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Injectable nanorobots may help heal spinal injuries

Despite significant medical advances, spinal cord damage remains one of the most difficult physical injuries to treat. Scarring frequently gets in the way of nerve fiber regrowth, while nerve cells usually cannot regenerate on their own. A possible solution? A fleet of stem cell-infused, injectable nanorobots that can help nerve cells regenerate. The tiny bots are detailed in a study recently published in the journal Nature Materials.

To build their new tools, a team at ETH Zurich in Switzerland engineered microscopic machines that combine living neural progenitor cells (NPCs)—specialized stem cells developed for the spine—with customized nanoparticles. These customized nanoparticles feature two layers—one that is sensitive to magnetic fields and another that translates them into electrical signals.

“We place a reservoir in the center where we trap the cells. Then we inject the nanoparticles and wait for the two components to bind,” Salvador Pané i Vidal, a study co-author and ETH Zurich roboticist, said in a statement.

Each nanorobot is about six micrometers wide, making them smaller than a red blood cell. However, the number of robots required to pull off a procedure is immense. Millions of nanobots are needed during animal trials. Even with such a high number, the initial experimental results are promising. In tests involving mice with severed spinal cords, nerve cells stimulated by the microrobots began reconnecting at the injury site within 28 days. By the end of the trial, the mice displayed major improvements in movement, gait, coordination, and exploratory behavior. 

Significantly more research is required before these nanobots are ready for primetime, but the team hopes to one day begin testing similar devices in humans. Before that, they need to determine the most effective magnetic fields and how long to apply them to patients. In the meantime, the overall design could also be applied to help treat regenerative issues in organs and wounds.

“The reproducible and scalable production of microrobots using our lab-on-a-chip system demonstrates that the platform’s application potential extends beyond basic research,” added Pané i Vidal.

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Georgia is battling invasive, 4-foot-long lizards

Wildlife experts in Georgia are urging locals to keep on the lookout for any four-foot-long lizards wandering around the Peach State. As its name implies, the Argentine black and white tegu (Salvator merianae) isn’t native to the United States, and it’s quickly becoming a nuisance.

Although the black and white tegu resembles many monitor lizard species, they are actually only distantly related to the reptiles. The speckled omnivores can weigh upwards of 10 pounds, largely thanks to a diet that regularly includes eggs, small animals, fruits, and vegetables. They are also extremely prolific animals, with a single female capable of producing around 35 eggs every year. These typically hatch during the summer between June and July, meaning many in Georgia have a decent chance of spotting a tegu in the near future.

It’s still unclear how the tegus were first introduced into the state, although illegal releases by exotic pet owners are the most likely explanation. Georgia’s Department of Natural Resources (DNR) first responded to reports of the rogue reptiles in 2018, with sightings spreading ever since. Tegus are currently particularly concentrated in southeastern Georgia’s Toombs and Tattnall counties, but experts fear a lack of predators means the lizard population could soon explode without concerted conservation efforts. As non-native “wild” species, trapping and hunting tegus is legal in Georgia throughout the year.

That said, the DNR still cautions hunters against coming into direct contact with the reptiles. Although not particularly aggressive or dangerous, tegus may carry exotic parasites as well as harmful bacteria including salmonella. Experts encourage people to instead contact the DNR if they see one of the lizards, either by emailing gainvasives@dnr.ga.gov or calling (478) 994-1438.

Unfortunately, Georgia isn’t the only state contending with an unwanted tegu problem. According to an ongoing mapping project from the U.S. Geological Survey and Georgia Southern University, residents across Florida, Alabama, South Carolina, and Texas have also reported sightings in recent years.

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Rare meteorite proves our solar system almost had an extra planet

A rare meteorite discovered in the Sahara Desert proves that our solar system almost had at least one extra planet. In a study published in the journal Earth and Planetary Science Letters, astronomers say the chunk of space rock known as Northwest Africa (NWA) 12774 once belonged to a protoplanet possibly as large as Mars. That is, until a cosmic crash likely blew it to smithereens. 

The solar system includes eight known planets (sorry, Pluto). Barring interstellar catastrophe, this number will remain the same until the sun finally dies about 5 billion years from now. However, this total planetary count was never a guarantee.The solar system’s earliest era featured multiple embryonic protoplanets that had the potential to grow together into additional cosmic neighbors.

The remnants of these long gone celestial bodies are scarce, but traces still exist. That said, astronomers didn’t expect to find protoplanetary evidence in a meteorite like NWA 12774. Discovered in 2019, NWA 12774 is an angrite—one of the oldest known types of volcanic rock that was formed during the solar system’s era about 4.56 billion years ago. They’re also very rare. Of the roughly 80,000 meteorites discovered on Earth so far, only 68 are angrites.

A slice of NWA 12774. The green circle is an olivine crystal, a magnesium-rich mineral. Credit: John Kashuba
A slice of NWA 12774. The green circle is an olivine crystal, a magnesium-rich mineral. Credit: John Kashuba

Unlike rocky planets such as Mars and Earth, angrites do not have a lot of silicon dioxide. Because of this, astronomers have long assumed that angrites always originated in asteroids no larger than about 124 miles wide. NWA 12774 blows this theory apart..

While analyzing the meteorite, researchers at the University of Colorado Boulder detected clinopyroxene, a mineral crystal that exists throughout Earth’s mantle and crust. NWA 12774’s clinopyroxene was also heavy in aluminum, which directly points to formation under massive amounts of pressure underground. The team then calculated the conditions necessary to create an angrite like NWA 12774, and settled on at least 17.5 kilobars of pressure. To put that in perspective, the pressure experienced at the bottom of the roughly 35,875-foot-deep Mariana Trench is barely one kilobar.

Small asteroids simply don’t possess the conditions needed to generate a rock like NWA 12774. What’s more, the angrite’s sharp crystalline edges also indicate that it formed at comparatively shallow depths in its host body. Based on all of these factors, astronomers now believe NWA 12774 once belonged to a young protoplanet with a radius anywhere from 621 to 2,050 miles wide. This means that instead of an asteroid, the angrite may have existed inside something as big as Mars.

“It’s incredible to think there was once a world this large,” Aaron Bell, a UC Boulder earth scientist and study co-author, said in a statement. “We only know it existed because a few fragments of it happened to land on Earth. These meteorites preserved evidence of a completely different pathway through which early planets developed.”

Although it’s unclear how the protoplanet met its demise, some type of crash between early solar system denizens is definitely a possibility. Regardless, the ramifications are huge for astronomers’ understanding of our cosmic neighborhood’s history.

“The materials that formed the angrite parent body are fundamentally different from the ingredients of Earth and Mars,” explained Bell. “It points to a distinct and separate evolutionary path in planetary formation in the early history of our solar system.”

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Golf ball-sized octopus discovered near the Galápagos Islands

A tiny, bright blue octopus Microeledone galapagensis is small enough to fit inside the palm of your hand, but good luck trying to meet one. According to marine biologists, you’ll likely have to settle with admiring it from afar for now unless you have access to a deep sea submersible—and a ticket to the Galápagos Islands.

M. galapagensis is described for the first time in a study published today in the journal Zootaxa, but scientists actually first encountered the octopus in 2015. While conducting a deep sea expedition aboard the research vessel E/V Nautilus, biologists spotted the diminutive invertebrate as they piloted a remotely operated vehicle (ROV) along the ocean floor near Darwin Island. Its vibrantly blue coloration stood out from the underwater mountainslope at a depth of about 5,800 feet, prompting a closer inspection.

“Is that a cute little guy, or what?” one researcher can be heard saying over the audio feed of an ROV recording.

The team successfully soon scooped up the specimen and eventually recorded footage of two others during their expedition. A closer lab inspection stumped the experts, however, which prompted them to send a photo along to Field Museum octopus expert Janet Voight.

“Right away, I knew it was something really special. I’d never seen anything like it,” the study co-author recalled in a statement.

There was a big problem, however. Determining if a specimen is a never-before-seen species usually requires a full autopsy that inevitably destroys the sample. Since this was the only M. galapagensis ever collected, Voight didn’t want to lose such a valuable example.

The solution eventually came in the form of micro-computer tomography (CT) scanning technology. With the help of Field Museum X-ray CT laboratory manager Stephanie Smith, the team could finall get a highly detailed look at M. galapagensis’ anatomy by compiling thousands of thin X-ray images into a 3D model.

“Because CT imaging is non-destructive, it’s especially important for type specimens like this one. And that’s great for me because people are often bringing me these incredibly rare and stunningly beautiful specimens that I get the privilege of virtually opening up,” explained Smith, also a study co-author. 

After years of work, Voight and colleagues could finally confirm the octopus belonged to a novel species that deserved its own name. What’s more, M. galapagensis represents the first octopus species officially described by Voight in her over 40-year career.

“These are little octopuses that live in the deep sea, and hardly anybody on Earth has ever gotten to see them. I just feel lucky that I got to work with them,” she said.

“Getting the specimen to Janet was a long process, but one I would gladly repeat if it means getting to know the most precious parts of our ocean just a little bit better,” added study co-author and University of California Los Angeles marine scientist Salome Buglass.

The post Golf ball-sized octopus discovered near the Galápagos Islands appeared first on Popular Science.

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New box jellyfish name warns of ‘death from behind’

A recently discovered box jellyfish species living in near Singapore looks nearly identical to another jellyfish previously discovered by the same scientist. But regardless of whether or not you can tell Chironex blakangmati and Chironex yamaguchii apart, you’ll want to steer clear of both of them. Box jellyfish didn’t earn their “sea-wasp” nickname for yellow-and-black stripes.

Cheryl Ames, a marine biologist at Japan’s Tohoku University, collected C. blakangmati during an expedition near the coast of Singapore’s Sentosa Island. The team initially assumed the invertebrate was an example of C. yamaguchii, but later genomic testing revealed something else entirely.

“We realized they were completely distinct,” Ames explained in a statement. “I actually went back to dust off an old sample of C. yamaguchii I still had in storage in Okinawa to help with the comparisons.”

Apart from genetics, the key difference setting C. blakangmati apart from its three known Chironex relatives is its perradial lappets. This anatomical feature on the bottom of the box jellyfish’s bell-shaped body strengthens the pulsating musculature that propels it through the water. Other Chironex species include pointy canals at the tips of their perradial lappets, but C. blakangmati notably does not.

Canals or not, they are remarkable creatures. The vast majority of jellyfish don’t rely on vision and passively float in ocean currents, but members of the Chironex genus do not. Instead, they have evolved complex eye organs that help them locate prey. They then use that same musculature supported by the perradial lappets to actively swim through the water towards its target.

In this sense, C. blakangmati certainly lives up to its scientific name. Sentosa may be Malay for “peace and tranquility,” but the island once called something very different. Historically, it is also known as Pulau Klakang Mati, which translates to the “Island of Death from Behind.”

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Handyman adapts Barbie Dream Camper to handle soaring gas prices

There are over 283 million cars cruising the United States, and over 90 percent of them are still guzzling gas. Apart from the obvious environmental problems, fuel prices also continue to skyrocket thanks to the ongoing war in Iran. The average price for gas is currently around 33 percent higher than it was before the crisis, and there is little sign that those numbers are going down anytime soon.

The strain is forcing many drives to reconsider how they get around—and they’re getting creative with it. In Georgia, a 30-year-old handyman is showing everyone how to properly adapt to uncertain times. According to a recent Reuters profile, Mali Hightower has retrofitted a discarded, bright pink Power Wheels Barbie Dream Camper with a two-gallon, one-piston engine for his shorter commuting needs.

“I drive this when I can,” Hightower said on May 19. 

To get it going, a driver simply pulls the rip cord that’s attached to the former power washer engine. At less than four-feet-tall, the Dream Camper may not be the most comfortable ride for a full-grown adult,but it’s definitely cheaper. Hightower likely still prefers driving his 1996 Mercedes-Benz convertible, but with a full tank costing him around $90 right now, he’s more than willing to use his Power Wheels alternative for errands like grocery runs.

While somewhat surreal to see at a gas pump, the DIY solution underscores a more important issue: the need for more people to divest from fossil fuel rides in favor of public transportation and electric vehicles (EVs). Unfortunately, that’s easier said than done for many people. The U.S. is dramatically underfunded when it comes to options like commuter bus routes and trains, while EVs are still out of many people’s price ranges. The Dream Barbie Camper may be one-of-a-kind right now, but there’s a good chance that similar, intentionally constructed alternatives are on the way. At least those will be able to comfortably fit the driver.

The post Handyman adapts Barbie Dream Camper to handle soaring gas prices appeared first on Popular Science.

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