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Queen Odor Mediates Reproductive Suppression in Eusocial Mammals

16 July 2026 at 13:26

Naked mole-rats have long puzzled biologists with their striking eusocial structure, where most adults remain reproductively suppressed while a queen controls the colony’s future. Now, a new study identifies a chemical “queen odour” that links social status to endocrine control, revealing a mammalian analogue to insect queen pheromones.

The molecule, termed IPM, is enriched by the queen and acts as the key mediator of reproductive suppression in non-breeding females. When IPM is present, circulating prolactin rises while progesterone is suppressed, locking the colony into a stable reproductive hierarchy characterized by reduced conflict and maintained group cohesion.

Crucially, the team connects this behavioural outcome to the brain. Using multiple approaches—including non-invasive functional ultrasound imaging (fUSI)—they show that IPM provokes strong activation of olfactory neurons and central neural circuits. This provides a neural substrate for how a chemical cue can trigger colony-wide physiological change, rather than relying on social learning or passive association.

The experiments also clarify sensory routing. Ablating olfaction abolishes aggression initiation and lowers prolactin levels, directly tying IPM detection to reproductive suppression. While the findings are consistent with sensing through the main olfactory epithelium, the authors note that the vomeronasal system may still contribute.

Queen removal normally destabilizes colonies, leading to aggression, reproductive competition, prolactin decline, and, in extreme cases, mortality. Yet when IPM is added to queenless bedding, the colony remains stable for months. During this period, fecal progesterone metabolite levels stay low, indicating sustained ovarian quiescence alongside elevated prolactin.

The study also addresses a longstanding paradox: transferring soiled bedding and urine from parent colonies fails to maintain suppression in isolated individuals. The authors propose that IPM’s chemistry helps explain this discrepancy. As a long-chain fatty acid ester with low volatility, IPM may persist within the colony environment but fail to travel effectively over distance or survive transfer pathways that preferentially carry other chemicals.

Comparative work extends beyond naked mole-rats. IPM is detected in breeding females of four additional Fukomys species. Although reproductive suppression mechanisms may differ across species, the presence of a similar queen-linked odorant suggests convergent chemical strategies for managing reproductive skew in eusocial mammals.

Overall, the research reframes reproduction control as a chemosensory-to-endocrine pathway: IPM activates olfactory–hypothalamic signalling, elevating prolactin and inhibiting GnRH release. This “social hormone” model offers a new principle for social evolution—chemical cues can synchronize behaviour and physiology at the scale of an entire mammal colony.

Subject of Research: Reproductive suppression and social hierarchy in eusocial mammals (naked mole-rats and related Fukomys species)

Article Title: A queen odour mediates reproductive suppression in a eusocial mammal

Article References:

Khallaf, M.A., Hart, D.W., Luo, W. et al. A queen odour mediates reproductive suppression in a eusocial mammal.
Nature (2026). https://doi.org/10.1038/s41586-026-10772-5

Image Credits: AI Generated

DOI: https://doi.org/10.1038/s41586-026-10772-5

Keywords: IPM; queen odour; reproductive suppression; prolactin; GnRH; olfaction; eusociality; functional ultrasound imaging; Fukomys

Orange-lipped monkey that roars and snorts deep in Congo rainforest is new species to science

15 July 2026 at 19:00

Scientists have identified a new species of monkey that has orange lips and makes unique roars and snorting sounds. The distinctive monkey lives in a remote region of the Democratic Republic of the Congo (DRC).

It is only the fifth new monkey species to be identified in Africa in the past 75 years, and there might be more unknown monkey species in the region, scientists behind a new study suggested. Researchers named the newly identified species of monkey Colobus congoensis, after the region, and it is known by the common name "lik­weli" in the local Kilanga language.

"This is remarkable because it's not very common these days to find a new, never-before-documented primate species, let alone a relatively large species of monkey," said Joshua Linder, an anthropologist and president and co-founder of the The Forest Collective, a nonprofit that aims to conserve and restore tropical rainforests.

In 2008, conservationists in the dense rainforests of Lomami National Park, within the Congo Basin in the DRC, photographed an unidentified monkey, but it was partially obscured. Then, in 2018 a similar-looking animal was captured on camera, prompting study co-author Junior Amboko, a Lomami National Park researcher and a Florida Atlantic University anthropologist, to set out to find the mysterious monkey.

To see what was already known, Amboko and his colleagues showed the pictures to people from 52 villages around the park.

"These people really know the fauna and flora in the forest," Amboko told Live Science. "In only eight villages, people knew the monkey ‪—‬ and these were hunters, who know the economic value of animals or how much food each animal can provide, but even they didn't know much."

Two men wearing long sleeves and hats stand in the middle of a dense jungle.

The researchers worked in the Lomami National Park, within the Congo Basin in the Democratic Republic of Congo. (Image credit: Daniel Rosengren, Frankfurt Zoological Society  )

Hunters of the Balanga ethnic group called the monkey "likweli," although the meaning of this name isn't known. Some in the Mituku local communities called the species "kasaba nkoni," which Amboko said means "the branch shaker." This refers to the way colobus monkeys leap from branch to branch, Amboko said.

In their searches between 2018 and 2022, the researchers recorded 114 sightings of the species across an estimated range of about 660 square miles (1,700 square kilometers) naturally isolated between the Lomami and Lualaba rivers. They reported their findings July 15 in the journal PLOS One.

The monkeys, seen hanging out in groups of between one and 20 individuals, are mainly glossy black, but they have a conspicuous orange patch around the mouth and nose. Bare gray skin on their cheekbones makes it look as if they're wearing masks. They also have a patch of white fur around the anus.

"We're going with the face and the rump as the two distinctive traits," said study co-author Kate Detwiler, an anthropologist at Florida Atlantic University. "If you see the face, you see this unique bare skin that's orange cream. And then if you're coming from behind, you see this white patch."

Images of three black monkeys in trees.

DNA analysis confirmed C. congoensis was a previously unknown species. (Image credit: Daniel Rosengren, Frankfurt Zoological Society  )

The monkeys, which weigh about 15 pounds (7 kilograms), also make deep, loud roars, punctuated by distinctive snorts. These unique‬ vocalizations distinguish them from other colobus monkeys, Detwiler told Live Science.

By taking samples, and sequencing DNA, from monkeys killed by hunters and destined for the illegal bushmeat trade, and comparing the results with what’s in museum collections and datasets of genetics, skulls, teeth and pelts for other colobus monkeys, the team confirmed that C. congoensis was a previously unknown species.

"My lab got the tissue sample and did the genetics, and we were shocked by how divergent the key area of the mitochondrial genome was from other colobus monkeys," Detwiler said.

A close up of an orange-lipped monkey in a tree

Researchers think the new species diverged up to 5.78 million years ago. (Image credit: Daniel Rosengren, Frankfurt Zoological Society  )

The monkeys live in the same forest as the Angola colobus (Colobus angolensis), but their closest relatives are black colobus monkeys (Colobus satanas), which live around 750 miles (1,200 kilometers) to the west, in Cameroon, Gabon and Bioko Island.

"The fact that the results show that the closest living relative to this new species is the black colobus located 1200 km away in West Africa is equally remarkable," Linder, who was not involved in the new study, told Live Science via email.

Detwiler estimates that these close relatives diverged between 5.78 million and 3.44 million years ago ‪—‬ the longest known split between species within the Colobus genus. "The discovery is reshaping our understanding of African monkey evolution," she said.

Given the small geographic range, rare sightings and increasing habitat loss, the researchers recommend that C. congoensis be classified as endangered on the IUCN Red List.

The discovery also emphasizes the importance of Lomami National Park, where another previously undescribed monkey, the lesula (Cercopithecus lomamiensis), was reported in 2012 by a team that included Detwiler.

The Congolian rainforest ranging across this part of Africa is the world's second-largest tropical forest, after the Amazon, and about 60% of it is in the DRC. "It is a paradise for biodiversity," Amboko said, adding that there might be more undescribed primate species there. "If we are able to discover two big new primate species, who knows how many other new mammals, fish, reptiles or plants there could be?"

What do you know about chimpanzees and great apes? Test your smarts with our primate quiz!

Scientists are deep-freezing koala eggs and sperm to protect the species from extinction

Scientists in Australia are deep-freezing koala eggs and sperm as a "genetic backup" to save the wild population from future extinction.

The backup could be used to create healthy koala embryos through artificial insemination and in vitro fertilization (IVF), the researchers said in a statement. When koalas (Phascolarctos cinereus) die, unique traits and diverse genes that may help them adapt to changing environments are lost, but the new project offers a way to store this valuable material, the team said.

"Losing genetic diversity can weaken future generations and decreases the ability of the species to adapt to challenges," Andres Gambini, a reproductive biologist at the University of Queensland who is involved in the project, said in the statement. "This project will create a safe and systematic way to rescue and preserve koala spermatozoa and eggs to support future conservation programs."

Australia is facing a paradox with its koalas. In some regions of Queensland and New South Wales, koala populations have crashed by as much as 80% since the late 1990s due to deforestation, bushfires, drought and disease. This prompted the Australian government to change koalas' conservation status in their eastern range from "vulnerable" to "endangered" in 2022.

Meanwhile, in parts of southern Australia, koalas are overabundant. However, the places where koalas are currently thriving may not be able to support a booming population much longer, because the animals are overbrowsing and killing the trees they need to survive, recent research suggests.

To protect against koalas' decline, the scientists will freeze koala reproductive cells in liquid nitrogen (LN2), which has a boiling point of minus 321 degrees Fahrenheit (minus 196 degrees Celsius). This method would enable the team to cryopreserve the cells for several decades until they are needed, said Vincent Lynch, an evolutionary developmental biologist and associate professor of biological sciences at the University at Buffalo in New York.

Every year, many koalas are admitted to wildlife hospitals because of illness or injury and sadly, not all of them survive.

Andres Gambini, reproductive biologist at the University of Queensland

"I've successfully woken cells up that were frozen in LN2 a couple of decades ago," Lynch, who is not involved in the koala project, told Live Science in an email.

The sperm and eggs will be supplied by wildlife hospitals that will harvest sex cells from dead koalas or koalas that can no longer breed due to disease or trauma, according to the statement.

"Every year, many koalas are admitted to wildlife hospitals because of illness or injury and sadly, not all of them survive," Gambini said.

The researchers will then test the cells for Chlamydia pecorum, a highly contagious and deadly form of chlamydia. In koalas, this infection causes painful urinary tract infections, gastrointestinal issues, and conjunctivitis, which can lead to blindness. It can also cause infertility in females. C. pecorum is one of the main contributors to koalas' decline in recent years, with infertility driving a sharp reduction in the number of koala joeys being born. In the worst-affected populations, situated mostly in Queensland and New South Wales, almost 90% of koalas are infected with chlamydia.

If the reproductive cells contain C. pecorum, "we have the technology now to remove the infection from the samples," Steve Johnston, an associate professor of animal reproduction and captive husbandry at the University of Queensland who works on the koala project, said in the statement.

Two scientists posing with a liquid nitrogen storage cannister in a laboratory.

Andres Gambini and doctoral student Patricio Dandy Palacios, who participated in the project, want to preserve koala sex cells in liquid nitrogen. (Image credit: The University of Queensland)

In 1998, Johnston was part of a research team at the University of Queensland that created the world's first koala joey born through artificial insemination. The new project also builds on a 2025 study, led by Gambini, that produced the first-ever IVF kangaroo embryos. (These did not result in live births; at the time, the scientists said that would take another decade.)

It's unclear how many sperm and egg cells the researchers plan on freezing, and it's hard to say how many cells they would need to ensure the survival of healthy koala populations, as the number of cells required is probably increasing with time, Lynch said. As koala populations shrink, genetic material is being lost at an accelerating pace, so the team will have to get more samples as time goes on to obtain the same amount of diversity.

The project does not replace more traditional conservation approaches — such as habitat protection, disease management and population monitoring — but researchers cannot afford to wait until populations are smaller and genetic diversity is harder to recover, Gambini said.

Although conservationists are concerned about the fast rate of koalas' decline, "there is a chance" that scientists can save the species through cryopreservation, Lynch said.

"I support multipronged approaches like this," he said. "By preserving the environment with traditional conservation we allow re-introductions because the species have somewhere to live."

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