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Nearly half of reef-building corals face elevated relative risk of extinction
Nature, Published online: 15 October 2026; doi:10.1038/s41586-026-11263-3
Nearly half of reef-building corals face elevated relative risk of extinction
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Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1
A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.
Parity-dependent coupling of molecular spin chains to a superconductor
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11117-y
Scanning tunnelling spectroscopy shows that the fractional spin-1/2 end states of molecular Haldane chains couple differently to a superconducting condensate depending on whether the chain contains an even or odd number of spin-1 triangulene units.
Divergent genomic evolution in astrocytomas and oligodendrogliomas
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11150-x
Longitudinal genomic analyses in patients with astrocytoma or oligodendrioglioma suggest that these two types of tumour differ in the mechanisms by which they become resistant to treatment, with astrocytomas accumulating copy-number alterations and chromosomal instability markers but oligodendrogliomas acquiring new driver mutations.
Interhemispheric monsoon dynamics over the past 450,000 years
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11166-3
A 450 ka Andean speleothem record shows Southern and Northern Hemisphere monsoons generally vary out of phase, but occasionally synchronize during rapid climate change and glacial terminations.