New data from NASA’s Juno spacecraft show temperatures spike more than 20 degrees Celsius just a few meters under Io’s surface, providing the first look at what’s happening below the crust of the Solar System’s most volcanic world.
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Scientists from the Salk Institute have determined that brain waves in the visual cortex serve as a computational engine, allowing the brain to construct internal representations of the external world that enhance prediction, reconstruction, and perception capabilities.
While the scientists behind the new study focused their work on the visual cortex, they suspect that similar brain waves washing over other areas of the brain’s surface likely serve a similar role for other sensory systems.
The human brain uses electricity to communicate between synapses. Research has shown that this electrical activity can travel in waves across the brain’s surface. Called neural traveling waves, the phenomenon’s role in brain function and consciousness is not completely understood.
Previous studies have established that traveling brain waves play a significant role in behavior and attention. In 2020, Salk neuroscientist John Reynolds, PhD, successfully identified traveling brain waves in the visual systems of animals during a wakeful state.
According to a statement from Reynolds, the senior and co-corresponding author on the new paper, and colleagues, the 2020 research effort also found a direct correlation between traveling brain waves in the visual cortex and an animal’s ability to perceive objects directly in front of them. The authors suggest this discovery explained the “classic conundrum” of searching for something like a pair of keys or a phone that was right in front of you the whole time.
Although the connection between traveling brain waves and an awake animal’s ability to perceive objects seemed solid, Reynolds said he was left wondering why.
In their newly proposed theory, Reynolds and colleagues suggest that traveling brain waves are not simply “electrical noise” resulting from the brain’s normal relaying of signals. Instead, the Salk Institute team proposes that the neural connections responsible for the generation of traveling brain waves change their physiological structure, or “synaptic weights,” to more accurately reflect the outside world.
“Each sight, smell, sound, and action of an animal alters the connections that generate these waves, building the neural circuitry that the brain uses to construct an internal representation of the external world,” the team’s statement explains.
In the visual cortex, the part of the brain responsible for receiving and processing visual information, the team proposed that traveling brain waves perform four distinct functions. These include modulating visual perception from moment to moment and turning recent visual sensory inputs into “internal representations” of objects, people, and surroundings.
The team proposes that traveling brain waves also help humans generate short-term predictions about their surroundings, and “store and replay patterns that represent memories of events unfolding in time.” Reynolds said the process laid out by his team is analogous to how ChatGPT and other LLMs translate and interpret data.
“They learn statistical structure from language and use that knowledge to generate meaningful and appropriately structured text that reflects the patterns of language,” the researcher explained. “The brain may be doing something functionally similar—a biological generative model built from the ground up by experience.”
When detailing the potential impact of their proposed role for traveling brain waves in the visual cortex, the team highlights the contrast between a rich and complex world and its general predictability.
“Objects around you exist in 3D space, you see the world in retinal images that change with your eye and body movements, and the laws of physics and physiology overlay this all,” they explain.
Reynold’s team says that traveling brain waves are merely the brain’s way of internalizing these predictable “regularities” and encoding them in its synapse network. If correct, they said that this encoding would allow the brain to “infer the likely causes of sensory input and construct an internal model of the world.”
“This framing brings us one step closer to understanding how our brains compute the busy, messy world around us, turning a complicated sensory onslaught into behaviors and experiences,” they conclude.
The study “Neural traveling waves in cortex: network mechanisms and potential roles in neural computation” was published in Neuron.
Christopher Plain is a Science Fiction and Fantasy novelist and has spent the last six years as Associate News Editor and Head Science Writer at The Debrief. Follow and connect with him on X, learn about his books at plainfiction.com, or email him at christopher@thedebrief.org
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Thousands of metres below the ocean’s surface, there are tiny waves moving through the water. Much like breaking waves at the beach, these small waves within the ocean must eventually break. When they do, they create turbulence and mixing, similar to what you feel from a big wave breaking on the beach. This might seem […]
A groundbreaking study unveils how the ARP2/3 complex orchestrates the dynamic behavior of neurites, providing fresh insights into neuronal growth and polarity. Researchers utilized advanced optogenetic tools to manipulate RAC1, an upstream regulator of ARP2/3, revealing spatially distinct roles of actin assembly in neuronal morphology.
By employing photoactivatable RAC1 (PA-RAC1), the team demonstrated that ARP2/3-mediated actin assembly at neurite tips promotes growth cone activation and neurite extension. Local activation of PA-RAC1 triggered robust growth cone dynamics, driving neurite elongation. Conversely, activation of a dominant-negative RAC1 mutant led to collapse of the growth cone and neurite retraction, underscoring ARP2/3’s role in sustaining neurite advancement.
Intriguingly, PA-RAC1 activation at the soma induced lamellipodia formation reminiscent of nascent actin waves, which were associated with neurite retraction events. This phenomenon mirrored intrinsic cellular behaviors where somatic actin waves correspond with retracting neurites. The study elegantly showed that the emergence of these waves reduced somatic actin patch intensity, indicating a tightly regulated cytoskeletal oscillator mechanism.
The authors further explored the effects of ARP2/3 inhibition using CK-666 perfusion at distinct cellular locales. When applied over the soma and proximal neurites, CK-666 induced neurite retraction, whereas neurites outside this region continued growing unabated. Notably, actin waves were initiated in neurites outside the inhibited zone, propagating retrogradely toward the soma but dissipating upon entering CK-666-exposed areas. This highlights a spatial dependence of ARP2/3 activity for wave initiation and propagation.
Remarkably, simultaneous activation of PA-RAC1 at multiple growth cones revealed competitive dynamics in actin assembly, with enhanced growth cone activity limited to one or two sites. This suggests an intrinsic cellular mechanism balancing cytoskeletal resources and neurite growth across the complex neuronal arborization.
Together, these findings articulate a dual role for ARP2/3: driving actin wave initiation at the soma that triggers neurite retraction, and supporting growth cone expansion at neurite tips to promote extension. This oscillatory interplay mediated by ARP2/3 and RAC1 underscores the cytoskeleton’s fundamental role in establishing neuronal polarity.
This study not only provides a mechanistic framework for how neurons spatially regulate growth and retraction but also suggests that intrinsic cytoskeletal oscillators underpin the dynamic remodeling necessary for proper neuronal circuit formation. These insights pave the way for future investigations into cytoskeletal dysregulation in neurodevelopmental disorders and neuronal regeneration strategies.
The precise spatial control of actin dynamics mediated by ARP2/3 complex activity advances our understanding of neuronal development, highlighting how local cytoskeletal modulators can dictate overall neuronal architecture through oscillatory growth behaviors.
Subject of Research: Neuronal cytoskeletal dynamics and polarity establishment
Article Title: An intrinsic cytoskeletal oscillator establishes neuronal polarity
Article References:
Lin, Tc., Coles, C.H., Alfadil, E. et al. An intrinsic cytoskeletal oscillator establishes neuronal polarity. Nature (2026). https://doi.org/10.1038/s41586-026-10755-6
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Com mais de 155.000 observações reais de voos, o Starlink Flights identifica quais as companhias aéreas e aeronaves que já têm o serviço de internet via satélite da SpaceX instalado a bordo.
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