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An operational perturbation proteomics-based virtual cell model

By: Rui Sun · Liujia Qian · Yongge Li · Tong Liu · Honghan Cheng · Xuedong Zhang · Xueya Zhou · Yuecheng Zhan · Guangmei Zhang · Zhengchao Luo · Kunpeng Ma · Chunlong Wu · Dongchen Ji · Zhangzhi Xue · Hongxue Meng · Yuhang Xiang · Dingwei Lei · Qianhe Zhou · Wenbin Hu · Yuhan Deng · Lingling Tan · Qi Xiao · Zhiwei Liu · Lei Zeng · Liqin Qian · Xuan Zheng · Qiong Hu · Nianzi Luo · Weinan E · Peijie Zhou · Han Wen · Yi Zhu · Tiannan Guo

9 September 2026 at 01:00

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11001-9

Temporal protein-abundance measurements from systematically perturbed breast cancer cell lines were generated to develop ProteinTalks, a virtual cell model that functions as an operational tool for diverse drug discovery tasks.

Towards the construction of a virtual yeast

Nature

By: Liujia Qian · Zizhuo Zhou · Peijie Zhou · Zhen Dong · Xudong Zhang · Zhenwu Dai · Zhangyang Gao · Siqi Sun · Kevin R. Roy · Shuaiyao Wang · Nicola Zamboni · Charles Boone · Michael Costanzo · Jianzhe Li · Gianni Liti · Jia-Xing Yue · Markus Ralser · Evan Williams · Mattia Zampieri · Heng Jiang · Tailin Wu · Yalin Wang · Feiran Li · Joseph Schacherer · Rui Sun · Zhaoxing Li · Yaming Deng · Yi Chen · Zhiping Xie · Huiqiang Lou · Xiaowen Wang · Linhai Xie · Han Wen · Liangyi Chen · Kai Lei · George Rosenberger · Xue Cai · Yingrui Wang · Qi Xiao · Huaizong Shen · Gaowen Liu · Lei Ma · Brenda Andrews · Hui Lu · Kiryl Piatkevich · Yi Zhu · Lei Bai · Yizhi Cai · Yuping Chen · Weinan E · Ge Gao · Fuchu He · Luonan Chen · Stan Z. Li · Hongwu Ma · Liang Qiao · Lars M. Steinmetz · Leihan Tang · Tang Tang · Xiaofan Zhang · Jing Yang · Yifan Yang · Kaicheng Yu · Jianyang Zeng · Yefeng Zheng · Bowen Zhou · Tiannan Guo

1 July 2026 at 01:00

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10574-9

A virtual yeast, an artificial intelligence-driven agent for modelling eukaryotic cellular behaviours, is described.