A naturally occurring anti-inflammatory protein fragment is showing promise in early Parkinson’s disease research. Parkinson’s disease affects millions of people worldwide, yet current treatments mainly address symptoms rather than the underlying damage occurring in the brain. Now, researchers in Brazil have identified a promising new approach that targets a different aspect of the disease: inflammation. [...]

Tiny lab-grown brain models and the particles they release may reveal hidden differences among Alzheimer’s patients. Personalized treatment remains one of the biggest challenges in Alzheimer’s disease. Two patients can receive the same medication for symptoms such as depression, anxiety, or agitation and experience very different outcomes, leaving doctors with few ways to predict who [...]

Researchers have uncovered a previously underappreciated mechanism involved in Alzheimer’s disease and developed a compound that interrupts it. For decades, Alzheimer’s research has largely focused on amyloid plaques and tau tangles, the protein abnormalities that accumulate in the brain as the disease progresses. Yet despite billions of dollars in research and numerous drug development efforts, [...]

A contraceptive drug helps human nerve cells regenerate by unlocking their forgotten embryonic healing abilities.

A new study suggests that subtle changes in the brain’s immune cells could help explain why some people remain mentally sharp despite Alzheimer’s pathology. For decades, Alzheimer’s research has focused on the buildup of amyloid plaques and tau tangles, the two hallmark features of the disease. Yet a puzzling reality has continued to challenge scientists: [...]

Scientists have uncovered an early brain mechanism that may help explain why people carrying the APOE4 gene face a higher risk of Alzheimer’s disease. For millions of people who carry the APOE4 gene, the strongest known genetic risk factor for Alzheimer’s disease, changes in brain activity may start years before memory problems become noticeable. Researchers [...]