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Polyamines: New Hope Against Deadly Short QT Arrhythmias
In a groundbreaking advance that could reshape the treatment landscape for cardiac arrhythmias, researchers have unveiled a novel therapeutic strategy employing polyamines to combat life-threatening irregular heart rhythms specifically associated with Short QT Syndrome type 3 (SQTS3). This genetic condition, known for dramatically shortening the heart’s repolarization phase, predisposes individuals to sudden cardiac events, often without prior warning. The research, published in Nature Communications, represents a significant leap in understanding the molecular underpinnings of SQTS3 and presents polyamines as potent modulators capable of restoring normal cardiac electrophysiology.
Short QT Syndrome encompasses a rare yet perilous spectrum of inherited cardiac channelopathies characterized by an abnormally abbreviated QT interval on the electrocardiogram, indicating faster than normal electrical recovery of heart muscle cells after each heartbeat. Among its subtypes, SQTS3 is tied to mutations affecting the cardiac sodium channel’s late current, a critical factor in modulating myocardial excitability. These mutations accelerate repolarization, compromising the heart’s rhythm stability and elevating risks of syncope, atrial fibrillation, ventricular tachycardia, and sudden cardiac death. Traditional treatment options—including implantable devices and antiarrhythmic drugs—offer limited efficacy and often entail significant side effects.
The research team, led by Moreno-Manuel et al., embarked on an exploration of polyamines—naturally occurring organic cations ubiquitously present in mammalian cells known to participate in a variety of physiological processes including cellular growth and ion channel regulation. Through an integrative approach combining electrophysiological assays, molecular dynamics simulations, and in vivo cardiac modeling, the investigators demonstrated that certain polyamines can fine-tune defective sodium channel kinetics implicated in SQTS3. This modulation effectively prolongs the action potential duration, thereby rectifying the shortened QT interval hallmark of this syndrome without inducing proarrhythmic effects.
Central to their findings is the discovery that polyamines achieve this modulation by specifically interacting with allosteric sites on the sodium channel alpha subunit encoded by the SCN5A gene. Mutations causing gain-of-function late sodium current diminish the usual window for ion flow, which polyamines counterbalance by stabilizing conformational states conducive to controlled sodium influx. Notably, this action preserves physiological ion gradients and electrical stability while mitigating the rapid repolarization that predisposes to arrhythmogenic vulnerability. Such molecular specificity underscores the potential for polyamine-based therapies to selectively target the dysfunctional channel machinery underlying SQTS3.
Their multidisciplinary methodology included patch-clamp recordings from cardiomyocytes harboring the mutant SCN5A channels, illustrating that polyamine treatment extends the duration of late inward sodium currents. Complementary computational models provided mechanistic insights into the electrostatic and steric features facilitating polyamine binding and channel gating modulation. Moreover, pharmacokinetic assessments confirmed favorable bioavailability and cardiac tissue penetration of the tested polyamine analogs, positioning them as viable candidates for therapeutic development.
One particularly compelling aspect of this work is the repurposing paradigm: leveraging endogenous molecules whose physiological roles have been extensively characterized, thereby accelerating the translational pipeline. This contrasts with traditional drug discovery routes, which often involve extensive high-throughput screening and optimization of synthetic molecules. By harnessing polyamines, the study circumvents many hurdles of safety and toxicity profiles, given their intrinsic presence and metabolization pathways in the human body.
Beyond the immediate implications for SQTS3, the findings extend to a broader context of cardiac electrophysiology disorders encompassing mutations in various ion channels. The concept of modulating channel function via small endogenous compounds might inspire innovative approaches for other arrhythmias linked to gain- or loss-of-function anomalies, including Long QT Syndrome, Brugada Syndrome, and catecholaminergic polymorphic ventricular tachycardia. This opens new vistas for precision medicine aimed at fine-tuning ion channelopathies at their source.
Importantly, the research comprehensively addressed potential off-target effects by rigorous in vitro and in vivo screening. No deleterious alterations in cardiac contractility or autonomic regulation were observed, highlighting polyamines’ selective efficacy and safety. This crucial aspect paves the way for clinical trial designs where polyamine derivatives can be tested as monotherapies or adjuncts to existing treatments with the aim of reducing arrhythmia burden and improving patient survival.
From a pathophysiological viewpoint, the study advances understanding of how subtle perturbations in ion channel gating profoundly impact whole-organ function through their influence on action potential morphology and conduction velocity. The successful restoration of action potential duration through polyamine interaction underscores the finely balanced electrochemical environment critical to maintaining cardiac rhythmicity. Such insights reaffirm the importance of detailed molecular characterization to inform therapeutic innovations.
The societal implications of this research are substantial. Short QT Syndrome, though rare, often goes undiagnosed until catastrophic events occur, underscoring an urgent need for preventive interventions. The advent of polyamine-based treatments could transform clinical management by offering less invasive, pharmacological options that directly target the underlying channel dysfunction rather than merely mitigating symptoms or resorting to implantable devices.
From a translational perspective, the investigation combines cutting-edge bioinformatics, molecular biology, and electrophysiology to fast-track bench-to-bedside application. The researchers emphasize the necessity of continued longitudinal studies to monitor long-term outcomes and to optimize dosing regimens, as well as investigations into polyamine effects under variable physiological and pathological conditions including stress and comorbidities.
Finally, the work highlights a paradigm shift toward complexity-informed drug design where endogenous molecular interactions are exploited to achieve maximal therapeutic specificity and efficacy. This paradigm champions a future where personalized medicine harnesses the biochemical language of the cell to rectify disease at its molecular inception rather than relying solely on symptomatic management.
In summary, the repurposing of polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3 marks a landmark achievement with profound clinical and scientific ramifications. It unveils new mechanistic dimensions of cardiac ion channel regulation and proposes a safe, targeted, and effective therapeutic avenue for a devastating yet currently undertreated condition. As the field advances, this approach holds promise not only for SQTS3 but also for a spectrum of cardiac channelopathies, ushering in a new era of molecular precision cardiology.
Subject of Research: Therapeutic modulation of ion channel dysfunction in Short QT Syndrome type 3 using polyamines.
Article Title: Repurposing polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3.
Article References:
Moreno-Manuel, A.I., Cruz, F.M., Macías, Á., et al. Repurposing polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3. Nat Commun (2026). https://doi.org/10.1038/s41467-026-74259-7
Image Credits: AI Generated
Gene therapy reverses Fragile X deficits in mice
Trump touts Apple, Intel chip deal
US President Donald Trump (pictured) stated Apple has struck a deal with Intel to produce computer chips inside the US, a move which marked a significant moment in his administration’s push to reshore semiconductor manufacturing.
“I decided to help Intel because we need to design and build our Chips right here in America,” Trump wrote on Truth Social today (18 June).
He added Apple’s agreement was the latest in a series of wins for his domestic chip strategy, following similar commitments from Nvidia and Elon Musk’s TeraFab project with Intel.
The Apple agreement marks another significant win for Intel. CEO Lip-Bu Tan, who spent much of last year shoring up the company’s balance sheet through major external investments, now appears to be delivering on operational improvements which seemed unlikely just a year ago.
For Apple, the partnership offers a chance to diversify a supply chain which currently depends heavily on TSMC to produce the processors powering its iPhones, iPads and Mac computers.
Any agreement will likely be a foundry deal, since Apple already designs its own silicon.
Apple price increases
Apple CEO Tim Cook told the Wall Street Journal price increases for its products are now unavoidable, citing soaring costs for memory and storage chips driven by the AI boom. He stated Apple had absorbed rising costs for as long as possible, but the pressure has become too great to avoid passing increases on to customers.
A domestic chip supply deal from Intel could give Apple more flexibility in an increasingly constrained global market, though analyst Ming-Chi Kuo has previously suggested any production through Intel’s advanced 18A-P process node is unlikely to reach mass scale before late 2027.
Trump’s post also gave him an opportunity to tout the government’s earlier bet on Intel. Last August, his administration converted roughly $8.9 billion in federal funding into an equity stake of around 10% in the company.
He noted in his post Intel was worth around $100 billion when the government made its offer.
“Now they are worth over 600 BILLION DOLLARS! Nine months, and they’ve increased in value over HALF A TRILLION DOLLARS. America’s stake is now over 60 Billion Dollars.”
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KAIST Creates Next-Generation Self-Powered Wearable Sensor withstanding 668% Stretch
In a groundbreaking advancement that promises to reshape the landscape of wearable technology and soft robotics, researchers at the Korea Advanced Institute of Science and Technology (KAIST) have developed a pioneering self-powered piezoelectric fiber sensor exhibiting unprecedented stretchability and resilience. This novel device, capable of enduring elongations up to 668%, heralds a new era of flexible sensors that can reliably monitor physiological signals over extended periods without relying on external power sources such as batteries.
Wearable medical devices designed to continuously track vital signs—heart rate, respiration, and joint movement—have long been limited by the mechanical and electrical degradation of their sensing components under repeated deformations. Traditional piezoelectric fiber sensors, which convert mechanical forces into electrical signals, often suffer from diminished performance as their thin electrode layers and fragile piezoelectric materials falter during routine bending and stretching. Overcoming this barrier, the KAIST research team led by Professor Miso Kim has introduced a transformative approach that stabilizes sensor function even after thousands of mechanical cycles.
Central to this breakthrough is the adoption of a meticulously engineered “Hierarchical Resilient Design,” wherein resilience is embedded across multiple structural levels of the sensor. This concept mirrors the elasticity of a rubber band, allowing the piezoelectric fibers to recover their original form and function after extensive stretching. The research team achieved this by dispersing elastic polymer microparticles within the piezoelectric nanofibers, creating a Velcro-like interlocking microstructure that enhances the sensor’s mechanical robustness and self-restorative capabilities.
The interface engineering between the sensor’s electrical components also proved critical. By enhancing the bonding between the piezoelectric layers and the electrodes, the team prevented delamination—a common failure mode under deformation—that typically degrades signal integrity. This strong adhesion at the material interfaces ensures continuous charge transfer and maintains stable electrical outputs even when the sensor is twisted, pressed, or stretched significantly.
One of the most remarkable aspects of the sensor’s design is its coil and knot structures. By coiling the piezoelectric fibers, the researchers capitalized on geometric extensions, enabling the sensor to stretch over six times its initial length without losing sensitivity. Furthermore, knot configurations were tested to validate sensor durability under complex and dynamic mechanical stresses such as sudden impacts or localized pressure, demonstrating stable electrical signals regardless of deformation mode.
Beyond mechanical resilience, the KAIST team integrated artificial intelligence techniques to interpret the electrical outputs from the sensor. Utilizing machine learning algorithms, they could accurately distinguish between distinct mechanical stimuli—such as bending, stretching, and pressing—offering a valuable platform for intuitive and precise biosignal monitoring in real-world environments. This capability opens new horizons for dynamic human-machine interfacing, where nuanced movement detection is critical.
What sets this breakthrough apart is its self-powered nature. Unlike conventional wearable sensors that depend on finite battery life, the piezoelectric polymer fibers harvest mechanical energy directly from body movements, converting it into usable electrical signals. This sustainable mechanism not only eliminates maintenance concerns but also allows for ultra-lightweight, unobtrusive devices suitable for long-term wear.
The implications of this technology extend well beyond healthcare monitoring devices. Electronic skins capable of mimicking human sensory reception, soft robotic actuators with sensitive feedback loops, and next-generation digital health tools could all benefit from the combination of stretchability, mechanical resilience, and stable self-generated electrical outputs demonstrated by this platform. Such multifunctional usability places this development firmly at the forefront of flexible electronics innovation.
Professor Miso Kim emphasized the significance of their approach: “By simultaneously achieving mechanical resilience and electrical reliability through fiber structure design combined with precise electrode interface engineering, we have laid the foundation for wearable devices capable of long-term operation under strenuous conditions,” she remarked. This robust design paradigm, she asserts, will empower a new generation of devices that continuously monitor biosignals with unprecedented accuracy and durability.
Published in the prestigious journal ACS Nano, the team’s research showcases both fundamental materials science and applied engineering excellence. The paper titled “Mechanically and Functionally Resilient Piezoelectric Fiber Coils and Knots for Reliable Self-Powered Sensing” details the synthesis of the nanofiber composites, the meticulous fabrication of coil and knot geometries, and a comprehensive analysis of the sensor’s electromechanical performance over extensive cyclical tests.
The scientific community has lauded this work for addressing long-standing issues in flexible sensor design. By merging nanoscale material innovations with macrostructural strategies, the KAIST team has created a versatile sensing platform that bridges the gap between laboratory prototypes and real-world applications. Their work sets a precedent for future interdisciplinary efforts aimed at wearable electronics that demand both high performance and durability.
Funded by multiple National Research Foundation of Korea initiatives, this research underscores Korea’s growing leadership in advanced materials and smart sensor development. The integration of elastic polymer microparticles within piezoelectric nanofibers, combined with interface science and architectural engineering, exemplifies the kind of holistic approach necessary to push boundaries in next-generation electronics.
Looking ahead, this resilient, self-powered fiber sensor technology could transform how we collect and interpret physiological data in ambulatory settings, enable more sophisticated prosthetics with tactile feedback, and empower soft robots with human-like sensory capabilities. As devices become lighter, more adaptable, and energy-autonomous, the convergence of materials science and artificial intelligence will accelerate innovations that make previously impossible applications a reality.
In conclusion, the KAIST team’s pioneering piezoelectric fiber sensor offers a robust and reliable solution to historic challenges in wearable sensory technology. Its remarkable combination of extreme stretchability, stable electricity generation without batteries, and intelligent signal analysis marks a significant leap forward that is poised to impact multiple sectors, from healthcare to robotics and beyond.
Subject of Research: Development of highly stretchable, mechanically resilient, self-powered piezoelectric fiber sensors for wearable devices and soft robotics.
Article Title: Mechanically and Functionally Resilient Piezoelectric Fiber Coils and Knots for Reliable Self-Powered Sensing
News Publication Date: June 18, 2026
Web References: https://doi.org/10.1021/acsnano.5c19628
References: Choi, Y. J., Park, J., Nam, J., Sim, G.-D., Kim, M.-G., & Kim, M. (2026). Mechanically and Functionally Resilient Piezoelectric Fiber Coils and Knots for Reliable Self-Powered Sensing. ACS Nano.
Image Credits: KAIST
Keywords
Self-powered sensor, piezoelectric polymer, wearable medical devices, stretchable electronics, fiber coil sensor, interface engineering, mechanical resilience, electrical stability, nanofiber composites, artificial intelligence, biosignal monitoring, flexible sensors.
Liquid Metal Microcoils Revolutionize Endoscopic Haptics
In a remarkable leap forward for medical technology, a team of researchers led by Zou, X., Zhang, J., and Chan, C.P.Y. have unveiled a groundbreaking advancement in haptic feedback systems designed specifically for endoscopic teleoperation and remote palpation. Detailed in their recent publication in npj Flexible Electronics, this innovative approach employs dense elastomeric liquid metal microcoil-based interfaces to transform how surgeons and medical professionals interact with remote internal environments. The intersection of flexible electronics, smart materials, and precision control opens new vistas for minimally invasive procedures and telemedicine.
At the heart of this breakthrough lies the integration of liquid metal microcoils encapsulated within elastomeric substrates, forming a highly sensitive yet mechanically robust haptic interface. These microcoils are capable of generating precise electromagnetic fields which can be finely tuned to mimic various tactile sensations encountered during palpation of organic tissues. The elastomeric medium ensures that the device remains soft and compliant, paralleling the flexibility of biological tissues, a critical characteristic for interfacing with delicate anatomical structures during endoscopic maneuvers.
Traditionally, the lack of tactile feedback in endoscopic teleoperation has been a significant barrier limiting the surgeon’s ability to perform nuanced examinations and manipulations remotely. Without real-time haptic cues, operators must rely heavily on visual data, often constraining them to less precise interventions. The dense microcoil architecture introduced here circumvents this limitation, delivering graded force feedback that enhances situational awareness and operational dexterity. This certainly augurs well for improved patient outcomes and expanded applicability of robotic-assisted minimally invasive surgeries.
The engineering challenge of embedding electrically conductive liquid metals within stretchable matrices is particularly formidable due to factors such as metal leakage, durability under repeated mechanical deformation, and signal fidelity. By leveraging advanced microfabrication techniques, the research team has managed to arrange multiple liquid metal microcoils in closely packed networks, maintaining electrical continuity while allowing for substantial skin-like elasticity. The resulting elastomeric platform simultaneously exhibits excellent mechanical endurance and electromagnetic responsiveness, making it highly suitable for continuous use in clinical settings.
Further advancing the technology, the microcoils’ electromagnetic emissions can be dynamically modulated to emulate various textures and firmness levels characteristic of different tissue types. Thus, the interface can replicate sensations ranging from firm nodules to soft cystic formations, invaluable during diagnostic remote palpation. This capacity to differentiate subtle differences in tissue compliance could revolutionize tele-diagnostic methodologies and enable the virtual presence of expert clinicians regardless of their physical location.
Additionally, the researchers demonstrated that the compactness and biocompatibility of their design allow seamless integration with existing endoscopic instruments. Since these haptic interfaces are fabricated on flexible substrates that conform to complex geometries, retrofitting current devices for enhanced tactile perception becomes feasible without significant hardware overhaul. This compatibility introduces a pragmatic pathway for rapid clinical adoption and accelerates the translation from lab prototype to bedside tool.
Significantly, the device’s exceptional spatial resolution stems from the microcoil density that surpasses conventional haptic arrays by an order of magnitude. This density enables highly localized force feedback, empowering surgeons to discern minute anatomical features and manipulative pressures, akin to natural touch. Enhanced spatial acuity not only minimizes inadvertent tissue damage but also refines the precision of surgical gestures performed remotely, a vital enhancement for robotic endoscopy.
The durability tests conducted reveal that the elastomeric microcoil arrays withstand thousands of mechanical cycles without degradation in electrical or tactile function. This endurance is crucial for clinical reliability, as surgical procedures often extend over hours and necessitate consistent tactile feedback. The elastomer’s resistance to bodily fluids and sterilization processes further underscores its practicality for repeated use within sterile operating room environments.
Beyond endoscopy, the principles underpinning this technology have vast implications across medical robotics and wearable health devices. From remote rehabilitation to advanced prosthetics, densely packed liquid metal microcoil arrays embedded in soft elastomers could deliver highly intuitive haptic sensations that bridge the gap between man and machine. Their ability to accurately simulate touch and force presents a paradigm shift in direct human-machine interaction technologies.
Expanding the scope of teleoperation, this innovation paves the way for real-time remote palpation performed by specialists thousands of miles away. The combination of high-fidelity haptic feedback with tactile sensation mapping can enable remote diagnosis with unprecedented accuracy. This is particularly transformative for geographically isolated healthcare facilities, where access to expert practitioners is limited, enhancing healthcare equity on a global scale.
Further insights from the study highlight that the electromagnetic microcoils can operate efficiently with low power consumption, vital for portable and battery-operated surgical tools. Efficient energy usage not only extends operational time but reduces heat generation, an important factor in preserving tissue safety and user comfort. The smart material approach balances functionality with operational pragmatism, addressing key limitations in current haptic technologies.
From a materials science perspective, the marriage of liquid metal and elastomer illustrates a masterclass in multifunctional composite design. The liquid metal component, inherently conductive and deformable, harmonizes with the elastomer’s resilience to achieve electro-mechanical transduction without compromising softness. This synergy redefines the possibilities of flexible electronics by providing a multi-physics platform capable of sensing, actuating, and adapting simultaneously.
Another notable aspect lies in the scalability of the fabrication method. This enables mass production of the microcoil arrays with reproducible quality and design flexibility tailored to varied endoscopic devices. Scalability is essential for widespread clinical deployment and cost-effectiveness. By providing a reliable route for industrial manufacturing, the researchers have addressed one of the critical barriers to translating cutting-edge soft electronics into real-world medical accessories.
In conclusion, Zou et al.’s pioneering contribution in developing dense elastomeric liquid metal microcoil-based haptic interfaces represents a landmark achievement with far-reaching consequences for telemedicine and minimally invasive surgery. Their meticulous integration of fluid mechanics, materials engineering, and electromagnetic control offers a new standard for tactile interaction in remote medical procedures. This breakthrough invigorates the field of flexible electronics and sets a blueprint for next-generation human-machine interfaces enhancing surgical precision and patient care worldwide.
As the medical community faces the continuing challenge of providing expert care in increasingly complex and constrained environments, innovations such as these provide a beacon for safely extending human touch beyond physical boundaries. Dense elastomeric liquid metal microcoil haptics are poised to redefine surgical telepresence, promising a future where distance no longer limits the healing power of human touch.
Subject of Research: Dense elastomeric liquid metal microcoil-based haptic interfaces for improving tactile feedback in endoscopic teleoperation and remote palpation.
Article Title: Dense elastomeric liquid metal microcoil-based haptic interfaces for endoscopic teleoperation and remote palpation.
Article References:
Zou, X., Zhang, J., Chan, C.P.Y. et al. Dense elastomeric liquid metal microcoil-based haptic interfaces for endoscopic teleoperation and remote palpation. npj Flex Electron (2026). https://doi.org/10.1038/s41528-026-00608-7
Image Credits: AI Generated
Snap sets out vision for $2,000 smart glasses
Social media company Snap officially unveiled its new AR glasses priced at $2,195, the company’s latest push into the segment.
A decade in the making, Snap stated the AR glasses developed by its dedicated Specs subsidiary would bring AI assistance, work tools, entertainment and shared experiences “into the world around us”.
The device is scheduled to ship later this year, initially in the US, UK and France.
Specs are priced at more than 15-times the price of Snap’s original $130 camera-only Spectacles, which debuted in 2016 and struggled to gain traction.
Snap emphasised main selling points of Specs as being fully standalone, made from Swiss TR90 polymer and available in two sizes.
A 47mm model weighs 132 grams and a 52mm version 136 grams.
Snap argued current smart glasses are lightweight but limited in what they can do, while headsets “are powerful but can feel isolating and cumbersome”.
Specs are designed to address those drawbacks. The display system is powered by Snap’s proprietary liquid crystal on silicon technology, delivering a 51-degree field of view and 16 million colours. It claimed the display “feels like a 24-inch monitor” while working, or a 115-inch home cinema screen placed 10 feet away when watching a movie.
Other highlights include up to four hours of mixed battery life spanning audio and video playback, AI assistance for services including maps and general queries, and the ability to cast a screen and stream content wherever the user is.
Specs run two Qualcomm Snapdragon processors, with one dedicated to computer vision and the other running developer tool Lenses.
Lenses enables the glasses to access interactive features including academic and music educational tools.
Qualcomm struck a multi-year platform deal with the Specs subsidiary in April.
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Google launches Android 17 with multitasking, security upgrades
Google started rolling out Android 17 on its Pixel devices, though some of its headline AI features will not arrive for another few months.
The initial version of Android 17 became available yesterday (16 June) on its devices, with other hardware brands to follow throughout 2026.
A new feature available in the launch is Bubbles, a multitasking tool which lets users collapse any app into a floating window which stays visible on screen, Google stated in a blog post.
Bubbles can be stacked, dragged to position and resized as required. On large-screen and foldable devices, bubbles are docked in a dedicated bar at the bottom of the display.
Google positions the feature as useful for referencing maps, writing notes during a call or keeping texts visible without opening the app switcher.
Screen recording has been updated with a new toolbar and feature called Screen Reactions, which lets users record themselves via the selfie camera while simultaneously capturing what’s on their phone screens.
Bloomberg reported the tool is Google’s response to the growing popularity of reaction-style video across social media, building the format directly into Android to reduce reliance on third-party apps such as CapCut and Instagram Edits.
For foldable device owners, Android 17 introduces a dedicated gaming mode with an optimised 50/50 layout placing a game view on top and a dynamic gamepad below.
Google has also reduced frame drops and improved memory cleanup for high-definition gaming, with native controller remapping available for external controllers.
Security
On the security and privacy front, users can now grant apps one-time location access rather than making a permanent decision and share only specific contacts rather than their full address book.
Lost Mode has been tightened to require biometric authentication alongside a PIN, making it harder for thieves to access a missing device even if they know the passcode.
Live Threat Detection has also been improved to block a greater range of suspicious apps and scams, and enhanced Advanced Protection mode helps keep users safe from sophisticated threats.
To stop bad actors trying to guess their way into users’ phones, Google reduced the number of times someone can guess a PIN and added longer wait times between failed attempts.
Many of Android 17’s more advanced features will follow later this year. Gemini Intelligence, redesigned emoji, smarter voice dictation and vibe-coded widgets will arrive soon, coming first to the Pixel 11 series and upcoming Samsung devices.
Google is also updating Wear OS 7 with longer battery life, better interoperability with connected devices including smart glasses, and Gemini Intelligence features including multi-step app automations.
The Android updates came a week after Apple unveiled a long list of AI and Siri improvements due in the coming months, highlighting the intensifying rivalry between the two mobile platforms.
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KAIST Enhances Humanoid Robot Vision Using Minimal Memory
In a groundbreaking development that promises to revolutionize the way artificial intelligence perceives the world, a collaborative research team from KAIST, MIT, and Microsoft has unveiled a novel technology named “Upsample Anything.” This pioneering innovation substantially enhances the visual acuity of AI systems while drastically reducing the memory demand on hardware, specifically GPU memory. The new method achieves up to a sixteenfold increase in memory efficiency, addressing one of the most critical bottlenecks in real-time AI vision applications for mobile and embedded devices.
The cornerstone of this advancement lies in overcoming the traditional compromise faced by AI-driven image processing systems. Historically, achieving higher resolution visual input required extensive GPU memory and computational power, creating a significant barrier to real-time implementation on resource-constrained devices such as smartphones and humanoid robots. Conversely, compressing images into low-resolution features, which is a common practice to conserve resources, often leads to the loss of crucial visual details like small objects and fine structural elements. This trade-off has long hindered the deployment of precise AI vision in dynamic and mobile environments.
The “Upsample Anything” technology ingeniously sidesteps this issue by introducing a training-free upsampling mechanism capable of reconstructing high-resolution features from low-resolution inputs without additional data training. Unlike conventional methods that necessitate retraining or complex optimization when exposed to new data or environmental conditions, this approach adapts instantly by leveraging the edge and structural information inherent within a single input image. This capability drastically simplifies deployment and customization across diverse AI vision applications.
At the heart of the method is a sophisticated process called test-time optimization (TTO), which refines pixel-wise anisotropic kernel parameters based on the specific low-resolution image. These learned kernels are then applied to foundational feature maps to generate high-resolution representations. The final phase involves pixel-wise anisotropic Joint Bilateral Upsampling, a technique that preserves edge details and texture fidelity while reconstructing the image in high resolution. This multi-stage pipeline ensures that essential visual information is restored with remarkable accuracy and efficiency.
Highlighted through an illustrative example, the research team demonstrated the restoration of a 224×224 pixel image— a common resolution in AI research— to a clarity nearly identical to the original, within approximately 0.4 seconds of computation. This substantial leap in processing speed and memory efficiency heralds a new era for real-time AI vision, where systems can now maintain high precision without the prohibitive cost of extensive hardware resources. The direct implication is that AI can better understand and interact with its environment, making it invaluable for applications requiring fine object detection and manipulation.
The utility of “Upsample Anything” stretches far beyond humanoid robots. Autonomous driving systems stand to benefit immensely, as they depend heavily on the rapid and accurate interpretation of complex visual scenes. With this technology, vehicles can process crucial visual cues in a more resource-efficient manner, enhancing safety and navigation capabilities. Additionally, on-device AI for smartphones and other portable gadgets can achieve superior visual comprehension while minimizing battery drain and thermal load— critical factors for consumer electronics.
The research team’s achievement was officially recognized at CVPR 2026, the most prestigious conference dedicated to computer vision and artificial intelligence. The work earned the “CVPR Compute Gold Star” award, a distinction granted to research that excels in computational efficiency. Furthermore, it was named the “Transparency Champion” for leading in research process transparency and reproducibility, emphasizing the team’s commitment to responsible and open scientific practices. This dual recognition highlights not only the technological ingenuity but also the ethical and procedural rigor of the research.
One of the most remarkable attributes of this technology is its universality and plug-and-play nature. Its training-free design means that no additional datasets or retraining cycles are required when deploying it in different settings. This contrasts sharply with existing upsampling methods that often demand labor-intensive tuning or environment-specific learning. Consequently, “Upsample Anything” can seamlessly integrate into a wide array of AI frameworks, simplifying engineering workflows and accelerating the timeline from development to deployment.
Professor Changick Kim, the project lead from KAIST’s School of Electrical Engineering, emphasized the transformative potential of this technology. He noted that by boosting visual precision with minimal resource demands, the algorithm can catalyze the commercial viability of complex AI entities like humanoid robots and enable more powerful on-device AI applications. The convergence of computational efficiency and high visual fidelity, he added, represents a critical step forward in the quest to bring sophisticated AI capabilities to everyday devices.
This advancement is particularly significant in the context of emerging AI models based on world models— frameworks that aim to understand and predict changes in physical environments. Effective deployment of such models often requires processing a large volume of visual data accurately and expediently. By enabling high-resolution feature upsampling without overwhelming hardware limitations, “Upsample Anything” paves the way for smarter, faster, and more adaptive AI models that truly comprehend their surroundings in detail.
The first author of the study, Minseok Seo, a doctoral student at KAIST, alongside co-authors from MIT and Microsoft, detailed their findings in a paper titled “Upsample Anything: A Simple and Hard to Beat Baseline for Feature Upsampling.” The work is publicly accessible via the arXiv repository (DOI: 10.48550/arXiv.2511.16301), facilitating further exploration and innovation by the wider research community. Their approach exemplifies a blend of elegance and practicality, challenging the assumption that high computational cost is a prerequisite for high-quality visual reconstruction in AI.
In conclusion, the “Upsample Anything” technology marks a significant leap in AI visual processing by resolving a longstanding dilemma between image resolution and hardware resource constraints. Its immediate applicability across various AI-driven fields— ranging from robotics to autonomous systems and portable devices— underscores its impact and longevity. As AI continues to entwine itself with daily human interaction and technological progress, innovations like this will form the backbone of smarter, more capable, and accessible intelligent systems.
Subject of Research: Not applicable
Article Title: Upsample Anything: A Simple and Hard to Beat Baseline for Feature Upsampling
News Publication Date: 17-June-2026
Web References: https://dx.doi.org/10.48550/arXiv.2511.16301
References: Upsample Anything: A Simple and Hard to Beat Baseline for Feature Upsampling, DOI:10.48550/arXiv.2511.16301 (Seo et al., 2026)
Image Credits: KAIST
Keywords
AI vision, upsampling technology, GPU memory efficiency, real-time image processing, test-time optimization, pixel-wise anisotropic kernels, Joint Bilateral Upsampling, on-device AI, humanoid robots, autonomous driving, world models, computer vision, computational efficiency
Innovative Heat Sensor Developed to Monitor Living Cells
In a groundbreaking advance at the intersection of bioengineering and microbiology, researchers at Harvard’s John A. Paulson School of Engineering and Applied Sciences have unveiled a pioneering device known as a pico-calorimeter. This remarkable instrument is capable of directly detecting heat signals emanating from minute populations of living cells, a feat that until now has remained technologically elusive due to the vanishingly small scale of these thermal signatures. By enabling real-time metabolic tracking at unprecedented sensitivity, the pico-calorimeter promises to revolutionize our understanding and monitoring of cellular activity, bacterial growth, and antibiotic response.
At the core of this innovation is the principle that living cells, as they metabolize nutrients, grow, divide, and react to external stimuli such as drugs, intrinsically emit heat. This metabolic heat, although incredibly subtle, offers a direct, unmediated insight into the physiological state of cells. Unlike conventional methods that infer cellular metabolism indirectly through oxygen consumption or chemical byproducts, the pico-calorimeter provides a direct calorimetric measurement, offering a more immediate and accurate assay of cellular energetics.
The technical architecture of the device is a marvel of microengineering. It consists of three ultrafine glass capillaries aligned on a delicately micromachined membrane with near-atomic precision. One of these capillaries harbors the biological sample suspended in a liquid growth medium, while the remaining two serve as thermodynamic reference points. As the bacteria or other cells within the sample metabolize and proliferate, they release minute quantities of heat. This thermal flux generates infinitesimal temperature gradients relative to the reference capillaries, which are then transduced into electrical signals by a nearby thermopile—an exquisitely sensitive heat-to-electricity converter capable of resolving fluctuations on the order of picowatts.
A critical enhancement in this iteration of the pico-calorimeter lies in its housing within a vacuum chamber. This vacuum environment thermally isolates the sensor assembly from ambient thermal noise, dramatically amplifying sensitivity by nearly an order of magnitude compared to antecedent designs. The prior versions employed liquid droplets on suspended membranes, which, while innovative, presented operational challenges and limited sensitivity. The current vacuum-sealed, microfluidic integration advances robustness, usability, and measurement fidelity, marking a milestone in the delicate art of thermal detection at the cellular scale.
Demonstrating the device’s prowess, the research team employed the pico-calorimeter to monitor Escherichia coli growth dynamics, beginning with an initial seed population as modest as thirty to forty individual bacterial cells. This capability to detect and analyze such small biological communities unveils immense potential for applications ranging from fundamental microbiology to clinical diagnostics. Notably, the device was employed to examine bacterial metabolic responses upon introduction of antibiotics with varying mechanisms of action—chloramphenicol, rifampicin, and ampicillin—capturing differential heat signatures indicative of altered cellular viability and activity.
These direct calorimetric measurements have revealed metabolic perturbations well in advance of what traditional culture-based microbiological assays could discern. This capability is particularly transformative in clinical scenarios such as sepsis, where detecting and characterizing bacterial populations at extremely low concentrations in blood is vital but presently time-consuming. The pico-calorimeter’s sensitivity could drastically truncate diagnostic timelines from days to hours, allowing more timely and targeted antimicrobial interventions.
Beyond measuring growth and antibiotic susceptibility, the pico-calorimeter enables continuous, real-time monitoring of fundamental cellular parameters including viability, proliferation rate, and stress responses. This temporal resolution offers researchers the invaluable ability to dynamically track cellular states and transitions, capturing metabolic shifts as cells respond to environmental perturbations or pharmacological treatments. Such insights may open new frontiers in cell biology, pharmacodynamics, and personalized medicine.
This breakthrough device represents the culmination of roughly two decades of meticulous research in the Vlassak laboratory, with contributions building from initial exploration of nano-calorimetry techniques aimed at materials science phenomena such as phase transitions in shape memory alloys and metallic glasses. The interdisciplinary bridge extended to biological systems has ushered in ultrasensitive calorimetry methods capable of assessing metabolic heat production in large cells and complex embryonic development processes, laying foundational expertise for this current bio-calorimetric leap.
Technologically, the fabrication of the pico-calorimeter draws upon state-of-the-art micro- and nanofabrication facilities, including the Harvard Center for Nanoscale Systems. The integration of microfluidics and micromachined sensing elements within thermally isolated environments exemplifies the cutting-edge convergence of materials science, electrical engineering, and biological instrumentation. The multidisciplinary synergy underscores the technological sophistication essential for detecting thermal signals billions of times smaller than everyday heat fluxes.
Commercially, the Harvard Technology Development office has filed multiple patents covering the pico-calorimeter and its applications in antimicrobial susceptibility testing. Juanjuan Zheng, a pivotal figure in this research and founder of an innovative startup, is leveraging the technology to deliver practical, label-free, real-time metabolic readouts. These tools hold promise for broad adoption in life sciences research, pharmaceutical development, and clinical diagnostics, harnessing the power of heat measurement to glean functional insights from minute biological samples.
As the research community embraces this transformative platform, interest has surged from a diverse array of scientific domains. The ability to capture direct metabolic information from tiny, dynamic living systems resolves a long-standing challenge in single-cell and small-population analysis. This heralds a new era where functional metabolic data provides early and actionable information on biological states, ranging from cellular growth and stress response to drug efficacy and resistance patterns.
In essence, the Harvard pico-calorimeter transcends conventional bioanalytical tools by transforming infinitesimal heat emissions into a vivid metabolic narrative. This technological breakthrough not only augments our scientific toolkit but also possesses the potential to accelerate biomedical discovery, enhance therapeutic precision, and ultimately improve patient outcomes by enabling rapid, noninvasive interrogation of cellular function. The implications for healthcare, research, and biotechnology are profound, heralding an exciting frontier where the subtle warmth of life becomes an unequivocal signal of cellular health and response.
Subject of Research: Cells
Article Title: A pico-calorimeter for cellular metabolism and antimicrobial susceptibility testing
References: Proceedings of the National Academy of Sciences
Image Credits: Vlassak Group / Harvard SEAS
Keywords: Calorimetry, Chemical analysis, Life sciences, Biophysics, Single cell profiling, Single molecule analysis, Materials science, Physics, Applied sciences and engineering, Applied physics, Engineering, Electrical engineering, Chemical engineering, Mechanical engineering, Health and medicine, Biomedical engineering
Broadband Photodetection via Si3N4/n-Si Interface
In a groundbreaking advancement for optoelectronic technology, researchers have unveiled a novel approach harnessing the unique properties of Si₃N₄/n-Si hybrid devices to achieve interface-controlled broadband photodetection. This development promises to revolutionize the efficiency and spectral range of photodetectors, devices integral to a wide array of applications from telecommunications to environmental monitoring. The study, recently published in Scientific Reports, highlights how meticulous control over material interfaces can dramatically enhance device performance, marking a significant leap forward in photodetector design and fabrication.
Photodetectors serve as the eyes of modern electronic systems, converting light into electrical signals that enable everything from digital imaging to fiber optic communication. Traditional photodetectors, however, have long been limited by narrow operational bandwidths and sensitivity constraints, curbing their effectiveness in emerging high-performance applications. By integrating silicon nitride (Si₃N₄) with n-type silicon (n-Si), the researchers have engineered a hybrid platform that deftly overcomes these limitations, exploiting interface phenomena to extend detection capabilities across a broad spectrum of electromagnetic radiation.
At the heart of this innovation lies the strategic manipulation of the Si₃N₄/n-Si interface. Silicon nitride, known for its excellent dielectric properties and chemical stability, acts as both a passivation layer and an optical modulator when interfaced with silicon. This interplay at the atomic and electronic scale shapes charge carrier dynamics, reduces surface recombination losses, and enhances photon absorption efficiency. Such interface engineering ensures that the hybrid device is not only highly sensitive but also capable of operating seamlessly over a wide range of wavelengths, from ultraviolet through visible to near-infrared.
The research team deployed advanced fabrication techniques to precisely control the deposition and interface formation of Si₃N₄ on the n-Si substrate. Utilizing plasma-enhanced chemical vapor deposition (PECVD), they achieved a uniform and defect-minimized nitride layer that adheres perfectly to the silicon surface. This meticulous fabrication step is essential as interface traps, commonly induced by imperfections, can severely degrade photodetector responsiveness and noise levels. By minimizing such imperfections, the hybrid device attains an unprecedented signal-to-noise ratio crucial for sensitive detection tasks.
Optical characterization of the Si₃N₄/n-Si hybrids revealed remarkable broadband responsivity, a parameter quantifying the device’s ability to convert incoming photons across various wavelengths into electric current. The devices demonstrated enhanced photoresponse not only in the visible spectrum but also extended into ultraviolet and infrared regions, surpassing conventional silicon-based photodetectors limited by the bandgap constraints of pure silicon. This broadband sensitivity opens the door to new applications where multispectral light detection is necessary without the need for separate sensors.
One of the pivotal mechanisms for this extended response is the formation of interfacial states that facilitate charge transfer and broaden the spectral detection range. These states effectively lower the energy barriers that typically restrict silicon’s photoresponse, enabling efficient utilization of photons with energies both above and below the traditional silicon bandgap. This effect is modulated by the thickness and stoichiometric composition of the Si₃N₄ layer, parameters finely tuned during device fabrication to optimize performance.
Beyond spectral coverage, the temporal response of these hybrid photodetectors is equally impressive. The devices exhibited fast switching times and low dark currents, essential characteristics for high-speed communications and low-light detection scenarios. Reduced dark current, a measure of unwanted noise in the absence of illumination, directly correlates with enhanced sensitivity, thereby allowing the detection of weak optical signals with unprecedented clarity.
Integration compatibility is another striking advantage of the Si₃N₄/n-Si system. Both materials are well-established in mainstream semiconductor manufacturing, meaning that this innovation can be seamlessly incorporated into existing silicon-based electronic platforms. This compatibility facilitates scaling production while maintaining cost efficiency, a critical factor for commercial adoption in industries such as consumer electronics, healthcare diagnostics, and environmental sensing.
The research also delves into the underlying physics governing the device operation. Through combined experimental and theoretical analyses, the study elucidates charge carrier transport across the interface, the role of interface dipoles, and modulation of the built-in electric field that directs photogenerated carriers. Such detailed understanding offers a roadmap for further improvements, potentially inspiring future hybrid systems with tailored optoelectronic properties suitable for specific industrial applications.
In terms of real-world application, these hybrid photodetectors could significantly enhance the performance of cameras, optical coherence tomography devices, and remote sensing instruments. The broadband detection capability reduces the reliance on multiple sensors, simplifying device architectures and improving reliability. Additionally, their fast response times and stability under various environmental conditions are promising for deployment in harsh or variable environments, including space exploration and autonomous vehicle navigation.
This research marks a notable shift in photodetector technology by emphasizing interface engineering to transcend inherent material limitations. By capitalizing on the complementary properties of Si₃N₄ and n-Si junctions, the study injects fresh momentum into the pursuit of universal photodetectors that excel in speed, sensitivity, and spectral range. The findings underscore the vast potential lying in hybrid material systems, motivating continued exploration into interface-controlled photonic devices.
Looking forward, the researchers suggest exploring further modifications to the Si₃N₄ layer such as doping or introducing nanoscale structuring to tailor the interface behavior. Such advancements may unlock new functionalities like polarization sensitivity or even tunable wavelength selectivity, pushing hybrid photodetectors beyond current performance frontiers. These directions align with the broader scientific quest to develop smarter, more adaptable optoelectronic components for the next generation of information and sensing technologies.
In conclusion, the Si₃N₄/n-Si hybrid photodetector described in this study represents a pivotal development that combines material science innovation with practical engineering to address longstanding challenges in photodetection. Its broadband capability, operational stability, and integration potential poise it as a top candidate for a wide spectrum of applications demanding fast, efficient, and reliable light detection. As industries continue to demand more from photonic devices, such interface-controlled systems stand out as a transformative solution poised to redefine the future of photodetection technology.
Subject of Research: Interface-controlled broadband photodetection in Si₃N₄/n-Si hybrid devices
Article Title: Interface-controlled broadband photodetection in Si₃N₄/n-Si hybrid devices
Article References:
Manfo, T.A., Yıldız, D.E., Bağcı, C. et al. Interface-controlled broadband photodetection in Si₃N₄/n-Si hybrid devices. Sci Rep (2026). https://doi.org/10.1038/s41598-026-57951-y
Image Credits: AI Generated
Lab-grown brain-spinal cord model shows ‘irreversible’ nerve damage may be reversed
Ultrathin diamond layer solves major heat problem in future 6G devices

A team of researchers from the Massachusetts Institute of Technology (MIT) and other institutions has developed a new way to improve the performance of powerful electronic devices by using an ultrathin layer of diamond. The breakthrough could help future technologies such as 6G wireless networks, satellite communications, radar systems, and even data centers operate faster […]
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New material approach could lead to lower-power devices
GLP-1 Medications Are Changing Healthcare Faster Than Most People Realize
Telefonica slashes e-waste footprint
Telefonica revealed it reused or recycled more than 4 million devices in 2025, as the operator steps up efforts to hit its zero-waste target by 2030.
The Spanish operator said 95% of its waste was reused or recycled during the year, including 3 million routers and set-top boxes. Devices were collected from customers, operations and offices, with 75% reused and the remaining 25% recycled.
Telefonica also reused more than 780,000 units of network equipment in 2025, adding this enabled it to meet the GSMA-backed industry commitment to reuse and recycle 100% of collected equipment.
In addition, the company claimed progress in mobile devices, collecting nearly 95 tonnes of handsets and reusing more than 357,000 units. It noted this represented 15% of all devices distributed, with all recovered handsets either reused or recycled.
Supplier engagement also forms part of the programme, with the operator working to include circularity in the procurement and equipment design stage through recycling, durability and repairability requirements. Telefonica explained its zero-waste strategy prioritises reuse, with recycling used when equipment cannot be put back into service. This approach helps avoid the manufacture of new equipment and cuts associated resource use and CO2 emissions.
Maya Ormazabal, global director of sustainability at Telefonica, said: “The circular economy is a priority pillar in our sustainability strategy and a key driver for advancing toward a more efficient, innovative, and competitive company.”
She added the approach enables the operator to “contribute to a more responsible use of resources and the reduction of environmental impacts associated with technological activity”, while supporting “more sustainable access to digital capabilities for society”.
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Dutch Authorities Block $115 Million Deal by a U.S. Tech Company
Apple lands Siri AI at WWDC as Cook takes a bow
After two years of over-promising and under-delivering, Apple unveiled an overhauled Siri AI voice assistant with new capabilities, a dedicated app and a foundation built on Google’s Gemini AI.
In January 2026, Apple struck a landmark deal with Google, licencing a custom-built Gemini model purpose-built for Siri and Apple Intelligence and larger than Apple’s previous cloud-based AI models.
At the event, Apple revealed that for the first time the assistant has its own dedicated app with a chatbot-style interface, as the iPhone-maker looks to close the AI gap against Samsung and Google devices.
Siri AI can see what is on a user’s screen, search the web in real time, remember past conversations and surface information such as a friend’s address buried in an old message thread.
“We believe truly helpful AI must be centred around you and your needs,” Apple SVP of software Craig Federighi stated, while laying out a philosophy built around privacy, personal context and deep integration with apps users rely on daily.
Siri AI is now a more conversational assistant capable of understanding context, handling multi-step tasks and interacting more naturally across apps and services. It is also compatible with Visual Intelligence in addition to working across existing apps.
A Search or Ask interface opens when users swipe down from the top centre of the screen, allowing users to search the web using Apple’s AI-powered search and launch apps, send messages, create calendar events, search notes, and perform other tasks.
Apple also plans to introduce an AI agent integration with the App Store, allowing users to delegate tasks such as booking reservations, managing everyday tasks, editing documents, or controlling smart home devices.
On the camera side, a Visual Intelligence section within the Camera app introduces a dedicated Siri mode which sits alongside Photo, Video, Portrait, and Panorama, with the feature using Google Image Search to accurately identify objects the user captures.
Siri AI is embedded directly into Dynamic Island, accessible by swiping down from it, pressing the side button, or saying “Hey Siri”. When a user activates Siri with a wake word or the side button, a Siri animation appears in the Dynamic Island.
The feature will launch in English first, with other languages to follow, and it requires iOS 27. The iOS 27 developer beta dropped June 8, immediately after the keynote.
A public beta is expected in July for those who want to test it early, with the full stable release arriving in September alongside the iPhone 18 lineup
Federighi said Siri AI will not be available initially in the European Union on iOS and iPadOS.
“In China, Siri AI and the other new Apple Intelligence features will not be available while we work through regulatory requirements,” he added
Analyst take
Ben Wood, chief analyst at CCS Insight, noted many of the Apple Intelligence capabilities will be familiar to people who have been using an Android smartphone for some time and in some instances are already available to Apple users who have installed third-party AI apps such as ChatGPT.
“Although it is late to the party, the company has a strong record of taking existing technology and implementing it in a more intuitive way, allowing users to easily discover capabilities in daily use,” he said. “I think the most obvious example of this is the integration of Siri into the Dynamic Island at the top of an iPhone.”
Child safety
New parental controls will, by default, allow children to access only the apps which parents have approved to flip the model from opt-in restriction to opt-out permission. A “ask to browse” feature requires children to seek permission before visiting every new website and not just flagged ones.
On the content side, Apple is expanding its existing nudity-detection tools by adding automatic blurring of gore in messaging apps, with parents alerted when such images are encountered, which builds on earlier features that already blurred nudity by default.
Wood noted Apple’s child-safety push is a welcome and timely move as concerns about smartphones and online harm grow among parents and regulators.
He explained the parental controls, tools and developer APIs are positive steps, but they do not go far enough on their own.
“I believe that stronger cross-industry safeguards need to be built into operating systems at a deeper platform level that deliver protection not only in native apps but for every interaction a child has with a device,“ he said. “Apple is well-positioned to be a driving force in this area.”
Cook’s swan song
Outgoing CEO Tim Cook (pictured) opened and closed the conference’s presentation, in what many expect will be his last appearance before his planned transition to executive chairman on 1 September, when SVP of hardware engineering John Ternus will take over as CEO.
“Tim Cook’s last WWDC keynote as Apple CEO may be the most important one and it was a clear reflection of his leadership: disciplined, ecosystem-first, privacy-led, and focused on making technology useful at scale,” stated Francisco Jeronimo, VP of client devices at IDC.
Cook closed the keynote by stating creating the best products in the world to deliver experiences that enrich people’s lives has always been Apple’s North Star.
“It’s been the honour of a lifetime to help advance that mission with teams whose creativity, care, and conviction continue to make a lasting difference in people’s lives,” he said.
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Charlie Kirk Assassination | The Weapons of Our Warfare are Not Carnal
