O Apple Creator Studio desbloqueia vários recursos bacanas de aplicativos já conhecidos pelos usuários de dispositivos da Maçã.
Dentre os exemplos, estão os apps Pages, Numbers e Keynote. Com eles, assinantes do Creator Studio podem gerar imagens e adicioná-las aos seus documentos, planilhas e apresentações de slides.
Com o Pixelmator Pro e uma assinatura do Apple Creator Studio, o processo de edição de imagens fica muito mais fácil e eficaz, graças às ferramentas avançadas disponibilizadas.
Uma dessas ferramentas é a Super resolução (Super Resolution). Com ela, é possível ampliar qualquer foto, ao mesmo tempo que se tenta preservar a nitidez e os detalhes.
As parents look for alternatives to unrestricted smartphones, a growing number of companies are building phones designed specifically for kids, from feature-limited mobile devices to minimalist home phones.
On Thursday, the New York Times reported that the Centers for Disease Control and Prevention had linked the outbreak of cyclosporiasis, an infection notorious for inducing explosive diarrhea, to iceberg lettuce from Taylor Farms that was supplied to Taco Bell.
Per the reporting, Taco Bell said it was voluntarily pulling the lettuce from select states where it received the contaminated produce: Indiana, Kentucky, Michigan, Ohio, and West Virginia. An announcement from the CDC warned the public not to eat food items with shredded lettuce from Taco Bell, but hasn’t identified Taylor Farms as the source.
But while Taco Bell may have served the tainted lettuce, it would be remiss to lay all of the blame on the fast food chain (although one aggrieved customer is already suing it after contracting the illness).
The contamination occurred at the farms or facilities where the food was processed, from a single supplier in Mexico, Food and Drug Administration officials said. The supplier, Taylor Farms, has been involved in previous outbreaks, including another outbreak of cyclosporiasis in a salad mix in 2013.
Taco Bell, to its credit, also immediately pulled its ingredients from some of its locations last week as soon as it learned about the situation, according to local reports.
And then there’s the broader political context that many experts are drawing attention to: how the Trump administration has slashed funding to the CDC and paralyzed the nation’s food safety bodies.
Last February, shortly after Trump took office, the US Department of Agriculture (USDA) dissolved its National Advisory Committee on Microbiological Criteria for Foods, which provided scientific guidance on food safety policy. Ryan Cooper at The Prospect notes that the committee was working on advice for foodborne illness outbreaks before being terminated. The FDA also shut down its National Advisory Committee on Meat and Poultry Inspection.
Not spared during the wave of cuts that wreaked the federal government, the USDA lost over 20,000 workers last year, with 913 of them coming from its Food Safety Inspection Service.
Last year, the CDC — which has lost some 3,000 employees under Trump — scaled back its food surveillance program called FoodNet that monitored eight common foodborne pathogens, changing it so that surveillance of the cyclospora parasite that causes cyclosporiasis was optional.
Dan Jernigan, a former director of CDC’s Center for Emerging and Zoonotic Infectious Diseases, told the Washington Post that the decision was made because funding for food safety had not been maintained over the past few years. That the US is now on track to have more cyclospora cases this year than any previous year in history is likely no coincidence.
Jernigan left the agency last August in protest of Trump ousting its then director Susan Monarez and the policies of health secretary Robert F Kennedy Jr. But he said that the Trump cuts would have little impact on the ongoing outbreak, adding that FoodNet wasn’t designed for real-time outbreak detection or response.
As the WaPo reporting notes, federal and state health authorities have insisted that the cyclosporiasis investigation hasn’t been impeded because the parasite is still reportable to a separate national database. Still, Jernigan said that scaling back FoodNet wasn’t inconsequential.
“Routine outbreak investigators are the firefighters responding to a specific blaze. FoodNet is the citywide system that tracks how often fires occur and whether the overall risk is rising,” he told WaPo. “Removing cyclosporiasis from FoodNet does not take the firefighters away from the current outbreak, but it does remove part of the system that tells us how large the problem is and whether it is getting worse over time.”
Cyclosporiasis is a particularly tough illness to track. Symptoms can take weeks to present, making it difficult for health officials to trace back where sufferers were infected. A recent Wired piece drew attention to how many people may be wrongly misdiagnosing themselves as news of the diarrhea dilemma spread across social media.
Linda Yancey, an infectious disease specialist at Memorial Hermann Health System in Texas, warned that large outbreaks like this could become more common.
“Unfortunately with so many budget cuts, every federal agency is hurting for personnel and resources,” she told Time Magazine earlier this month. “We could be at greater risk of foodborne infections because the FDA is so understaffed and underfunded right now.”
So far, Michigan, the epicenter of the outbreak, has alone tallied over 4,300 cases of infection, while nationwide there could be 7,000 cases, though the Centers for Disease Control and Prevention has only confirmed 1,600 of them.
Entre as novidades anunciadas pela OpenAI e pela Meta estão mais controlos para os pais, mecanismos de segurança reforçados e ferramentas concebidas para adaptar a experiência aos utilizadores mais jovens.
Durante décadas se creyó que neandertales y Homo sapiens vivían en mundos culturales distintos, pero una cueva del Levante mediterráneo revela una historia mucho más compleja que obliga a replantear los orígenes de nuestra propia especie.
Thousands of fossilized bones from a Cretaceous-period bonebed in Wyoming, the United States, offer rare physical evidence that Tyrannosaurus rex fed on the carcasses of a duck-billed dinosaur species called Edmontosaurus annectens.
Apocryphal tales of its meals causing the runs have plagued Taco Bell since time immemorial. But this latest parasitic outbreak is something else entirely.
As the Washington Post reports, federal and state authorities are investigating whether the fast food chain is behind the outbreak of explosive diarrhea cases across the country — further cementing its scatological legacy.
The illness, caused by the cyclosporiasis parasite, has sickened as many as 5,100 people across the country, according to the Centers for Disease Control and Prevention. In Michigan, which appears to be the epicenter of the outbreak, over 3,700 people have been infected, state authorities said.
Taco Bell’s suspected role in the outbreak comes after reports that the chain’s Michigan locations began pulling some of its ingredients. Signs in front of the restaurants stated that they were no longer serving lettuce, cilantro, onion, pico de gallo, and guacamole due to a “nationwide recall,” though what recall they were referring to is unclear.
Health officials have so far struggled to narrow down how the parasite is spreading. While usually found on fresh produce, symptoms can take weeks to manifest, making it difficult to trace back to the source.
Lettuce has emerged as one of the likeliest culprits. In an update this week, Michigan’s chief medical executive Natasha Bagdasarian said that “early information has shown lettuce as a common product that regularly comes up during the investigation.”
“Although we do not have a definite product identified as the source of the outbreak, we want to let Michiganders know what we have learned so far so they can take steps to protect their families,” Bagdasarian added.
Federal authorities haven’t singled out any veggies yet, though acting Food and Drug Administration director Don Prater acknowledged Michigan’s fixation on lettuce.
“What I can say at this point is that we’re continuing our traceback investigation on multiple produce items, including the lettuce,” he said, per WaPo.
So far, no nationwide recalls have been made related to the outbreak. One person familiar with the federal investigation, however, praised Taco Bell’s response.
“It’s good the chain has already voluntarily stopped serving a number of items,” they told the newspaper. They added that some who became sick said they didn’t eat at the chain, suggesting that it’s not the only one responsible.
O governo britânico anunciou esta terça-feira um "toque de recolher digital" que bloquearia por defeito o acesso ao Instagram, TikTok, YouTube e outras durante a madrugada para utilizadores de 16 e 17 anos. A medida complementa a já anunciada proibição total para menores de 16 anos, prevista para entrar em vigor na Primavera de 2027.
In Israel’s Qafzeh cave, archaeologists have discovered an intriguing set of ancient human remains that reveal a story of illness, violence, death, and survival in the remote past.
The international team of archaeologists from Centro Nacional de Investigación sobre la Evolución Humana (CENIEH) and Tel Aviv University revealed their analysis of ancient humanfossil remains, known as Qafzeh 25, in a recent paper published in Scientific Reports.
The findings provide rare evidence of interpersonal violence, care for the injured, and early funerary practices in a human population that lived between 92,000 and 145,000 years ago.
Analyzing Ancient Human Remains
The researchers used a range of techniques to examine one particularly intriguing skull, including high-resolution micro-computed tomography (microCT) alongside macroscopic and microscopic analyses. Their investigation revealed a linear lesion across the mandible and lower premolars, with characteristics consistent with trauma inflicted by a sharp object.
Despite the severity of the injury, the researchers concluded that the individual survived the ordeal based on evidence of bone remodeling. The extent of healing suggests the person lived for a considerable period after suffering the wound.
Although the available evidence does not allow archaeologists to determine exactly how the injury occurred, they consider interpersonal violence the most likely explanation. The discovery is particularly significant because evidence of sharp-force trauma in Middle Paleolithic human remains is exceedingly rare.
The Qafzeh 25 skull revealed significant dental pathologies uncommon to such ancient humans. Credit: CENIEH/Ana Pantojah-Perez et al.
Never-Before-Seen Conditions
Beyond the apparent head injury, the Qafzeh 25 skull yielded another remarkable discovery. Detailed examination of the teeth revealed dental conditions that had not previously been documented in humans of this antiquity.
The microCT scan revealed a hidden carious lesion in a lower premolar, along with enamel defects. These sorts of tooth decay issues are uncommon in early homo sapiens, as they are largely caused by bacteria that thrive on sugars. Before the advent of agriculture and later processed carbohydrates and refined sugars, such tooth decay was rare due to diets high in meats, nuts, and fibrous vegetables, which helped clean the teeth.
Ancient Human Funerary Practices
Looking beyond the skull, the researchers also examined the broader funerary context of the skeleton in an effort to reconstruct the burial practices of these ancient humans.
A broader analysis of the entire skeleton suggests it was deliberately buried, as it lacks evidence of carnivore predation or damage consistent with exposure to the elements. According to the researchers, this makes Qafzeh Cave one of the most important sites in the world for studying Homo sapiens’ earliest internment practices and the relationship not just between the living and the dead, but also between the living and the dying.
“These findings provide new evidence in the ongoing debate about the origins of complex behaviours such as interpersonal violence, the care of injured or ill individuals, and funerary practices—fundamental aspects for understanding the social and cultural evolution of our species,” said lead author Ana Pantoja Pérez, a member of the DEATHREVOL research group.
The find represents one of the earliest known well-preserved human populations outside of Africa at this time, residing in the Levant at least 90,000 years ago. With evidence of a healed traumatic injury, unusual dental disease, and intentional burial, the Qafzeh 25 skeleton offers a rare glimpse into the lives—and deaths—of some of our earliest ancestors.
Ryan Whalen covers science and technology for The Debrief. He holds an MA in History and a Master of Library and Information Science with a certificate in Data Science. He can be contacted at ryan@thedebrief.org, and follow him on Twitter @mdntwvlf.
Anthony Albanese will deliver a landmark speech on AI this week as MPs are torn between attracting datacentre investment and protecting the rights of creatives
When Anna Funder stood before a pack of journalists at Parliament House this month, she presented herself not just as a writer but also a “victim of crime”.
The Stasiland author was using the analogy to illustrate how technology companies have flagrantly “hoovered up” her literary works for their own profit.
As an explosive diarrhea outbreak splatters across the country, Taco Bell is preparing for the worst.
This week, the fast food chain — or at least its locations in Michigan — began temporarily pulling some of its staple ingredients to help stop the spread of cyclosporiasis, a foodborne parasite that causes sufferers to go running to the toilet even more often than a standard Taco Bell meal might.
Many of your favorite menu items, like the Crunchwrap Supreme and the Cantina Chicken bowl, may be imperiled.
“We are currently unable to sell Lettuce, Cilantro Onion, Pico de Gallo, and Guacamole due to a nationwide recall,” a notice posted at locations in Metro Detroit reads, Michigan outlet WWJ reported. “Any items ordered that normally come with these items WILL NOT contain them,” it stressed.
It doesn’t sound like any cases of cyclosporiasis-related explosive diarrhea have been linked to Taco Bell yet, so the fast food chain is probably just trying to err on the side of caution.
So far, nearly 3,000 people have been infected with the foodborne parasite, with around 86 hospitalized, NBC News reported, citing data from the Centers for Disease Control and Prevention. Michigan appears to be one of the epicenters, accounting for over half the reported cases so far.
Cyclosporiasis symptoms are pretty gnarly, but usually not life threatening. It can cause stomach cramps and a lengthy bout of explosive diarrhea. The intensifier is warranted: one sufferer who spoke to the New York Post was in awe of the “amount of pressure when it comes out,” adding that the “force is crazy.”
No food items have been recalled yet related to the outbreak. The virus is usually found on fresh produce, but we don’t know what specific food items are spreading it or the supplier they come from. Cyclosporiasis is notoriously hard to track because the symptoms usually don’t present until at least a week after the contaminated food is ingested.
They may not all come from the same source, the CDC cautioned, and what we’re seeing could be a cluster of unrelated outbreaks.
To protect yourself, the best thing to do is thoroughly wash and cook your veggies, which you should still eat. And maybe skip on the fast food.
Üçağızlı II Cave on Türkiye’s Mediterranean coast has yielded a rare and detailed record of two Homo species living the same way of life, one after the other, over more than 20,000 years, offering new evidence that the transition from Neanderthals to modern humans in the region was far more culturally seamless than previously understood.
Ezekiel's vision features radiant angelic beings in disk-like UFOs, described as hybrid creatures with multiple faces and wings. This imagery links to Jewish mysticism and was popularized by Erich von Däniken in "Chariots of the Gods?". Here I suggest that these UFOs carry spiritual beings, highlighting a connection between the celestial and earthly realms.
In February 2026, President Trump directed the U.S. government to release documents on UFOs, UAPs, and alien life. Questions arise about the nature of these phenomena, ranging from interdimensional entities to possible deceptions involving spiritual beings, echoing long-standing debates on extraterrestrial existence and their implications for faith.
Chromosome instability and aneuploidy have long posed a conundrum in cancer biology, profoundly shaping tumor genomes yet remaining challenging to decode functionally. In a groundbreaking study published in Nature, Al-Zahrani et al. unveil a novel approach, CRISPR-KOALA, that systematically links large-scale chromosomal alterations to specific cancer-driving genes in basal-like breast cancer (BLBC).
BLBC, a highly aggressive subtype characterized by extensive copy-number alterations (CNAs), often harbors arm-level chromosomal imbalances whose contribution to tumorigenesis remains elusive. The researchers developed CRISPR-KOALA to conduct high-throughput bidirectional genetic screens directly in immunocompetent mouse models, overcoming previous barriers related to the complexity and scale of genes affected by aneuploidy.
By focusing on the ten most frequent human chromosome-arm alterations seen in BLBC, the team screened over 3,700 mouse orthologues of genes located on these arms. The screen identified 90 putative cancer driver genes—a majority of which had not been previously linked to cancer—revealing a diverse functional landscape shaping tumor biology. Among the implicated pathways were key signaling networks such as MAPK, HIPPO, and WNT, highlighting the heterogeneity intrinsic to BLBC progression.
Strikingly, manipulating these driver genes in Trp53-mutant mouse models was sufficient to bypass the need for whole-arm CNAs, suggesting that tumors exploit specific genes within broad chromosomal alterations to fuel oncogenesis. This finding challenges the traditional view that arm-level aneuploidies function merely as genomic chaos, instead presenting them as evolutionary selections for particular drivers.
One gene, PLGRKT, localized on chromosome 9p, emerged as a potent oncogene. The team showed that PLGRKT promotes tumor growth by enhancing mitochondrial robustness and boosting reactive oxygen species detoxification. This mechanistic insight connects chromosomal instability not only to genetic selection but also to metabolic adaptations that support cancer cell survival under stress.
Overall, this study delivers a transformative platform and a compendium of cancer drivers that illuminate how aneuploidy sculpts tumor heterogeneity. By delineating driver genes nested within widespread CNAs, it provides an invaluable resource for targeting breast cancer’s genetic complexity with greater precision.
The implications extend beyond breast cancer, offering a blueprint for dissecting arm-level aneuploidy in diverse malignancies. As cancer therapies increasingly focus on genetic vulnerabilities, CRISPR-KOALA represents a leap toward untangling the intricate link between chromosome-level alterations and oncogenic processes.
This work underscores the power of integrating genomic data with functional genetics in vivo, setting the stage for novel drug targets and therapeutic strategies aimed at the underexplored realm of aneuploidy-driven tumorigenesis.
Subject of Research: Chromosome instability and cancer driver genes in basal-like breast cancer
Article Title: Aneuploidy selects for the acquisition of driver genes in breast cancer
Article References:
Al-Zahrani, K.N., Langille, E.R., Nurtanto, J. et al. Aneuploidy selects for the acquisition of driver genes in breast cancer. Nature (2026). https://doi.org/10.1038/s41586-026-10752-9
Une nouvelle espèce de requin vient d'être identifiée dans les eaux de Papouasie-Nouvelle-Guinée. Sa particularité ? Comme les autres rares « requins marcheurs », il utilise ses nageoires pour se déplacer sur les récifs peu profonds, une adaptation étonnante qui intrigue les scientifiques.
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