For patients with disorders of consciousness such as coma, vegetative states, or unresponsive wakefulness, clinicians face a longstanding challenge of determining whether any awareness remains. While surface brain recordings can measure general electrical activity, they do not reveal what is happening deep within the brain.

Now, a new study from Ludwig-Maximilians-Universität München may bring clinicians closer to a measurable indicator of brain states in these conditions.

Researchers at LMU have found a new type of electrical rhythm in the central thalamus, a small area deep inside the brain. Published in Nature Human Behaviour, the study suggests that this rhythm could serve as a biological indicator of conscious states.

A Signal That Tracks Awareness

The signal does more than just appear with consciousness. It also changes as the brain moves between different states. For example, the rhythm becomes stronger during REM sleep, which lets researchers see small shifts in awareness even within the same stage of sleep.

“Our results show that the central thalamus plays an important role in regulating brain states,” said Dr. Aditya Chowdhury, lead author of the study. “In the context of existing research, our results show that this small deep-lying brain structure could actively influence our states of consciousness.”

Professor Tobias Staudigl, who led the research team, argues the signal’s consistency makes it more than just an interesting discovery. “These characteristic rhythm patterns can be reliably attributed to specific states and thus have the potential to serve as a measurable biological signature of states of consciousness,” Staudigl said.

Getting Inside the Deepest Part of the Brain

Recording electrical activity from deep brain structures is one of neuroscience’s most persistent technical problems. Standard surface EEG can detect general patterns from the brain’s outer layers, but it misses details from deeper areas. Since the thalamus sits at the center of the brain, it has remained largely inaccessible through non-invasive methods.

The LMU team had a rare chance to study this. Their research involved patients already undergoing deep-brain stimulation therapy for epilepsy, which uses electrodes in the thalamus to help control seizures. These electrodes let the researchers record signals directly from inside the thalamus, something that is almost never possible otherwise.

The team combined these recordings with surface EEG, eye-tracking, and detailed sleep-stage analysis. This approach allowed them to see how thalamic activity changes as patients transition between wakefulness and different sleep stages. Their findings offer the most detailed picture yet of what the thalamus actually does as consciousness changes.

Medical Implications

Disorders of consciousness, like coma, vegetative state, and minimally conscious state, are some of the hardest problems in neurology. One reason is that doctors have lacked reliable biological markers to assess patients’ awareness. The thalamic rhythm found in this study could help solve that problem.

If this signal truly tracks brain states linked to consciousness, it could help doctors evaluate awareness in patients who cannot communicate, guide treatment choices, and monitor how patients respond to care over time. The researchers believe it could also be used to improve deep brain stimulation therapy by allowing doctors to adjust treatment based on real-time thalamic activity rather than general clinical signs.

Staudigl was recently awarded funding by the European Research Council to explore the clinical potential of this discovery and to develop applications for treating neurological disease.

Understanding consciousness has always been one of science’s most difficult challenges. While the study does not answer the fundamental question of what consciousness is, these findings provide a consistent, measurable signal that indicates how the brain moves between conscious and unconscious states.

Austin Burgess is a writer and researcher with a background in sales, marketing, and data analytics. He holds an MBA, a Bachelor of Science in Business Administration, and a data analytics certification. His work focuses on breaking scientific developments, with an emphasis on emerging biology, cognitive neuroscience, and archaeological discoveries.

Synesthesia (noun, “sin-es-THEE-jah”)

Synesthesia is a trait that some people have in which one kind of sensory input triggers other senses. To someone with synesthesia, different colors may have different tastes. Or hearing certain sounds may cause them to see certain shapes.

This phenomenon is not a mental illness. Rather, it is considered a form of neurodiversity. Up to 4 percent of people may have some form of synesthesia.

This trait takes many forms. Grapheme-color is one type. This means that a person sees letters or numbers in different colors. For instance, when a person sees the number 7, it may always appear yellow. About 1 percent of people share this trait.

Another type is called chromesthesia. That’s when hearing a sound causes a person to see colors or shapes around them. Historians think that Vincent van Gogh, a 19th-century painter, may have had this trait. He described seeing colors around him when he played the keys of a piano.

Other famous artists, such as singer and songwriter Billie Eilish, have described this experience, too. “Everything that I make I’m already thinking of what color it is, and what texture it is, and what day of the week it is, and what number it is, and what shape,” the musician told iHeart Radio.

Scientists are not sure exactly what causes synesthesia. But they believe it is at least partly linked to a person’s genes.

In a sentence

Taria Camerino — a chef based in Atlanta, Ga. — was born with a form of synesthesia that links certain sounds with flavors.

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