The viruses that gave rise to SARS-CoV-2 have been circulating in horseshoe bats and related mammals across Asia for millennia, and most of them have never spilled over into people. Yet a small number of these bat sarbecoviruses clearly can infect humans, as the COVID-19 pandemic demonstrated. A central question for pandemic preparedness has therefore been whether scientists can look at the properties of a newly discovered bat coronavirus and make an evidence-based judgement about how dangerous it might be. A new study published in PLOS Biology suggests that one measurable property, the breadth of species whose ACE2 receptor a virus can use, may be a surprisingly informative signal, predicting not only which animals a virus can infect but also how closely related it is to SARS-CoV-2 in the eyes of the human immune system.

Sarbecoviruses, the subgenus of coronaviruses that includes SARS-CoV and SARS-CoV-2, attach to their host cells through the receptor-binding domain, or RBD, of the Spike protein. This domain grips the angiotensin-converting enzyme 2 receptor, ACE2, on the surface of host cells, and it is also the principal target of neutralising antibodies. That dual role creates an intimate link between host range and antigenicity: the same molecular surface that determines which species’ receptors a virus can engage also determines how well antibodies raised against one virus recognise another. The research team, led by scientists at The Pirbright Institute together with collaborators including researchers at King’s College London, set out to map that relationship systematically across a diverse collection of bat sarbecoviruses.

The experimental strategy combined three complementary approaches. First, the researchers used binding assays to test whether the Spike proteins of different sarbecoviruses could attach to ACE2 proteins from a wide panel of mammalian species. Second, they used pseudotype-entry assays, in which harmless lentiviral particles are decorated with each coronavirus Spike protein, to test whether receptor binding actually translates into cell entry. Third, they measured how sera from SARS-CoV-2 convalescent individuals and monoclonal antibodies from vaccinated people who had experienced breakthrough infections neutralised the different viruses. By running the same viruses through all three assays, the team could directly correlate receptor usage with antigenic behaviour.

The results revealed a striking pattern. Sarbecoviruses in clade 1, the group that contains SARS-CoV-2 itself and the BANAL viruses isolated from bats in Laos, tended to be generalists. Their Spike proteins could productively engage ACE2 receptors from many different bat species, indicating that they are not finely tuned to a single host. In contrast, viruses from clade 3, exemplified by RhGB07, and clade 5, exemplified by Rc-o319, behaved as specialists, using a much narrower range of ACE2 receptors. Rc-o319, which was previously known to be unable to use human ACE2 efficiently, fits this specialist profile, whereas the BANAL viruses, which can use human ACE2, sit firmly in the generalist camp alongside SARS-CoV-2.

To understand the structural basis of this specialism, the team solved a novel structure of the RhGB07 Spike protein. The structure allowed them to identify specific residues within the RBD that are associated with the restricted receptor usage of this clade 3 virus. These residues presumably shape the receptor-binding interface in ways that favour particular bat ACE2 variants while excluding others. Such structural insights are valuable because they point to the molecular features that distinguish viruses capable of flexible receptor engagement from those locked into narrow host ranges, and they may help predict the properties of newly discovered sarbecoviruses from sequence data alone.

When the researchers extended their receptor panel beyond bats to include more diverse mammalian ACE2 proteins, the generalist phenotype largely held. Clade 1 viruses could bind and enter cells expressing ACE2 from humans, non-human primates, livestock, and rodents, as well as from species considered potential intermediate reservoir hosts, such as civets, raccoon dogs, and pangolins. This is significant because intermediate hosts are thought to have played a role in previous coronavirus spillovers, including the emergence of SARS-CoV in 2002. A virus that can already use the receptors of many species faces fewer barriers on the path from bat to human. The specialist viruses, by contrast, showed wider phenotypic diversity across this expanded panel, with RhGB07 exhibiting a more idiosyncratic pattern of receptor usage that did not simply mirror its bat-host profile.

The study also examined how SARS-CoV-2’s ongoing evolution in humans has changed its receptor preferences. Comparing variants that have emerged during the pandemic, the researchers found an expanding and, in some cases, shifting pattern of generalism, particularly for Omicron and its many sub-lineages. Omicron’s Spike has accumulated numerous mutations in the RBD, and these changes appear to have broadened or reconfigured the range of ACE2 molecules the virus can engage. This observation underscores that receptor usage is not a fixed property of a virus but a dynamic trait that can evolve under immune pressure and changing transmission landscapes, with potential consequences for which animal species might serve as new reservoirs for human-derived variants.

The antigenic side of the analysis produced equally important findings. When convalescent sera from people who had recovered from COVID-19 were tested against the panel of bat sarbecoviruses, clade 1 viruses, being phylogenetically closest to SARS-CoV-2, were antigenically the most similar. There was robust evidence for cross-neutralisation of these viruses, meaning that immunity generated against SARS-CoV-2 offers meaningful protection against its closest bat relatives. Importantly, however, the team also found evidence for limited cross-neutralisation across the entire subgenus, suggesting that even the more distantly related specialist viruses are not completely invisible to immunity primed by SARS-CoV-2 infection. This graded pattern of cross-reactivity maps closely onto the phylogenetic and receptor-usage relationships the researchers had established.

Using monoclonal antibodies derived from COVID-19 vaccinees who subsequently experienced breakthrough infections, the researchers were able to pinpoint which classes of antibody epitopes are responsible for the broader neutralisation observed across the sarbecovirus panel. Because antibodies recognise specific structural features of the RBD, identifying the epitope classes that mediate cross-neutralisation provides a rational basis for designing vaccines and therapeutics with deliberately broad coverage. Antibodies directed against more conserved features of the receptor-binding interface, rather than those specific to SARS-CoV-2’s particular configuration, appear to underpin the wider neutralising activity.

Taken together, the study delivers a unifying message: generalist ACE2 usage, phylogenetic proximity to SARS-CoV-2, and antigenic similarity travel together. A bat sarbecovirus that can flexibly use receptors from many mammalian species is likely to be a close relative of SARS-CoV-2 and likely to be partially neutralised by existing human immunity. This constellation of traits offers surveillance teams a practical framework for triage. When a new sarbecovirus is discovered, characterising its receptor-binding breadth through binding and pseudotype assays could provide an early, laboratory-based assessment of both its zoonotic potential and the degree to which current vaccines and antibodies might protect against it. As bat habitats are disturbed and human-wildlife interfaces expand, such tools for distinguishing the generalists from the specialists among the thousands of circulating bat coronaviruses could prove essential for anticipating, and perhaps preventing, the next spillover.

Subject of Research: ACE2 receptor usage breadth as a predictor of host range and antigenic relatedness across bat sarbecoviruses

Article Title: Breadth of ACE2 receptor usage predicts host range and antigenic relatedness across bat sarbecoviruses

Article References: Thakur, N., Newman, J., Ni, D., Seow, J., Hay, A. L., Lee, Y., Upadhyay, A., Ekundayo, B. E., Hammond, J. A., Peacock, T. P., Lau, K., Doores, K. J., & Bailey, D. (2026). Breadth of ACE2 receptor usage predicts host range and antigenic relatedness across bat sarbecoviruses. PLOS Biology, 24(10), e3003944. https://doi.org/10.1371/journal.pbio.3003944

Image Credits: AI Generated

DOI: 10.1371/journal.pbio.3003944

Keywords: sarbecoviruses, ACE2, SARS-CoV-2, host range, receptor-binding domain, antigenicity, cross-neutralisation, bat coronaviruses, zoonotic spillover, Omicron, monoclonal antibodies, pseudotype assays

A discussion of smart TV privacy examines reports of LG televisions collecting viewing data, whether TVs should ever be connected to the internet, and when firmware updates are worthwhile. The MacVoices Live! panel also considers hotel TV privacy, Microsoft’s increasingly pervasive Copilot strategy and organizational changes, and the enduring influence of Star Trek technology on real-world innovation.

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A bipartisan pair of US lawmakers tell WIRED they plan to introduce legislation today that would strip federal funding from states that fail to restrict the use of Flock cameras and other automated license plate readers. The devices, which help police track the location of vehicles tied to crimes, have become the subject of nationwide backlash in recent months over more nefarious uses by officers.

The No FLOCK Act—for Federal License-Plate Observation and Camera Keeping—directs the US secretary of transportation to withhold 10 percent of annual financial support due to states for highways, roads, and bridges if it fails to ban Flock and similar devices for all but five use cases. Congressmen Raja Krishnamoorthi, a Democrat representing Chicago suburbs, and Michael Cloud, a Republican whose Texas district includes Corpus Christi, are cosponsoring the bill.

The legislation says that Flock cameras could be used only for “enforcing toll systems, identifying stolen vehicles, missing or endangered persons, vehicles registered to persons with a warrant for a felony offense, or investigating a vehicle involved in a felony offense.” Notably absent are uses like conducting traffic studies, investigating minor drug crimes, and enforcing parking and speeding rules.

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Report comes two days after former employee quit claiming company’s models could cause human extinction by 2030

Criminals, state-sponsored groups, spyware vendors, scientists and propagandists have attempted to use Anthropic’s powerful artificial intelligence models to design missiles and bombs, create deadly pathogens and surveil dissidents, according to a threat intelligence report the company published on Thursday.

“The cases we share here aren’t typical misuse, but rather examples of the most notable and novel threat activity we’ve identified to date,” Anthropic wrote in its 154-page report. “We’re publishing this work because we believe we have a responsibility to disclose malicious misuse of our services.”

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© Photograph: Dado Ruvić/Reuters

© Photograph: Dado Ruvić/Reuters

© Photograph: Dado Ruvić/Reuters

Politicians on the right and left are pushing back against Flock as more Americans voice opposition to the tech

Growing factions from both sides of the political aisle in the US are pushing back against surveillance cameras made by a single company, a rare response in a sharply divided country with a president pushing an unwaveringly pro-tech agenda.

The bipartisan backlash against Flock Safety cameras resembles nationwide rage toward the construction of large datacenters that power artificial intelligence. Polling shows roughly 75% of Americans oppose new datacenter construction in their areas.

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© Photograph: Brian Snyder/Reuters

© Photograph: Brian Snyder/Reuters

© Photograph: Brian Snyder/Reuters

Flock cameras have ignited a debate over surveillance, privacy, data collection, and public resistance. The MacVoices panel weighs in on the debate. They also discuss the risks of government-sponsored cyberattacks carried out by private companies, growing opposition to data centers over power and infrastructure demands, and the regulatory challenges surrounding their expansion.

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On-device AI takes center stage as the panel explores MacPaw’s work with Liquid AI, personal assistants, and workplace restrictions. The conversation also discusses the panel's experiences with AI note-taking recording consent and privacy in both business and health care.

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Cameras in airline seatback screens and increasingly sophisticated driver-monitoring systems spark a debate over safety, privacy, data access, and surveillance. The MacVoices Live! panel examines EU vehicle requirements, Tesla interior cameras, dash cams, accident evidence, connected devices, and whether consumers receive enough disclosure and control over technologies designed to watch them. Panel members include: Chuck […]

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This edition of Foreshadowing Tech considers how so many AI speculations from Colossus: The Forbin Project have come true in both surprising and subtle ways. Regular panelists Chuck Joiner, Marty Jencius, Jeff Gamet, are joined by guest AI enthusiast Jill McKinley to look at how the film predicted things like machine autonomy, surveillance, privacy and self-improving systems. Wrapped in a thriller that is as much political as it is tech, there are questions about freedom and security that we have yet to address today. The panel mixes film trivia, tech analysis, and unsettling parallels to today’s AI debates in a thoughtful discussion. 

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Meta,privacy,surveillance,glasses,Apple,Vision,AI,Zuckerberg,Ray-Ban,

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A multidisciplinary team from Baylor College of Medicine, Rice University and the University of Texas School of Public Health has received the inaugural Climate + Health Excellence award from the Burroughs Wellcome Fund. The five-year, $10 million award will support FORECAST, an ambitious program designed to investigate how climate change, extreme weather and environmental disruption influence the emergence and spread of infectious diseases. Led by infectious disease researcher Dr. Anthony Maresso, the project will combine wastewater surveillance, metagenomic sequencing, climate science, epidemiology and public education to create an early-warning system for pathogen activity across Texas.

FORECAST will build on Texas’s expanding wastewater-monitoring infrastructure, including the Texas Wastewater Environmental Biomonitoring Network, or TexWEB. The statewide network samples sewage from 15 Texas cities and analyzes biological material shed by communities. Unlike clinical surveillance, which depends on people seeking medical care and receiving diagnostic tests, wastewater epidemiology captures population-level signals from entire communities. Viral genetic fragments, bacterial DNA and other biological markers can appear in sewage before hospitals and clinics register a rise in patients, providing public health officials with valuable time to investigate and respond.

The program will use metagenomic surveillance, a technique that examines genetic material recovered from environmental samples rather than searching only for a predetermined pathogen. In conventional testing, laboratories typically use targeted molecular assays designed to detect a known virus or bacterium. Metagenomic sequencing can survey a much broader range of organisms, including variants and potentially unfamiliar pathogens. Researchers can then compare these signals with clinical data, geographic information and environmental measurements to determine whether changes in temperature, rainfall, flooding, drought or other conditions are associated with shifts in infectious disease activity.

The scientific goal is not simply to identify pathogens after they appear, but to uncover relationships between microbes and the environmental conditions that help them enter or circulate within human populations. Climate change can influence disease transmission through several pathways. Warmer temperatures may expand the geographic range or seasonal activity of mosquitoes and other vectors. Heavy rainfall and flooding can overwhelm sanitation systems and redistribute contaminants, while drought can alter water use and concentrate biological material. Changes in human behavior, animal movement and ecosystems may create additional opportunities for pathogens to cross species boundaries.

Maresso and his colleagues demonstrated during the COVID-19 pandemic that SARS-CoV-2 signals in wastewater could precede increases in clinically diagnosed infections. Viral RNA released in feces entered sewage systems, where researchers tracked changes in concentration over time. Although wastewater measurements cannot determine which individuals are infected, they can reveal whether pathogen activity is increasing or declining within a catchment area. The approach has since been extended to a wider range of targets, including avian influenza, measles, HIV and viruses associated with cancer. FORECAST aims to develop this surveillance capacity into a predictive climate-health platform.

Rice University climate scientist Dr. Sylvia Dee will help connect pathogen observations with weather and climate data. The team plans to examine whether specific environmental patterns consistently occur before increases in particular infectious agents. Such models could eventually function like a public health weather report, indicating when conditions are becoming more favorable for disease transmission. The researchers emphasize that predictive systems will require careful validation because the presence of pathogen genetic material does not necessarily indicate infectious virus, active transmission or a future outbreak. Interpreting the signal will require laboratory studies, clinical evidence and knowledge of local infrastructure.

The project will also investigate diseases transmitted by vectors such as mosquitoes. Dr. Peter Hotez and colleagues at the National School of Tropical Medicine will focus on vector-borne pathogen transmission and the growing health risks associated with changing climate conditions. Texas is particularly relevant for this work because it contains diverse ecological regions and experiences heat waves, hurricanes, flooding and rapid urban growth. These factors can affect mosquito habitats, human exposure and the movement of pathogens across communities. Integrating wastewater findings with vector surveillance could help reveal connections that would remain hidden if either system were used alone.

Education and public communication will form a central part of FORECAST. The team plans to create a “Middle to Medical” climate-health education track extending from middle school through medical training and professional development. Dr. Nancy Moreno, who developed Baylor’s BioEd online program, will lead educational efforts with Rice University’s Dr. Joseph Campana, director of the university’s Center for Environmental Studies and EcoStudio. The curriculum will explain how pathogens spread, how climate conditions alter disease risk and how scientific evidence can guide decisions by students, clinicians, policymakers and communities.

The award is particularly significant because FORECAST was selected as the sole funded project from 161 applications submitted to the new CHEX program. The initiative is intended to strengthen research, education and public engagement at the intersection of climate change and human health. Dr. Eric Boerwinkle, dean of the UT School of Public Health and a project co-investigator, will contribute access to large clinical datasets that can be used to evaluate wastewater and environmental signals against reported illnesses. The investigators say the work could improve outbreak preparedness while advancing the still-developing field of wastewater science.

By combining environmental sequencing with climate modeling and health education, FORECAST seeks to shift infectious disease surveillance from a largely reactive system toward earlier detection and prevention. Its findings may help officials recognize emerging threats before they produce widespread clinical disease, while also clarifying how environmental changes shape viral evolution, transmission and geographic spread. The researchers describe wastewater as an unusually candid public health resource: it aggregates biological information from a population without requiring individual testing. As climate pressures intensify, they argue, that collective signal could become an essential tool for protecting communities and preparing the next generation of scientists.

Subject of Research:
Climate-driven infectious disease emergence, wastewater epidemiology, metagenomic pathogen surveillance and climate-health education.

Article Title:
Texas Researchers Launch FORECAST Program to Link Climate Change With Emerging Viral Threats

Web References:
Baylor College of Medicine; Rice University; University of Texas School of Public Health; Burroughs Wellcome Fund; Texas Wastewater Environmental Biomonitoring Network (TexWEB).

References:
Information provided in the source news release concerning the FORECAST project, the Climate + Health Excellence award and TexWEB wastewater surveillance activities.

Keywords:
Wastewater epidemiology, viral surveillance, metagenomic sequencing, climate change, infectious diseases, pathogen emergence, public health, Texas, SARS-CoV-2, avian influenza, measles, vector-borne disease, climate health, epidemiology, wastewater science

Using ‘spy glasses’ made by Facebook owner leads to floods of negative comments, say content creators

It was hardly an offensive video. Amid the buzz of the Tour de France finale, Oliver Hooson filmed himself whipping up a delicious-looking flat white for a fellow cycling enthusiast. But after posting the footage on social media, the comments that soon rolled in were a real shock. “PERV,” read one. “Out here pushing creep glasses,” said another. His mistake? Documenting the moment with Meta’s “spy glasses”.

Despite being marketed as the latest must-have gadget, Meta’s smartglasses, which can record video footage while being worn, have faced a vicious backlash, particularly relating to concerns about surveillance. There are widespread fears about the glasses being used to film people, especially women, without their consent, and the resultant footage being posted on social media. This has earned them the label of “pervert glasses”, and content creators, no matter how they are used, have faced a flood of negative comments for deploying them.

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© Photograph: Carlos Barría/Reuters

© Photograph: Carlos Barría/Reuters

© Photograph: Carlos Barría/Reuters

Designers say that as well as offering a degree of protection from surveillance, their clothes make a powerful fashion statement about the importance of privacy

As facial recognition technology is rolled out across Britain’s public spaces, a new generation of designers say privacy could be the next big fashion trend.

Companies have started incorporating “adversarial patterns” in their garments – carefully designed arrangements of shapes, colours and repeated motifs said to exploit weaknesses in some computer vision systems.

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© Photograph: PR

© Photograph: PR

© Photograph: PR

More cities and towns deployed drones to spot illegal fireworks during the Fourth of July celebrations commemorating America’s 250th anniversary—leading to a $100,000 fine in one instance and coming as part of a broader national trend of first responders turning to drone surveillance.

Police and fire departments have described using both increased drone surveillance and steep fines to deter people from shooting off illegal fireworks, with many departments publicizing their drone videos on social media and warning that their drones will be watching in the future. Incidents involving illegal fireworks have led to costly fires, injuries, and even multiple deaths each year, along with creating local air and noise pollution for residential neighborhoods.

This year, the $100,000 fine for illegal fireworks came from the Sacramento Fire Department in Northern California deploying its own drones for the first time on the Fourth of July, according to CBS News Sacramento. Sacramento Fire Captain Justin Sylvia described the fire department’s drones as being capable of recording scenes in high-resolution video to help investigators identify the house or closest location using Google Maps.

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Mysterious drone flights that disrupted major European airports and flew over NATO member military bases hosting US nuclear weapons may be the work of a coordinated Kremlin campaign launched from Russian-linked commercial ships.

That recent assessment from the UK-based International Institute for Strategic Studies used automatic identification system (AIS) maritime tracking data and other publicly available data to show how Russian-linked ships and “shadow fleet” vessels that transport sanctioned Russian oil were often located nearby during various drone incidents. The report suggests that the drone incidents—which impacted a dozen NATO member countries and Ireland between August 2024 and February 2026—also revealed the vulnerability of European air defenses against surveillance and harassment incursions by low-cost drones.

The IISS report identified 144 drone sightings over Europe during that time period that were unlikely to involve hobbyist recreational drones or drone activity related to the war in Ukraine. About 48 percent of the sightings took place over military bases, 26 percent happened over critical infrastructure such as ports and energy or industrial facilities, and 18 percent occurred over civilian airports. Most occurred at night or in the early morning hours before sunrise, and the drones themselves were typically described in media reports as resembling “professional” or “military-style” drones.

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In a supposed “nationwide first” use of drones to disarm a person, the Sacramento County Sheriff’s Office in California promoted a video showing how a small quadcopter drone used a dangling magnet to remove a knife from the hand of a motionless suspect.

The promotional video shared to Facebook and Instagram on June 22, 2026, uses the Mission: Impossible film franchise theme to dramatize video footage of the incident that took place earlier in the month, which involved what the video describes as a “felony suspect armed with a knife and a firearm” who “was not responding to negotiators.” The sheriff’s office is just one among hundreds of US police departments and sheriff’s offices that have deployed camera-equipped drones to assist first responders.

In a Facebook post, the Sacramento County Sheriff’s Office described having surrounded the suspect’s residence with a SWAT team after the “known felon and parolee-at-large was seen earlier with a firearm.” A first drone deployed to the scene located the suspect hiding in a corner of the garage, but also spotted the motionless suspect holding a knife in one outstretched arm.

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© Sacramento County Sheriff’s Office

In a supposed “nationwide first” use of drones to disarm a person, the Sacramento County Sheriff’s Office in California promoted a video showing how a small quadcopter drone used a dangling magnet to remove a knife from the hand of a motionless suspect.

The promotional video shared to Facebook and Instagram on June 22, 2026, uses the Mission: Impossible film franchise theme to dramatize video footage of the incident that took place earlier in the month, which involved what the video describes as a “felony suspect armed with a knife and a firearm” who “was not responding to negotiators.” The sheriff’s office is just one among hundreds of US police departments and sheriff’s offices that have deployed camera-equipped drones to assist first responders.

In a Facebook post, the Sacramento County Sheriff’s Office described having surrounded the suspect’s residence with a SWAT team after the “known felon and parolee-at-large was seen earlier with a firearm.” A first drone deployed to the scene located the suspect hiding in a corner of the garage, but also spotted the motionless suspect holding a knife in one outstretched arm.

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© Sacramento County Sheriff’s Office

La DGSI rompt avec son prestataire américain historique Palantir, 10 ans après les attentats du 13-novembre. Un virage stratégique qui fait également école outre-Rhin. Futura fait le point sur l'inquiétant géant américain Palantir et son remplaçant, le français ChapsVision encore inconnu du...

New York expands street sensors to map crossings, near-misses and traffic patterns.

The generation and evolution of electricity is discussed, highlighting significant milestones from early static electricity experiments to modern AC power generation techniques. Dirty electricity, characterized by high-frequency electrical noise, can lead to health issues. There is a strong need for more research on this electromagnetic pollution and its health impacts.