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A first-in-class pulsatile FXR agonist for bile-acid-related liver diseases

By: Yi Zang · Jingjing Shi · Guanguan Zhao · Bixi Tang · Mingliang Liu · Benqiang Yao · Gaihong Wang · Hualing Pan · Shengsheng Yang · Rong Deng · Yishuang Zhao · Zhenwei Zhang · Hao-Ran Guo · Dan-Dan Sun · Hanlin Wang · Lixin Gao · Jinghua Yu · Xingxing Diao · Yong Li · Jia Li · H. Eric Xu

10 June 2026 at 01:00

Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10633-1

Linafexor is a rapidly cleared FXR agonist designed to mimic natural bile acid signalling, achieving transient receptor activation with strong efficacy and reduced toxicity in preclinical and early clinical studies.

A kinetic descriptor of solvent polarization for rational electrolyte design in lithium–metal batteries

RSC - Energy Environment

By: Xilin Liang · Lingyan Duan · Qing Liu · Qi An · Hanlin Tang · Mou Yang · Hongjia Liu · Ou Ka · Yongxin Yang · Guiquan Zhao · Yongjiang Sun · Xiaomin Yang · Hong Guo

10 June 2026 at 00:00

Energy Environ. Sci., 2026, Advance Article
DOI: 10.1039/D6EE01727D, Paper

Xilin Liang, Lingyan Duan, Qing Liu, Qi An, Hanlin Tang, Mou Yang, Hongjia Liu, Ou Ka, Yongxin Yang, Guiquan Zhao, Yongjiang Sun, Xiaomin Yang, Hong Guo
A kinetic descriptor of solvent polarization unifies bulk transport and interfacial stability, enabling rational electrolyte design.
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