A fast-moving wildfire, one of many raging across Spain, bore down on the Madrid Deep Space Communications Complex on Friday, forcing an evacuation and temporarily suspending operations at one of NASA's most important tracking stations.
The tracking station is part of NASA's Deep Space Network, operating in concert with similar facilities in California and Australia to provide global coverage as Earth's rotation brings the planets, stars, and deep space probes in and out of view. The network supports more than 40 missions from the Moon to the edge of the Solar System, including Artemis, the James Webb Space Telescope, and NASA's twin Voyager spacecraft.
A NASA spokesperson confirmed the tracking station in Spain, located in the hills nearly 40 miles (65 kilometers) west of central Madrid, was evaluated Friday "due to ongoing wildfires in the region. Photos and video from the area showed flames and smoke plumes rising over the ground station's antenna array, anchored by a 230-foot-diameter (70-meter) radio dish and a collection of smaller 112-foot (34-meter) antennas.
© Gabri Solera/Europa Press via Getty Images
A fast-moving wildfire, one of many raging across Spain, bore down on the Madrid Deep Space Communications Complex on Friday, forcing an evacuation and temporarily suspending operations at one of NASA's most important tracking stations.
The tracking station is part of NASA's Deep Space Network, operating in concert with similar facilities in California and Australia to provide global coverage as Earth's rotation brings the planets, stars, and deep space probes in and out of view. The network supports more than 40 missions from the Moon to the edge of the Solar System, including Artemis, the James Webb Space Telescope, and NASA's twin Voyager spacecraft.
A NASA spokesperson confirmed the tracking station in Spain, located in the hills nearly 40 miles (65 kilometers) west of central Madrid, was evaluated Friday "due to ongoing wildfires in the region. Photos and video from the area showed flames and smoke plumes rising over the ground station's antenna array, anchored by a 230-foot-diameter (70-meter) radio dish and a collection of smaller 112-foot (34-meter) antennas.
© Gabri Solera/Europa Press via Getty Images
Schistosoma mansoni is a parasitic worm that infects millions of people worldwide, entering the body through the skin. Unlike bacterial infections that often cause pain and inflammation, S. mansoni usually slips in unnoticed, rarely causing discomfort. Scientists have long wondered why our skin’s defenses don’t react more strongly to this invader.
Researchers from the University of Pennsylvania and Tulane University explored whether a specialized group of pain-sensing neurons, called TRPV1+, plays a role in detecting and fighting off S. mansoni during its invasion. TRPV1+ neurons are nerve cells in the skin that respond to heat, spicy foods, and certain bacteria and fungi. When activated, they can trigger pain and release molecules that alert the immune system. Previous researchers have shown that these neurons help defend against bacterial and fungal skin infections, but their role in fighting off parasites was unclear.
To examine how S. mansoni infects its hosts, the team conducted experiments using groups of 4 to 8 mice, matched for age and sex. They repeated each experiment 2 to 3 times to ensure their data was reproducible. They anesthetized the mice, exposed their ears to a solution containing 100 to 150 live S. mansoni larvae, and covered the area with vaseline to keep the solution in place. After 20 to 30 minutes, they counted the number of larvae remaining in the mice’s ears to assess how many had successfully penetrated their skin.
Next, the team measured pain sensitivity in the mice exposed to the parasite by placing them in chambers and applying an infrared heat source to their paws. They recorded how long it took each mouse to withdraw its paw as a sign of pain. They repeated this test 3 times per paw on each mouse, waited at least 5 minutes between each measurement, and calculated an average withdrawal time. They found that mice infected with S. mansoni were approximately half as sensitive to heat-induced pain as an uninfected control group, suggesting that the parasite could be suppressing the mice’s TRPV1+ neurons.
To investigate this further, the team isolated nerve cells that transmit sensory signals from the mice’s skin, known as dorsal root ganglia, and grew them in the lab. They stimulated these neurons by adding a spicy compound in chili peppers, known as capsaicin. Then they measured calcium influx, a sign the neurons were active, using a special dye that glows differently under a microscope depending on calcium levels. This allowed them to see how active the neurons were and how many molecules they released in response to infection and stimulation. They found that 68% of neurons from uninfected mice responded to capsaicin, but only 26% of neurons from infected mice did so, confirming that the parasite dampened their sensory neuron responses.
To test whether restoring the mice’s neuron activity could help their bodies resist parasite invasion, the researchers genetically engineered the mice to produce a light-sensitive protein in their TRPV1+ neurons, called channelrhodopsin. They “turned on” these neurons by stimulating them with blue light for 30 minutes every day for 5 days before infecting the mice with parasites. Six days later, they assessed the mice’s immune response by using a laser to count immune cells in samples of ear tissue. They also determined how far the parasites had spread by counting larvae in lung samples. They saw that mice with the artificially activated TRPV1+ neurons had nearly double the immune response, blocked roughly twice as many larvae at the skin, and had about 20% fewer parasites in their lungs.
Next, the researchers selectively destroyed TRPV1+ neurons in a new set of mice using a compound known as resiniferatoxin. Three weeks later, they confirmed the treatment had worked by testing the mice’s pain sensitivity using the same heat assay as before. After confirming the mice had lost their pain sensitivity, the team exposed the mice to the parasites. They found that the reinfected mice had 1% to 3% weaker skin immune responses and approximately 25% to 30% more parasites in their lungs than a control group, further confirming that TRPV1+ neurons play a protective role during early infection.
The team concluded that S. mansoni has evolved ways to silence pain-sensing neurons, like TRPV1+. Their discovery suggests that future scientists could boost skin immunity against parasites by targeting sensory neurons. For example, they could develop topical creams or therapies that activate these neurons to help our bodies fight off S. mansoni and similar parasitic invaders.
The post A parasite that numbs your pain appeared first on Sciworthy.
Exceptionally preserved skin of Montsecosuchus depereti, an extinct crocodylomorph no larger than a house cat that prowled the tropical wetlands of Early Cretaceous Spain, has allowed paleontologists to reconstruct details of its scales, sensory organs and even possible banded markings along its tail.
The post 125-Million-Year-Old Crocodile Relative Reveals Its True Colors appeared first on Sci.News: Breaking Science News.
Thinktank says decoupling electricity from gas prices has also helped shield Spain from hikes caused by Iran war
Spanish households save €10 a month on electricity bills because of wind turbines and solar panels installed in the last five years, a report has found.
Typical energy bills would be 19% more expensive if electricity costs were still as tightly coupled to gas prices as in 2021, according to Ember, a climate thinktank. It found Spain’s “strategic” expansion of renewables since Russia invaded Ukraine in 2022 has shielded Spanish households from the latest rises in fossil fuel prices caused by the Iran war.
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© Photograph: Bloomberg/Getty Images
© Photograph: Bloomberg/Getty Images
© Photograph: Bloomberg/Getty Images
Paleontologists have identified a previously unknown species of amphicyonid -- the extinct family of carnivorous mammals popularly known as bear-dogs -- from two specimens unearthed at a rich fossil site in the Vallès-Penedès Basin near Barcelona, Spain.
The post New Species of Ancient Bear-Dog Identified in Spain appeared first on Sci.News: Breaking Science News.
New radiocarbon dates from Sala Keimada, a hard-to-reach chamber of Cueva Palomera in the province of Burgos, northern Spain, suggest that generations of people returned to the sacred space from the end of the Ice Age through the Iron Age, leaving behind art, structures and offerings.
The post Spanish Cave Sanctuary Reveals More Than 11,500 Years of Activity appeared first on Sci.News: Breaking Science News.
Near-complete bovine skeletons unearthed the Early Pliocene site of Camp dels Ninots in northeastern Spain reveal that the ancestors of today’s buffalo and cattle were already growing to impressive sizes long before humans arrived on the continent.
The post Half-Ton Cattle Relatives Roamed Europe 4 Million Years Ago appeared first on Sci.News: Breaking Science News.
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