De novo design of cysteine proteases
Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w
De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w
De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2
RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications in therapeutics, biotechnology and bioremediation.Google is testing a new Gemini feature in Chrome for iPhone. The latest Chrome for iOS TestFlight beta adds a Tabs option to the Ask Gemini prompt, letting users select multiple recent pages and ask Gemini questions across them without leaving the browser. This builds on the Ask Gemini button Google has already been testing […]
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Nature, Published online: 10 June 2026; doi:10.1038/s41586-026-10631-3
Tumour network mapping of diffuse midline glioma (DMG) defines a conserved and prognostically important brain network in children with DMG, consistent with the hypothesis that DMGs exploit otherwise healthy brain circuits to promote tumour growth.
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