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RNA synthesis and substrate analog inhibition in the CCHFV polymerase
Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10913-w
RNA synthesis and substrate analog inhibition in the CCHFV polymerase
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Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase
Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10701-6
Structural studies of Crimean–Congo haemorrhagic fever virus (CCHFV) polymerase reveal the structural basis of CCHFV RNA synthesis and highlight druggable sites for designing both nucleoside antivirals and non-nucleoside antivirals.
CRISPR–Cas regulates expression of embedded anti-phage defence systems
Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10833-9
CRISPR–Cas systems transcriptionally tune diverse innate defences using CRISPR RNA-like guides to balance antiviral protection with fitness, and hyperactivate these defences when compromised, establishing a layered bacterial ‘immunity guard’ network.