Efficient and precise programmable DNA knock-in without double-strand breaks

By: Yanmin Gao · Yu Ma · Kexin Yu · Yintian Liu · Buming Gu · Hao Tang · Wenjie Yan · Shuangshuang Yang · Jingran Su · Xindong Wang · Xin Ma · Xinming Wang · Fang Wang · Qingyang Li · Mengying Liu · Haifeng Wang

22 July 2026 at 01:00

Nature, Published online: 22 July 2026; doi:10.1038/s41586-026-10819-7

Kilobase-scale nickase-targeting (KNIT) editing enables single-nick-based DNA insertion across genomic loci and cell types, supporting insertion of DNA fragments exceeding 10 kb, with high efficiency and minimal unwanted off-target effects.

Spermine is an endogenous iron chelator that inhibits ferroptosis

Nature

By: Man Li · Xuexin Yu · Shuqin Ouyang · Xiaohong Chen · Huiqi Yu · Yuanji Liu · Ziwen Li · Chunhua Yu · Rui Kang · Christine Gaillet · Ludovic Colombeau · Raphaël Rodriguez · Libing Song · Guido Kroemer · Daolin Tang · Jun Li

3 June 2026 at 01:00

Nature, Published online: 03 June 2026; doi:10.1038/s41586-026-10597-2

A non-canonical metabolic route for spermine synthesis mediated by ALDH18A1 limits iron availability and lipid peroxidation in hepatocellular carcinoma.

Navigating interfaces in solid-state sodium batteries: challenges, solutions, and future directions

RSC - Energy Environment

By: Daxian Zuo · Xin Yu · Jing-Chang Li · Yu Sun · Hangyu Zheng · Bo Peng · Yiwen Liu · Jie Yang · Haoshen Zhou · Shaohua Guo

6 May 2026 at 00:00

Energy Environ. Sci., 2026, 19,3401-3445
DOI: 10.1039/D6EE01558A, Review Article

Daxian Zuo, Xin Yu, Jing-Chang Li, Yu Sun, Hangyu Zheng, Bo Peng, Yiwen Liu, Jie Yang, Haoshen Zhou, Shaohua Guo
This review identifies the key interfacial challenges in solid-state sodium batteries and highlights materials design, interface engineering, characterization, and modeling strategies to enable stable, high-performance, and commercially viable SSSBs.
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