Researchers at the Massachusetts Institute of Technology (MIT) have developed an ultra-efficient computer chip that could help tiny robots and lightweight devices create detailed 3D maps of their surroundings while using very little energy. The new chip could allow small drones to fly through narrow spaces, such as air-conditioning ducts or industrial pipelines, to inspect […]
Chronic dietary cholesterol activates Ral GTPases, which promote LDLR internalization and lysosomal degradation through RalBP1–REPS1 and CTSA, thereby reducing cholesterol clearance, whereas CTSA inhibition restores LDLR function and may offer a therapeutic strategy for cardiovascular disease.
Global high-resolution mapping shows widespread seagrass loss and degradation since 2019, with most meadows outside protected areas, highlighting urgent conservation and climate-policy needs.
Integrated pharmacological, biochemical, biophysical and structural analyses of small-molecule β-arrestin inhibitors show how they block β-arrestin engagement with activated GPCRs, revealing their mechanism of action and uncovering a previously unrecognized allosteric regulatory site.
Researchers have tracked the electrical activity of individual brain cells during conversation in real time. Plus, the history of GPS and a cross-species transplant that could reveal clues about the origin of animals.
Plague swept through groups of hunter-gatherers in southeastern Siberia 5,500 years ago, leaving dozens dead in its wake—with DNA from Yersinia pestis bacteria still trapped inside their teeth.
University of Oxford ancient DNA researcher Ruairidh Macleod and his colleagues recently sequenced the telltale bacterial DNA in teeth from plague victims at four ancient cemeteries in the area around Russia’s Lake Baikal. The tragedy that befell these communities is now the earliest known plague outbreak, courtesy of the oldest strain of Y. pestis ever sequenced.
Unearthing a new backstory for the plague
Until recently, scientists who study the evolution of diseases have held two fairly solid ideas about the origins of plague, the disease caused by Yersinia pestis bacteria. It's a scourge so awful that it has gone down in history as not just a plague but the plague. The first idea is that the earliest strains didn't have the right genetic traits to be really lethal. And the second is that the plague first began menacing humans when the first farmers settled in densely packed towns alongside rats and domestic animals.
Plague swept through groups of hunter-gatherers in southeastern Siberia 5,500 years ago, leaving dozens dead in its wake—with DNA from Yersinia pestis bacteria still trapped inside their teeth.
University of Oxford ancient DNA researcher Ruairidh Macleod and his colleagues recently sequenced the telltale bacterial DNA in teeth from plague victims at four ancient cemeteries in the area around Russia’s Lake Baikal. The tragedy that befell these communities is now the earliest known plague outbreak, courtesy of the oldest strain of Y. pestis ever sequenced.
Unearthing a new backstory for the plague
Until recently, scientists who study the evolution of diseases have held two fairly solid ideas about the origins of plague, the disease caused by Yersinia pestis bacteria. It's a scourge so awful that it has gone down in history as not just a plague but the plague. The first idea is that the earliest strains didn't have the right genetic traits to be really lethal. And the second is that the plague first began menacing humans when the first farmers settled in densely packed towns alongside rats and domestic animals.
Heat flux across the core–mantle boundary is laterally variable, and heat may flow into the core beneath hot piles of dense material such as large low-shear-wave-velocity provinces, according to mantle thermochemical convection models.
A prototype differential atom interferometer operates at the standard quantum limit with no excess noise beyond atom shot noise, achieving performance in line with the specifications for future long-baseline atom interferometers.
The Pakistan Genome Resource compiles biobank data from 173,303 individuals with high familial relatedness, broadening the catalogue of human genetic variation and establishing a population-specific genomic reference for Pakistan.
A technique combining atomically resolved scanning tunnelling microscopy with neural-quantum-state quantum Monte Carlo simulation of disordered 2D electron Wigner solids establishes a powerful framework to enable the clear identification of two distinct defect-induced disorder regimes.
A tiny electronic sensor that can be swallowed like a pill may soon provide one of the most accurate ways to measure body temperature. Engineers at the Massachusetts Institute of Technology (MIT) have developed a miniature device that continuously monitors temperature from inside the digestive tract, potentially helping doctors detect infections earlier and better manage […]
Tariq Mahmood was alarmed when he found 19 sacks tucked away in a railway tunnel in the Chakwal district of northern Pakistan. Their contents were extremely disturbing: 45 rotting pangolin carcasses, all devoid of their distinct, orange-and-light-brown scales. That was in 2012. “It was very difficult to see these innocent, dead bodies,” said Mahmood, a wildlife biologist at Pir Mehr Ali Shah Arid Agriculture University in Pakistan, who began studying pangolins in 2009. Finding so many slain Indian pangolins (Manis crassicaudata) alerted Mahmood to a dark truth. Poachers were paying local citizens to capture them, so the overlapping scales that cover their bodies — the pangolin’s first line of defense — could be sold into the illegal wildlife trade. “It was terrible to know that.” At the time, global conservationists were realizing that demand for pangolin was driving trade, mostly to China. “We first saw the emergence of this intercontinental trafficking around 2010, and it’s continued to take place since then,” said Dan Challender, a pangolin expert at the University of Oxford who has studied international wildlife trade for 15 years. This shy, toothless, nocturnal animal has become the world’s most-trafficked mammal. When Asia’s four species were nearly poached to extinction, traders turned to the four African species and their numbers soon plummeted. All pangolins are on the IUCN Red list: Four of them, including the Indian pangolin, are endangered, and three hang on the brink, critically endangered. Pangolin scales command substantial prices on the black market. The demand is…This article was originally published on Mongabay
Researchers have uncovered more than 400 fossilized whale bones in an ocean-floor chasm. Plus, the working lives of scientists, in pictures, and how AI could slow the pace of research publication for the better.
A team of researchers from the Massachusetts Institute of Technology (MIT) and other institutions has developed a new way to improve the performance of powerful electronic devices by using an ultrathin layer of diamond. The breakthrough could help future technologies such as 6G wireless networks, satellite communications, radar systems, and even data centers operate faster […]
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