Risks of Parkinson's Disease May Increase With Prolonged Exposure to Road Traffic Noise
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Intrinsically disordered proteins (IDPs) do not form stable 3D structures. Instead, they remain flexible, adopt many conformations, and can interact with multiple molecules. Although proteins were once thought to require a fixed structure to function, many IDPs play essential cellular roles. Some IDPs can assemble into biomolecular condensates, membrane-less compartments that help organise processes such as gene expression and stress responses.
Many IDPs contain prion-like low complexity domains (PLCDs), which have defined sequence features known as molecular grammas. These IDPs are multivalent and can form hierarchies of interactions with one another. These interactions promote clustering and, under the right conditions, phase separation into a protein-rich condensate and a surrounding dilute phase. Dysregulation of condensates has been linked to disease.
In this study, researchers used computer simulations to investigate the PLCD known as A1-LCD. Their aims were to accurately identify the critical point where phase separation ceases, map the full phase diagram, and assess methods used to estimate the theta temperature (Tθ), a measure related to solvent quality and protein interactions.
The simulations revealed three distinct phase-separation regimes: a dilute phase containing mostly isolated proteins, an intermediate regime where clusters form before large condensates appear, and a regime near the critical point characterised by system-spanning networks. The study also showed that condensates behave as percolated networks of interconnected proteins. Importantly, the authors found that commonly used methods for estimating theta temperature may be inaccurate for these systems.
Overall, this work provides new insights into the phase behaviour of condensate-forming proteins and highlights the need for more reliable approaches to assessing solvent quality. These findings could improve future studies of biomolecular condensates and their roles in health and disease.
Distinguishing near- versus off-critical phase behaviors of intrinsically disordered proteins
Gaurav Mitra et al 2026 Rep. Prog. Phys. 89 068101
Biomolecular dynamics: order–disorder transitions and energy landscapes by Paul C Whitford, Karissa Y Sanbonmatsu and José N Onuchic (2012)
The post The physics of protein condensates appeared first on Physics World.
According to band theory, materials with partially filled energy bands and unpaired electrons should conduct electricity, but in Mott insulators this rule is broken. In these materials, the repulsion between electrons is so strong that they cannot move freely and become localized. When sufficient energy is supplied (for example by light), electrons can form a doublon (two electrons on one site) and a hole (an empty site). These excitations can move, enabling electrical conductivity.
A key question for Mott insulators is how these charge carriers are created and what controls their production. Traditionally, two regimes were known: multiphoton absorption, where several photons combine their energy, and tunnelling, where a strong electric field drives electrons across the gap.
In this work, the authors show that there are actually four regimes: multiphoton, tunnelling, a cooperative regime where the two processes work together, and an incoherent regime where weak fields and scattering dominate. They also show that the energy gap (the cost to create a doubloon-hole pair) is not fixed, but changes during the process because the generated carriers modify the system. This creates a feedback loop, making the dynamics nonlinear and time-dependent. As a result, carrier production can either slow down or suddenly speed up, even making the system more efficient without changing the driving field.
The behaviour depends on field strength, frequency, dissipation, and time, and each mechanism can be identified by its distinct momentum pattern. By tuning laser parameters, the system’s properties can be controlled in real time. Overall, this work shows that light can be used to dynamically reshape and control strongly interacting materials, opening possibilities for ultrafast, light-driven technologies.
Subgap pumping of antiferromagnetic Mott insulators: photoexcitation mechanisms and applications
Radu Andrei et al 2026 Rep. Prog. Phys. 89 068004
PLP-Logo-2.png, find out more. Quantum frustration in organic Mott insulators: from spin liquids to unconventional superconductors by B J Powell and Ross H McKenzie (2011)
The post Nonlinear photoexcitation in Mott Insulators appeared first on Physics World.
“Solar towers” that convert sunlight into heat could play a useful role in the renewable energy transition, but high installation costs and complex requirements limit their attractiveness to commercial operators. A team of researchers from Germany’s Karlsruher Institut für Technologie (KIT) and the German Aerospace Center (DLR) is now taking steps to change that. By creating a freely accessible database of information about how these plants work, they aim to accelerate research on solar thermal energy and drive improvements that could allow the technology to be more widely deployed in the future.
Unlike photovoltaic panels, concentrating solar power (CSP) plants do not convert sunlight directly into electricity. Instead, they generate heat by using an array of movable mirrors called heliostats to funnel sunlight onto a receiver located at the top of a tower. This heat can be used to drive a turbine to produce electricity immediately, but it can also be stored and used to generate electricity at night or on cloudy days. Depending on the plant’s location and setup, the heat could even be used directly for industrial applications and district heating.
The problem, explains study leader Kaleb Phipps, is that operating solar power tower plants safely and efficiently is a complex and expensive task. “CSP technologies have the potential to help the transition to a renewable energy system,” says Phipps, a research fellow at KIT’s Scientific Computing Center. “However, they are still not financially viable and there are operating challenges associated with them.”
Before researchers can develop and reliably test new, improved processes, Phipps explains that they need access to real-world operational CSP data. “We believe that modern data-driven machine learning methods like ours can help solve a lot of these problems,” he says.
To construct their database, which is known as PAINT, researchers collected data from the CSP tower near Jülich, Germany. These data include the exact positions of the tower’s 2014 mirrors, their dimensions, how they are warped and the way they rotate and tilt. The team also obtained fine-grained weather data for the entire 2021-2024 period under study, plus a further 218 000 images to help determine whether the mirrors were efficiently directing sunlight precisely to the top of the tower.
All in all, the PAINT database contains 849 gigabytes of operational data organized using the SpatioTemporal Asset Catalog (STAC) standard. To make these data FAIR (findable, accessible, interoperable and reusable), the researchers developed software to simplify access to the database and then published the data in a way that is freely available to all users.
Their goal, they say, is for other researchers to use this FAIR database to develop “digital twins”, or virtual replicas, of real-world CSP plants. When combined with machine-learning models, such twins can be used to answer questions such as whether the mirrors are aligned for maximal light absorption (one of the most important parameters for efficient operation) in near real time.
“The fact that we are receiving many positive responses regarding the data and that people seem to appreciate it is our biggest success,” Phipps says. Such responses are especially gratifying, he adds, because constructing databases like PAINT can be an arduous task.
“The main difficulties were about collecting the data, cleaning and unifying it into standard formats and parsing and organising all the metadata, which was originally complete chaos,” Phipps recalls. “We therefore put a lot of time and effort into creating standardized and automated workflows so that the process is as transparent as possible and can be reused for future data.”
The team also faced challenges when trying to convince peers that this work counted as “research”, he adds. “The fact that the data itself didn’t directly result in a new algorithm or method meant that lots of people didn’t believe we would be able to publish the results or achieve anything with them,” says Phipps. “Luckily, we were able to prove the doubters wrong.”
While the PAINT database currently contains data from only one CSP, the KIT researchers, who report their work in Nature Energy, are hoping to expand it. “We really need contributions from other CSP power plants around the world to transform the database into a truly international and diverse source for researchers,” Phipps says. “As data from different facilities is added in the future, it will be possible to develop a common standard for open operational data in solar tower research. This would speed up the development and promote a widespread adoption of this technology.”
The post Solar tower power plants get a data boost appeared first on Physics World.

“Strange” metals owe at least some of their peculiar properties to the quantum entanglement of their electrons. This finding comes from physicists at the Vienna University of Technology in Austria, who used a concept from quantum information science to guide their experiments. A similar approach, they say, could also yield a better understanding of certain high-temperature superconductors and other correlated quantum materials.
Electrons travel relatively unimpeded through most metals, but in the 1980s, scientists identified puzzling exceptions in certain cuprate high-temperature superconductors. Further examples of this “strange” metal behaviour subsequently turned up in other classes of materials, including heavy-fermion materials, pnictides and organic compounds. This resistive behaviour cannot be explained by theories that treat electrons as independent, non-interacting particles, nor by theories that include interactions while treating electrons as quasiparticles. And although multiple recent theoretical works suggested a possible role for entanglement, experimental evidence was lacking.
To investigate further, a team led by solid-state physicist Silke Bühler-Paschen used facilities at the Institut Laue-Langevin (ILL) in Grenoble, France to perform inelastic neutron scattering measurements on a heavy-fermion metal with the chemical formula Ce3Pd20Si6. According to team member Federico Mazza, who conducted this part of the study, the scattered neutrons would normally each transfer their energy to individual particles.
However, when the researchers analysed their data using a concept called quantum Fisher information – roughly, a measure of how sensitively a quantum state depends on a given parameter – they found that they could not explain what they were seeing in terms of particles behaving independently. Instead, the data indicated that groups of at least nine quantum-entangled entities were acting collectively. Mazza says this provides direct evidence of highly multipartite quantum entanglement in the material – and, in turn, a new way of understanding why strange metals are so strange.
The strange metal state is of great interest because physicists consider it the “parent” state of high-temperature superconductivity, though it also occurs across other materials platforms. “We had suspected that some of the intriguing properties of this state might be related to entanglement but were not able to pin it down until now,” Bühler-Paschen explains. “The results are a great success for us. They confirm that our unusual approach of using methods from quantum information science for solid-state physics studies of novel materials can reveal fundamentally new insight.”

The experiments, which are detailed in Nature Physics, were not without challenges. For starters, the researchers needed to identify an ideal material to study the effect they were looking for and then grow it as a large, high-quality single crystal. Once they secured inelastic neutron scattering beamtime at the ILL’s powerful high-resolution triple-axis spectrometer – a difficult feat in itself – Bühler-Paschen notes that they had to obtain and analyse the data at the highest standards and support it with simulations. “Last but not least, [we had to] communicate with our peers that multipartite entanglement contains valuable information beyond correlation functions and scaling analyses,” Bühler-Paschen recalls.
Rather than being a “detail” of one particular material, Bühler-Paschen says the team’s result suggests that enhanced multipartite entanglement might be an integral part of the strange metal state. Verifying this, however, will require studies on other strange metals across materials classes, she says.
“Looking further ahead, we can envision that this aspect of strange metals finds application in quantum devices,” she tells Physics World. “It could also help us better understand high-temperature superconductors and other materials in which electrons are so strongly correlated that they lose their (quasi)particle nature.”
The post Quantum entanglement explains why strange metals are so strange appeared first on Physics World.
An exceptionally loud gravitational wave signal has offered an unprecedented glimpse into the region of space near a black hole’s event horizon – the “surface of no return” beyond which nothing, not even light, can escape the pull of gravity. Denoted GW250114, the signal originated from the merger of two black holes, and its unusual strength and clarity meant that astrophysicists could extract information from it that was previously only accessible via theoretical modelling.
Physicists describe a black hole’s event horizon in terms of two parameters: the black hole’s rotation frequency ΩH and its surface gravity κ. When an object falls into a black hole, it appears to orbit at ΩH because of a phenomenon known as frame dragging in which the black hole literally drags nearby spacetime along with it as it rotates. This means that objects near a black hole’s edge are constantly in motion relative to observers on Earth.
Regions of space near an event horizon can be described very well theoretically, but observational data has been hard to come by – at least until recently. “Gravitational waves are changing that,” says Sizheng Ma, a postdoctoral researcher at Canada’s Perimeter Institute who led the new study alongside astrophysicist Ling Sun and PhD student Neil Lu from the ARC Centre of Excellence for Gravitational Wave Discovery (OzGrav) and the Australian National University.
Gravitational waves are ripples in spacetime produced whenever dense astronomical objects such as black holes and neutron stars collide. With facilities such as the Laser Interferometer Gravitational-Wave Observatory (LIGO), Virgo and KAGRA (Kamioka Gravitational Wave Detector) now routinely recording these ripples, Ma says, “something that once sounded almost like science fiction – learning about black-hole horizons through observations – is now becoming a real scientific programme”.
In earlier theoretical work, Ma and colleagues in Japan, China and the US predicted that if Einstein’s general theory of relativity is correct, the gravitational waves produced when two black holes merge should carry information about the near-horizon region during the final stage of the merger. This information takes the form of a gravitational-wave component known as a direct wave that oscillates around a value that is twice that of ΩH. “The big question was whether such a signal could actually be seen in real gravitational-wave data,” Ma says.

The main challenge, he explains, is that gravitational-wave data are hard to interpret. “Interesting features can appear for many reasons, so we had to be very cautious,” he says. “We needed to separate this possible direct-wave signature from the much stronger and better-known ‘ringdown’ signal of the final black hole, and then check whether the remaining pattern behaved as the theory predicted.”
When the LIGO-Virgo-KAGRA network detected GW250114 last year, the astrophysicists realized they were in luck. With a network signal-to-noise ratio of approximately 80, this event was around three times louder than LIGO’s first gravitational-wave signal in 2016, and it gave the team a rare opportunity to test their prediction against data. “Our new analyses have allowed us to decrypt the signal and measure ΩH and κ for the first time,” Ma says.
Even with an unusually clear signal, Ma acknowledges that the work required “careful modelling and many double-checks to make sure we were not overinterpreting a feature in the noise”. But if the team’s interpretation holds up, Ma tells Physics World that their method could become a new way of studying black holes. Gravitational-wave observations have already enabled scientists to study how black holes orbit, merge and settle down, Ma notes. The present work extends this by offering access to the near-event-horizon region during the merger’s final stage.
“That gives us a new observational handle on some of the most extreme predictions of Einstein’s theory, allowing us to perform sharper tests of this theory and better understand how black holes form and relax after a merger,” he says. “It also allows us to explore whether the near-horizon region behaves exactly as Einstein predicted.”
The researchers’ next step will be to improve their direct-wave model so that it describes realistic black hole mergers in greater detail. “On the observational side, we want to apply the analysis to more gravitational-wave events,” Ma says. “The result detailed in this study comes from one exceptionally loud and clean event, so the most convincing confirmation would be to see the same kind of near-horizon signature in other black-hole mergers.”
The good news is that as gravitational-wave detectors continue to improve, the researchers hope to collect more such high-quality events. “These will allow us to test whether this pattern appears consistently in the way general relativity predicts and eventually turn this first result into a more systematic way of studying the regions near black hole horizons,” Ma says.
The research is published in Nature.
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The New York Times recently published a 124-page special issue of its Style Magazine entitled “How to be cultured”. According to the cover of this glossy, ad-driven supplement, the contents were “idiosyncratic” but amounted to a “compendium of what you need to know right now”. The material had been “chosen by experts” for the purpose of “teaching readers how to be more cultured”.
Curious as to what would be included, my hopes were raised by the magazine’s lead editorial. It said that the issue “celebrates expertise, a quality ever less valued in our culture today, where learnedness and firsthand research can be overshadowed by slick presentation and dumb certainty”.
Now, I’m not naïve. I know that the New York Times Style Magazine caters to advertisers, who in turn cater to wealthy readers who feel the need to spend gobs of money to get culture. It didn’t therefore surprise me to have to leaf through 40 pages of adverts for jewellery, champagne, watches and home furnishings before finally coming across the table of contents.
I saw headings for film, food, music, theatre, fashion and the visual arts. Shakespeare showed up several times: over half a dozen plays, sonnet #94 and one of his monologues. There were entries for 1930s movies, animated videos and films from Brazil. One page on food and drink covered porridge from Norway, meat from Mexico, lemonade from Vietnam and wine from Austria.
There was no mention of science in “How to be cultured”, nothing at all
Novels from the US, UK, France, Japan, India and Brazil made the list, as did selections of music from medieval times to opera and hip-hop. Samples of theatre, puppetry and architecture made it in too. But there was no mention of science, nothing at all. The closest I found were architectural materials such as plaster, glass, steel and textiles.
The absence of anything scientific should not have shocked me; in fact, it reminded me of the British scientist and novelist C P Snow’s 1959 essay The Two Cultures and the Scientific Revolution. Even back then, Snow lamented that humanists and scientists were living in two separate cultures divided by a “gulf of mutual incomprehension”.
In the essay’s most famous passage, Snow wrote that “a good many times I have been present at gatherings of people who, by the standards of the traditional culture, are thought highly educated and who have with considerable gusto been expressing their incredulity at the illiteracy of scientists”.
“Once or twice,” he went on, “I have been provoked and have asked the company how many of them could describe the Second Law of Thermodynamics. The response was cold: it was also negative. Yet I was asking something which is about the scientific equivalent of ‘Have you read a work of Shakespeare’s?’”
Snow did not stop there. “I now believe,” he continued, “that if I had asked an even simpler question – such as, ‘What do you mean by mass, or acceleration’, which is the scientific equivalent of saying, Can you read? – not more than one in ten of the highly educated would have felt that I was speaking the same language.”
“So the great edifice of modern physics goes up,” he concluded, “and the majority of the cleverest people in the western world have about as much insight into it as their neolithic ancestors would have had.”
Snow’s tone was snobby and arrogant, but he was on to something. Can someone who knows nothing about, say, Einstein’s equation E = mc2 or about Heisenberg’s uncertainty principle really be called cultured? Sure, cultured individuals don’t need to know much about these topics. But they ought at least to realize that those equations concern how mass and energy work and the inherent limitations to what humans can know.
I’d say those are principles fundamental to the formation, maintenance and fate of the universe – and ones that a cultured person ought to know something about. Indeed, references to them are routinely found in arts and popular culture. Einstein’s equation has made the cover of Time magazine, while the uncertainty principle has been taken up by novelists, theologians and comedians.
Shouldn’t a cultured person be acquainted in some way with the existential threats facing the world?
Further, shouldn’t a cultured person be acquainted in some way with the existential threats facing the world? Wouldn’t such a person have to have an inkling of the way a carbon molecule absorbs and emits heat, of how vaccines work, and of safe and unsafe levels of substances toxic in high doses? How cultivated can an ostrich be?
Of course, there was nothing about the second law in “How to be cultured”, or about any other science of the sort Snow had in mind.
Nothing about scientific equations, experiments, theories or facts that a cultured person ought to know.
No discussion of dark matter, dark energy or of quantum physics, genes or vaccines. Nor about the Pythagorean Theorem or the double-slit experiment.
Culture refers to the influences and values that are embedded in the way we live. Judging such influences and values – deciding which influences and values ought to be so embedded – is a tempting but arrogant game.
So let’s play. Imagine that you are among the experts charged with compiling a “compendium of what you need to know right now”. What would you include of science – and why? Send me your contributions, and tell me why they are what we need to know, and I’ll write about them in a future column.
Send your thoughts to Robert P Crease at robert.crease@stonybrook.edu.
The post Tell us what science you need to know to be ‘cultured’ appeared first on Physics World.