Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11174-3

Optogenetic stimulation of motor-cortex neuron ensembles shows that precisely timed activity in the primary motor cortex can generate learned neural patterns and movements, demonstrating an active role in skilled motor control.

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10671-9

In a mouse model of Huntington’s disease, targeted modulation of neuronal activity restores network function and improves motor deficits.