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De novo design of cysteine proteases
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w
De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.
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Computational design of metalloproteases
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2
RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications in therapeutics, biotechnology and bioremediation.
Advancing subseasonal forecasting with machine learning
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11126-x
The AI framework probabilistic bias correction is shown to correct weather forecast errors 2 to 6 weeks ahead and boost forecast skill, making it promising for improved extreme-weather prediction.