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SPHEREx: The Niftiest Space Telescope You May Not Have Heard Of

5 October 2026 at 17:00

SPHEREx

Editor’s Note: Astrobites is a graduate-student-run organization that digests astrophysical literature for undergraduate students. As part of the partnership between the AAS and astrobites, we occasionally repost astrobites content here at AAS Nova. We hope you enjoy this post from astrobites; the original can be viewed at astrobites.org.

Title: The SPHEREx Satellite Mission
Authors: James J. Bock et al.
First Author’s Institution: California Institute of Technology; Jet Propulsion Laboratory
Status: Published in ApJ

You know JWST. You’ve likely heard about the recently launched Nancy Grace Roman Space Telescope. But did you know that NASA launched a third space telescope focused on infrared astronomy just last year? That telescope, called SPHEREx (short for Spectro-Photometer for the History of the Universe, Epoch of Reionization, and Ices Explorer, but we’ll forgive the tortured acronym), is currently carrying out its ambitious mission to record an infrared spectrum for every point in the sky. Let’s break down SPHEREx’s three main science goals and then discuss how SPHEREx will accomplish its mission.

Goal #1: Stress-Testing Cosmic Inflation

According to our best current models of cosmology, the very early universe experienced a rapid burst of accelerating expansion called cosmic inflation. During inflation, small regions of the universe that by chance had slightly higher energy density than their neighbors (due to quantum fluctuations) expanded to huge scales. Because these regions were very gravitationally attractive, once inflation ended, they became the seeds where matter accumulated and eventually formed galaxies.

This means that the distribution of galaxies that we see today is a reflection of the properties of inflation (i.e., what the quantum fluctuations were like and how inflation supersized them). SPHEREx will assemble the largest atlas of galaxies ever, recording the three-dimensional positions of hundreds of millions of galaxies across the entire sky. To do this, SPHEREx must figure out how far away these galaxies are from Earth, using their redshifts. SPHEREx’s low-resolution infrared spectroscopy allows for moderately precise measurements of these redshifts. By performing statistical analyses of how galaxies are separated from each other, SPHEREx will test different theories of inflation, like whether inflation was driven by multiple fields.

Goal #2: Frozen Assets

Astronomers are racing to find evidence for life (or at least habitability) in the atmospheres of exoplanets through transmission spectroscopy. However, we don’t know for sure how molecules that could be used in biological processes (called biogenic molecules, these include water, carbon dioxide, carbon monoxide, and methanol) even end up on planets.

We think that a large fraction of these molecules are frozen onto dust grains throughout the interstellar medium. When a new star forms in the interstellar medium, this ice and dust would become part of the star’s protoplanetary disk. The ice species can help create planetesimals (which may grow into planets) or can later deliver biogenic molecules to planetary surfaces. Earth’s oceans likely came (at least in part) from collisions with icy asteroids. As Figure 1 shows, SPHEREx will measure the abundance of ice species in different environments that track the history of solar system formation, from dense clouds in the interstellar medium that may soon form stars to regions around newborn stars and evolving protoplanetary disks. In this way, SPHEREx will track how biogenic molecules from the interstellar medium can end up on planets.

cartoon showing the types of sources SPHEREx will target in its search for biogenic molecules

Figure 1: Examples of the sources SPHEREx will look at to search for biogenic ice species. In the top left, what the spectra of these sources will look like if those species are present: each type of ice leaves a distinct fingerprint in an infrared spectrum. [Bock et al. 2026]

Goal #3: Your Noise Is SPHEREx’s Signal

SPHEREx will measure an infrared spectrum for every point in the sky — even those that don’t contain galaxies or stars that we can resolve. These points are instead dominated by diffuse extragalactic background light. This light comes from many different sources, including stars, dust, and quasars, from the early universe to the present day, all added together incoherently. For most telescopes, the extragalactic background light is just a frustrating source of noise. For SPHEREx, it’s a treasure trove. We can compare the properties of the extragalactic background light that SPHEREx measures (its spectrum and how it fluctuates across the sky) to theoretical predictions and see if we seem to be missing anything. SPHEREx’s very broad infrared spectra — capturing redshifted light from the very early universe — and total sky coverage are crucial for this purpose. For instance, the SPHEREx team will try to isolate emission from the first stars and galaxies, which ionized most of the gas in the universe in the epoch of reionization. By understanding this and other contributions to the extragalactic background light, we can test hypotheses about how galaxies form and evolve.

Making It Happen

Beyond inflation, ices, and extragalactic background light, SPHEREx’s all-sky infrared spectra will be invaluable for countless other science cases, like studying asteroids, characterizing the atmospheres of stars that host exoplanets, and even understanding the upper atmosphere of Earth, through which SPHEREx orbits.

But how can SPHEREx even make a spectrum for every point in the sky? An image of some part of the sky is fundamentally two-dimensional, and measuring how the brightness of every point changes with wavelength adds a third dimension. Astronomers have come up with many ways to solve this problem. Integral field spectroscopy approaches typically involve splitting an image into small regions or strips, then using a dispersive element like a prism or grating to make a spectrum of each region, and finally putting these spectra side by side on a camera. Figure 2 shows an example of this strategy, as well as what the final three-dimensional “datacube” looks like after processing.

demonstration of integral field spectroscopy

Figure 2: A demonstration of the principle of integral field spectroscopy. [ESO; CC BY 4.0]

This approach is fairly complicated, relying on fancy optics, a prism or grating, and oftentimes optical fibers. From Figure 2, note that you could also make the final “datacube” product if you simply took many images with narrow filters that let through different wavelengths of light. This takes to an extreme the approach astronomers use for spectral energy distribution fitting. Of course, this would require an exorbitant number of filters. Here, the SPHEREx team had a stroke of genius: instead of having many different filters, what if you had a filter where the transmitted wavelength changes linearly across the filter? Each row would let through a different wavelength. To get a full spectrum for all points in an image, you could take many exposures, moving the telescope slightly between each exposure so points in the image fall on different rows each time.

This is the SPHEREx survey strategy, with a few complications. First, before any filter, SPHEREx splits incoming light into two beams, with short-wave infrared light (SWIR, with 0.75 μm < λ < 2.42 μm) going in one direction and mid-wave infrared light (MWIR, 2.42 μm < λ < 5.00 μm) going in another. SPHEREx makes images with these two beams on different sets of detectors, so it can measure the brightness of an object at one SWIR wavelength and one MWIR wavelength simultaneously. The SPHEREx field of view covers 10.5° by 3.5°, with the SWIR and MWIR images each spread across three detectors. Every detector has a different linearly variable filter. To get a complete infrared spectrum of a given point in the sky, SPHEREx moves that point to 17 different positions on each detector. This requires 51 different telescope (17 × 3 detectors) pointings in all and yields 102 spectral values (51 × 2 for the SWIR and MWIR beams). Figure 3 shows the 17 bands on each of the six SPHEREx detectors, each corresponding to a different wavelength value.

plots showing the central wavelength of the spectral response of each pixel measured over the six detector arrays in the focal plane

Figure 3: The wavelength of light that each part of each SPHEREx detector is sensitive to. A point in the sky is imaged on one short-wave infrared detector (top row) and one mid-wave infrared detector (bottom row) simultaneously. SPHEREx measures each point in the sky at 102 different wavelengths by placing the point at 17 different positions on each of the detectors. [Adapted from Bock et al. 2026]

While it would take decades to collect spectra for every point on the sky with conventional methods for integral field spectroscopy, the SPHEREx team devised a nifty solution that will collect this dataset in a few years. Soon, SPHEREx will start answering questions about cosmic inflation, interstellar ices, and extragalactic background light, while its rich dataset will be relevant for decades to come. So tell all your friends about SPHEREx (even if you can’t remember what the acronym stands for)!

Original astrobite edited by Veronika Dornan.

About the author, Chris Layden:

Chris is a PhD candidate in astrophysics at the Massachusetts Institute of Technology. His primary research interest is developing instrumentation that enables high-speed astronomical observations. With such instruments, he studies the most rapidly varying phenomena in the sky, including millisecond pulsars, accreting black holes, and solar system objects whizzing past background stars. Outside of astronomy, Chris enjoys reading classic novels, playing ultimate frisbee, and hanging out with his wife and dog.

The post SPHEREx: The Niftiest Space Telescope You May Not Have Heard Of appeared first on AAS Nova.

Innovative Heat Sensor Developed to Monitor Living Cells

16 June 2026 at 21:20

In a groundbreaking advance at the intersection of bioengineering and microbiology, researchers at Harvard’s John A. Paulson School of Engineering and Applied Sciences have unveiled a pioneering device known as a pico-calorimeter. This remarkable instrument is capable of directly detecting heat signals emanating from minute populations of living cells, a feat that until now has remained technologically elusive due to the vanishingly small scale of these thermal signatures. By enabling real-time metabolic tracking at unprecedented sensitivity, the pico-calorimeter promises to revolutionize our understanding and monitoring of cellular activity, bacterial growth, and antibiotic response.

At the core of this innovation is the principle that living cells, as they metabolize nutrients, grow, divide, and react to external stimuli such as drugs, intrinsically emit heat. This metabolic heat, although incredibly subtle, offers a direct, unmediated insight into the physiological state of cells. Unlike conventional methods that infer cellular metabolism indirectly through oxygen consumption or chemical byproducts, the pico-calorimeter provides a direct calorimetric measurement, offering a more immediate and accurate assay of cellular energetics.

The technical architecture of the device is a marvel of microengineering. It consists of three ultrafine glass capillaries aligned on a delicately micromachined membrane with near-atomic precision. One of these capillaries harbors the biological sample suspended in a liquid growth medium, while the remaining two serve as thermodynamic reference points. As the bacteria or other cells within the sample metabolize and proliferate, they release minute quantities of heat. This thermal flux generates infinitesimal temperature gradients relative to the reference capillaries, which are then transduced into electrical signals by a nearby thermopile—an exquisitely sensitive heat-to-electricity converter capable of resolving fluctuations on the order of picowatts.

A critical enhancement in this iteration of the pico-calorimeter lies in its housing within a vacuum chamber. This vacuum environment thermally isolates the sensor assembly from ambient thermal noise, dramatically amplifying sensitivity by nearly an order of magnitude compared to antecedent designs. The prior versions employed liquid droplets on suspended membranes, which, while innovative, presented operational challenges and limited sensitivity. The current vacuum-sealed, microfluidic integration advances robustness, usability, and measurement fidelity, marking a milestone in the delicate art of thermal detection at the cellular scale.

Demonstrating the device’s prowess, the research team employed the pico-calorimeter to monitor Escherichia coli growth dynamics, beginning with an initial seed population as modest as thirty to forty individual bacterial cells. This capability to detect and analyze such small biological communities unveils immense potential for applications ranging from fundamental microbiology to clinical diagnostics. Notably, the device was employed to examine bacterial metabolic responses upon introduction of antibiotics with varying mechanisms of action—chloramphenicol, rifampicin, and ampicillin—capturing differential heat signatures indicative of altered cellular viability and activity.

These direct calorimetric measurements have revealed metabolic perturbations well in advance of what traditional culture-based microbiological assays could discern. This capability is particularly transformative in clinical scenarios such as sepsis, where detecting and characterizing bacterial populations at extremely low concentrations in blood is vital but presently time-consuming. The pico-calorimeter’s sensitivity could drastically truncate diagnostic timelines from days to hours, allowing more timely and targeted antimicrobial interventions.

Beyond measuring growth and antibiotic susceptibility, the pico-calorimeter enables continuous, real-time monitoring of fundamental cellular parameters including viability, proliferation rate, and stress responses. This temporal resolution offers researchers the invaluable ability to dynamically track cellular states and transitions, capturing metabolic shifts as cells respond to environmental perturbations or pharmacological treatments. Such insights may open new frontiers in cell biology, pharmacodynamics, and personalized medicine.

This breakthrough device represents the culmination of roughly two decades of meticulous research in the Vlassak laboratory, with contributions building from initial exploration of nano-calorimetry techniques aimed at materials science phenomena such as phase transitions in shape memory alloys and metallic glasses. The interdisciplinary bridge extended to biological systems has ushered in ultrasensitive calorimetry methods capable of assessing metabolic heat production in large cells and complex embryonic development processes, laying foundational expertise for this current bio-calorimetric leap.

Technologically, the fabrication of the pico-calorimeter draws upon state-of-the-art micro- and nanofabrication facilities, including the Harvard Center for Nanoscale Systems. The integration of microfluidics and micromachined sensing elements within thermally isolated environments exemplifies the cutting-edge convergence of materials science, electrical engineering, and biological instrumentation. The multidisciplinary synergy underscores the technological sophistication essential for detecting thermal signals billions of times smaller than everyday heat fluxes.

Commercially, the Harvard Technology Development office has filed multiple patents covering the pico-calorimeter and its applications in antimicrobial susceptibility testing. Juanjuan Zheng, a pivotal figure in this research and founder of an innovative startup, is leveraging the technology to deliver practical, label-free, real-time metabolic readouts. These tools hold promise for broad adoption in life sciences research, pharmaceutical development, and clinical diagnostics, harnessing the power of heat measurement to glean functional insights from minute biological samples.

As the research community embraces this transformative platform, interest has surged from a diverse array of scientific domains. The ability to capture direct metabolic information from tiny, dynamic living systems resolves a long-standing challenge in single-cell and small-population analysis. This heralds a new era where functional metabolic data provides early and actionable information on biological states, ranging from cellular growth and stress response to drug efficacy and resistance patterns.

In essence, the Harvard pico-calorimeter transcends conventional bioanalytical tools by transforming infinitesimal heat emissions into a vivid metabolic narrative. This technological breakthrough not only augments our scientific toolkit but also possesses the potential to accelerate biomedical discovery, enhance therapeutic precision, and ultimately improve patient outcomes by enabling rapid, noninvasive interrogation of cellular function. The implications for healthcare, research, and biotechnology are profound, heralding an exciting frontier where the subtle warmth of life becomes an unequivocal signal of cellular health and response.


Subject of Research: Cells
Article Title: A pico-calorimeter for cellular metabolism and antimicrobial susceptibility testing
References: Proceedings of the National Academy of Sciences
Image Credits: Vlassak Group / Harvard SEAS
Keywords: Calorimetry, Chemical analysis, Life sciences, Biophysics, Single cell profiling, Single molecule analysis, Materials science, Physics, Applied sciences and engineering, Applied physics, Engineering, Electrical engineering, Chemical engineering, Mechanical engineering, Health and medicine, Biomedical engineering

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