A newly identified protein may be one of the biggest obstacles holding CAR T-cell therapy back. Researchers found that NFIL3 causes these engineered immune cells to become exhausted and lose their cancer-fighting power over time. When NFIL3 was disabled, the cells remained stronger for longer and controlled tumors more effectively in animal models.

A major study suggests that some of the groundwork for brain development may be shaped before birth through a surprising partnership between a baby’s genes and gut microbes. Researchers found that epigenetic changes present at birth can influence how the gut microbiome develops during the first year of life, and certain combinations were linked to early signs of autism and ADHD by age three.

A massive global analysis found that nitrogen pollution can either speed up or dramatically slow the natural "breathing" of forest soils, depending on the ecosystem's condition. The results reveal hidden tipping points that could affect how forests store carbon and cope with climate change.

Scientists are venturing into the Grand Canyon’s hidden cave networks to solve a mystery: how snowmelt travels underground to supply the park’s vital springs. Their discoveries could help protect the canyon’s water from drought, contamination, and other growing threats.

Deer keds rely on flight and vision to find a host, but everything changes once they land. After shedding their wings forever, these parasites reduce the activity of key vision-related genes by about half. Scientists believe they are effectively trading sharp eyesight for extra energy that can be used for feeding and reproduction.

Astronomers have finally cracked the mystery behind a strange class of repeating cosmic signals that has baffled scientists for years. Using Australia’s ASKAP radio telescope, researchers traced the bursts to a rare stellar duo in which a dense white dwarf is relentlessly siphoning material from a nearby red dwarf companion. As the stolen matter spirals inward, the system unleashes powerful radio waves and X-rays every 1.4 hours.

Researchers found that social behavior begins in the brain before it becomes visible as movement. In zebrafish, a coordinated pattern of activity spread across the brain several seconds before the animals approached another fish. A higher brain region called the pallium played a key role, and fish with stronger neural signals were generally more social.

A surprising new study suggests that when it comes to pancreatic cancer, the kind of fat you eat may matter more than how much. Researchers found that oleic acid—the main fat in olive oil and several other common foods—sped up tumor growth in mice predisposed to pancreatic cancer, while omega-3-rich fats from fish oil dramatically slowed disease development.

A breakthrough hydrogen-production method could make clean fuel far cheaper and easier to generate. Researchers at the University of Birmingham developed a perovskite-based catalyst that splits water into hydrogen at much lower temperatures than existing technologies, potentially allowing factories, steel plants, cement works, and renewable energy sites to turn waste heat into valuable hydrogen.

Scientists have created a tiny chip that can generate, steer, and read light-based information all in one device, marking a major leap toward ultra-fast, energy-efficient computing. The breakthrough uses atomically thin materials and nanoscale structures to control a unique quantum property of light called the “valley” degree of freedom, allowing information to be encoded in new ways.

Kitchen sponges release microplastics as they wear down during everyday use, with some sponge types shedding far more than others. Researchers estimated that millions of households could collectively release hundreds of tons of microplastics annually.

A Salk Institute study found that a simple dietary amino acid, methionine, dramatically improved survival in mice facing severe infections and inflammatory conditions. Rather than directly targeting the immune system, methionine boosted kidney filtration, helping the body flush out excess inflammatory molecules that can cause tissue damage, brain dysfunction, wasting, and death.

A promising new study suggests rheumatoid arthritis may not be as inevitable as once thought for people at high risk. Researchers found that just one year of treatment with the immune-targeting drug abatacept delayed the onset of rheumatoid arthritis by up to four years, with benefits lasting long after treatment ended.

A major mouse study found that some inherited traits are passed down through epigenetic changes that break the classic rules of genetics. Researchers discovered hundreds of cases where these chemical DNA marks behaved unexpectedly, including some that seemed to emerge out of nowhere. They also identified the first known naturally occurring paramutation in a mammal, hinting that environmental influences may play a larger role in inheritance than scientists realized.

NASA’s futuristic X-59 jet is about to face its biggest challenge yet: breaking the sound barrier for the first time. After a successful series of test flights that pushed the aircraft to near-supersonic speeds, engineers are preparing to fly it faster than Mach 1 and eventually up to Mach 1.6 at 60,000 feet. The sleek experimental aircraft is designed to replace the thunderous sonic boom with a much quieter “thump,” a breakthrough that could help bring supersonic passenger travel back over populated areas.

A stunning spiral galaxy called Messier 88 is racing through the crowded Virgo Cluster on a journey that will dramatically reshape its future. At its heart lies a supermassive black hole about 100 million times the mass of the Sun, while its graceful spiral arms sparkle with young star clusters and dark clouds of dust. But as M88 plunges deeper into the cluster over the next few hundred million years, powerful forces will strip away much of the gas it needs to create new stars.

NASA’s Roman Space Telescope could revolutionize the search for alien worlds by discovering around 100,000 exoplanets—far more than all previous missions combined. It will look deep into unexplored parts of the Milky Way, helping scientists compare planetary systems across very different galactic environments. The mission will also uncover rare Earth-sized planets, study thousands of exotic alien atmospheres, and provide a treasure trove of data that could reshape our understanding of how planets form.

A long-overlooked organ may hold surprising clues to healthy aging and cancer survival. Researchers at Mass General Brigham used AI to analyze CT scans from tens of thousands of adults and found that people with healthier thymuses—a small immune-system organ once thought to become largely irrelevant after childhood—lived longer and had substantially lower risks of heart disease, cancer, and death.

A world-famous conservation program that helped save Sweden’s endangered wolverines is now struggling as funding stagnates and local trust erodes. Researchers say the decline offers a cautionary lesson: protecting wildlife requires long-term commitment, not just early success.

A remarkable crystal called molybdenum oxychloride could help make futuristic technologies like smart contact lenses and ultrathin AR glasses a reality. Scientists have created the first detailed experimental map of its optical properties, revealing the strongest light-bending effect ever measured in a natural material. The crystal can act either like a reflective metal or transparent glass, allowing it to manipulate light with extraordinary efficiency while being thousands of times thinner than a human hair.