A protein called TRAILshort may act as a central immune brake that limits T-cell responses and CAR-T therapy. Cancer cells can weaken the immune system by producing a protein that prevents its most important defenders from attacking. Mayo Clinic researchers have identified how this protein works, revealing a possible target for treatments designed to improve [...]

Clearing amyloid plaques may break the chain reaction that fuels brain cell destruction in Alzheimer’s disease. One Alzheimer’s brain offered researchers something they almost never get to see: a natural side-by-side experiment. In some regions, years of anti-amyloid treatment had removed most of the sticky plaques associated with Alzheimer’s disease (AD). Those areas contained little [...]

A steady daily routine may quietly protect the body from pain, depression, and the damaging effects of disrupted sleep. A University of Missouri study suggests that a predictable routine may support physical and emotional health by helping the body keep time. Rather than focusing only on sleep, the researchers examined the broader pattern of activities [...]

ASU researchers found that genetics alone cannot explain the origins of eusociality. Inside an ant colony, queens reproduce while workers care for young and maintain a society built around shared labor. For more than six decades, evolutionary biologists have debated whether this extraordinary arrangement, known as eusociality, arose partly because ants, bees, and wasps share [...]

Scientists have discovered China’s first known freshwater cave snail, an eyeless species so rare that only three living adults have been found. Deep inside a mountain cave in southwestern China, scientists found an animal that appears built for a world where sunlight never reaches. The tiny freshwater snail has no eyes, almost no color, and [...]

Antarctic guides walked away from their dream jobs after tourism’s environmental damage became impossible to ignore. “You’d see massive glacier calvings, and you’d just want to cry. But all the guests would be cheering. And you’d be like … ‘Can you not put two and two together?’” Those are the words of a former Antarctic [...]

Researchers at the University of Copenhagen found that a signaling mechanism in the cells’ ‘antennae’ may help explain why some fetuses develop disease in both the heart and other organs. About two of every 100 babies worldwide are born with congenital heart disease, but the biological processes responsible for these conditions are not fully understood. [...]

Reaching 90 without dementia may feel like clearing the final hurdle. But the risk does not necessarily end there. Dementia risk does not disappear after age 90. Even among people who reach their 10th decade without cognitive symptoms, the likelihood of developing the condition can vary substantially by sex, race, ethnicity, and genetics, according to [...]

The protein boom may be pushing many people to consume far more than their bodies need, and new research suggests that excess could come at a hidden cost. Protein has become one of the food industry’s favorite selling points. It is added to cereal, coffee, snack bars, desserts, and even water, often with the suggestion [...]

Mathematics shows that every electoral system must compromise among proportionality, local representation, and parliament size. Denmark’s 2022 national election came down to a single seat, even though its proportional voting system was designed to make party representation closely match the vote. That outcome points to a deeper mathematical problem: no electoral system can always preserve [...]

Analysis of living vertebrates shows that changes in brain evolution helped drive major shifts in reproduction across dinosaurs and birds. A bird egg can look surprisingly oversized for the body that produced it. That puzzle becomes even stranger when viewed through deep time: the largest known bird eggs exceed the largest eggs found from nonavian [...]

Modern humans and Neanderthals may have shared more than land and genes. They may have also shared culture. Modern humans and Neanderthals may have shared more than territory, tools, and genes. New evidence from a cave in southern Türkiye suggests the two groups may also have exchanged ideas and developed similar symbolic traditions over thousands [...]

T cells may use a previously unknown CD64-dependent pathway to attack acute myeloid leukemia. T cells are generally thought to identify cancer through a well-established molecular recognition system. Yet when researchers removed a key part of that system from acute myeloid leukemia (AML) cells, the immune cells continued killing them. The unexpected result led scientists [...]

Changing what you eat may begin reshaping how your genes behave in as little as a few weeks, even though your DNA itself remains unchanged. In a randomized clinical trial, researchers found that healthy adults who followed a vegan diet for one month developed changes in chemical markers attached to their DNA. Compared with participants [...]

A study of more than 5,500 people suggests that monitoring hormone levels and managing weight may help reduce the risk of premature death. For adults over 50, excess abdominal fat and low vitamin D levels may form a particularly dangerous combination. A study of more than 5,500 people found that participants with both conditions had [...]

Physicists at Göttingen University imaged three-dimensional wave functions using a tabletop soft X-ray laser. An electron inside a molecule does not occupy one fixed point. Quantum mechanics instead describes it through a “wavefunction,” a mathematical map that gives the probabilities of properties such as position and momentum. Within molecules, these electron wavefunctions are known as [...]

A rare tidal disruption event exposed a massive wandering black hole about 30,000 light-years from its galaxy’s center. A star was torn apart nearly 30,000 light-years from the center of a massive nearby galaxy, exposing a black hole where astronomers rarely see one. The unusually distant flare revealed an extremely rare “wandering” black hole and [...]

Earth itself may be one of the world’s largest detectors for ultralight dark matter. Earth may already contain one of the largest dark matter experiments ever built. Instead of relying only on specialized equipment inside a laboratory, scientists have found a way to use the planet’s magnetic field, atmosphere, and surface as parts of a [...]

Scientists and citizen volunteers discovered two new snail species in northwestern Montenegro, revealing the region’s hidden biodiversity and strengthening calls to protect Komarnica Canyon within the Durmitor World Heritage Site rather than build a hydropower plant. Two previously unknown snails have been added to Europe’s documented wildlife. Named Cochlostoma komarnica and Cochlostoma dobrido, the species [...]

Researchers used quartz from fossilized wood to trace how Europe developed. A polished piece of fossilized wood may look like little more than a decorative stone, yet the quartz inside it can preserve the history of an entire region for hundreds of millions of years. Geologist Dr. Steffen Trümper of the University of Münster and [...]