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Cell-type-resolved genetic variation shapes inflammatory bowel disease risk

✇Nature
By: Tobi Alegbe · Bradley T. Harris · Laura Fachal · Lucia Ramirez-Navarro · Marcus Tutert · Monika Krzak · Mennatallah Ghouraba · Michelle Strickland · Matiss Ozols · Celeste E. Cohen · Saniya Khullar · Eleonora Khabirova · Nikolaos I. Panousis · David Ochoa · Noor Wana · May Xueqi Hu · Jason Skelton · Jasmin Ostermayer · Kimberly Ai Xian Cheam · D. Leland Taylor · Yong Gu · Claire Dawson · Tina Thompson · Kenneth Arestang · Nilanga Nishad · Biljana Brezina · Charry Queen Caballes · Wendy Garri · Steven Leonard · Vivek Iyer · Miles Parkes · Chris Wallace · Rebecca E. McIntyre · Cristina Cotobal Martin · Gareth-Rhys Jones · Tim Raine · Carl A. Anderson

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10627-z

Single-cell mapping of cis-expression quantitative trait loci in inflammatory bowel disease revealed distal, enhancer-enriched variants detected at the cell-type level more frequently co-localize with genome-wide association study loci than those identified at the tissue level.
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Nuclear shell structure governs short-range nucleon pairing

✇Nature
By: D. Nguyen · C. Yero · H. Szumila-Vance · F. Hauenstein · N. Swan · L. B. Weinstein · J. Kahlbow · G. A. Miller · A. Schmidt · E. Piasetzky · O. Hen · C. Ayerbe Gayoso · E. Cohen · P. Datta · A. Denniston · B. R. Devkota · M. Diefenthaler · C. Fogler · B. R. Gamage · D. Higinbotham · I. Korover · C. Morean · M. Nycz · M. Satnik · S. Seeds · P. Sharp · M. Suresh · A. S. Tadepalli · R. Wagner · E. W. Wertz

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10616-2

The scattering of high-energy electrons from three different nuclei demonstrated that short-range-correlated pairing depends far more on the specific quantum orbitals occupied by nucleons than predicted by theoretical models.
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