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Some stick insects have reproduced without sex for around one million years, yet they still carry a fully functioning genetic system associated with sexual reproduction, according to surprising new research. The discovery challenges a common assumption about evolution: that biological systems that are no longer useful will gradually break down or disappear. The research, led […]
The post A Million Years Without Sex Leaves Stick Insects with a Surprising Genetic Secret appeared first on Knowridge Science Report.
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How snails engineer their slime
Snails are well-known for their mucus. The slime is highly valued as an anti-inflammatory and anti-aging ingredient in certain skin care products, and snails can secrete different kinds of mucus with properties tailored to specific functions. A team of German scientists has determined a recipe for how snails achieve that so-called tunability: Collagen and calcium work in tandem to achieve the varying mechanical properties, according to a new paper in the journal Science.
Snail mucus is mostly water; it's the mucins (glycoproteins) and complex carbohydrates that give it that slimy, viscous texture. In addition to cosmetics, the mucus holds great potential for drug delivery. In 2020, scientists found that combining snail slime from a common garden snail with gold nanoparticles helped accelerate wound healing and exhibited anti-inflammatory properties in mice. Most relevant to this latest paper is a 2023 study on garden snail slime that identified three distinct types of secreted mucus: a hydrating version to protect its skin, one that acts as an adhesive glue, and a third that serves as a lubricant so the snail can more easily glide across a surface.
The team focused their research efforts on the grove snail/lemon snail (Cepaea nemoralis), which they deemed well-suited as subjects because the snails secrete five different kinds of mucus with distinct functions. As with the garden snails, there is one that acts as a lubricant to help with locomotion and an adhesive mucus to help the snail stick to various surfaces. Then there's a mucus layer known as the epiphragm that the snail secretes when it hibernates in winter, which contains calcite and effectively seals the shell to protect the snail from predators and harsh environmental conditions.


© Max Planck Institute of Colloids and Interfaces
How snails engineer their slime
Snails are well-known for their mucus. The slime is highly valued as an anti-inflammatory and anti-aging ingredient in certain skin care products, and snails can secrete different kinds of mucus with properties tailored to specific functions. A team of German scientists has determined a recipe for how snails achieve that so-called tunability: Collagen and calcium work in tandem to achieve the varying mechanical properties, according to a new paper in the journal Science.
Snail mucus is mostly water; it's the mucins (glycoproteins) and complex carbohydrates that give it that slimy, viscous texture. In addition to cosmetics, the mucus holds great potential for drug delivery. In 2020, scientists found that combining snail slime from a common garden snail with gold nanoparticles helped accelerate wound healing and exhibited anti-inflammatory properties in mice. Most relevant to this latest paper is a 2023 study on garden snail slime that identified three distinct types of secreted mucus: a hydrating version to protect its skin, one that acts as an adhesive glue, and a third that serves as a lubricant so the snail can more easily glide across a surface.
The team focused their research efforts on the grove snail/lemon snail (Cepaea nemoralis), which they deemed well-suited as subjects because the snails secrete five different kinds of mucus with distinct functions. As with the garden snails, there is one that acts as a lubricant to help with locomotion and an adhesive mucus to help the snail stick to various surfaces. Then there's a mucus layer known as the epiphragm that the snail secretes when it hibernates in winter, which contains calcite and effectively seals the shell to protect the snail from predators and harsh environmental conditions.


© Max Planck Institute of Colloids and Interfaces
Behe’s Breakthrough: Memories of Darwin’s Black Box
- The Debrief
- “One Origin of the Genetic Code, but Two Origins of Life”: Scientists Reveal the Ancient Evolutionary Split That Gave Rise to All Life on Earth
“One Origin of the Genetic Code, but Two Origins of Life”: Scientists Reveal the Ancient Evolutionary Split That Gave Rise to All Life on Earth
An international research team has uncovered how LUCA, the last common ancestor of all life on Earth, split into the first two branches of organisms—bacteria and archaea—allowinglife to thrive innew conditions and spread to other biomes.
Scientists from the Institute of Molecular Evolution at Heinrich Heine University Düsseldorf (HHU) led the research, revealing their findings in a recent paper published in Science Advances, investigating these early cells’ metabolisms.
The team discovered that the chemical reactions and energy sources behind these two types of cells told unique stories of separate evolutions, in new work that sheds light on the primordial processes that gave rise to some of Earth’s first free-living cells.
Life on Earth Begins
Roughly four billion years ago, life on Earth emerged as the first cells formed, most likely at hydrothermal vents, before evolving to explore new biomes.
“We would see two very different kinds of cells emerging, pioneer bacteria and pioneer archaea, making their first attempts at life outside the confines of a hydrothermal vent,” said lead author Natalia Mrnjavac, a biologist at the University of Düsseldorf.
The new study investigated protein structures, chemical reactions, and genomes involved in the evolution of these early free-living cells.
“These comparisons are giving us unprecedented insights into the phase of evolution when metabolism catalysed by enzymes was arising from spontaneous reactions catalysed by metals in the Earth’s crust,” said senior author William Martin, a Düsseldorf biologist.
Metabolism and Evolution
Among the new work’s major findings is a consideration of the entire set of 420 chemical reactions involved in metabolism that produce amino acids, RNA bases, and vitamins from the raw materials of hydrogen, ammonia, and carbon dioxide.
These reactions are preserved for modern researchers inside the genetic code, allowing the team to make a surprising discovery: about half of LUCA’s reactions were catalyzed by environmental metals instead of enzymes produced by the organism itself.
“Metals that naturally occur in hydrothermal vents can replace a surprisingly large number of enzymes in metabolism,” said co-author Harun Tüysüz, an inorganic chemist from the Max-Planck-Institut für Kohlenforschung and the IMDEA Materials Institute in Madrid.
In this study, the team reconstructed catalysis evolution from metal-only to a metal-enzyme hybrid present in LUCA, and finally to the divergence of the bacterial and archaeal lineages. This evolution helped life move on from the hydrothermal vents inhabited by the first cells by replacing the inorganic catalysts provided by that environment with new enzymes.
“We can see cases where the ancestors of bacteria and archaea independently evolved structurally distinct enzymes to catalyse the same essential metabolic reaction,” Mrnjavac explained, adding that “such parallel inventions could have paved the way to the independent emergence of free-living bacteria and archaea.”
The Energy for Life on Earth
A primary question involves what supplied the energy driving metabolic reactions in early life on Earth. A compound named ATP is the primary metabolic driver in most organisms today, but it comes from enzymes and is not present in hydrothermal vents. The researchers identified a new energy source in palladium, a natural catalyst used by chemists and also plentiful in hydrothermal vents.
“When we react phosphite, a form of phosphorus that naturally occurs in hydrothermal vents, with organic compounds, we get metabolic phosphorylation reactions overnight in water. Phosphite and palladium replace ATP and enzymes; it’s amazing, and it makes early evolution a lot easier to grasp,” Schlikker said.
Understanding the interconnection between so many reactions presents a significant mathematical challenge. For this reason, the team included not just biologists, but network scientists tasked with ordering the reactions by their complexity, which the researchers hoped would indicate the sequence in which they evolved. Using a machine learning algorithm, the team discovered that a clear order did appear to exist.
“The new data leave only one conclusion,” Martin concluded. “The bacteria and archaeal lineages made the transition to the free-living state independently. Only free-living cells are alive.”
“Let’s call it by name,” Martin added. “We are looking at one origin of the genetic code, but two origins of life.”
The paper, “Intermediate Stages in the Origin of Metabolism at a Phosphorylating Hydrothermal Vent,” appeared in Science Advances on August 5, 2026.
Ryan Whalen covers science and technology for The Debrief. He holds an MA in History and a Master of Library and Information Science with a certificate in Data Science. He can be contacted at ryan@thedebrief.org.
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Safety fears as scientists make first viruses designed by AI
Researchers say breakthrough offers hope for new medicines but also raises urgent biosecurity questions
Scientists have made the first viruses designed by artificial intelligence in a milestone that raises hopes for new medicines but also concerns over how to ensure the technology remains safe.
The viruses are specific kinds known as bacteriophages, which only infect bacteria and are used around the world to treat patients with persistent infections. In lab tests, a cocktail of the AI-designed viruses killed E coli bugs that were resistant to natural bacteriophages.
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© Photograph: Samyukta Lakshmi/Bloomberg/Getty Images

© Photograph: Samyukta Lakshmi/Bloomberg/Getty Images

© Photograph: Samyukta Lakshmi/Bloomberg/Getty Images