Psychedelic drugs are often described as throwing the brain into a state where the usual rules begin to break down. Under psilocybin, neural networks that normally organize perception, thought, and our sense of self loosen, blurring the boundaries between the mind and what we perceive as reality.

Close your eyes, and colors and shapes may appear from nowhere. Music can feel almost physical. Even the familiar boundary between where the self ends and the rest of the world seemingly begins to melt away.

From the outside, this altered state can look a lot like a neurological disorder—a brain becoming less synchronized, less structured, and increasingly chaotic.

But a major new brain-imaging study suggests an unexpected order may be hidden within that apparent chaos. Rather than simply scrambling the brain, psilocybin appears to reorganize its activity, making it unusually sensitive to what a person is experiencing in the moment.

Published in Nature, the study used functional magnetic resonance imaging (fMRI), electroencephalography (EEG), and machine learning to examine 62 adults before and after receiving psilocybin.

Researchers say their results uncover a previously hidden form of organization within the psychedelic brain that helps explain why setting and subjective experience can have such a powerful influence on the psychological effects of psychedelics.

“Under psilocybin, brain networks that help us process our inner world and the world around us became less distinct, but reorganized into patterns that reflected what people were experiencing,” lead author and Research Fellow at the Turner Institute for Brain and Mental Health in the Monash School of Psychological Sciences, Dr Devon Stoliker, said in a statement. “We uncovered hidden order within that disruption.”

Past studies have shown that psychedelics disrupt the brain’s usual organization. Psilocybin acts primarily on serotonin 5-HT2A receptors, reshaping communication between sensory regions and higher-level networks involved in cognition, perception, and our sense of self. Researchers have frequently characterized the resulting brain state as more entropic, desynchronized, and disordered.

The new study does not necessarily contradict those findings. Instead, it suggests conventional measurements may have been missing another layer of organization unfolding over time.

Participants, none of whom had previously used psychedelics, underwent both fMRI and EEG while experiencing four different conditions: resting with their eyes closed, guided meditation, listening to music, and watching a silent movie of moving clouds. Researchers recorded their brain activity during a baseline session and again after participants received a 19-milligram dose of psilocybin.

Standard brain-imaging measurements initially produced results consistent with previous psychedelic research. Psilocybin reduced the degree to which the brain remained divided into distinct functional networks. During eyes-closed conditions, connectivity between sensory areas and the wider brain decreased while integration involving associative regions increased.

One especially intriguing change involved the difference between eyes open and eyes closed. Normally, those states produce clearly distinguishable patterns of brain connectivity.

Under psilocybin, however, that distinction narrowed dramatically. In the visual network, the gap in global functional connectivity between eyes-open and eyes-closed conditions fell by 85 percent.

EEG measurements independently showed a similar convergence. Alpha-band activity, normally associated with suppressing visual information while the eyes are closed, decreased under psilocybin, while brain-wide signal complexity increased. Because the effect appeared using two different methods of measuring brain activity, the researchers argue that psychedelic-induced changes in blood flow cannot simply explain it.

Researchers also used machine-learning techniques to follow changes in brain activity over time. Instead of becoming increasingly random, the brain activity of participants experiencing stronger psychedelic effects formed tighter, more clearly distinguishable patterns corresponding to whether they were resting, meditating, listening to music, or watching the movie.

In other words, as the psychedelic experience intensified, researchers became better able to identify what participants were doing simply from the structure of their brain activity. That is essentially the opposite of what would be expected if psilocybin were merely introducing neural noise.

“This shows that context is not just background to the psychedelic experience,” co-author and researcher at the Turner Institute for Brain and Mental Health in the Monash School of Psychological Sciences,  Dr. Adeel Razi, explained. “What a person is doing and focusing on shapes how their brain responds.”

The effect was particularly strong among people reporting positive experiences involving unity, bliss, self-dissolution, and the disappearance of boundaries between themselves and their surroundings. It was weaker for purely sensory or hallucinatory effects and largely absent for negative experiences, such as anxiety or impaired cognition.

Researchers call this phenomenon “context alignment” and describe the corresponding subjective experience as “embeddedness.”

Embeddedness differs subtly from simply feeling connected to something. The researchers use the term to describe an experience in which the distinction itself begins disappearing—a feeling that the person is continuous with, rather than separate from, the surrounding environment.

Two brain systems appeared especially important. The default mode network, heavily involved in internally directed and self-referential processing, and the visual network, representing the opposite end of a broad gradient toward externally directed sensory processing. Together, changes in these systems accounted for nearly half of the machine-learning model’s improvement in distinguishing different contexts under psilocybin.

Those findings could influence psilocybin and psychedelic-assisted therapy, where a person’s mental state and surrounding environment have long been considered important.

Half of the participants later ranked their psilocybin session among the most meaningful experiences of their lives. One month later, the group also showed improvements in measures of personal meaning, acceptance of death, and bond with nature, although there was considerable variation between individuals.

However, the findings also come with important caveats. The study involved healthy volunteers rather than patients being treated for psychiatric disorders, meaning the results do not establish whether “embeddedness” itself contributes to the therapeutic benefits reported in clinical psychedelic research. Participants also knew they were receiving psilocybin.

While the researchers identified machine-learning signatures associated with subjective experience and subsequent psychological changes, they acknowledge that additional research is needed to determine whether those patterns hold across populations.

Nevertheless, the results present a different way of thinking about what psychedelics do to the brain. Psilocybin may loosen ordinary neural boundaries without eliminating organization. Beneath what looks like disorder when averaged across time, the brain may actually be reorganizing itself around the person’s immediate experience.

“Until now, brain-imaging studies have mainly told us what happens on average across a group. Using artificial intelligence, we could measure this reorganization in each person,” Dr. Razi notes. “If translated to patients, this could eventually help clinicians understand how someone is responding and predict who is most likely to benefit.”

The recent study, “Psychedelics Align Brain Activity with Context,” appeared in the journal Nature.

Tim McMillan is a retired law enforcement executive, investigative reporter and co-founder of The Debrief. His writing typically focuses on defense, national security, the Intelligence Community and topics related to psychology. You can follow Tim on Twitter: @LtTimMcMillan.  Tim can be reached by email: tim@thedebrief.org or through encrypted email: LtTimMcMillan@protonmail.com 

For thousands of years, humans have deliberately manipulated their breathing in search of something outside the ordinary waking mind. Now, scientists are finding measurable evidence that the right pattern of breathing may push consciousness into territory normally associated with psychedelic drugs.

In the first randomized controlled study to directly examine breathwork-induced altered states of consciousness, researchers found that a single 90-minute session of intense, continuous breathing produced significantly stronger psychedelic-like effects than meditation, including mystical experiences, feelings of oneness, visual changes, and powerful emotional breakthroughs.

Even more intriguingly, participants reported greater psychological understanding and behavioral changes a week later.

Published in Frontiers in Psychology, the findings add to a growing body of research investigating whether deliberately altering respiration can provide a drug-free pathway into altered states of consciousness,  possibly reproducing some of the psychological effects increasingly associated with psychedelic therapy.

The study focused on conscious connected breathing, or CCB, a form of high-ventilation breathwork involving continuous breathing without pauses between inhalation and exhalation.

Unlike the slow, deliberate breathing commonly associated with relaxation, high-ventilation breathwork intentionally increases the rate or depth of respiration.

During trials, participants continuously breathed through their mouths, actively inhaling and passively exhaling while listening to music that progressed from loud and fast-paced to progressively slower and softer over 90 minutes.

“Results from this preliminary experimental study indicate that breathwork is associated with larger acute psychedelic-like effects than meditation,” researchers write. “These exploratory relationships and preliminary observations provide greater context around breathwork-induced ASCs and support the feasibility of ASC-focused breathwork research for future confirmatory trials.”

Putting Breathwork Head-to-Head With Meditation

Breathing techniques have played a role in spiritual and contemplative practices for millennia. Yogic traditions include both slow and rapid breathing methods, while intentional respiration also appears in Qigong, Sufi dhikr, and shamanic practices.

Researchers say the scientific study of high-ventilation breathwork remains in its “embryonic” stage. However, that is slowly beginning to change.

As The Debrief previously reported, researchers using MRI and physiological measurements found that intense circular breathwork could produce altered states resembling those associated with psychedelics. The intensity of participants’ subjective experiences was tracked with changes in cerebral blood flow and autonomic nervous system activity.

However, those earlier investigations lacked a control group.

The new research, called the Airways to Alteration, or A2A, trial, attempted to address that limitation by directly comparing high-ventilation breathwork with an established contemplative practice: body scan meditation.

Researchers recruited 24 relatively healthy adults between 18 and 65. All had previously practiced conscious connected breathing without experiencing an adverse event.

Twelve participants were randomly assigned to the breathwork group. The remaining 12 underwent a 40-minute guided body scan meditation.

The researchers deliberately chose meditation as an active comparison rather than simply asking a control group to do nothing. Both groups lay on mats, used eye masks, listened to music, and participated in similar orientation and grounding procedures.

Meditation itself has also been associated with altered states and mystical experiences. In effect, the researchers were comparing two practices capable of shifting subjective awareness.

What happened next, however, was markedly different.

Breathwork Produced Stronger Mystical Experiences

Immediately after the sessions, participants completed several standardized psychological questionnaires commonly used in psychedelic research.

The breathwork group scored significantly higher in overall mystical experience, oneness, positive mood, and “ineffability”—the feeling that an experience is difficult or impossible to adequately describe in words.

On the study’s measure of total mystical experience, the median score for breathwork participants was 14. The meditation group scored 8.5.

The difference in emotional breakthrough was even more striking.

Participants who completed breathwork had a median Emotional Breakthrough Inventory score of 336. Those who meditated had a median score of 57.5.

Researchers also examined five dimensions commonly associated with altered states of consciousness. Breathwork participants reported significantly higher levels of “oceanic boundlessness” and “visionary restructuralisation.”

Oceanic boundlessness encompasses experiences including feelings of oneness, spiritual insight, bliss, and a loosening of the ordinary sense of self. Visionary restructuring includes changes in visual perception and imagery.

One participant described experiencing “very interesting visual hallucinations” alongside a “very cathartic emotional release.”

Another said the session produced stronger psychedelic qualities than they had experienced during previous breathwork sessions.

“The experience was emotional and cathartic,” the participant reported, noting that “at one time, I cried but not with sadness, more with a strong feeling of what life is all about and how incredible it is and how lucky we are.”

Not everyone described the experience as psychedelic. One participant said they remained fully present throughout the session and primarily experienced a physical and psychological release.

Still, the overall pattern revealed that compared with meditation, intense breathwork was associated with substantially stronger acute alterations in consciousness.

The Effects Didn’t Necessarily End When the Breathing Stopped

What may be the study’s most consequential finding emerged a week later. Researchers asked participants to complete a Psychological Insight Scale designed to assess meaningful personal realizations following psychedelic experiences.

The breathwork group reported a median psychological insight score of 33.67. The meditation group scored 5.83. Self-reported behavioral change followed a similar pattern. Breathwork participants had a median score of 50, compared with 5.5 among those who meditated.

Both differences represented large effect sizes.

The results suggest that the altered state produced during breathwork may be associated with psychological changes that go beyond the acute experience.

“Amongst the secondary outcomes, the breathwork group self-reported substantially greater psychological insight and accompanied behavioral change compared to the meditation group, with large effect sizes observed for both measures,” the researchers explain. “This finding suggests that breathwork could be connected to meaningful psychological breakthroughs, accompanied by translation of these insights into tangible behavioral modifications.”

The researchers caution that these personal accounts are anecdotal and that the qualitative portion of the study was limited. Still, the reports appeared broadly consistent with the measurable differences in mental insight and self-reported behavioral change.

A Surprising Connection to Sleep

The study also uncovered an unexpected difference involving sleep. Both groups showed improvements in stress, anxiety, depression, and overall mental well-being. However, researchers found a considerable difference between the two groups: breathwork produced significantly greater improvements in sleep-related impairment.

Median sleep impairment scores in the breathwork group dropped from 54.8 before the intervention to 39.2 afterward. Scores among meditation participants remained comparatively stable.

More intriguingly, improvements in sleep were correlated with the intensity of participants’ mystical experiences, feelings of oneness, and oceanic boundlessness.

In other words, participants who reported deeper altered states also tended to report greater improvements in sleep.

Exactly how the two may be connected remains unclear. The researchers note that sleep is itself an altered state of consciousness and plays an essential function in memory consolidation and insight, including the mental reorganization that can lead to new understanding. Still, the apparent link between deeper breathwork-induced altered states and improved sleep remains preliminary.

Breathwork Is Not Simply a Psychedelic Without the Drug

Despite the comparisons, researchers caution against treating every altered state of consciousness as the same phenomenon.

A psychedelic state induced by psilocybin, a hyperventilation-driven state produced through breathwork, and deep meditative absorption may overlap on psychological questionnaires. That does not mean the brain achieves those states through identical mechanisms.

Nevertheless, the similarities are difficult to ignore.

Previous research has found that high-ventilation breathwork can produce effects on standardized altered-consciousness measurements within the range observed after moderate-to-high doses of psilocybin.

The earlier neuroimaging research covered by The Debrief also found that the depth of breathwork-induced altered states tracked with changes in cerebral blood flow and autonomic nervous system activity.

This latest study takes that research one step further. Rather than simply demonstrating that breathwork can produce psychedelic-like experiences, the controlled comparison suggests those experiences are substantially more intense than the effects produced by body scan meditation under broadly similar environmental conditions.

Promising Results, but Major Limitations

Researchers repeatedly emphasize that the A2A trial was a small, exploratory study and does not yet provide evidence that breathwork is a proven replacement for psychedelic-assisted therapy.

All participants had prior breathwork experience, which may have led them to enter the experiment with expectations about what would happen. The study was also open-label, and participants knew whether they were breathing intensely or meditating.

Additionally, the breathwork session lasted 90 minutes compared with 40 minutes for meditation. Breathwork participants also listened to more intense music and were explicitly told about the possibility of expanded states of consciousness, emotional expression, and unusual physical sensations.

Those differences could have influenced the results.

The study also excluded people with a range of cardiovascular, respiratory, neurological, and psychological conditions. No adverse events were reported, but researchers acknowledge this was unsurprising, as participants had already practiced the technique without prior adverse reactions.

For that reason, the findings should not be interpreted as evidence that intense breathwork is safe or appropriate for everyone.

Future experiments will need to recruit people who have never practiced breathwork and tease apart the different ingredients involved.

The findings also leave several important questions unanswered. How much of the altered state is driven by rapid breathing itself, and how much comes from the music or group setting? Perhaps most importantly, researchers still need to determine how strongly the expectation of a profound experience shapes what a person ultimately experiences.

Yet, for a field increasingly interested in whether altered states can be harnessed for therapeutic purposes, the outcomes yield an interesting possibility.

Under carefully controlled conditions, consciously manipulating something as fundamental as breathing appears capable of profoundly changing how people experience themselves and the world around them.

“A logical next step would be replicating our study in breathwork-naïve participants to help mitigate expectancy effects and determine whether such ASCs emerge as profoundly as in experienced practitioners,” researchers write. “Future research contrasting HVB effects across participants with varying experience levels and in different environments is essential for informing the public about safe breathwork engagement.”

Tim McMillan is a retired law enforcement executive, investigative reporter and co-founder of The Debrief. His writing typically focuses on defense, national security, the Intelligence Community and topics related to psychology. You can follow Tim on Twitter: @LtTimMcMillan.  Tim can be reached by email: tim@thedebrief.org or through encrypted email: LtTimMcMillan@protonmail.com 

Psilocybin therapy involves more than the compound itself, and a new research initiative at the University of Southern California is investigating the effects of combining psilocybin with structured mental training.

A team from the Keck School of Medicine of USC, working with the USC Dornsife Brain and Creativity Institute and the USC Norris Comprehensive Cancer Center, has begun the university’s first clinical trial of psychedelic therapy. The study will examine whether structured mindfulness meditation can boost the effects of psilocybin, the active ingredient in psychedelic mushrooms, on mental well-being and cognitive performance.

Funding for the trial comes from ARPA-H’s EVIDENT initiative, a federal program designed to accelerate the development of rapid-acting treatments for mental and behavioral health conditions. The study will investigate whether adding mindfulness training to psilocybin-assisted therapy yields outcomes distinct from those of psilocybin-assisted therapy alone.

A Schedule 1 Drug With a Breakthrough Label

Although the Controlled Substances Act still classifies psilocybin as a Schedule I substance, the FDA has granted it a breakthrough therapy designation for major depressive disorder and treatment-resistant depression. In clinical settings, psilocybin has shown promise in treating these conditions, and other studies suggest it may also help with addiction.

Psilocybin alters a person’s perception, mood, and thought processes, and can influence how individuals experience their senses and their sense of time and space. With therapeutic support, people often report emotionally meaningful or spiritual experiences during these altered states.

Testing Whether Mental Training Changes the Outcome

About 72 middle-aged adults from the Los Angeles area will take part in the study. All participants will have no psychiatric or medical conditions and no previous experience with either psychedelics or meditation. Researchers will assign participants to one of two groups: one will receive supervised psilocybin alone, while the other will receive psilocybin alongside an eight-week mindfulness training program designed to build attention and focus through structured meditation.

The study is based on the hypothesis that mindfulness training, which has demonstrated mental and physical health benefits independently, may enhance the effects of psilocybin-assisted therapy when used together.

“Mindfulness meditation practice provides people with the tools to deconstruct unhelpful narratives, a process that may be amplified by psilocybin-assisted therapy,” said Rael Cahn, MD, PhD, director of the USC Center for Mindfulness Science and the study’s co-lead. The trial, he said, is meant to clarify how combining the two approaches “may enhance both the potential immediate and longer-term effects of psychedelic medicine.”

An Unusually Deep Data Set

The team will collect extensive biological, neurological, and psychological data from participants throughout the study. Participants will undergo EEG scans, brain MRI and fMRI imaging, and provide saliva, blood, and stool samples. Researchers will administer psychological and cognitive assessments before and after treatment and will survey participants again at three, six, and twelve months.

The team will use the data to track changes across psychological, cognitive, neurological, and biological measures, including well-being, spirituality, brain activity, and markers of inflammation and brain health. The open-label design means both participants and researchers are aware of group assignments, which allows for more comprehensive data collection at the expense of some blinding rigor.

Through the EVIDENT initiative, researchers will contribute anonymized trial results to a national repository. The resource will help researchers identify broader patterns in rapid-acting mental health treatments.

“Psilocybin-assisted therapy has the potential to revolutionize how we approach mental health research,” said Caryn Lerman, PhD, director of the USC Norris Comprehensive Cancer Center and the study’s other co-lead. Beyond addiction, she said, there’s growing evidence the treatment could improve “quality of life and emotional well-being for people facing serious illness and end-of-life challenges.”

A Test Case for the Next Wave of Psychedelic Medicine

If mindfulness training is shown to enhance the effects of psilocybin therapy, future protocols for psychedelic treatment may incorporate mental training as an additional component of treatment. Regardless of the outcome, the study will generate one of the most detailed biological and psychological datasets from a psilocybin trial to date.

Whether mindfulness ultimately amplifies psilocybin’s effects remains an open question. By tracking participants’ brains, biology, and psychological well-being over the course of a year, the USC team hopes to generate some of the clearest data yet on how mindset and psychedelic medicine interact.

Austin Burgess is a writer and researcher with a background in sales, marketing, and data analytics. He holds an MBA, a Bachelor of Science in Business Administration, and a data analytics certification. His work focuses on breaking scientific developments, with an emphasis on emerging biology, cognitive neuroscience, and archaeological discoveries.