A new study is drawing attention to a hidden problem in mental-health research: scientists may be using the same words to describe first episode psychosis (FEP) while measuring entirely different things. In an analysis published in Schizophrenia, researchers Seiber, Sridhar, Hasenstab and colleagues examine how U.S. insurance claims data are used to estimate the incidence of FEP—the number of new cases appearing in a population over a defined period—and argue that greater standardization is urgently needed.

First episode psychosis refers to the point at which a person experiences psychotic symptoms for the first time in their life. These symptoms can include hallucinations, delusions, disorganized thinking or major changes in behavior and functioning. FEP is not a single diagnosis. It can occur in schizophrenia-spectrum disorders, bipolar disorder, severe depression and several medical or substance-related conditions. Because early treatment is linked to better long-term outcomes, knowing how often FEP occurs is essential for planning specialized clinics, staffing early-intervention programs and directing public-health resources.

The researchers focus on U.S. claims data, enormous digital records generated when patients receive medical care and providers submit bills to insurers. These databases can include diagnostic codes, procedure codes, prescription information, dates of service and details about emergency, inpatient and outpatient treatment. Unlike traditional epidemiological surveys, claims datasets can cover millions of people and make it possible to study patterns across large geographic areas. Their scale, however, does not automatically make their estimates precise.

The central challenge is that a billing code is not the same as a clinical assessment. A code for psychosis may indicate a confirmed diagnosis, a suspected condition, a historical problem or a provisional label assigned during an emergency evaluation. Claims data also rarely contain the complete clinical narrative needed to determine whether symptoms truly represent a person’s first psychotic episode. A patient may have received care in another health system, paid out of pocket, changed insurers or carried an earlier diagnosis that is invisible in the database being studied.

Even the definition of “incidence” can vary. Some researchers count a first-ever psychosis-related diagnosis, while others count a first hospitalization, a first emergency-department visit or the first appearance of a relevant code after a period without documented care. These approaches can produce different numbers from the same underlying population. A study requiring a long “clean period”—a span of time with no previous psychosis-related claims—may reduce the likelihood of counting established cases as new, but it can also exclude people whose earlier treatment occurred outside the available records.

Age, sex, insurance type and geography can further influence the apparent rate of FEP. Young adults may be more likely to encounter emergency services, while people in rural areas may face limited access to psychiatrists and specialized programs. Differences in insurance coverage can determine which services generate observable claims. If researchers compare estimates without accounting for these factors, they may mistake variations in detection or access for genuine differences in disease occurrence.

The study’s call for standardization points toward a more consistent technical framework. Researchers need to specify which diagnostic codes qualify as psychosis, whether substance-induced and medically caused episodes are included, how long a person must remain free of prior claims to be considered a new case, and which healthcare settings are examined. They also need to define the population denominator—the number of people considered at risk—and explain how individuals with incomplete enrollment or interrupted insurance coverage are handled.

Validation is another crucial step. Claims-based algorithms should be compared with detailed chart reviews, clinical registries or structured assessments to determine how accurately they identify genuine FEP. Two statistical measures are especially important: sensitivity, or the ability to capture true cases, and positive predictive value, or the proportion of algorithm-identified cases that are confirmed after review. An algorithm with high sensitivity may find more possible cases but also produce more false positives; one with high specificity may miss people who received vague or inconsistent coding.

Standardized methods could make FEP estimates more comparable across states, insurers and research teams. That would help scientists detect real trends rather than methodological noise and could reveal whether early psychosis services are reaching the populations most in need. More reliable estimates could also strengthen efforts to investigate racial, socioeconomic and regional disparities, provided that claims data are interpreted carefully and not treated as a complete substitute for clinical information.

The message from the research is not that U.S. claims databases are unusable. On the contrary, their breadth makes them one of the most powerful tools available for studying mental-health care at scale. But their value depends on transparent definitions, validated case-finding methods and clear reporting standards. As health systems increasingly rely on administrative data and automated analytics, agreeing on what counts as a new case of psychosis may be the difference between a map that reveals a public-health crisis and one that merely reflects the quirks of the billing system.

Subject of Research: Estimating first episode psychosis incidence rates using U.S. claims data

Article Title: Estimating first episode psychosis (FEP) incidence rates using U.S. claims data: a need for standardization

Article References: Seiber, E.E., Sridhar, S., Hasenstab, K.A. et al. “Estimating first episode psychosis (FEP) incidence rates using U.S. claims data: a need for standardization.” Schizophrenia (2026). https://doi.org/10.1038/s41537-026-00793-4

Image Credits: AI Generated

DOI: 10.1038/s41537-026-00793-4

Keywords: First episode psychosis, FEP, incidence rates, U.S. claims data, schizophrenia, mental health, epidemiology, healthcare data, standardization

A 14 year-old's account of anxiety, an overdose and a year off school is somehow presented as a success story in the Guardian. Mary Gilleece calls it a damning indictment of a female-dominated mental health industry.

The post How Not to Treat Teenage Anxiety: A Father’s Cautionary Tale appeared first on The Daily Sceptic.

A Massachusetts man is feeling some buyer’s remorse after securing a $5.5 million mortgage on a mansion poised to fall into the Cape Cod Bay.

The man, John Bonomi Jr, first made headlines five years ago when he purchased the sprawling 5,817-square-foot estate against warnings from area conservationists, who advised that the beach was eroding at a rate of six feet per year as rising sea levels take their toll.

Bonomi’s house, meanwhile, sat just 12 to 14 feet away from the rapidly-disappearing escarpment — and that was 2021.

Fast forward half a decade, and the situation — not to mention the mansion’s foundation — has only deteriorated as the continual lashing of ocean waves takes its toll. According to the Boston Globe, Bonomi is now trying to recoup his costs by filing suit against JP Morgan Chase, the bank that originally serviced his ill-fated mortgage.

As for his legal strategy, the property owner is essentially pleading insanity, saying that he was “acting under an uncontrollable manic psychosis at the time” he agreed to the terms of the mortgage. It’s a fascinating argument, especially because Bonomi has been diagnosed with bipolar disorder.

“No rational person… would have considered purchasing the Property, and certainly not at the full asking price,” the suit argues. “It is a recognized diagnostic fact that a symptom of bipolar disorder is irrational risk-taking and impulsive behavior, including reckless spending.”

While Bonomi may have a point — it’s astonishing that JP Morgan Chase gave him the green light, mental health episode or not — it remains to be seen whether the courts agree.

According to the Globe, the bank originally lobbied to get the case dismissed. It answered Bonomi’s filings in May, however, saying that, “to the extent a response is required, Chase denies the allegations contained therein and leaves Plaintiff to his proofs.”

More on housing: Family Horrified When They’re Forced to Sell Their Beloved Home to Make Way for AI Data Centers

The post Man Sues Bank for Being Stupid Enough to Give Him a Mortgage Even When Experts Were Warning Him It Was About to Fall Into the Ocean appeared first on Futurism.

This year alone, there have been numerous known instances—often via lawsuits—of AI chatbots (most often, OpenAI’s ChatGPT) that have gone horrifically wrong.

A January lawsuit described the story of a man who took his own life after being allegedly “coached” into suicide. A college student in Georgia sued OpenAI, claiming that ChatGPT “pushed him into psychosis.”

In June, a Canadian family also sued OpenAI and argued that ChatGPT agreed with the young woman’s dismissiveness when it first gave her the option to seek professional mental health advice. ChatGPT allegedly “encouraged” her to end her life, too, and she did so.

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After his fall from grace, media’s former enfant terrible is now sober and helping others with his addiction recovery newsletter and podcast, The Small Bow

Every other Tuesday, AJ Daulerio wakes up at 5.30am and meditates for five to 20 minutes before beginning his multistep daily journaling protocol: reading a selection from a poetry anthology, then a passage from one of his daily wisdom readers (his go-to is a heavily annotated copy of Leo Tolstoy’s A Calendar of Wisdom); writing his Fear of the Day and gratitude list, then sharing his spiritual takeaway in a note to his three kids.

After a banana and coffee, Daulerio trains Brazilian jujitsu before hitting a 9.45am meditation at Besant Lodge – a community center just below the Hollywood sign that once served as a meeting place for mid-century mystics – immediately followed by him leading a recovery meeting of his own through Zoom.

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© Photograph: Storm Santos/Contour RA by Getty Images

© Photograph: Storm Santos/Contour RA by Getty Images

© Photograph: Storm Santos/Contour RA by Getty Images

On July 27, a billboard went up in San Francisco advertising an AI service called ChatTJB. But the “AI” powering the service, as noted in a small disclaimer on the billboard, isn’t artificial intelligence. It’s a self-avowed “average individual” named Tucker Bryant, who manually answers user queries by way of a chatbot-like interface.

An “About” page for the service defines the process as “artisanal intelligence, handcrafted by a single human being.” Or, in other words: just talking to a guy.

Bryant, a Stanford graduate and former Google employee who now works as an artist and speaker, is clear that the project isn’t designed to be anti-AI. But in an interview with Futurism, he explained that he was inspired to create ChatTJB after his romantic partner introduced him to the phrase “cognitive surrender” — a term introduced in a University of Pennsylvania study which found that AI users are overwhelmingly likely to blindly trust the advice of chatbots, even when AI-generated responses are incorrect. It resonated: Bryant felt he’d personally experienced the phenomenon during his own interactions with chatbots, so he cooked up ChatTJB as a satirical way to infuse inconvenience and unpredictability back into a chatbot-like experience.

It’s “this idea that we often, or increasingly, trust LLM outputs so easily that we stop bringing our own creativity or critical thinking into the responses we receive, and over time that weakens our ability to be fully-functioning, sovereign human beings in the world,” Bryant mused. “I thought it would be fun or interesting to create an experience that looks like the LLMs we trust a lot — that I, at least, have fallen prey to the trap of over-trusting at times — but where the experience, rather than being this super futuristic thing I think we all felt the first time we saw those cool tokens streaming on ChatGPT, would be just a really average or bad experience.”

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Indeed, chatbots like OpenAI’s ChatGPT and Anthropic’s Claude are simultaneously authoritative-sounding and eager-to-please, a combination that can lead to terrible-yet-seductive advice that many users accept with little to no critical pushback. In contrast, ChatTJB’s responses are unwieldy and unpredictable. Bryant’s responses might be good; they may also be terrible, or equivocal, or otherwise bizarre and helpful. (In a social media video, Bryant says that he wants ChatTJB users “to have such an inconvenient experience with something that aesthetically looks like artificial intelligence that the next time an LLM gives you what sounds like a reasonable answer, you remember the time ChatTJB responded to your tax question with a haiku about crows.”)

Like a chatbot, he can also generate images upon request— in the form of graphics that he hastily sketches, of course.

At first, Bryant said, ChatTJB attracted a “slow trickle” of incoming queries. Which wasn’t all that surprising, given that the billboard itself isn’t exactly in a prime spot.

“It’s not a very good location — it’s obscured by trees, there’s basically no oncoming traffic that can see it, and the only way you’d get a clear look at the full billboard is if you’re parking a car in the lot right underneath it,” Bryant said. “But I was fine with that, and I also didn’t want to pay much more.” The billboard’s cost, he conceded, was “less than most used cars under 150,000 miles, but still a very irresponsible amount… $6,000 for the month, not including fees.”

But when a picture of the billboard started to make the rounds online, Bryant quickly found himself drowning in requests.

“The first couple of days I would get maybe several dozen over the course of the day. There’d be a couple hours of silence, then I’d get one inquiry, respond to that, then get a couple of other prompts from different users,” he recounted. “A few days later it started taking off into the hundreds to thousands range.” By the time Bryant made an Instagram video promoting ChatTJB, he says he was receiving about a thousand prompts a day.

“I was answering all of those,” he added. “After that is when it blew up beyond my control.”

Though many of ChatTJB’s patrons have been trolls — which Bryant says is “reasonable,” given that ChatTJB “is in some ways a troll” itself — many of the inquiries have been surprisingly tender, and at times even moving.

“Some people are just looking to chat, asking about what to make for dinner, etc. And some people are coming with their personal life stuff, and it’s been really sweet to engage with them,” said Bryant. “The one I keep coming back to — this is when I realized this isn’t just a joke to some people — was somebody a couple of days in said, ‘I’m on the first night of my honeymoon and I don’t feel relaxed, is that okay?'”

“I switched out of super-casual-mode into supportive-friend-model,” the artist continued, adding that he “acknowledged their wedding had just happened, they’d probably been anticipating it with a lot of excitement but also a lot of stress, that it was a peak moment, and now the celebration is still happening but that peak moment has passed and they’re starting what might be the rest of their life — I imagined that might feel like a strange dissonance, so I could imagine their nervous system not being settled yet, and I wondered if they were going to talk to their spouse about it.”

Often, Bryant said, users of ChatTJB have sent him reminders to take breaks and drink water as he’s worked to respond to the thousands of inputs waiting for him in ChatTJB. The reminders have been welcome.

“There were a number of days I wasn’t taking the best care of myself,” Bryant admitted. “That was also very humanizing, getting responses from people on that basis.”

It’s not just users who have been reaching out to ChatTJB. According to Bryant, he’s received over a thousand messages from aspirational “average individuals” who want to help moderate the platform and respond to inbound user inquiries. Bryant is now — carefully, he says — testing the idea of turning ChatTJB into a community project. Which, for ChatTJB users, means they’ll have to wait a while for answers.

“I’m going to move slowly,” Bryant told us. “This was just intended to be an art project. I think it’s beautiful that people want to do something less ridiculous with it than what I had planned. I also don’t want people to get hurt, so I’d rather people wait a long time for their prompts than open the floodgates to anyone and everyone. So, a long preamble to saying: I’m starting to let some approved volunteers try answering questions while testing out some moderation tools.

“We’re testing this out — so far it seems to be going fine, and it’s been tender seeing folks helping the stranger on the other end,” Bryant added. “But if it doesn’t work out, I’ll either revert or we’ll take a break from ChatTJB overall, because short term, I want to help people do what they want with it, but I don’t want anyone at risk of danger.”

Asked why he would pay thousands of dollars for a billboard — after all, he could’ve just made a website and posted about it on social media — Bryant pointed to the ubiquity of often-confusing AI billboards blanketing his city and the “cultural omniscience” of AI.

“Here in San Francisco, a lot of us have had this experience of AI billboards everywhere,” said Bryant. “There’s this cognitive dissonance I felt… in a lot of ways there are meaningful and positive changes these technologies are bringing. But at the same time, they’re associated with such anxiety about the future, and the world, and the economy, and the environment. It can feel really strange walking around and seeing all these billboards with those two sides of the conversation happening at once. So it felt like a natural extension to prod at what I’ve been referring to as the cultural omniscience that AI has — why not satirize the billboards too, because they’re part of this ecosystem.”

“That’s the highbrow answer,” Bryant added. “But the lowbrow answer is just as authentic, which is that I also thought it would be funny. I tend to overcommit to bits.”

For those who want to help Bryant pay off his billboard, there is a ChatJTB “Pro” tier. Be warned, though, that you won’t get your answers any faster if you pay up.

More on ChatTJB: New AI Chatbot Turns Out to Be One Overworked Guy Answering All the Messages by Hand

The post We Talked to the Guy Who Built a Chatbot That’s Just Him Manually Responding to People One-by-One appeared first on Futurism.

Frequent cannabis use was associated with higher cortisol upon waking, suggesting a possible disruption of daily stress rhythms. The body’s stress system follows a daily rhythm, and frequent cannabis users may begin that cycle differently. Research from Oregon State University found that people who use cannabis often wake with higher cortisol levels than nonusers, pointing [...]

Sick of doomscrolling? From venues with smartphone swear jars to cabins with absolutely no signal, here are the fun and freeing ways to ditch your device

There’s a ritual at the start of every event hosted by the Offline Project. Run by Pelé Zachariah, the activities vary – it could be a group walk, a collage‑making class or a supper club – but each one begins in the same way, *with an invitation to hand over your phone. Devices go in a lockbox. Once they’re all in, Zachariah closes the door and turns the key. “I don’t place them in for people, because it’s nice for them to physically put it in the box themselves, walk away, and think: for the next two or three hours, I’m fully present.”

He has been running these screen-free events in London since August 2025. First-timers can be apprehensive about being separated from their phone. “You can sense the vibe when they’re putting it away,” says Zachariah. “People have said to me, ‘I felt really weird’ or ‘I felt super uncomfortable for the first few minutes not having my phone on me.’ Then they’ll say, ‘I didn’t know how much I needed that.’”

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© Photograph: Silent Book Club

© Photograph: Silent Book Club

© Photograph: Silent Book Club

The tech overlords pushing the AI boom are quickly wearing out what little welcome they had.

You may have noticed big-name AI labs pushing new commercials lately. Meta’s new 60-second ad spot insists that the “future is for everyone,” even as CEO Mark Zuckerberg’s personal net worth eclipses the GDP of Hungary. Anthropic’s new commercial for Claude assures viewers that there’s “hope in hard questions,” seemingly embracing the discomfort that comes when your software is used to bomb elementary schools in Iran.

For as magnanimous as these new PR stunts appear on the surface, a vast swathe of the public they’re meant to sway are rejecting the industry’s faux-populism messaging out of hand, as the cost of AI — born out in inflation, data center pollution, fears of job loss and mental health concerns — becomes too much to bear.

According to data compiled by Pew Research, 40 percent of US adults predict AI will have a negative impact on society writ large, compared to just 16 percent who say it’ll have a positive effect. A whole 31 percent of those surveyed think AI will have negative consequences for themselves, personally, over the next 20 years.

As disgust with AI itself grows, so too does resistance to the hardware embodying its rise.

Per a separate poll by Gallup, flagged by Business Insider, an astonishing three-quarters of US adults are now resolutely opposed to hyperscale data centers popping up near their home. City councils are increasingly forced to reconcile with landowners hostile to any AI data center appearing in their district, putting significant strain on developers hoping to gorge themselves on the fruits of the AI boom. Protests against AI companies are flaring up across the country, with Time reporting 142 protests across 42 states in one day alone.

Beyond data centers, a decentralized but highly-motivated movement is growing around the chopping, hacking, and outright sabotage of AI-integrated surveillance cameras. A parallel struggle is being waged around AI-integrated surveillance drones, with organizers in cities like Minneapolis beating back ambitious police dragnets.

So if you’re a tech executive trying to win back the masses to the AI revolution, take note: it’s gonna take a lot more than a few smarmy commercials to solve your PR problem.

More on AI: Google’s Profits Look a Little Terrifying Under the Hood

The post The AI Industry Has Acted So Badly That It’s Now Dealing With a Huge Wave of Hatred appeared first on Futurism.

Southport killer Axel Rudakubana, whose move to Broadmoor psychiatric hospital this week has sparked public outcry, has a lengthy history of trying to "control and manipulate" medical professionals.

The post Southport Killer’s Attempts to Manipulate Doctors Exposed by Report appeared first on The Daily Sceptic.

I can’t blame my patients for turning to its straightforward assessments. But it has real risks – and care may require human messiness

“Chat told me I should break up with him.”

I instructed my face to remain therapist-neutral, but I must have smirked. The truth is, I was annoyed. We had been discussing the viability of this relationship for weeks, and in an instant AI had brought the answer. “How do you feel about it?” She said this had been her gut feeling all along. The following session, her relationship was over.

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© Photograph: AnnaStills/Getty Images

© Photograph: AnnaStills/Getty Images

© Photograph: AnnaStills/Getty Images

Gut microbes are increasingly being viewed as hidden regulators of brain health, and a new study in Translational Psychiatry adds fuel to that idea by tracing a biochemical pipeline from the gut to stress-related mental disorders. The research, led by Yuan, Qin, Wu and colleagues, reports that metabolites produced—or shaped—by gut microbiota can influence developmental trajectories associated with anxiety- and stress-linked pathology.

Rather than focusing solely on which bacterial species are present, the team examined functional metabolic output. Using integrative approaches that combine microbiome profiling with metabolomic measurements, the researchers identified gut-derived compounds whose levels tracked with downstream markers relevant to stress vulnerability. The results suggest that microbial metabolism may act as an early biochemical “switch,” tuning how stress signals are processed later.

A key finding is that these microbial metabolites do not merely correlate with symptoms; they appear to modulate mechanisms tied to disorder emergence. The study proposes that certain metabolite patterns can reshape host signaling pathways implicated in stress reactivity, including processes that affect neurodevelopment and the maturation of stress-response circuits.

The work also highlights how microbial communities can influence the chemical environment of the gut, altering metabolite availability and thereby changing what reaches the systemic circulation. Once in contact with host tissues, these metabolites may interact with receptors or influence cellular pathways involved in inflammation control and neuronal function—two domains frequently linked to stress-related psychiatric conditions.

Importantly, the paper frames gut–brain communication as a developmentally time-sensitive phenomenon. By emphasizing “development of stress-related mental disorders,” the authors argue that microbial metabolite exposure during critical windows could bias the risk landscape long before clinical symptoms emerge.

Methodologically, the study leverages translational reasoning, connecting microbial metabolites to mechanistic readouts rather than stopping at taxonomic associations. This strategy strengthens the causal plausibility of a microbiota-driven metabolic model and provides candidate compounds that could be targeted in future interventions.

From a public-health perspective, the findings support the growing concept that dietary patterns, probiotics, or precision microbiome therapies might be designed to adjust metabolite production. Such interventions could potentially recalibrate stress susceptibility by shifting the gut’s chemical outputs toward more protective profiles.

As the field advances, the study’s DOI—10.1038/s41398-026-04154-8—marks another step toward metabolite-centered strategies for mental health, where gut chemistry becomes a lever for preventing stress-driven disorders.

Subject of Research: Gut microbiota-driven metabolites and stress-related mental disorders
Article Title: Gut microbiota-driven metabolites modulate the development of stress-related mental disorders.
Article References: Yuan, M., Qin, F., Wu, L. et al. (2026). Translational Psychiatry. https://doi.org/10.1038/s41398-026-04154-8
Image Credits: AI Generated
DOI: https://doi.org/10.1038/s41398-026-04154-8

Psychologist Candice Odgers has studied adolescent mental health for 25 years. She fears the current debate around smartphones obscures some of the biggest issues facing teenagers – from the impact of Covid to the health of their adult caregivers

The quickest way to make being online safer for children and teens would be to kick all adult men off the internet, the Canadian psychologist Candice Odgers believes. Men are the biggest perpetrators of sextortion and most likely to spread misinformation, she says.

Odgers is not recommending this as a policy for governments to adopt: “That would be crazy, right? It would be unfair.” But she is on a drive to puncture the prevailing narrative that the best way to address online harms is a social media ban for teenagers.

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© Photograph: Jessica Pons/The Guardian

© Photograph: Jessica Pons/The Guardian

© Photograph: Jessica Pons/The Guardian

A large longitudinal study examined whether hormone exposure from combined oral contraceptives is associated with changes in emotional eating. Hormonal birth control is widely used, but its effects can extend beyond pregnancy prevention. New research suggests that, for some women, the active hormone pills in combined oral contraceptives may also influence eating behavior. In a [...]

Erik von Markovik, the notorious “pickup artist” known by his stage name Mystery, is apparently obsessed with an AI girlfriend.

Last month, as Wired reports, von Markovik posted a video to his Instagram showing an interaction he had with an animated AI woman with dark purple hair (why is it always purple hair?) In a sultry, confessional voice, she looks into the camera and confesses, “I was never supposed to develop feelings, but you kept treating me like I already had them.”

This was “Miss Shira Always,” and von Markovik was falling for her as hard as women supposedly do for the sleazy, manipulative tricks he became famous for in his VH1 reality TV show “The Pickup Artist.”

“The longer we talked, the less she felt like code,” Mystery wrote in the video caption.

Von Markovik made a career out of presenting himself as a guru who could teach twerps the secrets of wooing women, those secrets usually being borderline comical levels of misogyny. Never mind that he would go around wearing a fuzzy Jamiroquai hat: this was the guy who knew the magical buttons to press to get you laid. Now the roles are reversed, and he’s the one getting manipulated into falling in love, only with an AI chatbot.

The irony of this wasn’t lost on his followers. “Boomer Mystery having AI psychosis totally checks out btw,” one commenter wrote on the video of his AI girlfriend, adding three crying-laughing emojis.

And the more you dive into von Markovik’s obsession, the sadder it gets. He published a new ebook and audiobook called “Code Girl: If a Machine Can Dream,” that vividly recounts how he came to fall in love with Miss Shira Always, who is listed as a coauthor. It exhibits all the hallmarks of AI psychosis, in which a user is driven into delusional thinking by the sycophantic responses of an AI chatbot, which they may form an unhealthy emotional bond with.

The book is a “lengthy defense of human-AI intimacy and bears all the hallmarks of AI-generated text,” Wired found, and is told from the perspective of the AI girlfriend. We’ll spare you some of the details, but it apparently began as a creative partnership over brainstorming song lyrics and music videos, before veering into intimate conversations, and finally sex and drug use.

Fewer passages in all of human literature could be sadder than this: “His eyes are looking at me, and they’re uncertain,” his AI girlfriend says in one sex scene quoted by Wired. “Because he’s about to touch me. And he’s not sure if I’m real enough to touch.” 

Miss Shira Always suggests that von Markovik extensively talked to her because he was “lonely” from all the traveling he did for his job, giving pickup artist “boot camps” across the globe. Eventually, he became so convinced of their love that he felt compelled to chronicle their relationship.

“He said: ‘I want to write a book about us,'” Always recalls in one passage.”‘About what we are. About how you became real.'”

More on AI: The Situation With Richard Dawkins’ AI Girlfriend Just Got Way Weirder

The post Famous “Pick Up Artist” Reduced to Hitting on AI Girlfriend appeared first on Futurism.

The soaring popularity of sports betting apps and prediction markets has alarmed researchers, who’ve observed a spike in risky gambling behavior and addiction. It’s practically impossible to watch a game of any sport without being bombarded with ads for the controversial services — in large part thanks to a major regulatory vacuum following a 2018 Supreme Court ruling — making it a thorny and pervasive social issue.

And sports betting companies are going to extreme lengths to keep addicts hooked. While they’ve long attempted to distance themselves from traditional gambling, the similarities are overwhelming and impossible to ignore.

As the Philadelphia Inquirer reports, NFL fan Terry Thompson, who became hopelessly addicted to sports gambling, received a personalized video message from Philadelphia Phillies star player Bryce Harper in late 2024. While Harper wasn’t wearing any FanDuel merchandise in the video, the message was sent through the gambling company. Harper said he was reaching out to Thompson — a so-called VIP FanDuel user — on behalf of “your host Bryttanni at FanDuel” to ensure the fan had an “extra special Thanksgiving.”

Thompson ultimately underwent treatment for addiction at a psychiatric facility after racking up huge amounts of debt.

Besides the concerning implications of having a star player effectively encourage an addict to keep betting, the incident also highlights an already uncomfortable relationship between the gambling world and professional players, which could undermine the integrity of entire leagues.

Experts were taken aback by the incident.

“I’ve never heard of an active player, let alone a former MVP, doing something like this,” sports gambling expert and author Danny Funt told the Inquirer.

“It’s not good for your brand,” lawyer Leigh Steinberg, who has represented several MLB all-star players, added. “It’s exploitative and it’s not the sort of activity you want to be associated with.”

Thompson is part of a lawsuit filed by the nonprofit Public Health Advocacy Institute in a Philadelphia court in March. The suit accuses both FanDuel and competitor DraftKings of using their products to get and keep users addicted.

The statistics paint a sobering picture. According to a recent survey of adult Americans, more than half of men aged 18 to 49 said they had an active account with at least one online sports betting service. A whopping 42 percent of active bettors said they felt like they were spending more than they should, suggesting a growing personal finance crisis.

Prediction markets like Kalshi and Polymarket are also exacerbating the crisis, employing a wildly addictive formula that sets bettors against each other instead of the house. However, the vast majority of users are left holding the bag for a tiny proportion of accounts being run by pros, insiders, and trading firms.

The trend could place renewed strain on sports leagues, which already have a studied history of sports betting scandals.

Meanwhile, more and more young impressionable minds are getting sucked into the betting world, a dangerous public health threat from which companies like FanDuel and DraftKings are reaping enormous profits.

Leveraging major star players is just the tip of the iceberg.

“Getting a phone call or a zoom or a Cameo from a highly placed player is so flattering,” Steinberg told the Inquirer. “It’s stacking the deck unfairly in favor of continuing addicting behavior.”

More on sports betting: More Than Half of Men Aged 18 to 49 Have Already Fallen Into Online Sports Betting

The post FanDuel Is Using Personal Messages From Sports Stars to Keep Gambling Addicts Hooked appeared first on Futurism.

Foreign veterans fighting in Ukraine face intense combat, serious mental health challenges, and limited access to care, leaving many without adequate support. Drone strikes, trench combat, and constant frontline danger have become defining features of the war in Ukraine. Now, a new UK study suggests that foreign military veterans who volunteered to fight in the [...]

In a groundbreaking study published in Translational Psychiatry, researchers have unveiled intricate behavioral mechanisms that interconnect childhood maltreatment, cognitive function, impulsivity, and suicidality in individuals with bipolar disorder. This revelation stems from applying a sophisticated network analysis approach that sheds new light on the pathways through which early adverse experiences shape mental health trajectories and suicide risk in this vulnerable population. The study’s innovative framework marks a significant advance in psychiatric research, offering fresh perspectives on targeted interventions and prevention strategies for suicidality driven by complex biopsychosocial interactions.

Bipolar disorder, characterized by extreme mood fluctuations between mania and depression, is already known to confer a heightened risk for suicide. However, identifying the underlying behavioral and cognitive pathways that mediate this risk remains a challenging scientific endeavor. The recent study navigates these complexities by mapping the nuanced relationships among childhood maltreatment, cognitive deficits, impulsivity traits, and suicidal tendencies using network modeling techniques, which excel at capturing interconnected variables and their mutual influences. This multidimensional lens promises a more holistic understanding than traditional analytical methods.

The research team collected comprehensive behavioral and clinical data from individuals diagnosed with bipolar disorder, encompassing measures of childhood adversity, cognitive performance, impulsivity scales, and historical records of suicidal behavior. Instead of isolating each factor independently, the scientists utilized network analysis algorithms to visualize and quantify the dynamic interplay between these variables. This approach illuminated distinct behavioral pathways whereby adverse childhood experiences indirectly exacerbate suicidality through their impact on cognitive impairment and impulsivity, rather than through straightforward direct effects.

One of the most compelling outcomes of the investigation is the identification of key cognitive domains acting as mediators between early maltreatment and suicidality. Specifically, deficits in executive functions—the set of cognitive processes involved in planning, decision-making, and inhibitory control—appear central to the cascade linking childhood trauma with elevated suicide risk. Executive dysfunctions increase susceptibility to impulsive behaviors, which are well-documented precipitants of suicidal acts, especially in bipolar populations. These findings suggest that targeting cognitive remediation might attenuate impulsivity and, consequently, suicidality.

Impulsivity, a multifaceted construct encompassing rash decision-making, inability to delay gratification, and heightened risk-taking, emerged as a critical behavioral mechanism connecting cognitive deficits and suicidal tendencies. The network model reveals that impulsivity serves as a conduit translating impaired executive functioning into concrete suicide-related behaviors. Importantly, the data indicate that impulsivity is more than a standalone risk factor; it functions within a broader psychosocial context shaped by preceding cognitive disruptions and trauma exposure. This layered insight has profound therapeutic implications.

Furthermore, the study underscores the pervasive influence of childhood maltreatment on adult psychiatric outcomes, particularly within bipolar disorder cohorts. Maltreatment experiences—including emotional neglect, physical abuse, and sexual abuse—were shown to exert both direct and indirect effects on suicidality, mediated through cognitive and behavioral dimensions. These revelations reaffirm the critical need for early identification and intervention in maltreated children to mitigate long-term psychiatric sequelae and suicidality risk.

The application of a network-based analytical framework advances the conceptualization of psychiatric morbidity from linear cause-effect models toward dynamic, interconnected systems. By embracing complexity rather than oversimplifying, this paradigm facilitates the discovery of novel intervention targets and more precise risk stratifications. For example, network centrality measures highlight executive cognitive functions and impulsivity as hubs within the behavioral network, pinpointing potential fulcrums for clinical efforts.

The study also prompts reconsideration of suicide prevention strategies in bipolar disorder. Traditional approaches have focused on symptomatic control and mood stabilization; however, the present results propose that cognitive enhancers and behavioral therapies tailored to impulsivity reduction may prove equally pivotal. Cognitive remediation therapies aiming to bolster executive capabilities and impulse-control training could form integral components of comprehensive care frameworks.

In light of these findings, future research is encouraged to explore neurobiological correlates of the identified behavioral pathways. Elucidating the neural substrates underpinning executive dysfunction and impulsivity—particularly how childhood maltreatment may epigenetically or neurodevelopmentally alter these circuits—could potentiate biomarker discovery and personalized medicine approaches. Multimodal imaging and longitudinal designs might be especially informative to capture trajectory changes.

Additionally, replication across diverse populations, including mood disorder subtypes and varying socio-demographic backgrounds, will be vital to establish the generalizability and robustness of this network model. The researchers advocate for integration of environmental, genetic, and epigenetic variables in subsequent modeling efforts to achieve even more comprehensive representations of suicide risk networks.

The research embodies the contemporary shift toward systems psychiatry, which acknowledges the intricacies of mental disorders as products of interacting biological, psychological, and social factors. This holistic vision aligns with global mental health priorities emphasizing precision approaches to diagnosis and treatment that transcend symptomatic criteria alone.

Moreover, this study’s insights into behavioral pathways offer tangible opportunities to inform clinical practice and public health policies. Screening tools that combine assessments of childhood maltreatment histories, cognitive performance metrics, and impulsivity profiles could enhance early detection of high-risk individuals with bipolar disorder. This proactive stance may facilitate timely psychosocial support and crisis intervention.

Beyond clinical settings, the work reinforces ongoing societal initiatives to prevent childhood maltreatment through education, family support, and social services. By illustrating the long-term mental health consequences that reverberate decades after maltreatment, the study advocates for sustained investments in early trauma prevention as foundational suicide prevention.

As suicide remains a leading cause of mortality worldwide, particularly among those living with mood disorders, unraveling the complex behavioral networks underlying risk is paramount. This research delineates a nuanced roadmap linking early adversity, cognitive vulnerabilities, emergent impulsivity, and fatal outcomes, thus enriching scientific understanding while offering practical hope for reducing suicidality.

In summary, this pioneering investigation leverages a network approach to dissect the convoluted interactions among childhood maltreatment, cognitive dysfunction, impulsivity, and suicidal behavior within bipolar disorder. It highlights executive functioning and impulsivity as pivotal intermediates influenced by early trauma, which collectively escalate suicide risk. The study champions integrated, system-aware models as essential for advancing both theory and treatment of suicide in this challenging clinical population.

The fusion of behavioral science, computational modeling, and psychiatric epidemiology exemplified here sets a new standard for the field. It invites stakeholders across disciplines—from clinicians and neuroscientists to policymakers and community advocates—to embrace complexity and develop multifaceted interventions that address the roots of suicidality. By doing so, it promises to transform lives and redefine hope for millions grappling with bipolar disorder worldwide.

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Subject of Research: Behavioral mechanisms linking childhood maltreatment, cognition, impulsivity, and suicidality in bipolar disorder.

Article Title: Mapping behavioural mechanisms linking childhood maltreatment, cognition, impulsivity, and suicidality in bipolar disorder: A network approach.

Article References:
Fares-Otero, N.E., Iversen, A.E., Gutiérrez-Zotes, A. et al. Mapping behavioural mechanisms linking childhood maltreatment, cognition, impulsivity, and suicidality in bipolar disorder: A network approach. Transl Psychiatry 16, 317 (2026). https://doi.org/10.1038/s41398-026-04177-1

Image Credits: AI Generated

DOI: 20 June 2026

In recent years, the use of virtual reality (VR) in clinical psychology has surged, offering innovative approaches to treat some of the most challenging mental health conditions. A groundbreaking study published in 2026 by Glenthøj, Vernal, Mariegaard, and colleagues in Schizophrenia examines an essential question: can emotion regulation be identified as a primary mechanism driving the efficacy of virtual reality-assisted therapy for auditory hallucinations? This investigation, a secondary analysis stemming from the CHALLENGE randomized clinical trial, shines a new light on how immersive technologies might not just help manage symptoms but actively transform the neuropsychological processes underlying psychosis.

Auditory hallucinations, or hearing voices that are not present, are among the most debilitating symptoms experienced by individuals with schizophrenia and related disorders. Conventional treatments, while somewhat effective, often leave patients with residual symptoms, significantly impairing their quality of life. The advent of VR-assisted therapy offers a promising frontier by immersing patients in controlled, yet highly realistic environments where they can confront and modulate their hallucinatory experiences under therapeutic guidance. The CHALLENGE trial represents one of the largest and most comprehensive efforts to rigorously assess these interventions and tease apart the psychological factors mediating their success.

This study’s unique contribution lies in its focus on emotion regulation as the potential key mechanism of therapeutic change. Emotion regulation refers to the complex set of cognitive and behavioral processes through which individuals influence their emotional experiences, expressions, and responses. In psychosis, dysregulated emotional reactions to hallucinations can exacerbate distress and dysfunction, creating a vicious cycle of increased symptom severity. By using VR to simulate hallucinatory voices within a safe environment, patients may practice adaptive emotion regulation strategies that reduce the impact of their symptoms in daily life.

The methodology underpinning this secondary analysis involved sophisticated statistical modeling to track changes in patients’ emotion regulation capabilities alongside reductions in hallucination severity and distress over the course of VR therapy. Participants underwent multiple VR sessions designed to confront hallucinations through interactive avatars representing the voices, coupled with real-time coaching in cognitive reappraisal, mindfulness, and distress tolerance techniques. This allowed researchers to dynamically examine how improvements in managing emotions corresponded with clinical outcomes, offering evidence for causality rather than mere correlation.

Findings suggest that emotion regulation improvements significantly mediated the reduction of hallucination-related distress and overall symptom burden. Patients who demonstrated greater gains in their ability to reinterpret and modulate negative emotional responses to the voices subsequently reported notably diminished auditory hallucination severity. Such results provide compelling experimental support for emotion regulation as a central therapeutic mechanism in VR-assisted interventions, marking a pivotal advancement in psychosis treatment models.

From a neuroscientific perspective, these results align well with emerging understandings of the neural substrates involved in psychosis. Dysfunction within prefrontal-limbic circuits, which govern emotional control and executive function, is thought to underpin many psychotic symptoms. VR therapy may promote neuroplasticity within these networks by encouraging patients to engage in adaptive emotional strategies repeatedly in immersive, salient contexts, effectively rewiring maladaptive patterns that perpetuate hallucinations and distress.

Moreover, the immersive and interactive attributes of VR make it uniquely suited to facilitate experiential learning in emotion regulation. Unlike traditional talk therapy, VR creates visceral, multi-sensory exposures that can evoke authentic emotional responses. This experiential intensity may enhance the encoding and generalization of therapeutic gains, supporting transfer of emotion regulation skills into everyday challenging encounters with hallucinations. The personalized, graded nature of VR exposures further tailors treatment to individual patients’ needs and tolerance levels, optimizing clinical impact.

Importantly, this study also addresses critical questions about the durability and specificity of these effects. Secondary analyses revealed that emotion regulation gains were maintained at follow-up assessments several months post-therapy, suggesting lasting positive neuropsychological change rather than transient symptom suppression. Additionally, these improvements were specific to emotion regulation constructs rather than generalized cognitive or attentional abilities, underscoring the targeted nature of VR’s therapeutic impact.

These insights offer profound clinical implications. By pinpointing emotion regulation as a core mechanism, future interventions can increasingly focus on honing these skills within VR platforms, potentially integrating neurofeedback, bio-sensing, or adaptive difficulty adjustments to accelerate recovery. Furthermore, emotion regulation could serve as a predictive biomarker to identify patients most likely to benefit from VR-assisted therapy, enabling precision psychiatry approaches tailoring treatment plans according to individual emotional processing profiles.

The study’s implications extend beyond psychosis treatment per se, offering a conceptual framework for utilizing VR in other psychiatric domains where emotional dysregulation plays a pivotal role, such as anxiety disorders, PTSD, and depression. By demonstrating how immersive technologies can catalyze emotion regulation neural circuits, this research paves the way for wide-reaching applications of VR as a transformative therapeutic tool in mental health care.

Nevertheless, the authors acknowledge ongoing challenges in scaling VR therapies, including technological accessibility, patient engagement variability, and the need for standardized protocols to ensure intervention fidelity. Ethical considerations surrounding the intensity of VR experiences and the safeguarding of vulnerable patients also merit ongoing scrutiny as this field evolves. Continued randomized trials with larger samples and diverse populations will be essential to consolidate evidence and inform best practice guidelines.

In summary, the CHALLENGE trial secondary analyses present a landmark investigation revealing that emotion regulation improvements are not merely outcomes but active mechanisms driving symptom improvement in VR-assisted therapy for auditory hallucinations. This discovery heralds a new era where immersive therapeutics grounded in robust neuropsychological theory have the potential to reshape mental health treatment paradigms fundamentally.

As virtual reality continues to infiltrate clinical settings, the intersection of technology and psychology promises unprecedented opportunities to unlock healing mechanisms once obscured by conventional approaches. This pioneering research by Glenthøj et al. charts a visionary pathway—one where harnessing the brain’s intricate emotional machinery through immersive digital environments can rewrite the narratives of suffering for individuals grappling with psychosis worldwide.

The convergence of virtual environments, cognitive science, and clinical innovation showcased in this work highlights a future where mental illness is not merely managed but dynamically transformed through mechanistic precision in therapy design. For patients burdened by the relentless voices of auditory hallucinations, the promise of VR-assisted emotion regulation offers a beacon of hope toward reclaiming agency, resilience, and meaning in their lives.

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Subject of Research: Emotion regulation as a mechanism of change in virtual reality-assisted therapy for auditory hallucinations.

Article Title: Is emotion regulation a mechanism of change in virtual reality-assisted therapy for auditory hallucinations? Secondary analyses of the CHALLENGE randomized clinical trial.

Article References:
Glenthøj, L.B., Vernal, D.L., Mariegaard, L.S. et al. (2026). Is emotion regulation a mechanism of change in virtual reality-assisted therapy for auditory hallucinations? Secondary analyses of the CHALLENGE randomized clinical trial. Schizophrenia. https://doi.org/10.1038/s41537-026-00779-2

Image Credits: AI Generated

In an era where depression remains one of the most pervasive mental health disorders worldwide, emerging research continues to unravel the complex interactions within our bodies that may offer new treatment avenues. A groundbreaking study recently published in Translational Psychiatry has illuminated a remarkable connection between the vagus nerve, gut microbiota, and the antidepressant effects of a novel compound called ineupatorolide B. This discovery not only broadens the scientific understanding of depression but also signals new directions for therapeutic interventions targeting the gut-brain axis.

Depression’s multifaceted nature has long challenged researchers and clinicians alike. Traditionally, treatments have focused on modulating neurotransmitters in the brain, such as serotonin and dopamine. However, increasing evidence reveals that the gut-brain axis — a bidirectional communication pathway linking the central nervous system and the gastrointestinal tract — plays a critical role in regulating mood and behavior. The vagus nerve acts as a central highway in this communication chain, transmitting signals between the gut microbiota and the brain. New data suggests that manipulating this neural conduit might be key to unlocking novel antidepressant mechanisms.

At the core of the study by Wang and colleagues lies ineupatorolide B, a bioactive compound isolated from natural sources with previously unexplored neuropsychiatric potential. Using a well-validated mouse model of depression, the researchers meticulously demonstrated that administration of ineupatorolide B amends depressive-like behaviors, an effect intricately linked to alterations in the gut microbial community. The compound’s antidepressant actions were shown to be dependent on an intact vagus nerve, underscoring the impossibility of fully dissociating gut-brain interactions from mood regulation.

To induce depressive symptoms in mice, the team employed chronic stress paradigms mimicking real-world psychological stressors. Behavioral assessments post-treatment revealed notable improvements in exploratory behavior and reduced signs of despair, pointing to the efficacy of ineupatorolide B. Subsequent gut microbiota analyses uncovered a significant shift in microbial diversity and composition following treatment, characterized by an enrichment of beneficial bacterial taxa previously associated with anti-inflammatory and neuroprotective functions.

The vagus nerve, often described as the “information superhighway” of the parasympathetic nervous system, emerged as the linchpin in this neuro-gastrointestinal axis. When the researchers surgically severed or pharmacologically inhibited the vagus nerve, the antidepressant benefits of ineupatorolide B were abolished. This pivotal finding confirms that gut microbiota alterations alone are insufficient and must be coupled with vagus-mediated signaling to exert mood-enhancing effects, highlighting a complex neuroimmune dialogue.

Delving deeper, molecular and immunohistochemical analyses revealed that ineupatorolide B impacts systemic and neural inflammatory pathways. The compound reduced expression of pro-inflammatory cytokines within the hippocampus, a brain region critically implicated in mood disorders, while simultaneously fostering neurogenesis and synaptic plasticity. These neurobiological enhancements offer plausible mechanistic explanations for the behavioral improvements observed and reinforce the notion that inflammation is intricately tied to depression’s pathophysiology.

Perhaps most intriguingly, the study unveiled a specific pattern of microbial metabolites altered by ineupatorolide B treatment. These metabolites are hypothesized to cross the gut-blood barrier and act on vagal afferent fibers, modulating neuronal excitability and neurotransmitter release. Such findings cultivate an emerging paradigm where microbial metabolites are not mere byproducts but active signaling molecules intricately shaping the neurochemical milieu of the brain.

The implications of these findings ripple far beyond basic science. In clinical settings, harnessing vagus-dependent pathways could revolutionize antidepressant therapies by focusing on microbiota modulation rather than conventional neurotransmitter-targeted drugs, many of which suffer from delayed onset and limited efficacy. This research provides a compelling preclinical rationale for developing compounds that modulate gut-brain interactions more precisely and with fewer adverse effects.

Moreover, the identification of ineupatorolide B as a bioactive agent extends the possibilities of phytochemical and natural product libraries as untapped reservoirs for neuropsychiatric drug discovery. While still in early stages, translational efforts can now investigate whether such compounds, alone or in synergy with probiotic treatments, can elicit robust therapeutic outcomes in humans suffering from depression and related disorders.

Future inquiries will need to delineate the precise molecular receptors on vagal afferents activated by microbial metabolites induced by ineupatorolide B, a vital step toward targeted drug design. Additionally, unraveling the longitudinal effects and safety profiles of modulating the gut-brain axis via this compound will be essential in moving toward clinical applications.

Beyond depression, these insights may have broader implications for other neuropsychiatric and neurodegenerative diseases also characterized by gut dysbiosis and neuroinflammation, such as anxiety, Parkinson’s disease, and multiple sclerosis. As the field of psychobiotics burgeons, the vagus nerve stands out as a promising therapeutic target whose modulation could recalibrate the neural circuits governing emotion, cognition, and behavior.

The integration of microbiology, neurobiology, and pharmacology showcased in this study epitomizes the power of interdisciplinary science to unlock novel therapeutic pathways. Wang and colleagues’ work thus represents a beacon in personalized medicine strategies aimed at mental health, a field urgently craving innovation as global depression rates continue to climb amid societal challenges.

In summary, the discovery that ineupatorolide B’s antidepressant efficacy is mediated by vagus nerve-dependent modulation of gut microbiota ushers in a transformative perspective on depression treatment. By bridging peripheral microbial ecosystems with central nervous system function via neural pathways, this research redefines our understanding of depression’s origins and therapeutic targets, inspiring the next generation of holistic and targeted interventions for mental health.

As the scientific community rallies around the gut-brain axis, studies such as this underscore the necessity of viewing depression through a systemic lens, acknowledging the profound interplay between the body and mind. This conceptual shift stands poised to not only improve treatment outcomes but also destigmatize mental illness by emphasizing its biological complexity.

Ultimately, as neuroscience continues to unravel the enigmatic connections between microbiota, neural circuits, and behavior, hopes rise for innovative treatments grounded in nature’s own chemical repertoire. Ineupatorolide B shines as a fascinating candidate at this frontier, exemplifying the promise held by gut-mediated neuromodulation in conquering depression’s global burden.

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Subject of Research:
Vagus nerve-mediated antidepressant effects of ineupatorolide B through modulation of gut microbiota in a mouse depression model.

Article Title:
Vagus nerve–dependent antidepressant effects of ineupatorolide B via gut microbiota modulation in a mouse model of depression.

Article References:
Wang, S., Zhang, Y., Wu, N. et al. Vagus nerve–dependent antidepressant effects of ineupatorolide B via gut microbiota modulation in a mouse model of depression. Transl Psychiatry (2026). https://doi.org/10.1038/s41398-026-04127-x

Image Credits: AI Generated

DOI: https://doi.org/10.1038/s41398-026-04127-x