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Centromeric footprints preserve telomere integrity in ALT cancers

✇Nature
By: Ragini Bhargava · Megan A. Mahlke · Tobias T. Schmidt · Christoph Bartenhagen · Baylee A. Smith · Katherine L. Ramsey · Takoda T. Zuehlke · Ray W. Bowman II · Michelle L. Lynskey · Anne R. Wondisford · Jean-Baptiste Ouriou · Sandra Schamus-Hayes · Michael J. Calderon · Simon C. Watkins · April E. Williams-Wehner · Jennifer M. Bone · Alok V. Joglekar · Matthias Fischer · Jan Karlseder · Yael Nechemia-Arbely · Roderick J. O’Sullivan

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10598-1

Centromeric DNA repeat insertions and CENP-A chromatin assembly are identified as genomic signatures that preserve telomere integrity in ALT cancer cells.
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