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Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1

A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.
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Structures and inhibition of the Crimean–Congo haemorrhagic fever virus polymerase

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10701-6

Structural studies of Crimean–Congo haemorrhagic fever virus (CCHFV) polymerase reveal the structural basis of CCHFV RNA synthesis and highlight druggable sites for designing both nucleoside antivirals and non-nucleoside antivirals.
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Electrodeposited self-assembled molecules for perovskite photovoltaics

Nature, Published online: 02 July 2026; doi:10.1038/s41586-026-10844-6

Electrodeposited self-assembled molecules for perovskite photovoltaics
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