In a finding that could reshape how medicinal chemists produce antioxidant compounds, a team of Italian researchers has developed a rapid, solvent-minimized ball-milling method for synthesizing thiazolyl–hydrazone derivatives — molecules that in laboratory tests proved to be more potent radical scavengers than vitamin C. The work, published in Results in Chemistry, combines green chemistry principles with computational modeling to deliver a class of compounds with significant promise for combating oxidative stress, the destructive process implicated in aging, cancer, and chronic disease.

The research, led by Roberto Scipione, Sebastiano Masuri, Ester Sedda, Tiziana Pivetta, Andrea Porcheddu, Maria Grazia Cabiddu, and Andrea Citarella at the University of Cagliari, tackles a long-standing challenge in synthetic chemistry: how to produce polyphenolic thiazolyl–hydrazones efficiently without drowning the process in solvents and energy. Traditional approaches require hours of refluxing in hot ethanol, consuming large volumes of solvent and generating substantial waste. The new protocol accomplishes the same transformation in two hours at room temperature using less than half a milliliter of ethanol.

The molecules at the heart of the study belong to a family of organic compounds that chemists prize for their antioxidant potential. Thiazole-containing heterocycles — five-membered rings containing both sulfur and nitrogen — are known to facilitate the decomposition of hydroperoxides and to chelate metal ions that would otherwise catalyze damaging reactions. Hydrazone linkers add a further dimension of reactivity: their nitrogen-hydrogen bonds can donate hydrogen atoms to neutralize free radicals, and the resulting radical species are stabilized through electron delocalization. When researchers attach catechol or guaiacol phenolic groups — structural motifs found in celebrated antioxidants like the polyphenols of olive oil and green tea — the molecules become even more effective at scavenging radicals, because the phenoxy radicals formed after hydrogen donation are exceptionally stable.

Oxidative stress arises when reactive oxygen and nitrogen species overwhelm the body’s endogenous antioxidant defenses. The resulting damage to lipids, proteins, and DNA is a hallmark of chronic inflammation, cancer progression, and aging. Designing small molecules that can intercept these reactive species has therefore been a major goal of medicinal chemistry for decades. The thiazolyl–hydrazone framework synthesized by the Cagliari team combines several radical-scavenging architectural elements in a single molecule, creating compounds whose potency in standardized assays exceeded that of ascorbic acid, the benchmark reference compound.

The synthetic breakthrough lies in mechanochemistry — the use of mechanical force, delivered by grinding balls in a laboratory mill, to drive chemical reactions without bulk solvent. The researchers used a Retsch MM500 mixer mill operating at 30 Hz with zirconia jars and balls, running the entire two-step sequence in a single jar without ever isolating an intermediate. In the first step, an aldehyde condenses with thiosemicarbazide to form a thiosemicarbazone; in the second, that intermediate cyclizes with a phenacyl bromide to close the thiazole ring. A catalytic amount of acetic acid and a tiny quantity of ethanol — a technique called liquid-assisted grinding, or LAG — proved essential: without any liquid additive, conversion was a dismal 10 percent, but adding ethanol at a ratio of one microliter per milligram of solid reagents pushed yields to around 85 percent.

The full telescoped protocol — both steps performed consecutively in the same jar — delivered the target compound in 80 percent yield, matching or beating the conventional two-step route that requires 12 hours of reflux at 80 °C in 25 mL of ethanol. When the team scaled the reaction up to 20 mmol using a 50 mL jar, the protocol held up remarkably well, affording a 71 percent yield with an even smaller amount of grinding liquid, simply reduced to a quarter of the original ratio. Product isolation required nothing more than adding ethanol and filtering — no column chromatography.

Green metrics quantified just how dramatic the improvement is. For the representative compound ES3, the mechanochemical route reduced solvent consumption by 99 percent, from 40.8 mL per gram of product to 0.38. The Process Mass Intensity, a measure of total material used per unit of product, plummeted from 35.3 to 2.05 — a seventeenfold improvement. The E-factor, which captures waste generation, fell from 34.3 to 1.05, roughly a thirty-threefold reduction. Reaction Mass Efficiency nearly doubled, rising from 32.3 to 57.1 percent, while overall yield climbed from 42 percent to 80 percent. These are not incremental gains; they represent a fundamental shift in the resource profile of the synthesis.

The antioxidant activity of the fifteen compounds in the series was assessed using two well-validated assays: DPPH and ABTS, both of which measure the ability of a molecule to neutralize stable free radicals. Every compound showed activity in the micromolar range, and several outperformed ascorbic acid in both assays. The standouts were those bearing the 3,4-dihydroxy (catechol) motif: compound ES26 recorded an EC50 of 8.4 μM in the DPPH assay and an extraordinary 2.59 μM in the ABTS assay, compared with 18.6 and 12.2 μM for ascorbic acid, respectively. Compounds ES27 and ES28 performed nearly as well, while several methoxy-substituted derivatives — ES9, ES16, and ES17 — also beat the vitamin C benchmark.

Density Functional Theory calculations provided mechanistic insight into why the catechol-bearing compounds are so effective. By computing bond dissociation enthalpies, ionization potentials, proton affinities, and related thermochemical descriptors, the team mapped the three canonical antioxidant pathways: hydrogen atom transfer (HAT), single-electron transfer followed by proton transfer (SET-PT), and sequential proton loss electron transfer (SPLET). The results indicate that in the gas phase, HAT is the thermodynamically preferred route, with the hydrazone NH group serving as the primary hydrogen donor in the simpler benzaldehyde-derived compounds. In vanillin-based molecules, hydrogen abstraction from the phenolic OH becomes competitive; in the catechol derivatives, abstraction from the 4-OH position is decisively favored, owing to the additional stabilization of the phenoxy radical by an intramolecular hydrogen bond with the adjacent hydroxyl group. In solution, the SPLET pathway gains relevance, as solvation stabilizes the anionic intermediates that form upon proton loss.

The structure–activity relationships that emerged are consistent with established antioxidant chemistry. Electron-releasing groups such as methoxy substituents on the thiazole ring enhance radical-scavenging activity, whereas electron-withdrawing bromine substituents diminish it — a trend that can be mitigated when a catechol group is present elsewhere in the molecule. The computational analysis of frontier molecular orbitals confirmed extensive π-conjugation across the molecules and showed how substituents tune the HOMO–LUMO gap in ways that correlate with observed reactivity. The authors note that the slightly reduced coplanarity in the dimethoxy-substituted ES26, evidenced by a dihedral angle of 172.9 degrees versus 176.95 degrees in its monomethoxy counterpart, subtly alters the electronic landscape of the frontier orbitals.

What distinguishes this study is the marriage of two agendas that are often pursued separately: the design of biologically active antioxidant scaffolds and the radical greening of the synthesis itself. Mechanochemistry has been gaining momentum across organic synthesis as a way to slash solvent use and energy input, but demonstrations that combine solvent-minimized one-pot telescoping with preparative scale-up and rigorous green-metrics accounting remain relatively rare. The Cagliari team has shown that a complex, multicomponent heterocyclic synthesis — involving condensation, cyclization, and the construction of a sulfur-nitrogen heterocycle — can be executed cleanly in a single milling jar without heating.

The implications extend beyond the laboratory bench. Antioxidant scaffolds like the thiazolyl–hydrazones synthesized here are candidates for further biological evaluation, and the authors indicate that future work will probe mechanistic aspects and explore preliminary biological evaluations to define the translational potential of these molecules. If the exceptional radical-scavenging activity observed in vitro carries through to cellular or in vivo contexts, the compounds could serve as leads for agents targeting oxidative-stress-related pathologies. And because the synthetic route is scalable, solvent-lean, and operationally simple, the barrier to producing gram quantities of these candidates for further testing is substantially lower than it would be with conventional methodology.

The study also underscores a broader lesson for the pharmaceutical and fine-chemical industries: green metrics such as PMI and E-factor are not abstract sustainability scores but concrete indicators of process quality — lower waste, lower cost, higher yield, and simpler workflows all at once. By demonstrating a sixfold reduction in reaction time, a near-total elimination of solvent, and improved yields in the same breath, the researchers have provided a compelling case study for how mechanochemistry can move from academic curiosity to practical synthetic platform.

As the search for effective antioxidant therapeutics continues, this work offers a template: design molecules around well-understood radical-stabilizing motifs, synthesize them with minimal environmental footprint, and validate their activity with rigorous in vitro and computational analysis. The thiazolyl–hydrazones that emerged from the zirconia jars in Cagliari — particularly the catechol-bearing champions ES26, ES27, and ES28 — now stand as both chemical achievements and potential starting points for the next generation of radical-scavenging agents.

The reagents of the feedstock are never produced by processes as on the early Earth. Production requires substantial energy and controlled industrial procedures

Source

A recent study published in Protist reports that a marine microorganism reproduces in a previously unknown way: by creating new cells inside its body, then rupturing to release them.

The bizarre process is reminiscent of the reproductive horror depicted in the movie Alien, albeit on a microscopic scale.

This microbe is part of the Labyrinthulomycetes, a group of marine microorganisms that play a key role in recycling nutrients by breaking down dead plants and animals in salty environments. Beyond their ecological importance, some species in this group are valued for producing omega-3 fatty acids like DHA, which is also found in oily fish, and carotenoids, pigments used in food coloring.

This newly discovered species also contains roughly 50% protein, adding to its potential commercial value for applications such as food supplements, infant formula, and aquaculture.

An “Alien” Reproductive Strategy

“Instead of dividing into two, as we would expect, the mature cells develop a large internal chamber in which entirely new daughter cells grow,” said Professor Peter Morris, a plant biologist at Heriot-Watt University.

“Some of those daughters already have another developing generation inside them, before they are released when the mother cell breaks open,” Morris added. “So, these microbes can be pregnant grandmothers, in the same way as some species of greenfly are born already pregnant.”

The researchers named the new species Caledochytrium aldermanii, drawing from Caledonia, the Latin name for Scotland, where it was discovered in three locations. The species name also recognizes Dr. David Alderman, whose early work culturing the microbe made the study possible.

This discovery resulted from a long-term collaboration among Heriot-Watt University, its spinout company Strameno, CEFAS Weymouth, and the Institute of Aquaculture at Stirling University.

Caught by Watching, Not Just Sequencing

Dr. Jane Polglase, who has spent nearly five decades studying Labyrinthulomycetes and co-founded Strameno with Alderman and Dr. Lydia Brown, helped document the microbe’s unusual reproduction. The team relied on traditional observation and description, an approach less common in today’s genomics-focused research.

“While lots of scientists now focus on the DNA of any creature, we’ve taken an old-fashioned approach, also observing the microbe’s behavior and describing its morphology fully,” Polglase said. “If we had not done that, we never would have captured this peculiar reproductive process on camera.” When the team finally caught it under an electron microscope, she said, “We couldn’t believe what we were seeing.”

Resourceful Marine Recyclers

Researchers found Caledochytrium in a variety of habitats, including octopus dens, on rainbow trout, and in a salt marsh along Scotland’s east coast. The researchers believe it contributes to nutrient recycling by breaking down animal and plant material.

An important part of this recycling process is the ectoplasmic net, a network of membranes the microbe creates to move around, feed, and stay buoyant. When it moves to a new surface, the microbe leaves the net behind, where marine larvae can feed on the leftover material, helping pass protein and lipids up the food chain.

What Comes Next

“Understanding how this species reproduces is key to understanding how it could be used in commercial settings, like aquaculture,” Morris said.

With this phase of research complete, the Heriot-Watt and Strameno team hopes others will continue the work. The discovery highlights how much remains to be learned about the diversity and behavior of life in the oceans.

Austin Burgess is a writer and researcher with a background in sales, marketing, and data analytics. He holds an MBA, a Bachelor of Science in Business Administration, and a data analytics certification. His work focuses on breaking scientific developments, with an emphasis on emerging biology, cognitive neuroscience, and archaeological discoveries.

A private oil company has struck a deal with the Trump administration to develop 17 areas in Venezuela, an effort that experts say will take years and billions of dollars.

© The New York Times

Major upgrade for the screenshot utility adds new editing and video enhancement capabilities. ($35 new, free update, 77.7 MB, macOS 13+)

The U.S. energy giant, which stayed in the country after other Western companies left, will invest $7 billion in the country to more than double its production there.

© Maryorin Mendez/Agence France-Presse — Getty Images

The Trump administration’s deal with a private oil company to increase oil production in the South American country could take many years to come to fruition.

© The New York Times

The administration will work with a private Venezuelan oil company that has close ties to the country’s government.

© Adriana Loureiro Fernandez for The New York Times

The president said an agreement between the countries covered more than 65 billion barrels of reserves. A U.S. official said it would involve a partnership with a private company.

© Adriana Loureiro Fernandez for The New York Times

Oil companies and governments are consuming their once vast stockpiles as Iran and the United States continue to struggle for control over the Strait of Hormuz.

President Trump’s administration has been pushing U.S. companies like Chevron to invest more in Venezuela’s oil industry.

© Marco Bello/Reuters

Horseshoe crabs are marine animals more closely related to spiders than crabs. These animals have existed for more than 450 million years, and are sometimes called “living fossils” because they appear to have changed very little throughout their evolutionary history. However, horseshoe crabs have a poor fossil record, so this apparent lack of change could also be due to a lack of evidence, particularly when it comes to their reproduction. Scientists want to know: Are horseshoe crabs truly living fossils?

Modern horseshoe crabs reproduce by releasing hundreds of eggs and sperm into tidal waters, via a process called external fertilization. Until now, scientists have assumed that horseshoe crabs have always reproduced this way. But paleontologists have only found 3 fossil horseshoe crabs from the past 252 million years with their reproductive systems preserved, so this assumption is mainly based on an absence of evidence to the contrary. 

Scientists in the past interpreted the horseshoe crab’s long history of external fertilization as indicative of its evolutionary consistency. However, James Lamsdell and colleagues recently discovered a new fossil species of horseshoe crab in the 450 million-year-old Big Hill Formation in Michigan that challenges this assumption. 

To study the specimen, the scientists photographed it under 2 types of microscopes. The first type of microscope used polarized light to see structures in the fossil that may have blended into the rock, like putting on special glasses to see subtle textures. The second type of microscope used fluorescent light to reveal soft tissue in the fossil. Only some tissues, like ovarian tissue and preserved eggs, glow under fluorescence, so this method helped the team rule out non-biological structures, like bubbles, cracks, or minerals. 

The researchers found that their analytical techniques revealed remarkable details about the ancient horseshoe crab. One unique feature of the fossil was the shape of its exoskeleton. The fossil’s exoskeleton had a more shovel-like appearance than that of modern horseshoe crabs, which are less elongated and more round. It was also about 11 times smaller than a modern adult horseshoe crab. 

The researchers also discovered that the fossil preserved an intricate network of ovaries containing unfertilized eggs. This ovarian network lined the interior surface of the shell in a band of interconnected tubes, preserving both unfertilized eggs and developing eggs. They noted that the fossil eggs were all about 0.1 to 0.15 millimeters in diameter, about the same width as a human hair. This size consistency suggested that all the eggs developed at the same time, via a process called synchronous development. 

Since the fossil crab’s ovarian tubes contained developing eggs, it was an adult, meaning that the earliest adult horseshoe crabs were significantly smaller and shaped differently than modern adult horseshoe crabs. Despite their differences in size and shape, the fossil horseshoe crab’s reproductive system closely mirrored its modern one, in terms of its ovarian system and synchronous development of eggs. As in previous studies, it showed no evidence of internal fertilization.

The researchers concluded that the earliest horseshoe crabs also reproduced through external fertilization. This fossil horseshoe crab is more than 215 million years older than preexisting fossils preserving evidence of external fertilization, and suggests that the horseshoe crab’s mode of reproduction has been conserved for almost half a billion years!

However, the team’s findings reveal a more nuanced evolutionary history for the horseshoe crab than previously assumed. Although they’ve maintained the same reproductive system for almost half a billion years, the size and shape of their exoskeleton have changed. This discovery reveals that different parts of the horseshoe crab evolved at different rates. It seems that horseshoe crabs are not entirely the living fossils scientists once thought… while their bodies have evolved, their reproduction has endured.

The post Are horseshoe crabs truly “living fossils”? appeared first on Sciworthy.

Toby Schmitz was the youngest attendee at Macstock X, so his perspective on how the conference and the accompanying Ecamm Creator Camp gave him the confidence and practical guidance to begin his own YouTube channel, podcast, and livestream. He reflects on learning from a wide variety of sessions, the influence of his family of creators, […]

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This time, the Road to Macstock takes us to Katie Fawkes, Director of Marketing and Doc Rock, Director of Strategic Partnerships for Ecamm, who talk about both their Creator Camp the day before Macstock, as well as their session during Macstock. They discuss how the hands-on event will help users of all experience levels build confidence with video production. They also cover Ecamm’s broader role beyond live streaming, practical uses for creators and businesses, the value of experimenting with gear, and why Macstock's welcoming community makes it a special gathering.

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At NAB Las Vegas, Madeleine Budd, Marketing Manager for Saramonic Audio, introduces the Air SE, a tiny dual wireless mobile microphone system with USB-C and optional Lightning receivers, and magnetic charging. No larger than a lipstick, it features AI noise cancellation, and a strikingly low price. She also demos the WeTalk 9X intercom system, built […]

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At NAB 2026, Russell Pompea, Account Executive from Topaz Labs, discusses major advances in Topaz Video, including Starlight Precise 2.5 for restoring low-quality footage, SDR-to-HDR conversion, and Apple Silicon optimization. The conversation also covers Topaz’s photography tools, model customization, subscription pricing, local vs. cloud processing, and shared responsibility for cloud security. 

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In the Riverside booth at NAB in Las Vegas, Danielle Baxter, Business Development Representative, explains how the platform supports podcasting, video interviews, webinars, testimonials, and live streams. She covers options like local recording, separate audio and video tracks, browser-based guest access, built-in editing, branding, captions, producer mode, and flexible plans for solo creators and businesses. 

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From NAB in Las Vegas, Dan May, President of Blackmagic Design, talks about DaVinci Resolve 21, local AI tools, the new photo page, Blackmagic Cloud collaboration, Fairlight Live, and the free Blackmagic Camera app. The conversation highlights Blackmagic Design's focus on accessible professional tools and creator growth paths. 

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Capturer la naissance d'une baleine à bosse relève presque de l'impossible. Pourtant, au large de l'Australie, un photographe animalier a filmé une scène exceptionnelle qui pourrait constituer une première mondiale.

RAM production capacity at Samsung Electronics, SK hynix, and Micron Technology is reportedly committed through the end of 2027, leaving consumer electronics manufacturers with little room to secure additional memory outside existing supply agreements.

Industry reports indicate that the three dominant manufacturers have allocated their available DRAM and high-bandwidth memory production for next year. Long-term contracts with cloud companies, AI chip developers, automakers, and device manufacturers have effectively reserved the output those suppliers expect to produce.

The claim does not mean every RAM module that will be sold in 2027 has already been manufactured or purchased by a consumer. It refers to future production capacity being assigned to customers before the chips leave the factory.

It also does not cover every memory producer worldwide. Chinese manufacturer ChangXin Memory Technologies, known as CXMT, and several smaller suppliers continue to produce DRAM. However, Samsung, SK hynix, and Micron control most of the advanced global DRAM market, making their available capacity the primary constraint for companies such as Apple.

RAM Production Is Already Committed

Selling out a year of production capacity means manufacturers have received enough contractual commitments to allocate the output they expect from their factories. Customers may have reserved specific volumes, product types, or manufacturing capacity under agreements that include minimum purchases and pricing protections.

Micron has been shifting toward this model through strategic customer agreements. The company disclosed 16 multiyear deals covering customers across data centers, consumer devices, automotive products, and industrial equipment.

Those agreements typically run for several years and include binding volume commitments. Some use fixed prices, while others establish price floors and ceilings. Micron has said that its signed contracts represent approximately $100 billion in expected revenue over their remaining terms.

Such agreements give memory manufacturers more predictable revenue than the traditional DRAM cycle, in which aggressive expansion frequently created excess supply and collapsing prices. They also give large buyers assurance that chips will be available for planned products.

The disadvantage falls on customers that did not reserve enough capacity early. A company needing more memory than its contract provides may have to pay higher prices, accept a different specification, delay production, or find another qualified supplier.

SK hynix CEO Kwak Noh-jung has described 2027 as potentially the worst year in the memory industry’s history from a supply perspective. He expects customer demand to remain above the company’s production capacity beyond 2030, despite major investments in new factories.

Samsung has issued a similar warning, expecting the constraints to become more severe in 2027 and continue into 2028. Analysts at UBS have projected that the DRAM market could remain undersupplied until at least the second quarter of 2028.

AI Memory Consumes More Factory Capacity

The shortage originates primarily from the rapid expansion of artificial intelligence infrastructure. AI accelerators require high-bandwidth memory, or HBM, to move large amounts of data between memory and processors at extremely high speeds.

HBM and the LPDDR memory used in Apple devices are different products. An iPhone or Mac is not competing directly for the same finished memory package installed beside an Nvidia AI accelerator.

They still depend on overlapping manufacturing resources. HBM begins with advanced DRAM dies, and producing a given capacity of stacked HBM consumes considerably more wafer output and packaging resources than conventional memory. Suppliers have also concentrated spending, equipment, and engineering work on the more profitable AI segment.

Every production line converted or optimized for HBM can reduce the industry’s flexibility to make standard server DRAM, PC memory, or mobile LPDDR. New investment may increase total memory output while doing little to relieve the parts of the market serving phones and personal computers.

Cloud companies are willing to enter multiyear agreements and make large financial commitments because a shortage of memory can leave costly AI processors unused. Memory manufacturers therefore have a powerful incentive to prioritize these customers over consumer device companies seeking lower component prices.

The pressure is also moving beyond HBM. AI servers need large quantities of conventional DDR5 memory, while storage systems supporting model training and inference consume enterprise NAND flash. This spreads the shortage across several categories that were previously less exposed to AI infrastructure spending.

Apple Faces Expensive Supply Decisions

Apple purchases enormous volumes of LPDDR memory for the iPhone and iPad, along with memory used across the Mac, Apple Watch, Vision Pro, Apple TV, and HomePod product families. Its size gives it substantial negotiating power, but it cannot purchase capacity that suppliers have already assigned to other customers.

The company has acknowledged that memory prices are continuing to rise. Tim Cook recently characterized the pricing environment as a “hundred-year flood” and said Apple expects to pay more for memory during the September quarter.

Apple has already raised prices across several Mac and iPad models while reducing or removing some high-memory Mac configurations. Although memory availability is not the sole influence on every product decision, eliminating configurations can help a manufacturer concentrate limited components around the models expected to sell in larger volumes.

The design of Apple silicon makes memory allocation especially sensitive. Unified memory is integrated closely with the processor package and cannot be upgraded after purchase. Apple must decide how many chips to secure for each configuration long before customers begin ordering those machines.

A shortage can therefore affect more than the cost of an individual RAM component. It can influence base memory capacities, upgrade pricing, the number of configurations offered, production volume, and the timing of product introductions.

Apple can absorb part of the increase through its margins, negotiate longer agreements, adjust retail pricing, or redesign its product mix. Each option carries a cost. Absorbing higher prices reduces profit per device, while passing them to customers could weaken demand. Restricting configurations risks pushing professional users away from Macs that no longer offer enough unified memory.

The company is reportedly evaluating DRAM from CXMT for products sold in China. Adding a fourth major source could improve access to conventional memory, but qualification takes time because Apple must confirm performance, reliability, manufacturing consistency, and compatibility with its hardware.

The political environment creates another obstacle. US lawmakers have raised national security concerns about American companies purchasing memory from Chinese semiconductor manufacturers. Apple could consequently find that a supplier is technically suitable for China-market products but difficult to introduce across its international supply chain.

Sold Out Does Not Mean Stores Will Be Empty

The reported capacity commitments do not guarantee a universal shortage of finished devices. Apple and other major manufacturers will still receive memory under agreements they have already negotiated.

Products can also continue reaching stores while component prices rise. Manufacturers may reduce discounts, increase retail prices, limit premium configurations, or give priority to their most profitable devices before allowing a shortage to stop production completely.

Contracted capacity can change if customers reduce orders or if AI infrastructure investment slows. Memory makers could redirect production between customers and product categories, although converting lines and qualifying different chips cannot happen immediately.

CXMT could also expand faster than expected, particularly in mainstream DRAM. Its products have reportedly attracted interest from HP, Asus, Acer, Dell, Lenovo, and Apple as established suppliers devote more resources to AI memory. CXMT is unlikely to replace the combined output of Samsung, SK hynix, and Micron during 2027, but it may provide an alternative for products sold outside the United States.

New production facilities offer little immediate relief. Semiconductor factories require construction, equipment installation, process development, yield improvement, and customer qualification before reaching dependable volume.

Micron expects the first wafer output from its initial new Idaho facility around the middle of 2027, with a second facility following in late 2028. Those first wafers will still need to pass through the production ramp and customer qualification process, leaving much of their effect on available device memory for 2028 and later.

The post RAM Production Capacity Is Reportedly Sold Out Through 2027 appeared first on AppleMagazine.