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De novo design of cysteine proteases
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w
De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.
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Computational design of metalloproteases
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2
RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications in therapeutics, biotechnology and bioremediation.
Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Nature, Published online: 07 September 2026; doi:10.1038/s41586-026-11094-2
Author Correction: A mouse brain stereotaxic topographic atlas with isotropic 1-μm resolution
Air-permeable hydrogels through viscoelastic phase separation of aerogels
Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10712-3
Viscoelastic phase separation is used to fabricate non-collapsible, air-rich networks in high-water-content hydrogels containing silica aerogel beads, allowing air to permeate through the material and enabling a tenfold increase in oxygen permeability over pristine hydrogels.
In situ nanocrystal confinement for efficient blue perovskite LEDs
Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10596-3
Efficient blue perovskite light-emitting diodes with an external quantum efficiency of 21.8% are achieved through in situ polymerization-driven nanocrystal confinement.