would slow M. fructicola resistance. Finally, they proposed that future researchers test biofungicide mixtures containing pyrrolnitrin in the field to observe real-world effects on stone fruit trees.
The post Using bacteria to fight fungal brown rot appeared first on Sciworthy.
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