Scientists at the Weizmann Institute of Science have engineered Nicotiana benthamiana, a fast-growing relative of tobacco, to produce five different psychedelic compounds.
The achievement, detailed in a study published in Science Advances, brings together biosynthetic pathways that nature distributes across three different kingdoms of life.
The five compounds (DMT, psilocybin, psilocin, bufotenin, and 5-MeO-DMT) are typically sourced from an Amazonian shrub, mushrooms, and the defensive skin glands of a desert toad. Extracting even one of these molecules from its natural source is a slow process. Producing all five in a single, easily cultivated plant had not been achieved before.
Despite coming from such different sources, all five of these molecules share a common origin: tryptophan, an amino acid found in every living thing. In humans, tryptophan is the building block for serotonin, which helps explain why these psychedelics interact with serotonin receptors in the brain. This shared chemistry gave the Weizmann team, led by Dr. Paula Berman and Prof. Asaph Aharoni, a logical starting point for their experiments.
The team began by focusing on DMT to address a previously unresolved question. Researchers knew the general biochemical pathway plants use to synthesize DMT, but they had not yet identified all the genes and enzymes responsible for each step. “At the heart of the study was the challenge of making DMT,” Aharoni says.
To identify the necessary genes, the team analyzed genetic material from the Amazonian chacruna shrub and an Australian acacia species. Introducing these genes into Nicotiana benthamiana allowed the plant to produce DMT within days.
The researchers applied the same gene transfer approach to the other four psychedelics, but the engineered plants initially produced only trace amounts of 5-MeO-DMT. Protein-design specialists Prof. Sarel Fleishman and Dr. Olga Khersonsky determined that the limitation was due to a poor molecular fit in one enzyme’s active site. Replacing a single amino acid resolved the issue.
“We mutated one amino acid in the sequence and got a 40-fold increase in the production of 5-MeO-DMT,” Berman says.
Once all five biosynthetic pathways were functioning separately, the researchers combined them within a single plant. The result was a tobacco relative capable of producing DMT from plants, psilocin and psilocybin from fungi, and bufotenin and 5-MeO-DMT from toads, all at the same time. “In effect, we created a kind of biological ‘cocktail’ — not by mixing substances externally, but by combining the underlying pathways inside one organism,” Aharoni says.
Combining all five pathways reduced the yield of each compound, as they competed for the same pool of tryptophan. The researchers also introduced bacterial enzymes to attach chlorine and bromine atoms to the psychedelic molecules, creating modified psychedelic molecules that do not naturally occur in the engineered plant. Some similar modified molecules have shown antidepressant-like effects in previous studies.
The bottleneck also highlighted a broader research question about the natural role of these compounds. These molecules likely function as defenses or as tools for interacting with microbes and insects in the organisms that produce them, rather than evolving to affect human consciousness.
“If we can move these pathways into a model plant that grows quickly and is easy to manipulate, we can start asking what these compounds actually do for the plant,” Berman explains.
There is a clear practical benefit to this approach. Plants used for ayahuasca are increasingly threatened by habitat loss and rising demand, and the Sonoran Desert toad is declining due to overcollection and habitat destruction. A fast-growing laboratory plant capable of producing these compounds within a week provides an alternative that does not rely on harvesting wild species.
The Weizmann researchers are now working on a plant that can produce the complete ayahuasca mixture, which includes both DMT and the compound required for it to be active when taken orally. They are also exploring whether these psychedelics could be produced in edible plants capable of delivering carefully regulated doses.
Whether this platform becomes a practical manufacturing system will depend on overcoming the metabolic bottleneck that currently limits production when multiple pathways operate simultaneously.
Austin Burgess is a writer and researcher with a background in sales, marketing, and data analytics. He holds an MBA, a Bachelor of Science in Business Administration, and a data analytics certification. His work focuses on breaking scientific developments, with an emphasis on emerging biology, cognitive neuroscience, and archaeological discoveries.
Scientists have discovered an abundance of molecules in the cosmos, but for the first time ever, they were able to detect one in interstellar space very familiar to us here on Earth: sugar.
The discovery, made in the vast clouds of gas and dust between stars, could help scientists better understand how some of the chemical ingredients necessary for life formed long before Earth existed.
Researchers at the Centro de Astrobiología, part of the Spanish National Research Council (CSIC), identified the sugar molecule erythrulose within the interstellar medium.
Sugars are considered fundamental building blocks of life. On Earth, they play vital biological roles, including forming the backbone of RNA and contributing to the chemistry that ultimately supports DNA, while also serving as an important source of energy. Scientists studying the origins of life have long sought to understand how the first sugars formed, since they are essential ingredients in the molecules associated with life’s earliest development.
“The detection of erythrulose is very exciting because it opens up the possibility of discovering in space other sugars such as ribose, which is part of RNA, and other important molecules for the origin of life,” says Carlos Briones, co-author of the study, in a statement.
Even so, one major question remains: where did the first biologically important sugars originate?
Previous studies have identified sugars such as ribose and glucose in meteorites and asteroid samples, suggesting that some organic compounds may have been delivered to the early Earth from space. Until now, however, no sugar had been directly detected in the cold molecular clouds where stars and planets form.
The newly identified molecule, erythrulose, was found in the molecular cloud G+0.693−0.027 near the center of the Milky Way. On Earth, erythrulose is a naturally occurring four-carbon ketose sugar.
The discovery was made using highly sensitive radio astronomy observations from the Yebes Observatory’s 40-meter radio telescope and the 30-meter telescope operated by the Institute for Radio Astronomy in the Millimeter Range. Researchers analyzed the unique radio signatures, or spectral fingerprints, emitted by molecules in space.
The team identified 12 spectral lines matching laboratory measurements of erythrulose, confirming the molecule’s presence.
The findings also challenge some existing ideas about how complex molecules form in space. Scientists have generally proposed that interstellar chemistry builds larger molecules by gradually adding carbon atoms. Yet erythrulose proved to be more abundant than related three-carbon sugars that researchers expected would appear first.
“This finding was unexpected, as the prevailing view in astrochemistry is that interstellar molecules grow in size through the sequential addition of carbon atoms,” said Izaskun Jimenez Serra (CAB), the lead author of the recent study.
Instead, the researchers found that erythrulose could form inside icy dust grains from simpler two-carbon alcohols and aldehydes. These frozen environments may function as natural chemical laboratories, allowing increasingly complex organic molecules to develop over time.
The team estimates that during the Late Heavy Bombardment—roughly 4.1 to 3.8 billion years ago, when Earth experienced intense asteroid and comet impacts—between 500,000 and 50 million tonnes of erythrulose may have been delivered to the planet’s surface.
The discovery adds another piece to the puzzle of life’s origins, suggesting that some of its essential ingredients may have arrived with something surprisingly sweet.
This paper was published in the journal Nature Astronomy.
Chrissy Newton is a PR professional and the founder of VOCAB Communications. She currently appears on The Discovery Channel and Max and hosts the Rebelliously Curious podcast, which can be found on YouTube and on all audio podcast streaming platforms. Follow her on X: @ChrissyNewton, Instagram: @BeingChrissyNewton, and chrissynewton.com. To contact Chrissy with a story, please email chrissy @ thedebrief.org.
The discovery hints that life’s ingredients may form before planets exist.The School of Science has announced the winners of its 2025 Awards for Excellence in Teaching and Mentoring. This year, the Teaching Prizes were restructured to acknowledge early- and mid-career teaching excellence, in addition to an overall prize for teaching excellence that includes instructors and non-tenured instructors or lecturers.
Olivia Corradin, assistant professor of biology and a member of the Whitehead Institute for Biomedical Research, received an Award for Teaching Excellence. Corradin’s nominators emphasized that she is an exceptionally clear and engaging educator.
Julien Tailleur, associate professor of physics, received an Award for Excellence in Mentoring and Advising in recognition of his dedication to mentorship. Nominators describe Tailleur as an outstanding research supervisor and group leader who cultivates an open and respectful environment.
John Urschel, Class of 1956 Career Development Assistant Professor of Mathematics, received an Award for Teaching Excellence. Many students call Urschel the best instructor they have had and their favorite professor at MIT, noting that he cares greatly about his students’ success and shows them why linear algebra is “so cool.”
Recipients of the School of Science Awards for Excellence in Teaching and Mentoring were honored alongside School of Science Infinite Expansion and Mile Award winners at a celebratory luncheon.
The School of Science welcomes nominations for the teaching prize at the end of each semester. Nominations can be submitted to the School.
The post Three win School of Science Awards for Excellence in Teaching and Mentoring appeared first on MIT School of Science.
The microbes don't exactly digest uranium, but their metabolism made it far less mobile.New research suggests aging ovaries may help shape inflammation across the body.Coastal animals are creating an unexpected new community.Slow-motion video reveals that buff-tailed bumblebees (Bombus terrestris) respond to sweet and bitter tastes with distinct, context-dependent behaviors resembling mammalian expressions of pleasure and disgust, adding fresh evidence to the debate over insect consciousness.
The post Bumblebees Display Emotion-Like Reactions to Sweet and Bitter Tastes appeared first on Sci.News: Breaking Science News.
When I was first learning to write, my letters and words ran from right to left, reversed as if in a mirror. Being left-handed, I was imitating the hand strokes of my right-handed teachers instead of reversing their strokes to replicate the letters. I gradually got the hang of writing in the correct direction, but it still feels natural for me to mirror-write. I have a mirror-written childhood…
Nitrogen is an essential building block of proteins, amino acids, and DNA. Without nitrogen, cells can’t function or reproduce. Nitrogen is abundant in the atmosphere as dinitrogen gas, but plants and animals can’t access atmospheric nitrogen. Instead, we rely on biologically available forms like ammonia and nitrate.
Specialized microbes can transform atmospheric nitrogen into ammonia via a process called biological nitrogen fixation. Nitrogen-fixing soil bacteria have a unique protein complex, the nitrogenase complex, that facilitates this nitrogen transformation. The nitrogenase complex is activated by a group of genes known as nif genes.
Legume plants like peanuts, peas, and beans have nitrogen-fixing bacteria in the soil zone around their roots, called the rhizosphere. The symbiotic relationship between nitrogen-fixing soil bacteria and legume plants supplies most of the biologically available nitrogen to life on Earth.
Bacteria attached to plant roots “feed” nitrogen to plants through the soil, and in turn receive organic acids for energy from plants performing photosynthesis. Source: Wikimedia Commons
However, one piece of the puzzle remains unexplored: the role of soil viruses in these nitrogen transformations, referred to as the nitrogen cycle. Viruses are microscopic particles made up of genetic material and proteins, but they can’t reproduce without a host cell. Scientists consider viruses to be biological entities that are halfway between living and non-living.
To reproduce, viruses contact a host cell and inject their genetic material into it. The virus’s genetic material takes over the host cell’s genome and forces the cell to produce proteins that assemble into new viruses. As new viruses are created, they can incorporate genes from the host cell into their own genetic material. Genes that are transferred from a host cell to a virus are known as auxiliary metabolic genes (AMGs). Viruses can carry AMGs and pass them to other hosts or use them to increase their own ecological fitness.
Scientists from China, Spain, and the Czech Republic set out to investigate whether viruses from legume roots could increase local soil nitrogen fixation by expressing nif AMGs or by transferring nif genes to other bacteria. First, they determined the global distribution of viral nitrogen-fixing genes by analyzing about 8.6 million viral genomes from the Integrated Microbial Genomes/Virus database. They looked for the DNA sequences of known nitrogen-fixing genes and the locations where the viruses were sampled. They found that only 0.003% of the viruses in the database had at least 1 nitrogen-fixing gene, but they clustered in the same locations as nitrogen-fixing bacteria.
The team also found 3 types of viruses that most commonly carried nitrogen-fixing genes: Kyanoviridae, Nudiviridae, and Bronfenbrennervirinae. Kyanoviridae viruses carried a nif gene called nifU. The researchers used a computer program called DRAM-v to confirm that nifU was a fully functional gene and a real tool that viruses could use.
Next, the team collected soil samples from a cowpea field in Nanjing, China, to test whether the cowpea roots influenced the abundance of viruses using nitrogen-fixing genes. They collected soil from the cowpea rhizospheres and soil away from the plants. They analyzed both viral and bacterial RNA in the soil samples to identify active genes, using a sequencing process called metatranscriptomics. They found that the viral nifU gene was actively expressed in the cowpea rhizosphere samples more than in the non-crop soil. Although about 96% of nifU genes were being expressed by bacteria, viruses contributed about 4%.
The researchers then assessed whether rhizospheric viruses changed the amount of nitrogen being fixed in these soils. They set up small, enclosed containers of sterile soil and added either bacteria or a mixture of bacteria and viruses extracted from the cowpea rhizospheres. They found that soil with viruses had higher total nitrogen (36 milligrams per kilogram, or mg/kg) than soil without viruses (17 mg/kg).
Finally, they adjusted the air in each container to have a different form of dinitrogen gas. Atoms of the same element that have different atomic masses are known as isotopes. Nitrogen has 2 stable isotopes: lighter nitrogen-14 and heavier nitrogen-15. Bacteria or viruses that fix nitrogen at natural isotope abundances will take up nitrogen-14. But scientists can track who in the population fixes nitrogen by adding nitrogen-15 to the air, a process called nitrogen-15 stable isotope probing. Nitrogen-fixers will incorporate the heavy nitrogen-15 into their biomass over time and increase their weight, allowing researchers to separate and identify them.
The team grew the bacteria and viruses with nitrogen-15 for 35 days, then used stable isotope probing to separate the nitrogen fixers. They detected viral nifU AMGs among the heavier biomass, confirming that rhizospheric viruses were fixing nitrogen.
The team concluded that rhizospheric viruses and the viral nifU AMG can increase nitrogen fixation in cowpea soils. The team suggested that although viruses with nitrogen-fixing genes are rare, they can influence the soil nitrogen cycle. They recommended that future researchers further test the contribution of viral nifU genes to plant nitrogen fixation with controlled infection experiments.
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The strange grin of the Happy-Face spider has been spotted far from the Hawaiian Islands, its only previously known home, much to scientists’ surprise.
In a recent paper published in Evolutionary Systematics, researchers from the Forest Research Institute and the Regional Museum of Natural History have found a spider bearing the unmistakable grin in Uttarakhand, India’s Montane mountains.
The researchers call it the Himalayan Happy-Face spider, Theridion himalayan, named for the unexpected combination of its highly recognizable markings and strange new location.
As with many scientific discoveries, the Himalayan Happy-Face Spider was discovered entirely by accident; the researchers, Ashirwad Tripathy and Devi Priyadarshini, were initially focused on the region’s ants.
“So, one fine day, when he shared this image from the underside of a Daphniphyllum leaf, I froze in shock because I had seen the Hawaiian spider during my master’s program itself, and I knew instantly we had a jackpot because of its striking resemblance,” said Priyadarshini, a researcher with the Regional Museum of Natural History in Bhubaneswar, and the co-author of a new study deatiling the discovery.
“I asked him to send all morphs that he found, and that led to the discovery in the next few months, from October 2023 onwards.”
According to Priyadarshini, she has always been interested in high-altitude spiders because the significant differences in landscape and vegetation in these regions compared with low-altitude plains offer “a gateway to look at other polymorphic species from this region.”
According to Tripathy, this discovery may only be the beginning for the documentation of Himalayan Happy-Face spiders, as more variations may be identified in future surveys.
“The name Himalayana was decided as the species name because we both wanted to pay our respects to the mighty Himalaya mountain ranges, which have been standing tall not just guarding our country but also holding a plethora of biodiversity within them, said co-author Ashirwad Tripathy, of the Forest Research Institute in Dehradun. “Since this spider was the first polymorphic from this region, we decided to make it an ode to the amazing mountain ranges.”
So far, the species has been found in three locations around Uttarakhand, including Makku, Tala, and Mandal, yielding 32 distinct color variations. In their investigation, the researchers conducted a DNA analysis of the new species, discovering that it differed by approximately 8.5% from the previously known Hawaiian Happy-Face spider. This indicates that the Himalayan version evolved independently.
While the markings are fascinating, perhaps partially due to a certain amount of pareidolia in humans, the researchers are uncertain exactly why the spiders evolved to feature them. Notably, other creatures in the region bear similar colorful body markings.
“The reason behind the expression of polymorphism is also very complex and unique,” Priyadarshini explained. “These patterns definitely help them survive better in the wild, which is understood prima facie, but why do they resort to such patterns on their back, and what functional role in their life cycle does it exactly serve is yet to be deciphered. This is definitely indicative of a deeper genetic mystery.”
One strange connection between the Hawaiian and Himalayan varieties was their shared propensity to cling to ginger plants. This is especially notable because ginger is not native to Hawaii, suggesting an evolutionary connection between the species.
“How did the spiders choose an invasive species and ginger exactly?” Priyadarshini asks, noting this adds an unusual layer to the mystery, especially “if T. himalayana is an elder cousin of T. grallator, although discovered 125 years later!”
“Although this sounds like a tall claim now, it will be our further scope of work to establish any missing links,” Priyadarshini adds.
The paper, “On the Discovery of a New Polymorphic Happy-Face Spider (Araneae, Theridiidae) from the Western Himalayas, India, with Notes on its Natural History,” appeared in Evolutionary Systematics on April 24, 2026.
Ryan Whalen covers science and technology for The Debrief. He holds an MA in History and a Master of Library and Information Science with a certificate in Data Science. He can be contacted at ryan@thedebrief.org, and follow him on Twitter @mdntwvlf.
Does intelligent life exist elsewhere in the universe? The question has captivated us for centuries, but despite decades of searching it remains frustratingly unanswered. Every so often a curious signal appears — fossilized structures in a meteorite, say, or an unusual gas in an exoplanet’s atmosphere — and for a moment it seems possible that we are not alone before the excitement gives way to a…
In March 2021, the carcasses of at least 260 marine organisms from 81 species, including large animals called megafauna, washed ashore in South Africa. Scientists questioned whether this event was the result of an extreme temperature drop that can happen when deep, cold water rises to the surface along coastlines. Scientists refer to these rapid cooling events as coastal upwelling.
Climate change is making oceans warmer, but it’s also making coastal upwelling stronger, with unknown consequences for marine megafauna. Scientists recently studied 2 boundary currents that are rapidly warming and creating strong upwelling near the edges of sharks’ geographic ranges: the Agulhas Current in southern Africa and the East Australian Current in eastern Australia. They wanted to determine whether climate-driven changes in upwelling zones are making cold-shock events more frequent and intense, and how these events are pushing sharks beyond their temperature limits.
First, the researchers analyzed sea surface temperature data from satellites to see if rapid cooling from upwelling caused the mass marine die-off in 2021. They also obtained hourly temperature recordings from temperature loggers to measure subsurface temperature changes during the event. They found that during the March 2021 event, sea surface temperatures along the coast dropped by up to 7°C (12°F) in less than 48 hours, from 24°C (75°F) to below 17°C (63°F). Subsurface temperatures dropped faster, by more than 9°C (16°F) in 24 hours, from 21°C (70°F) to 12°C (54°F).
Bullsharks experience physiological stress at temperatures below 19°C (66°F), which is near their lower thermal limit, when migrating through rapid cooling zones. Therefore, the researchers deduced that during the 2021 cold-shock event, the sharks were exposed to temperatures several degrees below their thermal limit, possibly more than 5°C (or 10°F) colder.
The researchers also tagged 66 bull sharks with acoustic and satellite transmitters – including 41 at the Agulhas Current in South Africa and 25 at the East Australian Current in eastern Australia – to determine how they responded near their lower thermal limits in these zones. The acoustic tags record when sharks pass underwater receivers, providing information on their movements, locations, and water depths at those specific locations. In contrast, satellite tags continuously record the water temperatures and depths the sharks experience over time.
The researchers used these data to compare sharks living in warm subtropical waters with those living in cooler waters at the edge of their temperature range. The researchers found that low temperatures that persisted for long periods prevented the sharks and other megafauna from physiologically recovering. They saw that some sharks try to swim to shallower depths and look for warmer water, but cooling sometimes happened faster than they could respond.
The researchers also obtained wind records from the South African Weather Service to determine if upwelling-favorable winds happened before the 2021 event. They reported strong easterly winds pushing cold water on the surface along the coastline immediately before the event occurred. Because the cooling, strong winds, and animal deaths happened at the same time and place, the researchers inferred that upwelling was the main reason for the die-off.
Finally, the researchers examined 41 years of sea surface temperature data and used mathematical models to compute changes in the frequency and intensity of these events. Their analysis showed that rapid cooling events linked to upwelling can last a lot longer than the usual 1 to 3 days. For example, the March 2021 event lasted for 7 days.
They found that these events have increased in both frequency and intensity in the past decades, and produce more extreme temperature drops than typically happen within 24 hours. Their results suggested that the 2021 die-off was part of an increasing trend, where warming oceans allow species to move into different areas, but intense upwelling can suddenly expose them to fatal cold events. This pattern is what scientists call a climate bait-and-switch.
The researchers concluded that climate change is making coastal upwelling stronger, which can push marine megafauna beyond their thermal limits, even when initial warming appears to be beneficial. Their findings highlight an understudied aspect of climate change in the context of how temperature and upwelling cause shifts in species survival. They concluded their findings could help predict how marine ecosystems respond to future changing ocean conditions.
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In 1993, a team led by the planetary scientist Carl Sagan tentatively concluded that there is life on Earth. Not much of a deduction, you might think — except that the researchers confined their evidence to observations made by the Galileo spacecraft, which had flown past our planet three years earlier on a looping journey to Jupiter. So great is the transformative power of life that its presence…
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