A systematic evaluation shows that contemporary humanoid robots can perform laparoscopic surgical tasks through teleoperation, highlighting both their promise and key technical challenges before clinical deployment.
Epitope editing of KIT enables antibody-based, non-genotoxic conditioning that selectively enriches therapeutic BCL11A-edited haematopoietic stem/progenitor cells, supports durable engraftment, preserves clonal diversity and enhances induction of fetal haemoglobin, a therapeutic approach for conditions such as sickle cell disease and β-thalassemia.
By integrating reinforcement learning with quantum error correction, a quantum computer continuously self-calibrates during computation, achieving record logical error rates and enhanced resilience to drift.
Screening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity is associated with highly stress-resistant mitochondria and enhanced detoxification of reactive oxygen species.
Using LARES-2, LAGEOS and GRACE satellites, researchers measured Earth’s frame-dragging with unprecedented precision, strongly confirming general relativity, constraining alternative gravity theories, and improving measurements of Earth’s tides.
An ATAC-seq-based approach is used to classify acute myeloid leukaemia (AML) into 16 epigenomic subgroups, and provides insight into the role of non-genetic mechanisms in determining pathogenesis, clinical behaviour and drug sensitivity in this disease.
The scientific consensus is that burning fossil fuels drives the climate crisis, yet the world’s biggest oil companies are planning to increase production
As the world swelters in ever more dangerous heat, why are oil companies being allowed to turn up the gas instead of paying for the consequences of their greed?
That ought to be the question on everyone’s minds amid baking heat domes over much of the northern hemisphere, temperature records being smashed day after day, children dying in locked cars, hospitals filling with heatstroke victims and emergency services tackling wildfires.
The amount of energy that soil microbes can obtain from oxidizing available organic carbon is limited, which keeps many of them dormant and restricts their growth, necromass production and ultimately the accrual of soil carbon, according to analyses of soil carbon and energy fluxes.
Two independent studies imply that a remarkable burst of voluminous volcanism on the Pacific plate during the Cretaceous is attributable to coupled plate–mantle dynamics. Together, their findings show how enhanced subduction, mantle heterogeneity, and plate tectonic boundaries collectively controlled the timing and expression of these oceanic large igneous provinces.
An immunopeptidomics analysis identifies numerous Plasmodium T cell antigens that are conserved across malaria parasite species and expressed at several phases of the parasite’s life cycle, with possible applications in the development of a malaria vaccine.
Liver steatosis increases formation of replacement liver metastases by increasing MYC stability through acetylation, which increases proline synthesis and collagen production.
In the mouse visual cortex, multimodal cell-type definitions, gene expression patterns and cell location predict long-range projection targets of excitatory neurons, linking transcriptomic identity with morphological, electrophysiological and circuit-level properties.
Integrated multi-omic profiling of glioblastoma reveals GPNMB as a shared antigen in tumour cells and the surrounding microenvironment, and GPNMB-targeted chimeric antigen receptor T cells demonstrate therapeutic activity in vitro and in animal models.