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Received today — 3 June 2026 ⏭ Nature

Spermine is an endogenous iron chelator that inhibits ferroptosis

✇Nature
By: Man Li · Xuexin Yu · Shuqin Ouyang · Xiaohong Chen · Huiqi Yu · Yuanji Liu · Ziwen Li · Chunhua Yu · Rui Kang · Christine Gaillet · Ludovic Colombeau · Raphaël Rodriguez · Libing Song · Guido Kroemer · Daolin Tang · Jun Li
3 June 2026 at 01:00

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10597-2

A non-canonical metabolic route for spermine synthesis mediated by ALDH18A1 limits iron availability and lipid peroxidation in hepatocellular carcinoma.
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