❌

Normal view

Received today — 3 June 2026 ⏭ Nature

A natural depsipeptide antibiotic binds the E-site of the bacterial ribosome

✇Nature
By: Manpreet Kaur · Dmitrii Y. Travin · Max J. Berger · Manoj Jangra · Martino Morici · Haaris A. Safdari · Dorota Klepacki · Wenliang Wang · Michael Cook · Sommer Chou · Allison K. Guitor · Kalinka Koteva · Min Xu · Linda Ejim · Aline Fiebig · Yeganeh Yousefi · Brian K. Coombes · Lesley Macneil · Nora Vázquez-Laslop · Alexander S. Mankin · Daniel N. Wilson · Gerard D. Wright
3 June 2026 at 01:00

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10589-2

Improved fractionation strategies can identify antibiotics with previously unseen scaffolds and mechanisms, exemplified by manikomycin from Streptomyces rimosus, which acts by targeting the E-site of the bacterial large ribosomal subunit.
❌