Welcome boost for chancellor with unexpected rise put down to rapid growth of AI in services sector outweighing Iran war fallout

The UK economy grew in July as the rapid expansion of AI appeared to outweigh the economic damage from the Iran war, in a welcome boost for John Healey.

Figures from the Office for National Statistics (ONS) showed a surprise 0.4% increase in gross domestic product (GDP), compared with 0.3% growth in June. City economists had forecast zero growth.

Continue reading...

© Photograph: Bloomberg/Getty Images

© Photograph: Bloomberg/Getty Images

© Photograph: Bloomberg/Getty Images

Idiopathic pulmonary fibrosis, a relentlessly progressive and fatal scarring disease of the lungs, has long frustrated clinicians with only two approved drugs that slow but cannot reverse its course. Now, a team of researchers in Taiwan has identified a surprising new player in the disease’s destructive machinery: doublecortin-like kinase 1, or DCLK1, a kinase better known for its role in cancer stem cells. Their study, published in the Journal of Biomedical Science, demonstrates that DCLK1 drives fibroblast activation in the lung and that blocking it—either genetically or with an oral inhibitor—slows fibrosis and preserves lung function in mice. The findings position DCLK1 as a promising therapeutic target in one of medicine’s most stubborn diseases.

The research, led by Lee-Yuan Lin, Wun-Hao Cheng, Chien-Huang Lin and Bing-Chang Chen of Taipei Medical University, together with collaborators at National Taiwan University Hospital and Universitas Gadjah Mada, began with a question that has lingered in the literature. Gene expression analyses had previously hinted that DCLK1 might be implicated in IPF, and earlier work reported that the kinase is markedly enhanced in the alveolar epithelial cells of patients with pulmonary fibrosis and in mice with bleomycin-induced fibrosis. But its function in fibroblast activation—the cellular engine of fibrosis—had remained unexplained.

To begin untangling that role, the team mined a publicly available single-cell RNA sequencing data set containing more than 312,000 cells from healthy lungs, IPF lungs, and lungs with chronic obstructive pulmonary disease. After stringent quality control filtering, they focused on roughly 240,000 cells from the control and IPF groups and mapped DCLK1 expression across the major lung cell lineages: epithelial, endothelial, lymphoid, myeloid, and stromal cells. The signal was unmistakable. DCLK1 was expressed across many cell populations, but the highest expression appeared in the stromal compartment, particularly in myofibroblasts—the specialized, contractile fibroblasts that churn out the extracellular matrix and stiffen lung tissue in IPF.

Human tissue told the same story. The researchers examined lung samples from eleven patients with IPF, obtained during lung transplantation or surgery, alongside fourteen nonfibrotic control samples. Histological staining with hematoxylin and eosin and Masson trichrome confirmed the expected picture of interstitial consolidation and collagen deposition in the IPF specimens. More importantly, immunohistochemistry revealed that both total DCLK1 and its phosphorylated, activated form were significantly upregulated in the fibrotic lung interstitium compared with control tissue. DCLK1, in other words, was not merely present in scarred lungs—it was switched on.

DCLK1 is an intriguing molecule to find at the center of a fibrotic process. It is a serine/threonine kinase belonging to the calcium/calmodulin-dependent kinase family, distinguished by two microtubule-binding domains. In oncology, DCLK1 overexpression has been documented in colorectal, pancreatic, gastric, renal, and hepatocellular carcinomas, where it correlates with poor prognosis, high recurrence, and metastasis, promoting tumor initiation and the epithelial–mesenchymal transition in cancer stem cells. It has also been linked to inflammatory signaling in SARS-CoV-2 infection, where inhibiting it blocks proinflammatory caspase-1/interleukin-1β signaling. The new study extends this portfolio of mischief to the fibrotic lung.

To test causality rather than mere correlation, the researchers turned to mice. They crossed animals carrying loxP sites flanking exon 3 of the DCLK1 locus with Pgk1-RFP-Cre/ERT2 transgenic mice, generating a system in which tamoxifen administration triggers global deletion of the Dclk1 gene. When these DCLK1 knockout mice and littermate controls were given intratracheal bleomycin, a chemotherapy drug used to induce pulmonary fibrosis in laboratory animals, the difference was striking. Knockout mice showed far less lung infiltration and collagen deposition, reduced numbers of cells staining positive for DCLK1 together with fibroblast surface protein and alpha-smooth muscle actin, and significantly lower levels of the profibrotic proteins fibronectin, α-SMA, and connective tissue growth factor, or CTGF.

The protective effect extended well beyond molecular markers. Using the FlexiVent FX system to measure lung mechanics, the team found that bleomycin treatment significantly reduced respiratory system compliance and pressure–volume performance and increased the normalized work of breathing in control mice—hallmarks of a stiffening, fibrotic lung. In the DCLK1 knockout animals, these functional deficits were substantially attenuated. In vivo microcomputed tomography, acquired at 34.75-micrometer voxel resolution, painted the morphological counterpart: bleomycin caused parenchymal destruction and volume loss in control lungs, while knockout mice retained lung structure and volume. Density histograms shifted toward fibrotic tissue in wild-type animals but stayed largely preserved in the knockouts, and peripheral blood neutrophil percentages, which climbed after bleomycin injury, were significantly reduced in the knockout group.

With the in vivo evidence established, the investigators dissected the molecular wiring in cultured normal human lung fibroblasts. Transforming growth factor beta, the master profibrotic cytokine, induced DCLK1 phosphorylation within 30 minutes and DCLK1 expression within 8 hours. Chromatin immunoprecipitation assays showed that after TGF-β stimulation, both Smad3—the canonical transcriptional mediator of TGF-β signaling—and the nuclear factor kappa B subunit p65 enriched at the DCLK1 promoter, indicating that TGF-β switches on DCLK1 through both Smad-dependent and noncanonical NF-κB pathways. Silencing DCLK1 with small interfering RNA then blunted the fibroblast’s profibrotic response, reducing TGF-β-induced expression of fibronectin, collagen 1A1, α-SMA, and CTGF.

The pathway, however, does not stop there. The team found that TGF-β also phosphorylated Akt, and that transfecting fibroblasts with a dominant-negative Akt construct reduced TGF-β-induced DCLK1 phosphorylation and the expression of fibronectin and CTGF—placing Akt upstream of DCLK1. Downstream, DCLK1 knockdown reduced Smad3 phosphorylation while DCLK1 overexpression enhanced it. Coimmunoprecipitation revealed a physical association between DCLK1 and Smad3, and immunofluorescence microscopy showed the two proteins colocalizing in the nucleus within 30 minutes of TGF-β treatment. A ChIP assay using a DCLK1 antibody pulled down DNA from the Smad3-binding region of the CTGF promoter, and pretreatment with the selective DCLK1 inhibitor DCLK1-IN-1 reduced TGF-β-induced CTGF expression. Together, the results sketch an Akt/DCLK1/Smad3 axis through which TGF-β drives the production of connective tissue growth factor, a potent profibrotic mediator.

The clinical payoff came in the pharmacological arm of the study. Mice receiving oral DCLK1-IN-1 at 10 milligrams per kilogram daily, beginning on day 7 after bleomycin instillation and continuing until day 28, showed visibly reduced fibrotic progression on histology, lower expression of fibronectin, α-SMA, and CTGF in lung tissue and lysates, preserved pulmonary compliance, improved pressure–volume loops, and reduced work of breathing. Serial microCT scans on days 7, 17, and 27 documented less severe fibrotic remodeling in the treated animals, with lung attenuation histograms showing a smaller fraction of dense, nonaerated voxels. Blood neutrophil counts were also lower. In short, a pill-like oral inhibitor measurably slowed the disease in a model that mirrors the human condition.

The implications are significant because the current therapeutic landscape for IPF is so thin. Only nintedanib, a tyrosine kinase inhibitor targeting growth factor receptors, and pirfenidone, which suppresses TGF-β production and activity, are approved by the US Food and Drug Administration, and both merely slow progression. The recent failure of pamrevlumab, a monoclonal antibody against CTGF, in the phase 3 ZEPHYRUS-1 trial suggested that targeting downstream fibrotic end products alone may be insufficient—pointing to the value of upstream signaling regulators such as DCLK1. Adding to the appeal, a DCLK1 inhibitor has already been shown to prevent inflammatory responses in acute lung injury, hinting at dual anti-fibrotic and anti-inflammatory potential.

The authors are careful to note limitations. DCLK1 is expressed across multiple lung cell types, and the tamoxifen-inducible knockout used here was global rather than cell-type-specific, so the contributions of fibroblasts versus epithelial, endothelial, and immune cells could not be fully separated. Human control tissue, as in most fibrosis studies, came from heterogeneous sources, including tumor-adjacent lung. The precise subcellular mechanics of the DCLK1–Smad3 interaction, whether DCLK1 inhibition can promote fibrosis resolution rather than merely slow progression, and the systemic safety of long-term DCLK1 blockade—all relevant given the kinase’s role in cancer and other processes—remain open questions.

Even so, the convergence of evidence is striking: DCLK1 is upregulated in human IPF, amplified in experimental fibrosis, mechanistically coupled to the TGF-β–Smad3 engine of fibroblast activation, and its suppression by both genetics and a small molecule preserves lung structure and function. What began as a cancer stem cell marker has now emerged, unexpectedly, as a central node in the scarring of the lung—offering fresh hope that a disease long considered irreversible may one day be stopped at its molecular source.

Late last week, word started leaking that the National Institutes of Health (NIH) had reached an agreement with the Department of Defense that would see part of the NIH's budget used to fund research at the Department of Defense. So, on the Friday just prior to a US holiday weekend, the Department of Defense released a copy of the agreement and confirmed that it had been signed roughly a month earlier. The move is striking for a number of reasons, ranging from the existing budget disparities between the two parties involved to the fact that the money would be used for projects that the current NIH leadership has explicitly rejected.

The agreement itself sets up a system where the NIH would transfer money to the Department of Defense to fund staff and projects that would "support the advanced development of medical countermeasures against pandemic influenza, chemical, biological, radiological, and nuclear (CBRN) threats, and emerging infectious diseases." The money would come out of the budget for the NIH's National Institute of Allergy and Infectious Diseases, or NIAID, to which Congress has allocated $6.6 billion in 2026. The agreement is set to run for a decade.

Left unspecified is just how much of the NIAID budget will be spent on Defense projects. Reporting by Nature suggests that the Department of Defense was looking for up to a third of its total budget but was being told to settle for about 10 percent. There's obviously an enormous disparity between the budgets of these two agencies, given that the 2026 Defense budget is roughly $1 trillion. That budget is under considerable strain, however, due to the open-ended nature of the conflict with Iran. The deal has also been announced at a time when the NIH has been struggling to issue sufficient grants to use the money that Congress allocated to it.

Read full article

Comments

© Artem Onoprienko

Late last week, word started leaking that the National Institutes of Health (NIH) had reached an agreement with the Department of Defense that would see part of the NIH's budget used to fund research at the Department of Defense. So, on the Friday just prior to a US holiday weekend, the Department of Defense released a copy of the agreement and confirmed that it had been signed roughly a month earlier. The move is striking for a number of reasons, ranging from the existing budget disparities between the two parties involved to the fact that the money would be used for projects that the current NIH leadership has explicitly rejected.

The agreement itself sets up a system where the NIH would transfer money to the Department of Defense to fund staff and projects that would "support the advanced development of medical countermeasures against pandemic influenza, chemical, biological, radiological, and nuclear (CBRN) threats, and emerging infectious diseases." The money would come out of the budget for the NIH's National Institute of Allergy and Infectious Diseases, or NIAID, to which Congress has allocated $6.6 billion in 2026. The agreement is set to run for a decade.

Left unspecified is just how much of the NIAID budget will be spent on Defense projects. Reporting by Nature suggests that the Department of Defense was looking for up to a third of its total budget but was being told to settle for about 10 percent. There's obviously an enormous disparity between the budgets of these two agencies, given that the 2026 Defense budget is roughly $1 trillion. That budget is under considerable strain, however, due to the open-ended nature of the conflict with Iran. The deal has also been announced at a time when the NIH has been struggling to issue sufficient grants to use the money that Congress allocated to it.

Read full article

Comments

© Artem Onoprienko

On Tuesday, the House of Representatives passed a stopgap measure that would continue funding the US government through early December. While the measure still requires the signature of President Trump, it's widely expected that he will act to avoid a government shutdown immediately before the midterm elections.

This is a normal part of how the US government has operated in recent years, as it's often difficult to build the political support needed to pass a full year's budget in advance. In fact, dissent within the House's Republican caucus prevented them from agreeing on their own measure to keep the government open; instead, the House simply adopted a version of the spending bill that had previously passed the Senate.

From the perspective of scientists and their supporters, that adoption turned out to be a very good thing, because the Senate's budget bill, passed in early August, contains a provision that blocks the Office of Management and Budget (OMB) from implementing new rules that would give political appointees full control over what science is funded and allow them to cancel any grant at any time. The proposed rule has been widely decried as catastrophic for science, and it faced widespread opposition from scientific and health-focused organizations.

Read full article

Comments

© Getty Images | Bloomberg

From NAB in Las Vegas, Matt Bach, Senior Product Manager at Puget Systems, explains PugetBench, a free benchmarking tool for end users that tests real applications such as Premiere Pro, Photoshop, After Effects, DaVinci Resolve, and soon Unreal Engine. Matt discusses why real-world benchmarks beat synthetic scores, how software updates can dramatically change performance, and […]

💾

Lung adenocarcinoma is one of the most common forms of lung cancer and remains a major cause of cancer-related death worldwide. Although advances in imaging, molecular testing and targeted treatment have transformed care for some patients, the disease can behave very differently from one person to another. A new study published in the British Journal of Cancer is examining whether a protein called PDLIM2 could help explain that difference—and potentially become both a prognostic biomarker and a target for future therapies.

The research, led by Ashouri, Sun, Krause and colleagues, focuses on the biological and clinical significance of PDLIM2 in lung adenocarcinoma. A prognostic biomarker is a measurable feature that helps indicate how a disease may progress, including the likelihood of recurrence, treatment resistance or reduced survival. A therapeutic target, by contrast, is a molecule or pathway that can be manipulated with a drug or other intervention. The possibility that one protein could serve both roles makes PDLIM2 particularly interesting to cancer researchers.

PDLIM2 belongs to a family of proteins containing LIM domains, compact structural modules that help organize interactions between proteins. These proteins can act as molecular adaptors, bringing signaling components into the same cellular neighborhoods and influencing how cells respond to external stimuli. PDLIM2 has also been linked to the regulation of transcription factors, including nuclear factor kappa B, or NF-κB, a signaling regulator involved in inflammation, immune responses, cell survival and cancer biology. Because these processes are frequently altered in tumors, changes in PDLIM2 activity could have consequences extending far beyond a single cellular pathway.

Lung adenocarcinoma develops through the accumulation of genetic, epigenetic and environmental changes that allow abnormal cells to grow, invade surrounding tissue and spread to distant organs. Tumor cells also interact continuously with immune cells, connective tissue and blood vessels in their surrounding microenvironment. A protein such as PDLIM2 could influence cancer progression directly inside tumor cells or indirectly by altering inflammatory communication between the tumor and its surroundings. Understanding which of these possibilities is most important is essential before the protein can be considered a reliable clinical marker.

The investigators’ work explores whether PDLIM2 levels or activity are associated with meaningful features of lung adenocarcinoma. Such analyses typically compare molecular patterns in tumor and normal tissue, relate gene or protein expression to clinical outcomes, and examine whether a biomarker adds information beyond established factors such as tumor stage, histological characteristics and patient treatment. If PDLIM2 consistently tracks with disease behavior, it could eventually help doctors identify patients whose tumors require closer monitoring or more intensive treatment.

However, a biomarker is not automatically useful simply because it is statistically associated with cancer. For a molecule to become clinically valuable, researchers must establish how accurately and reproducibly it predicts outcomes, whether the result applies across different patient groups, and whether testing can be performed using practical samples and standardized methods. The distinction between correlation and causation is equally important. A high or low level of PDLIM2 may reflect an underlying cancer process without being responsible for it. The study’s therapeutic implications therefore depend on experimental evidence showing whether changing PDLIM2 can alter tumor-cell behavior.

The therapeutic-target question is especially challenging in lung adenocarcinoma, a disease that often contains several cancer-driving alterations at once. Targeted drugs against molecules such as EGFR, ALK, ROS1 and KRAS have produced significant benefits for selected patients, but resistance commonly emerges. Tumors can bypass blocked pathways, acquire new mutations or recruit protective signals from their microenvironment. If PDLIM2 participates in a separate or complementary network, targeting it could theoretically provide another way to disrupt tumor survival or progression. That possibility remains a research hypothesis requiring validation rather than an established treatment strategy.

Laboratory studies will be crucial for determining how PDLIM2 functions in different cellular contexts. Researchers may need to silence or increase the protein in lung adenocarcinoma models, monitor effects on proliferation, migration, invasion and cell death, and test whether PDLIM2 changes the response to existing therapies. Studies using animal models and patient-derived tumor systems could further reveal whether manipulating the protein affects tumor growth in a complex biological environment. At the same time, clinical datasets will be needed to establish whether PDLIM2 has independent prognostic value and whether it can support treatment decisions.

The appeal of the new research lies in its attempt to connect molecular biology with patient outcomes. Modern oncology increasingly depends on biomarkers that do more than describe a tumor; the most useful markers help predict what will happen and guide what should be done next. PDLIM2 could become part of that effort if future studies confirm its role across diverse populations and demonstrate that it can be measured reliably. For now, the work adds to a growing investigation into the signaling architecture of lung adenocarcinoma, where proteins once considered secondary components may hold clues to why some tumors remain controllable while others become aggressive and treatment-resistant.

Subject of Research: PDLIM2 as a prognostic biomarker and potential therapeutic target in lung adenocarcinoma.

Article Title: Exploring PDLIM2 as a prognostic biomarker and therapeutic target in lung adenocarcinoma.

Article References: Ashouri, K., Sun, F., Krause, H. et al. Exploring PDLIM2 as a prognostic biomarker and therapeutic target in lung adenocarcinoma. Br J Cancer (2026). https://doi.org/10.1038/s41416-026-03570-3

Image Credits: AI Generated

DOI: 10.1038/s41416-026-03570-3

Keywords: PDLIM2, lung adenocarcinoma, lung cancer, prognostic biomarker, therapeutic target, cancer signaling, precision oncology, NF-κB, molecular oncology

Fechando a semana e o mês de julho com a nossa seleção de promoções na App Store!

O nosso destaque do dia é Pin To Wall: Photo Widget, um app simples e direto ao ponto, pensado para quem quer manter uma única foto sempre à mão no iPhone, iPad ou Apple Vision Pro.

Ele funciona como um quadro digital: você escolhe uma imagem, fixa na Tela de Início como widget e pronto, ela fica ali até você trocar.

A proposta é armazenar apenas uma foto por vez, seja da sua biblioteca ou com uma nova captura, evitando acúmulos desnecessários na biblioteca de fotos e tornando o app leve e fácil de usar.

Para quem gosta de foco e não quer gerenciar álbuns, é uma solução prática. Aproveite a oferta! 🌠

---

Abaixo outros jogos/apps que, juntos, somam quase R$100 em descontos:

Jogos

Puzzles.

Jogo de estratégia.

Jogo de cartas.

Aplicativos

Editor de vídeos.

Utilitário para desenvolvedores.

---

Aproveite as ofertas e tenha um excelente final de semana! Vale lembrar que as ofertas são sempre por tempo limitado, então é bom correr. 🦖

O app de leitura Instapaper foi atualizado hoje para a sua versão 10.0 com uma série de novidades — incluindo uma interface repaginada e adaptada ao Liquid Glass (e outras mudanças de design em grande parte do app), bem como novos recursos e melhorias de desempenho.

O Menu de Seções, por exemplo, agora pode mostrar as Contagens de seção em todos os lugares, bem como permite ordenar pastas e etiquetas por nome, ordem de adição ou contagem. Também há melhorias na exibição e suporte completo ao Liquid Glass no iPad.

Quando falamos na Lista de Artigos, ela foi redesenhada com um novo modo Condensado, opções de tipografia e uma nova ação de deslize para mover artigos para o topo. Ela também cria automaticamente listas de reprodução a partir da lista de artigos completa.

Por fim, o Leitor agora conta com quatro novas fontes de leitura (Literata, New York, Open Sans e Atkinson Hyperlegible), bem como permite escolher o que é aberto ao se tocar em um artigo (a Vista de Artigo, a Vista Web, o navegador integrado ou o padrão).

Também contando agora com um widget para ver os artigos lidos no momento ou os salvos recentemente, o Instapaper é grátis para baixar na App Store, mas para usá-lo por completo é necessária uma assinatura Premium, que sai por R$10/mês ou R$100/ano.

Uma das coisas mais chatas ao usar lançadores de apps no iOS é o redirecionamento que acontece antes de um software ser aberto na maioria deles — o que faz com que o usuário veja brevemente o launcher aparecer na tela antes do app que quer verdadeiramente usar.

De acordo com o MacStories, o app Lock Launcher, um dos mais populares do gênero para iOS, resolveu esse problema. Agora, ao tocar no ícone de um app por ele, a abertura do software é direta — bem, pelo menos visivelmente não é possível ver o lançador intermediando o processo.

Outra novidade muito bacana que chegou ao software recentemente foi o suporte aos aos widgets do tamanho extra grande — o que permite ao app ocupar uma página na Tela de Início do iOS quase que por completo, tal como a grade de apps nativa.

Embora (como o seu próprio nome já indica) o app tenha sido desenvolvido com o foco principal em abrir apps direto da Tela Bloqueada, colocá-lo como um widget na Tela de Início é uma opção bem interessante para quem quer uma experiência ainda mais personalizada.

O Lock Launcher pode ser baixado gratuitamente na App Store, mas para usá-lo por completo é necessário aderir ao plano Pro, que pode ser adquirido por uma compra única de R$60, bem como assinado por R$8/mês ou R$40/ano.

On Monday, Citi raised its price target on Apple to $365 from $315 while maintaining its Buy rating. The move reflects stronger margin expectations and rolled-forward financial estimates amid what the bank sees as Apple’s continued resilience in a tough environment for devices.

Apple shares were trading at new all-time highs in Monday morning trading, as investors digested the positive commentary ahead of the company’s upcoming earnings report. Citi remains constructive on the stock, highlighting Apple’s ability to gain market share even as broader smartphone and PC markets face headwinds.

Outperforming a Declining Market

Citi notes that smartphone and PC markets are likely to decline by mid-to-high teens percent. Despite this, Apple is positioned to outperform. According to the note:“continues to outperform the broader smartphone market through share gains, design-driven demand, and strong positioning in the mid-range price segment via promotions and subsidies.”

The firm also stated that Apple “should continue gaining market share despite a slowing devices market.”

Pricing Power and Margin Protection

A key driver behind the higher price target is Apple’s demonstrated ability to implement selective price increases. Citi observed that Apple raised prices on several products mid-quarter amid rising component costs and is evaluating additional memory suppliers to diversify its supply chain.

While iPhone prices remain unchanged for now, Citi expects price increases in the upcoming September launch cycle:“with more focus likely on the higher end models where demand is more resilient.”

The bank also flagged an expected foldable iPhone launch in the fourth calendar quarter. These factors support higher margin expectations following recent price increases.

AI Outlook: Measured Near-Term, Optimistic Longer-Term

On Apple Intelligence, Citi takes a pragmatic view. The note states that Apple Intelligence is:“unlikely to drive a significant upgrade cycle in the near term.”

However, the bank sees meaningful longer-term potential from enhanced Siri AI capabilities, which should increase user engagement and support growth in high-margin services revenue.

September Launch as Key Catalyst

Citi identifies the September iPhone launch as:“an important catalyst that could further strengthen investor sentiment.”

This event is viewed as a potential positive for both hardware momentum and overall investor confidence.

Services Growth: iCloud and Advertising in Focus

On the services side, Citi notes that Sensor Tower data showed App Store revenue in the June quarter grew just 3% year-over-year — tracking below company guidance. That said, the bank views iCloud and advertising as stronger drivers for future revenue growth.

Citi’s raised price target to $365 reflects a combination of:

• Continued market share gains in a challenging devices environment
• Ability to protect and expand margins through selective pricing
• Rolled-forward estimates and stronger margin expectations

MacDailyNews Take: Citi’s note underscores Apple’s structural advantages — brand strength, ecosystem lock-in, and pricing power — even as near-term AI-driven upgrade cycles remain limited.

---

‎
Please help support MacDailyNews — and enjoy subscriber-only articles, comments, chat, and more — by subscribing to our Substack: macdailynews.substack.com. Thank you!

Support MacDailyNews at no extra cost to you by using this link to shop at Amazon.

The post Citi hikes Apple price target to $365; bullish on market share gains and pricing power appeared first on MacDailyNews.

Welcome to this edition of The Intelligence Brief… This week, the Pentagon announced a major milestone in the development of President Trump’s proposed Golden Dome missile defense system after successfully testing a next-generation directed-energy weapon capable of intercepting drones and cruise missiles. In our analysis, we’ll be looking at 1) what the Pentagon revealed about the new directed-energy technology, 2) how the Golden Dome aims to defend against ballistic, cruise, and hypersonic missile threats, 3) why the program has drawn comparisons to Ronald Reagan’s “Star Wars” initiative, and 4) the growing debate over what could become one of the most expensive defense projects in U.S. history.

“With Golden Dome, the War Department will defend our homeland more powerfully than ever before. Golden Dome is real, powerful, and on track.”

– U.S. Secretary of War Pete Hegseth

If you enjoy the news and perspectives offered by The Debrief, make sure that you aren’t missing our stories by making us one of your “preferred sources” on Google News. You can simply follow this link to add The Debrief to your list of favorites, and you can read more about Google’s preferred sources in our article here.

---

RECENT NEWS from The Debrief

• Scientists have made a breakthrough using a light phenomenon discovered two centuries ago.
• Researchers have developed a solid material that converts visible light into high-energy UV energy.
• Researchers are unlocking the secrets of an ancient “cursed” artifact—what could possibly go wrong?
• Get all the latest stories from The Debrief, with more breaking stories at the end of this week’s newsletter.

---

Golden Dome Advances with Deployment of New Counter-Missile Capability

This week, it was revealed that the Pentagon has made significant strides with the development of its proposed Golden Dome missile defense system, with tests involving a next-generation directed-energy weapon.

Capable of destroying incoming drones and cruise missiles, the weapon has been characterized as a major step toward strengthening America’s future air and missile defense capabilities.

Planned as a multi-layer missile defense system that aims to be operational by the end of President Trump’s term, the Golden Dome aspires to be capable of spotting and destroying a range of missile threats, including ballistic, hypersonic, and cruise missiles.

With the deployment of the new directed-energy weapon this week, the Pentagon has now implemented the first use of next-generation technology that U.S. officials say will lead the way in redefining America’s future air and missile defenses.

The Pentagon’s New Directed-Energy Weapon

In a statement, U.S. Secretary of War Pete Hegseth called the recent test a “first milestone test” for the Golden Dome system.

“Cutting edge directed energy was harnessed and the Dynamic Defense Autonomous Defeat (DDAD) system flawlessly and autonomously cued, targeted, and eliminated a multitude of incoming threats,” Hegseth’s statement read. “This test was executed on schedule — and dynamically defeated every threat.”

Hegesth, who said he was present for the demonstration, “watched our elite warfighters integrate with next-generation technology to stop incoming drones and cruise missiles dead in their tracks,” crediting the advancement to Trump’s One Big Beautiful Bill, a sweeping legislative package put forward in an effort to solidify the permanence of the 2017 Tax Cuts and Jobs Act, along with enacting various other Trump administration priorities.

Hegseth said the legislation provided “the funding to deliver on the ultimate shield to protect America,” and builds on the efforts of former U.S. President Ronald Reagan’s Strategic Defense Initiative (SDI).

Few Technical Details Available

While the Pentagon did not provide technical details about the new system, Hegseth refers to the new weapon as “cutting edge directed energy” technology.

For several years, the Pentagon has been developing directed-energy systems for use in the interception of unmanned aerial vehicles and cruise missiles, with Israel previously reporting operational use of prototype laser capabilities as well.

America’s Golden Dome is partly inspired by Israel’s Iron Dome, although the U.S. counterpart’s design will aim to defend America against longer-range missile attacks—a key element which has encouraged comparisons to Reagan’s SDI.

Unprecedented Expense

The project also carries a large price tag. Presently, the Congressional Budget Office estimates that the initiative could cost as much as $1.2 trillion—an amount nearing the total requested $1.5 trillion defense budget for fiscal year 2027, making it one of the most expensive defense initiatives in U.S. history.

The high cost of the initiative is also impacted by the recent costs associated with the U.S. conflict with Iran, which, by some estimates, could exceed $200 billion. Additionally, a recent controversial memorandum of understanding aiming to halt the conflict agrees to supply $300 billion to Iran, which, as noted by some analysts, is an amount that exceeds the current Iranian defense budget by well over a dozen times.

On Wednesday, the U.S. Senate voted 47-50-1 to block a war powers resolution led by Sen. Tim Kaine that sought to limit President Trump’s authority to conduct military operations against Iran.

Although the measure narrowly advanced in an earlier procedural vote, a surprise upset resulted in a loss of support after Republican Sens. Bill Cassidy and Rand Paul changed their positions. The latest vote came just hours after a heated exchange between Trump and Cassidy, during which Cassidy challenged the president over the duration and objectives of the conflict with Iran.

Many have expressed concerns over the unprecedented U.S. defense spending under the current administration, including U.S. Senator Merkley (D-Oregon), Ranking Member of the U.S. Committee on the Budget, who rebuked a recent addition that asks Congress to spend an additional $88 billion in the form of a supplemental request.

“Padding the pockets of their defense contractor friends does nothing to help Americans get ahead,” Merkley said on Wednesday.

That concludes this week’s installment of The Intelligence Brief. You can read past editions of our newsletter at our website, or if you found this installment online, don’t forget to subscribe and get future email editions from us here. Also, if you have a tip or other information you’d like to send along directly to me, you can email me at micah [@] thedebrief [dot] org, or reach me on X: @MicahHanks.

Here are the top stories we’re covering right now…

Com as novas ofertas de roaming da NOS e da Vodafone, bem como a proliferação dos eSIM digitais, nunca houve tantas opções para manter o telemóvel a funcionar no estrangeiro. Mas escolher a solução certa depende do destino, e as diferenças podem ser tremendas.

The post Roaming em 2026: O guia completo para quem vai viajar este Verão appeared first on Tek Notícias.

In a groundbreaking study set to reshape our understanding of polar carbon dynamics, researchers have uncovered that the lithology of catchment areas along the Antarctic Peninsula plays a pivotal role in regulating the net carbon balance of these fragile ecosystems. This revelation not only challenges previous assumptions regarding carbon sequestration in polar regions but also highlights the complex interplay between geology and climate change in one of the planet’s most sensitive areas.

For decades, scientists have grappled with accurately quantifying carbon fluxes in polar environments due to the extreme conditions and limited accessibility. The Antarctic Peninsula, stretching northwards from the main Antarctic continent, represents a unique geophysical interface where ice, rock, and ocean converge. Prior research predominantly focused on biological and climatic factors controlling carbon balance but seldom accounted for the geochemical contributions borne from the underlying lithology. This new research sets a transformative precedent by rigorously dissecting how rock types influence carbon absorption and release processes, thereby painting a more nuanced picture of the peninsula’s carbon budget.

The study relied heavily on state-of-the-art field measurements coupled with advanced geochemical modeling to parse out the contributions of catchment lithology—essentially the rock makeup and mineral composition of drainage basins—to net carbon balance. Geological substrates act not only as passive backdrops but as active participants in biogeochemical cycles. Chemical weathering of silicate and carbonate minerals can sequester atmospheric carbon dioxide, while other rock forms may facilitate carbon release via mineral dissolution or hydrological transport mechanisms. The research team meticulously sampled various catchment zones along the peninsula, integrating data from frozen soils, sediment runoff, and meltwater streams to decode these lithological influences.

One of the most striking findings from the investigation was the spatial variability of carbon fluxes directly correlated with geological heterogeneity. Catchments dominated by silicate-rich bedrock exhibited higher carbon sequestration capabilities through rock weathering processes compared to those underlain by carbonate lithologies, which tend to release carbon dioxide during dissolution. This variability suggests that predictions of polar carbon dynamics need to incorporate detailed geological maps and lithological classifications for greater precision. Such insights could significantly improve climate models that currently struggle with polar region parameterization.

Moreover, the researchers illuminated the role of mineral weathering as a long-term sink for atmospheric CO2, contrasting the widely documented biological sinks such as phytoplankton blooms and moss growth. In particular, the slow yet persistent process of silicate mineral weathering draws down carbon dioxide, converting it into bicarbonate ions that are flushed into the ocean. This naturally occurring geological carbon pump could be particularly impactful in the Antarctic Peninsula where rapid glacial retreat exposes fresh silicate rock surfaces, enhancing weathering rates. These observations offer compelling evidence that geological processes may buffer climate change effects, at least regionally, by locking away carbon in mineral forms.

Intriguingly, temporal data spanning multiple melt seasons revealed that net carbon balance is highly sensitive to seasonal variations in temperature and hydrology, which themselves are modulated by lithological factors. For example, catchments composed of permeable volcanic rocks exhibited more pronounced meltwater infiltration, accelerating mineral weathering and carbon sequestration during warm months. Conversely, less permeable sedimentary formations tended to trap water and organic carbon within soils, affecting the timing and magnitude of CO2 fluxes to the atmosphere. This complex feedback between lithology, hydrology, and climate underscores the necessity of interdisciplinary approaches when assessing polar carbon systems.

The implications of these findings reverberate far beyond academic curiosity. As the Antarctic Peninsula experiences some of the fastest warming rates on Earth, understanding the controls on carbon balance is critical for forecasting future climate trajectories. If lithological variability leads to differential carbon sequestration zones, then localized geological disruptions caused by melting glaciers or human activity could substantially alter regional carbon budgets. This knowledge is paramount for policymakers designing effective climate mitigation strategies, particularly in sensitive high-latitude environments where carbon feedbacks may accelerate global warming.

In addition to geochemical and climatological impacts, the study also highlights the potential for emerging technologies such as remote sensing and machine learning to map lithological controls at unprecedented resolution. By integrating satellite imagery with field data, researchers can create predictive models that swiftly identify carbon hotspots and areas vulnerable to carbon loss. This approach holds promise not only for Antarctic research but for global efforts to monitor and manage terrestrial carbon stocks in the face of escalating environmental change.

Furthermore, the interdisciplinary team behind this research underscores the importance of collaboration across geology, ecology, and atmospheric science disciplines. Only through such synergies can the subtle yet powerful effects of geological substrates on biogeochemical cycles be fully appreciated. This holistic perspective marks a paradigm shift in polar science, encouraging future studies to transcend traditional boundaries between earth sciences and climate research.

The work also invites a reevaluation of how catchment-scale processes are incorporated into Earth system models. Historically, these models have neglected fine-scale lithological heterogeneities, instead favoring generalized assumptions about soil and sediment carbon storage. The evidence provided by this study advocates for embedding lithological parameters into model architectures, enabling more accurate simulations of polar carbon dynamics under variable climatic scenarios. Such advancements are vital for anticipating tipping points in Antarctic ecosystems where abrupt changes could trigger widespread carbon release.

As global attention intensifies on polar regions as bellwethers of climate change, the intricate connection between rocks beneath our feet and atmospheric carbon cycles comes sharply into focus. The Antarctic Peninsula serves as a natural laboratory, revealing that the geology beneath evolving ice landscapes is not merely inert background but an active, dynamic component influencing the Earth’s carbon footprint. These insights champion a new era where geosciences play a central role in unraveling planetary carbon mysteries and inform global climate stewardship.

To realize the full potential of these findings, continuous monitoring and expanded field campaigns will be indispensable. The study sets a benchmark for future Antarctic research by demonstrating how integrative methodologies can decode complex environmental phenomena. With accelerating climate pressures threatening polar ecosystems, unraveling the lithological control on carbon balance becomes not just an academic endeavor but an urgent imperative for humanity’s environmental resilience.

In conclusion, this landmark research elegantly reveals how the mineral composition and geological characteristics of Antarctic catchments exert profound control over carbon exchanges between land, atmosphere, and ocean. By amalgamating detailed geochemical analyses with ecological and climatic data, the study enriches our comprehension of polar carbon cycling and offers tangible pathways to improve global climate models. As the Antarctic Peninsula continues to reshape itself under warming skies, understanding the lithological underpinnings of its carbon dynamics will be essential for predicting its role in the Earth’s future climate narrative.

---

Subject of Research: Geology and carbon cycling in the Antarctic Peninsula catchments

Article Title: Catchment lithology controls net carbon balance along the Antarctic Peninsula

Article References:
He, S., Zhang, X., Hu, H. et al. Catchment lithology controls net carbon balance along the Antarctic Peninsula. Nat Commun (2026). https://doi.org/10.1038/s41467-026-74667-9

Image Credits: AI Generated

Draft defense bill funds Pentagon at requested discretionary levels but excludes $350 billion in proposed reconciliation spending, casting doubt on Golden Dome and other space programs

The post House appropriators back $55.5 billion Space Force budget, omit reconciliation funds appeared first on SpaceNews.

Particle physics is the epitome of ‘big science’. To answer our most fundamental questions out about physics requires world class experiments that push the limits of whats technologically possible. Such incredible sophisticated experiments, like those at the LHC, require big facilities to make them possible,  big collaborations to run them, big project planning to make dreams of new facilities a reality, and committees with big acronyms to decide what to build.

Enter the Particle Physics Project Prioritization Panel (aka P5) which is tasked with assessing the landscape of future projects and laying out a roadmap for the future of the field in the US. And because these large projects are inevitably an international endeavor, the report they released last week has a large impact on the global direction of the field. The report lays out a vision for the next decade of neutrino physics, cosmology, dark matter searches and future colliders. 

P5 follows the community-wide brainstorming effort known as the Snowmass Process in which researchers from all areas of particle physics laid out a vision for the future. The Snowmass process led to a particle physics ‘wish list’, consisting of all the projects and research particle physicists would be excited to work on. The P5 process is the hard part, when this incredibly exciting and diverse research program has to be made to fit within realistic budget scenarios. Advocates for different projects and research areas had to make a case of what science their project could achieve and a detailed estimate of the costs. The panel then takes in all this input and makes a set of recommendations of how the budget should be allocated, what should projects be realized and what hopes are dashed. Though the panel only produces a set of recommendations, they are used quite extensively by the Department of Energy which actually allocates funding. If your favorite project is not endorsed by the report, its very unlikely to be funded. 

Particle physics is an incredibly diverse field, covering sub-atomic to cosmic scales, so recommendations are divided up into several different areas. In this post I’ll cover the panel’s recommendations for neutrino physics and the cosmic frontier. Future colliders, perhaps the spiciest topic, will be covered in a follow up post.

The Future of Neutrino Physics

For those in the neutrino physics community all eyes were on the panels recommendations regarding the Deep Underground Neutrino Experiment (DUNE). DUNE is the US’s flagship particle physics experiment for the coming decade and aims to be the definitive worldwide neutrino experiment in the years to come. A high powered beam of neutrinos will be produced at Fermilab and sent 800 miles through the earth’s crust towards several large detectors placed in a mine in South Dakota. Its a much bigger project than previous neutrino experiments, unifying essentially the entire US community into a single collaboration.

DUNE is setup to produce world leading measurements of neutrino oscillations, the property by which neutrinos produced in one ‘flavor state’, (eg an electron-neutrino) gradually changes its state with sinusoidal probability (eg into a muon neutrino) as it propagates through space. This oscillation is made possible by a simple quantum mechanical weirdness: neutrino’s flavor state, whether it couples to electrons muons or taus, is not the same as its mass state. Neutrinos of a definite mass are therefore a mixture of the different flavors and visa versa.

Detailed measurements of this oscillation are the best way we know to determine several key neutrino properties. DUNE aims to finally pin down two crucial neutrino properties: their ‘mass ordering’, which will solidify how the different neutrino flavors and measured mass differences all fit together, and their ‘CP-violation’ which specifies whether neutrinos and their anti-matter counterparts behave the same or not. DUNE’s main competitor is the Hyper-Kamiokande experiment in Japan, another next-generation neutrino experiment with similar goals.

Construction of the DUNE experiment has been ongoing for several years and unfortunately has not been going quite as well as hoped. It has faced significant schedule delays and cost overruns. DUNE is now not expected to start taking data until 2031, significantly behind Hyper-Kamiokande’s projected 2027 start. These delays may lead to Hyper-K making these definitive neutrino measurements years before DUNE, which would be a significant blow to the experiment’s impact. This left many DUNE collaborators worried about its broad support from the community.

It came as a relief then when P5 report re-affirmed the strong science case for DUNE, calling it the “ultimate long baseline” neutrino experiment. The report strongly endorsed the completion of the first phase of DUNE. However, it recommended a pared-down version of its upgrade, advocating for an earlier beam upgrade in lieu of additional detectors. This re-imagined upgrade will still achieve the core physics goals of the original proposal with a significant cost savings. With this report, and news that the beleaguered underground cavern construction in South Dakota is now 90% complete, was certainly welcome holiday news to the neutrino community. This is also sets up a decade-long race between DUNE and Hyper-K to be the first to measure these key neutrino properties.

Cosmic Implications

While we normally think of particle physics as focused on the behavior of sub-atomic particles, its really about the study of fundamental forces and laws, no matter the method. This means that telescopes to study the oldest light in the universe, the Cosmic Microwave Background (CMB), fall into the same budget category as giant accelerators studying sub-atomic particles. Though the experiments in these two areas look very different, the questions they seek to answer are cross-cutting. Understanding how particles interact at very high energies helps us understand the earliest moments of the universe, when such particles were all interacting in a hot dense plasma. Likewise, by studying the these early moments of the universe and its large-scale evolution can tell us about what kinds of particles and forces are influencing its dynamics. When asking fundamental questions about the universe, one needs both the sharpest microscopes and the grandest panoramas possible.

The most prominent example of this blending of the smallest and largest scales in particle physics is dark matter. Some of our best evidence for dark matter comes analyzing the cosmic microwave background to determine how the primordial plasma behaved. These studies showed that some type of ‘cold’, matter that doesn’t interact with light, aka dark matter, was necessary to form the first clumps that eventually seeded the formation of galaxies. Without it, the universe would be much more soup-y and structureless than what we see to today.

To determine what dark matter is then requires an attack from two fronts: design experiments here on earth attempting directly detect it, and further study its cosmic implications to look for more clues as to its properties.

The panel recommended next generation telescopes to study the CMB as a top priority. The so called ‘Stage 4’ CMB experiment would deploy telescopes in both the south pole and Chile’s Atacama desert to better characterize sources of atmospheric noise. The CMB has been studied extensively before, but the increased precision of CMS-S4 could shed light on mysteries like dark energy, dark matter, inflation, and the recent Hubble Tension. Given the past fruitfulness of these efforts, I think few doubted the science case for such a next generation experiment.

The P5 report recommended a suite of new dark matter experiments in the next decade, including the ‘ultimate’ liquid Xenon based dark matter search. Such an experiment would follow in the footsteps of massive noble gas experiments like LZ and XENONnT which have been hunting for a favored type of dark matter called WIMP’s for the last few decades. These experiments essentially build giant vats of liquid Xenon, carefully shield from any sources of external radiation, and look for signs of dark matter particles bumping into any of the Xenon atoms. The larger the vat of Xenon, the higher chance a dark matter particle will bump into something. Current generation experiments have ~7 tons of Xenon, and the next generation experiment would be even larger. The next generation aims to reach the so called ‘neutrino floor’, the point as which the experiments would be sensitive enough to observe astrophysical neutrinos bumping into the Xenon. Such neutrino interactions would look extremely similar to those of dark matter, and thus represent an unavoidable background which would signal the ultimate sensitivity of this type of experiment. WIMP’s could still be hiding in a basement below this neutrino floor, but finding them would be exceedingly difficult.

WIMP’s are not the only dark matter candidates in town, and recent years have also seen an explosion of interest in the broad range of dark matter possibilities, with axions being a prominent example. Other kinds of dark matter could have very different properties than WIMPs and have had much fewer dedicated experiments to search for them. There is ‘low hanging fruit’ to pluck in the way of relatively cheap experiments which can achieve world-leading sensitivity. Previously, these ‘table top’ sized experiments had a notoriously difficult time obtaining funding, as they were often crowded out of the budgets by the massive flagship projects. However, small experiments can be crucial to ensuring our best chance of dark matter discovery, as they fill in the blinds pots missed by the big projects.

The panel therefore recommended creating a new pool of funding set aside for these smaller scale projects. Allowing these smaller scale projects to flourish is important for the vibrancy and scientific diversity of the field, as the centralization of ‘big science’ projects can sometimes lead to unhealthy side effects. This specific recommendation also mirrors a broader trend of the report: to attempt to rebalance the budget portfolio to be spread more evenly and less dominated by the large projects.

What Didn’t Make It

Any report like this comes with some tough choices. Budget realities mean not all projects can be funded. Besides the pairing down of some of DUNE’s upgrades, one of the biggest areas that was recommended against were ‘accessory experiments at the LHC’. In particular, MATHUSULA and the Forward Physics Facility were two experiments that proposed to build additional detectors near already existing LHC collision points to look for particles that may be missed by the current experiments. By building new detectors hundreds of meters away from the collision point, shielded by concrete and the earth, they can obtained unique sensitivity to ‘long lived’ particles capable of traversing such distances. These experiments would follow in the footsteps of the current FASER experiment, which is already producing impressive results.

While FASER found success as a relatively ‘cheap’ experiment, reusing detector components from and situating itself in a beam tunnel, these new proposals were asking for quite a bit more. The scale of these detectors would have required new caverns to be built, significantly increasing the cost. Given the cost and specialized purpose of these detectors, the panel recommended against their construction. These collaborations may now try to find ways to pare down their proposal so they can apply to the new small project portfolio.

Another major decision by the panel was to recommend against hosting a new Higgs factor collider in the US. But that will discussed more in a future post.

Conclusions

The P5 panel was faced with a difficult task, the total cost of all projects they were presented with was three times the budget. But they were able to craft a plan that continues the work of the previous decade, addresses current shortcomings and lays out an inspiring vision for the future. So far the community seems to be strongly rallying behind it. At time of writing, over 2700 community members from undergraduates to senior researchers have signed a petition endorsing the panels recommendations. This strong show of support will be key for turning these recommendations into actual funding, and hopefully lobbying congress to even increase funding so that more of this vision can be realized.

For those interested the full report as well as executive summaries of different areas can be found on the P5 website. Members of the US particle physics community are also encouraged to sign the petition endorsing the recommendations here.

And stayed tuned for part 2 of our coverage which will discuss the implications of the report on future colliders!