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MIT Engineers Testing Exotic ‘Electrospray’ Propulsion for Faster, More Maneuverable Spacecraft


Massachusetts Institute of Technology (MIT) engineers are testing a new category of advanced-propulsion “electrospray” thrusters that combine the benefits of modern chemical and electrical thrusters used to drive satellites and other spacecraft into one hybrid system.

The team behind the novel propulsion technology said that electrospray thrusters could allow mission planners to design smaller, more nimble satellites and spacecraft capable of performing faster, more powerful maneuvers or slower, more precise adjustments, depending on mission requirements.

Electrospray Combines the Best of Chemical and Electric Propulsion

Launching rockets into space still requires chemical thrusters, but once spacecraft and satellites reach orbit, engineers continue to develop novel propulsion methods that are more efficient than chemical propulsion technologies. Given the strict weight requirements of spacecraft launches, finding alternatives to chemical propellants has opened up a wider range of mission profiles.

Among the most common alternatives to chemical thrusters are designs that combine electrical energy with small amounts of propellant to produce small but sustainable thrust. Although electric thruster designs require less fuel, saving significantly on launch weight, they also lack both the power and the rapid, quick burst performance of chemical thrusters.

According to study author Amelia Bruno, a former postdoc in MIT’s Department of Aeronautics and Astronautics (AeroAstro), combining chemical and electrical propulsion into a single system is “the best of both worlds.”

“This opens the door for small satellites to do even more science, more observations, and more interesting missions, all on a smaller and cheaper platform,” Bruno explained to MIT News.

Study co-author Paulo Lozano, the Miguel Alemán Velasco Professor of Aeronautics and Astronautics at MIT, agreed, noting that combining both technologies could enable a CubeSat mission to Mars “where they could make the journey slowly, using electrospray thrusters.”

“You could then use your chemical thrusters to quickly move to look at interesting features,” the professor added. “You could have a lot more flexibility to do a lot more things.”

ASCENT Rocket Fuel as the Thruster’s Ionic Liquid Propellant Enables Hybrid Design

According to a statement detailing the new electrospray thruster’s design, the ones developed by the MIT team are about the size of a thumbnail. Each thruster is also placed directly above a small fuel reservoir. For the MT electrospray thrusters, the fuel is an ionic liquid propellant, a liquid composed of salts that remain dissolved in a solution.

electrospray propulsion
These four flight-unit electrospray thrusters were delivered by the MIT Space Propulsion Laboratory to NASA for the upcoming Green Propulsion Dual Mode (GPDM) mission. Image Credit: Amelia Bruno

“Ionic liquids are very stable and can even remain a liquid in space, which not a lot of materials can do,” Bruno explained. “And it’s basically a sea of ions, which is why we base our technology around it, so we can pull those ions out into an electrospray.”

When a spacecraft’s battery delivers an electric charge to the fuel reservoir, the ions within the fuel also become charged. The thruster’s design channels the charged particles from the reservoir and through the thruster tips, expelling them into space.

Although the team has tested several types of ionic propellant in its electrospray propulsion thrusters, Bruno and Lozano have collaborated with the U.S. Air Force to synthesize an all-new ionic liquid propellant, which they are calling the Advanced SpaceCraft Energetic Non-Toxic propellant, or ASCENT.

Originally designed as a “green” alternative to extremely hazardous hydrazine rocket fuel that has been the staple in the rocket industry for decades, Bruno notes that ASCENT “happens to be an ionic liquid mixture.”

“And we said, hey, that’s the stuff we typically use,” the researcher added. “Theoretically, this should work. Let’s go figure out how.” 

Tests: Chemical Propellant Equally Efficient as Conventional Ionic Liquids

To test their electrospray design, each tested thruster was attached to a small reservoir about the size of a single Lego brick, and then the reservoir was filled with ASCENT. Next, electrospray thrusters were mounted on opposite sides of a traditional CubeSat.

To simulate the microgravity environment of Near-Earth Orbit, the team placed the thruster-equipped CubeSat on a MagLev stand. The team noted that the MagLev in Lozano’s lab is installed inside a large vacuum chamber. This design allows the researchers to fine-tune the environment to best mimic the conditions in space.

During a series of tests, the team applied varying voltage levels to the electrospray thrusters. As expected, the reaction produced a spray from the thruster nozzles, which spun the CubeSat around on the MagLev stand like a freely spinning top.

During each thruster firing, the team measured the amount of thrust produced. This data, combined with the voltage and fuel data, allowed the team to calculate ASCENT’s fuel efficiency during continuous operation. Some tests lasted up to 100 hours.

When the MIT group evaluated the results, they first determined that the choice of ASCENT was correct, as it successfully fueled each electrospray thruster. Even more significantly, the tests revealed that the readily available chemical propellant was equally efficient as conventional ionic liquids.

“Compared to our normal electrospray propellants, ASCENT can provide similar performance in terms of thrust,” Bruno explained. “Now that we know our thrusters work with ASCENT, we can start thinking of all the ways we can make them even better.”

Testing Electrospray Thrusters on NASA’s Green Propulsion Dual Mode Mission

When discussing the benefits of their successful electrospray thruster tests, Lozano noted that a spacecraft with electric and chemical thrusters can share a single fuel tank. Due to its compact design, this hybrid electrospray thruster could be mounted on a small satellite.

Fortunately, the team won’t have to wait long to see their thruster in action. According to the research team, whose work was partially supported by NASA, their design will be incorporated into NASA’s upcoming Green Propulsion Dual Mode mission scheduled to launch in November. The Green Propulsion Dual-Mode mission will carry a briefcase-sized CubeSat with a primary chemical thruster and specially designed electrospray thrusters, making it the first attempt to combine electrical and chemical propulsion in a small spacecraft.

“This will be the first time that a satellite will have a shared propellant tank,” Lozano explained.

Although a large portion of proposed electric propulsion missions that might employ the new electrospray thruster are designed to explore deeper into the Solar System and beyond, Lozano also highlighted the technology’s possible applications closer to home. For example, satellites equipped with both technologies could rapidly respond to environmental or climate changes in real time with a speed and efficiency unavailable with current propulsion options.

“Say there’s a storm coming, and you’d want to deploy your constellation of small satellites to observe over one location,” the researcher explained. “You could choose to send them quickly or slowly, depending on the nature of the observation.”

“And the only way to do that is if you have two propulsion systems, which is now possible,” he added.

Although the mission will not launch before November, Bruno noted that a successful test could allow engineers to consider missions they never thought possible.

“Now that we know our thrusters work with ASCENT, we can start thinking of all the ways we can make them even better,” the researcher explained.

The study “Performance Characterization of Electrospray Thrusters with Energetic Ionic Liquid Monopropellant” was published in the Journal of Propulsion and Power.

Christopher Plain is a Science Fiction and Fantasy novelist and Head Science Writer at The Debrief. Follow and connect with him on X, learn about his books at plainfiction.com, or email him directly at christopher@thedebrief.org.

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Decades of NASA Satellite Data Reveals the Elusive, Enigmatic ‘Urban Pulse” of Six Major Cities


A multi-institutional team of researchers led by University of Connecticut Professor Zhe Zhu has developed a method for measuring the dynamic, real-time activity of urban environments from space, which they are calling an “Urban Pulse.”

The research team behind the novel urban activity metric said that monitoring a city’s Urban Pulse could help mitigate uncontrolled urban sprawl or decay and enable environmentalists and urban planners to intervene before disasters become unavoidable.

Measuring an Urban Pulse Could Reveal Neighborhoods ‘Not Doing Well”

Although environmentalists and urban planners have a wide range of tools to measure the activities within a city, Zhu notes that scientists have spent decades merely capturing the “outcome of urbanization,” such as a finished road or a newly completed home. However, the researcher and lead author of a study detailing the Urban Pulse methodology added that, even with all the current tools, “you don’t really see the dynamics within an urban area.”

According to a statement detailing the new approach, a city’s pulse is determined by all construction activity within it. Along with new construction, the metric includes repairs, infrastructure improvements, or expansion into previously undeveloped green spaces. When used correctly, the researchers said that it can help determine “if and where their city is not doing well.”

“This would allow (authorities) to be proactive rather than conducting a metaphorical autopsy after the decay of an area is evident,” the team explained.

Bridging the Gap Between Abstract Urban Theories and Measurable, Real-World Data

To test their approach, the team evaluated the Urban Pulse of six cities: Seattle, Shenzhen, Lagos, Mumbai, Dubai, and Mexico City. This involved a deep examination of what the team termed “decades of dense time-series data” collected by NASA’s Harmonized Landsat and Sentinel-2 (HLS)  satellites for physical transformations in an urban environment, such as new construction, measurable infrastructure improvements, and demolition.

Instead of analyzing each city’s changes manually, the team evaluated the above changes on what they called “the neighborhood level” using a deep-learning and time-series-analysis approach called CAPES, developed by former UConn postdoctoral researcher Ji Won Suh. The team said that, by observing these “high-frequency rhythms of development” from a broad ‘outer space’ perspective, their approach “bridges the gap between abstract urban theories and measurable, real-world data.”

Urban Pulse
This figure visualizes Dubai’s rapid expansion as a glowing “urban pulse.” Mapping monthly construction data from the city’s top 65 most active locations, the ridge plot reveals how distinct neighborhoods grow through spiky, cyclical, and asynchronous bursts. Rather than a steady wave, urbanization unfolds as dynamic, localized heartbeats, exposing the complex rhythms driving a modern metropolis. Image Credit: Zhe Zhu/GERS Lab.

After examining CAPES’ results, the team found several key markers within the Urban Pulse. For example, the view from space revealed that growth within cities is not smooth and steady. Instead, Zhu and colleagues said that development happens in “abrupt, intense, and episodic bursts of construction.”

CAPES also revealed that the rhythms of an urban environment are cyclical. For example, while a city may show relatively steady growth on a broader level, individual neighborhoods go through “dramatic boom-and-rest cycles” of expansion and dormancy that don’t appear to follow predictable annual seasons.

The third pattern revealed by measuring the six cities’ Urban Pulse from space was that cities are “asynchronous,” meaning a single city does not ‘beat’ in unison. The team noted that neighborhoods “pulse at completely different times.” When it functions properly, this “uncoordinated rhythm” helps prevent the city’s infrastructure and labor markets from “overheating.”

Unlike previous methods for tracking a city’s evolution, the team noted that their Urban Pulse approach can help researchers “visualize a city’s reaction to global shocks.” For example, the team said that their analysis captured “the exact moment the COVID-19 pandemic triggered a widespread, synchronized ‘cardiac arrest’ in urban development worldwide.”

However, their new tool also revealed what the researchers termed “profound inequalities” in how individual cities recovered from the dramatic halt to urban growth. For example, the team said that the Urban Pulse of Shenzhen revealed synchronized ‘dips’ in activity, followed almost immediately by “rapid, policy-driven rebounds.” However, the same Orban Pulse analysis showed that the reactions in Mumbai and Mexico City were much more “muted.”

“It’s like in human beings,” Zhu explained. “When you get a disease, it’s not going to show up exactly the same in different people.”

A ‘Very Impactful Tool’ for Navigating Cities

Although the Urban Pulse metric offers a tantalizing tool for academics, the team noted real-world benefits for global policymakers, urban planners, and environmentalists, adding that “it serves as an early warning system.”

“By monitoring the rhythm, rate, and amplitude of neighborhood pulses, governments can identify early signs of urban decay or unsustainable sprawl and intervene before crises become entrenched,” they explained.

The team also suggested that making Urban Pulse data publicly available could “revolutionize how everyday people interact with their cities.” For example, an urban family considering a move to a new city or a new part of their current city could track a target neighborhood’s pulse to spot early warning signs of decay or early indicators of positive-trending growth. The same data could help business owners plan new locations or expanded service routes, depending on the business profile and the local Urban Pulse trends.

“This is going to be a very impactful tool influencing not only top-down policy decisions from governments but also bottom-up decisions from everyday people navigating their cities,” Zhu explained.

In a recent study, “The Urban Pulse: Diagnosing the urbanization process as spiky, cyclical, and asynchronous” was published in the Proceedings of the National Academy of Sciences.

Christopher Plain is a Science Fiction and Fantasy novelist and Head Science Writer at The Debrief. Follow and connect with him on X, learn about his books at plainfiction.com, or email him directly at christopher@thedebrief.org.

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“SpiderCam, SpiderCam, Does Whatever a Spider Can?” 3D Camera Inspired by Jumping Spider is First to Operate Below One Watt


Northwestern University engineers have unveiled an extremely energy-efficient 3D camera, called SpiderCam, inspired by how jumping spiders judge depth before making a calculated leap.

The research team behind the novel device said their technology could help engineers build wearable technologies, assistive devices, robots, drones, and other futuristic technologies that benefit from quickly and efficiently gauging their surroundings.

How Jumping Spiders Inspired Energy-Efficient SpiderCam

According to a statement announcing SpiderCam, 3D cameras typically estimate image depth in two ways. The first approach involves captured images from multiple viewpoints and comparing them, and the second involves projecting a light source, often an infrared (IR) laser, and then measuring the reflection.

Although both methods can produce realistic three-dimensional images, they can require significant computing power, additional operational energy, and often expensive hardware such as lasers.

Fortunately, millions of years of evolution have resulted in a creature that possesses a hyper-efficient way of estimating depth: the jumping spider.

“Jumping spiders jump to catch prey, to avoid predators and to get around, and that requires excellent vision,” said Northwestern’s Emma Alexander, the study’s corresponding author and an expert in bio-inspired computer vision. However, the researcher notes that their brains are extremely small, requiring the ability to calculate distances in an energy- and computationally efficient way.

According to Alexander, jumping spider eyes have multiple layers of retinas in each eye, rather than just one as in human eyes. When measuring distance, each retina focuses on an image at a slightly different distance, resulting in some images being blurrier than others.

“They see multiple levels of focus at all times,” Alexander explained. “So, they are always collecting pairs of images.”

After collecting these images in real time, the fly’s poppyseed-sized brain compares their sharpness, yielding a surprisingly accurate depth estimate, as evidenced by the creature’s ability to jump with precision.

Prototype Captures Images at Two Distances and Compares Their Blurriness

Inspired by nature’s hyper-efficient, extremely accurate depth estimation method, Alexander’s team decided to build a 3D camera using the same basic approach.

“We wanted to understand whether we could borrow some of the same principles to create an extremely energy-efficient depth sensor that could be used in resource-constrained situations where users don’t have unlimited access to power,” Alexander explained.

SpiderCam camera jumping spiders
Called SpiderCam, the new device senses depth the same way that jumping spiders judge distances before making a high-precision hop. The camera produces real-time 3D maps while consuming less than a watt of power. That’s less energy than used by a standard nightlight. Image Credit: Emma Alexander/Northwestern University.

Instead of capturing images at multiple distances, as the jumping spider’s eye does, the Northwestern team’s initial design captures two images of the same scene at different focal lengths. Next, the system uses a custom algorithm to analyze the sharpness of the edges and textures captured in each image. The team said this analysis acts as a “translator between blur and distance” in the fly’s brain, resulting in “depth measurements in real time.”

To best approximate the naturally evolved energy efficiency of a jumping spider’s eye, Alexander’s team built the algorithm directly into a customizable computer chip specifically optimized for energy efficiency called a field-programmable gate array (FPGA).

The final prototype integrating the team’s dual-lens system generates depth maps at 32.5 frames per second. Critically, it generates this level of accurate 3D maps while consuming 624 milliwatts of power. For comparison, the team notes that 624 milliwatts is “less energy than used by a standard nightlight.”

Future Versions Could be Even More Energy Efficient

Although the team said that the current version of the SpiderCam is the “first passive FPGA-based 3D camera system to operate below one watt,” they hope to improve its optics and expand its field of view. Once they have a commercial-grade version, the team hopes to integrate SpiderCam into wearable devices and small robots.

Beyond proposed applications, the Northwestern team said that they “envision” a future, ultra-energy-efficient version  of the chip capable of “bringing 3D vision to applications where conventional depth sensors are impractical.”

“I’m very interested in settings where you’re very resource constrained and can’t just plug a camera into a wall,” Alexander explained. “For example, it could be deployed in field settings with limited power.”

“Separately, I also think it’s particularly exciting for applications like augmented reality where you’re interfacing with the physical world and need to know the locations of objects around you,” the researcher added.

The study’s co-first authors, Marcos Ferreira and Tianao Li, presented this work at the Computer Vision Foundation’s Conference on Computer Vision and Pattern Recognition (CVPR) in Denver. Complimentary registration is available for members of the media.

Christopher Plain is a Science Fiction and Fantasy novelist and Head Science Writer at The Debrief. Follow and connect with him on X, learn about his books at plainfiction.com, or email him directly at christopher@thedebrief.org.

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Ancient Europeans Ate Some Pretty Gross Things, but The Ickiest One Was Probably by Accident


An analysis of dental tartar containing traces of human diets dating back over 33,000 years has revealed that ancient Europeans and many early Asian populations likely only ate insects by accident, perhaps as larvae in the carcasses of dead animals.

Conversely, the new study found that intentional insect consumption, called entomophagy, was more common in tropical regions and among Neanderthal populations.

Although the difference has some cultural and religious roots, the team found evidence that the abundance of insects in the tropics and the decreasing ability of humans migrating away from the tropics to digest insects likely led to the modern-day separation over thousands of years.

The Institute of Evolutionary Biology (IBE), a joint center of the Spanish National Research Council (CSIC) and Pompeu Fabra University (UPF), research team behind the new findings suggests their research could help explain why some modern populations still consume insects as food while other parts of the world consider it gross or taboo, especially given the increasing food demands of a rising world population.

Insect Consumption in Ancient Northern Europeans Likely Accidental

According to a statement announcing the new research, hundreds of millions of people currently include insects in their diet. However, they also note that most of the Western world continues to “show an aversion” to including any of the more than 1,611 insect species designated as edible by the Food and Agriculture Organization of the United Nations (FAO) in theirs. Although some theories suggest the difference is almost purely cultural, the team concedes that “its origin remains unknown.”

To explore the origins of human entomophagy, the IBE analyzed 745 samples of ancient human dental tartar dating back to 33,000 before present. According to the team’s results published in the journal Science Advances, dental tartar (sometimes called dental ‘calculus’) is a critical archaeological tool because it preserves the DNA of the species these human ancestors consumed during their lifetimes.

Although the analysis found evidence for entomophagy amongst virtually all ancient populations sampled in the study, the levels varied dramatically. Notably, the evidence suggested that ancient humans in northern Eurasia did not routinely eat insects in measurable quantities. Instead, any consumption was likely incidental, including consumption of insect larvae in rotting food.

Curious whether the lack of entomophagy in ancient European and Central and Northern Asian populations was purely cultural or whether genetic and geographic factors were involved, the team studied human genes involved in chitin digestion. Chitin, which can be found in some marine animal shells, is also part of an insect’s hard exoskeleton.

According to the study authors, the analysis revealed that the ‘chitinase’ genes in North Eurasian human populations “carry mutations that confer a reduced capacity to digest insect exoskeletons.” Their analysis revealed that this reduced capacity to digest insect exoskeletons has persisted in the genomes of modern Eurasian populations “for the last 9,000 years,” which would coincide with the widely accepted date for the origin of agriculture.

Pablo Librado, study leader and a principal investigator at the IBE, said the “scarce presence of insects in the diet of northern Eurasians” suggests that the cause may not lie solely in more recent cultural factors but also in ecological and evolutionary components dating back several millennia. 

Neanderthals and Denisovans Probably Ate Insect Larvae in Rotting Meat

When the team compared data from ancient human tartar with that of ancient Neanderthals, they found that Neanderthals engaged in much higher levels of entomophagy than humans living in the same regions. According to the study authors, Neanderthal insect consumption levels were similar to those found in western chimpanzee populations, which the researchers note “rely on entomophagy to supplement their diet on the savanna, especially during periods of drought.”

Further analysis of the extracted insect DNA showed that the group most commonly consumed by the Neanderthal specimens included flies and mosquitoes. Although the team only analyzed the DNA, they noted that a recent hypothesis suggests Neanderthals ate carcasses laden with mosquito larvae.

“The abundance of mosquito remains reinforces the possibility that the carcasses of their prey were kept in ponds and marshy areas, where mosquitoes lay their eggs,” the team’s statement explained.

An analysis of the Neanderthal DNA and the DNA from the lone Denisovan study subject revealed that both ancient hominid populations could digest chitin. This result reinforced the genetic basis for increased or reduced entomophagy beyond cultural factors. 

Humans Ate Fewer Bugs When They Moved Away from Tropical Regions

One geographic component identified by the chitinase DNA analysis showed higher levels of digestive enzyme expression among humans living in or near the tropics. However, the expression of these enzymes gradually decreased as populations moved away from tropical regions. The team said this variation, which has been maintained for at least the last 9,000 years, “reflects the abandonment of entomophagy in European populations.”

Manuel Piñero, a predoctoral researcher at the IBE and first author of the study, noted that large numbers of insects must be consumed to offset the “high caloric cost” of collecting them, which might explain the higher levels of entomophagy in this region.

“In the tropics, there is a greater availability of social insects, such as termites and locusts,”  Piñero  explained, adding that the biomass and diversity of tropical edible insects enable “sustainable exploitation throughout the year.” The researcher also noted that insect consumption “adds to pest control.”

When discussing the implications of their findings, Librado highlighted the DNA and geographic factors the IBE team uncovered.

“Beyond cultural or religious factors, our results suggest that the reduced availability of insects in non-tropical areas may have been a key factor in the abandonment of entomophagy, leading to a reduced capacity to digest insect exoskeletons,” the researcher explained.

Christopher Plain is a Science Fiction and Fantasy novelist and Head Science Writer at The Debrief. Follow and connect with him on X, learn about his books at plainfiction.com, or email him directly at christopher@thedebrief.org.

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After Swiss Scientists Injected ‘Repair’ Microrobots into the Injured Spinal Cords of Fish and Mice, Something Incredible Happened


Scientists from ETH Zurich in Switzerland have announced a series of successful experiments involving the repair of injured spinal cords in zebrafish and mice after being injected with magnetically controlled microrobots containing pluripotent stem cells.

According to a statement announcing the ETH team’s work, both the zebrafish and mice injected with the microrobots showed improved movement and normalized exploratory behavior within just a few days after treatment.

Although the initial studies were confined to lab animals, the team hopes their magnetically controlled microrobot approach to the precision delivery of pluripotent stem cells could eventually be adapted for humans with spinal cord injuries.

Spinal Cord Repair Microrobots Treat Nerve Cells That Resist Regeneration

Unlike some cells in the human body, nerve cells within the spinal cord rarely regenerate on their own. If the spinal cord is injured, scarring can further reduce the ability of the nerve fibers within the cord to regrow. For people living with spinal cord injuries, this scenario can offer a bleak prognosis for recovery.

In recent decades, scientists have turned to the natural regenerative properties of pluripotent stem cells. Although the use of stem cells was initially controversial due to the need to extract neonatal stem cells, scientists ultimately learned to convert ordinary stem cells into pluripotent stem cells capable of becoming any cell type in the human body.

The most promising approach involves implanting stem cells at the site of the injury and then using electrical stimulation to promote the growth of new cells. However, according to the ETH team behind the new approach, the current method has several drawbacks.

First, stimulating the cells requires the use of implanted electrodes. Second, the team notes that after transplantation, many of the stem cells “do not always survive or integrate properly into the existing tissue.”

To improve healing and increase the chance of restoring spinal cord nerve cell function, they said their new approach combines therapeutic stem cells with magnetoelectric nanoparticles and uses magnetic fields to guide them to the “precise site of an injury” and “stimulate the stem cells to accelerate repair.”

NPCbots Combine Stem Cells and Magnetically Controlled Nanoparticles

To construct their magnetically guided spinal cord repairing robot, the team built what they termed a “biohybrid microrobot.”

First, the team creates pluripotent stem cells from adult cells by genetically manipulating them in the lab. The result is what researchers call an “induced” pluripotent stem cell (iPS). According to the study authors, these newly pluripotent iPS cells are used to derive living neural progenitor cells (NPCs), meaning “they have the potential to differentiate into various types of nervous system cells.”

Next, the team creates customized magnetic nanoparticles consisting of two layers. The inner layer responds to the “commands” from the magnetic fields used to control them, and an outer layer that converts this response into an electrical signal.

According to Professor Salvador Pané i Vidal of the Multi-Scale Robotics Lab at ETH Zurich, each tiny robot has a reservoir near the center “where we trap the cells.” The professor said the best way to accomplish this is to inject the nanoparticles into a solution with the NPC, “and wait for the two components to bind.”

After 30 minutes, the process is complete, and the team is left with a batch of nanobots, each around 6 micrometers in size. Since the new robots combine a magnetic bot and a reservoir of NPCs, the team named them ‘NPCbots.’

In preparatory cellular experiments, the researchers used hundreds of thousands of NPCbots. However, several million were required for animal trials.

Zebrafish and Mice Regain Movement After Injections

To test the efficacy of their new NPCbots, the ETH team injected millions of them into the spinal cord of zebrafish larvae with spinal cord injuries. To improve the chances of nerve regeneration, the NPCbots were injected directly into the site of the injury.

After injecting the microrobots, the injury site was subjected to electromagnetic fields. Although the repair was not immediately evident, the team noted that after three days, the zebrafish with the injured spinal cords “exhibited nearly normal swimming and exploratory behaviour.”

microrobots spinal cord
At the start and after three days: the top images show the uninjured spinal cord of a zebrafish; those in the middle show the injured spinal cord; and those at the bottom illustrate how the nerve cells grow thanks to the microrobots. Image Credit: ETH Zurich.

Next, the team injected millions of NPCbots into mice with completely separated spinal cords. According to the team, the results were “very promising.”

“After 28 days, the animals’ nerve cells had reconnected at the site of the injury,” they explained.

The team said further observation of the treated mice revealed “increasingly normal movement patterns,” including improvements in gait, stride length, and coordination. The ETH team also noted that the mice’s exploratory behavior “improved significantly.”

microrobots spinal cord repair
Schematic illustration of nerve cell recovery in zebrafish and mice. Image Credit: ETH Zurich.

When discussing the mouse experiments, the team described the result as “particularly significant” because zebrafish spinal cords regenerate, whereas mouse spinal cords do not. They also noted that the treatment was “well tolerated by the animals,” with no reported immune reactions or adverse effects.

Minimally Invasive and More Precise Treatments with Microbots

Unlike science fiction movies, where tiny robots repair tissue mechanically, the research team said that the stem cells carried by the NPCbots are exposed to electrical stimulation, “greatly enhancing their differentiation after transplantation.” This means the nanoparticles convert the electric signals from the EM field into electrical impulses, stimulating healing.

Unlike more complicated stem cell procedures that use implanted electrodes and cables, the team said they only needed to apply external magnetic fields around the spinal cord injury site. The team said this simplification was “crucial,” since the spinal cord is considered extremely sensitive. They also note that the ability to manipulate the frequency and field strength of magnetic fields, combined with their ability to penetrate deeply into tissue, makes the entire process safe and easy to control.

“Microrobotic guidance makes the treatment more precise and minimally invasive,” Hao explained.

After the NPC bots have delivered and stimulated the stem cells, the team said they “essentially dissolve” within the tissue. Because the bots contain a barium titanate coating, the researchers also believe that they will be “stable and minimally reactive” with surrounding tissue. Still, they concede that “further studies will determine whether and how the particles are degraded or excreted over the long term.”

Expanding NPCbot Therapies to Increase the Effectiveness of Other Targeted Therapies

Although the team described the animal trials of their NPCbots as “promising,” they noted that further research is needed before the process can be attempted on human patients with spinal cord injuries. For example, Hao noted that in addition to ‘clinical aspects’ that require more exploration, the team needs to start by determining which magnetic fields “work best in humans” and determining the “optimal stimulation duration” for human NPCs. Nevertheless, the team noted, they are “already considering further applications.”

“The reproducible and scalable production of microrobots using our lab-on-a-chip system demonstrates that the platform’s application potential extends beyond basic research,” Professor Vidal explained.

Some potential biomedical applications mentioned by the RETH team include cardiology, oncology, wound healing, “and other targeted therapies,” adding that their process could make such treatments “safer, more controllable and more effective.”

The study “Magnetoelectric Microrobots for Spinal Cord Injury Regeneration” was published in Nature Materials. 

Christopher Plain is a Science Fiction and Fantasy novelist and Head Science Writer at The Debrief. Follow and connect with him on X, learn about his books at plainfiction.com, or email him directly at christopher@thedebrief.org.

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“A Game Changing Warfighting Capability”: DIU-Funded Hermeus Says Autonomous, High-Mach Payload Release Test Flights to Begin


Days after successfully flying its Quarterhorse unmanned aircraft at supersonic speeds, an industry-first defense aviation company, Hermeus, has received the largest-ever contract awarded by the Defense Innovation Unit (DIU) to demonstrate high-Mach flight combined with high-Mach payload release.

The new $ 159 million award, which increases the original contract to a total of $219 million, will allow Hermeus’ engineers to expand on previous high-Mach test flight milestones in direct partnership with the U.S. Air Force and the U.S. Navy, with the goal of providing the American warfighter with the most advanced arsenal capable of delivering munitions and payloads around the world at record-setting speeds.

“By delivering flight-ready aircraft and demonstrating payload release at speed, we will prove this technology can create a decisive military advantage on a timeline that matters,” explained Hermeus CEO and co-founder, AJ Piplica. “Our focus is on providing the Air Force and Navy with the validated data they need to transition these platforms into the future force.”

High Mach Payload Release: “A Game Changing Warfighting Capability”

When announcing the new DIU award, Hermeus executives noted that the program will include a series of “intensive flight tests.” The first is expected later this year, while the final flights are expected sometime in 2027.

Although few specifics were provided, the company said the flights will “prove the aircraft can maintain high speeds and expand its performance limits” while also demonstrating the successful carry and release of payloads at high velocity. The company also noted that all flight data gathered during the development and testing phases “will directly inform service experimentation and future acquisition decisions.”

high-Mach flight
In May, Hermeus’ Quarterhorse Mk 2.1 unmanned aircraft successfully completed its first supersonic flight, reaching a top speed of Mach 1.21. Image Credit: Hermeus.

Although the U.S. Military has several aircraft capable of exceeding the speed of sound, and several more hypersonic (exceeding five times the speed of sound) aircraft and missile prototypes, delivering payloads from high-Mach aircraft has remained a challenge. However, some military experts argue that the U.S. would benefit greatly from the capability.

When discussing the need for high-speed payload release, DIU Military Deputy Major General Joe “Solo” Kunkel said that the largest problems the military is facing in the future are “generally around time and distance,” and the associated challenges with getting to distant locations “in a timeframe that matters.”

“I care about the warfighting capability, providing advantage to our partners and us in the fight, and making sure that we can walk into every fight with swagger,” General Kunkel said, adding that mass producing the technology developed by Hermeus could move it from a test platform to a “game-changing warfighting capability.”

“I think we found a significant number of use cases where it can be used as a weapon,” the General added. 

Moving High-Mach Capability Out of the Lab

When discussing the company’s approach that convinced the DIU to offer its largest award in the organization’s history, including what they describe as “reclaiming the lost art of rapid iterative prototyping to build the fastest aircraft in the world today,” Hermeus noted that directly partnering with the USAF and USN allows their engineers to align tests with future mission needs and shorten the path from testing to deployment.

“By prioritizing relentless hardware iteration, we deliver high-speed systems at the pace of the modern battlefield,” the company’s statement explained. “We work with the Department of War to provide the high-speed capabilities our nation and its allies need to maintain a durable, asymmetric advantage.”

High-Mach flight
Image Credit: Hermeus.

When discussing the significance of the upcoming tests and the overall need for high-Mach flight payload deployment, including the benefit of the performance data, the company CEO heralded the DIU’s award, noting that the financing will help them move their successful demonstrations into real-world high-Mach platforms.

“This program is about moving high-Mach capability out of the lab and into an operationally relevant environment,” Piplica said. 

Christopher Plain is a Science Fiction and Fantasy novelist and Head Science Writer at The Debrief. Follow and connect with him on X, learn about his books at plainfiction.com, or email him directly at christopher@thedebrief.org.

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