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Experimental Copper-Based Drug Clears Alzheimer’s Plaques and Boosts Memory in Mice

Using the APP/PS1 mouse model of familial Alzheimer’s disease, Pyun et al. investigated the effect of Cu(ATSM) on brain microvascular abundance and function of P-glycoprotein and the associated effects on exogenous amyloid-beta clearance, brain amyloid burden, and cognitive function. Image credit: Pyun et al., doi: 10.1021/acschemneuro.6c00252.

Copper diacetyl bis(4-methyl-3-thiosemicarbazone), or Cu(ATSM), restored a key waste-removal system in the brain, reducing toxic amyloid-beta buildup and improving spatial memory in lab models of Alzheimer’s disease, according to a team of researchers at Monash University.

The post Experimental Copper-Based Drug Clears Alzheimer’s Plaques and Boosts Memory in Mice appeared first on Sci.News: Breaking Science News.

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Featured Image: Low-Mass Brown Dwarfs in a Class of Their Own?

IC 348

The glowing green nebula in this JWST image surrounds the star cluster IC 348, which is the subject of a recent study by Kevin Luhman (Penn State University) and Catarina Alves de Oliveira (European Space Agency). Using JWST’s Near-Infrared Camera, Luhman and Alves de Oliveira searched the cluster’s young stellar population for free-floating brown dwarfs β€” objects that are less massive than stars but more massive than most planets β€” and discovered multiple candidates with masses down to just twice the mass of Jupiter. Follow-up JWST spectroscopy confirmed the masses of these objects, making them the lowest-mass brown dwarfs known to date. In addition to their mass, these newly discovered brown dwarfs are remarkable because their spectra show evidence of hydrocarbon molecules, the exact identities of which are not yet known. Luhman and Alves de Oliveira proposed that low-mass brown dwarfs bearing this chemical signature be inducted into a new spectral class called β€œH” for β€œhydrocarbon.” To add to the intrigue of these objects, the authors also discovered signs of circumstellar disks around two of them, suggesting that they may be capable of forming and harboring planets. To learn more about the low-mass brown dwarfs in IC 348, be sure to check out the full research article linked below.

Citation

β€œA New Spectral Class of Brown Dwarfs at the Bottom of the IMF in IC 348,” K. L. Luhman and C. Alves de Oliveira 2025 ApJL 986 L14. doi:10.3847/2041-8213/addc55

The post Featured Image: Low-Mass Brown Dwarfs in a Class of Their Own? appeared first on AAS Nova.

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Event 201 Again | 2024 Desktop Exercise War-Gamed Bioterrorist Attack that Kills 280,000 Americans in a Single Day – on 4 July 2025

In a podcast discussion, Dr. David E. Martin warns of a predicted bioterror attack on July 4, 2025, as outlined in the β€œNational Blueprint for Biodefense” report, which anticipates 200,000 animal and 280,000 human casualties in one day. He compares it to the prior Event 201 exercise related to COVID-19, urging public alertness.

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