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TRI-611, a selective, brain-penetrant molecular glue degrader of ALK

By: Andrew R. Conery · Daniel S. La · Artyom A. Alekseyenko · David Marcoux · Aaron G. Bart · Matt L. Harlow · Patrick R. Arsenault · Nico R. Cantone · Rebecca L. Casaubon · Alexander Constan · Hari B. Kamadurai · Aravind Prasad Medikonda · Duncan E. Nunes · Hannah Szeto · Tim J. Wigle · Maolin Yu · Aleksandra Zagulyaeva · Christine M. Zarate · Lauren Highfield · Nobuyuki Kondo · Aaron N. Hata · Kenneth Ngo · Jisu Lee · Prafulla C. Gokhale · Caroline Germa · Kathleen I. Seyb · Patrick Trojer · Vito J. Palombella

9 September 2026 at 01:00

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-10998-3

TRI-611 induces the degradation of ALK fusion proteins via a previously undescribed CRBN recruitment motif, and its preclinical anti-tumour activity highlights TRI-611 as a potential new way of treating ALK-positive non-small-cell lung cancer.

Molecularly engineered dual-network eutectogel electrolytes for high-loading and stable zinc–iodine batteries

RSC - Energy Environment

By: Ling Wang · Jinpeng Guan · Na Li · Jing Li · Zhaoyu Wang · Jin Yin · Yi-Lin Liu · Maolin Yu · Yongbiao Mu · Zetao Chen · Yuwei Li · Jianxiong Xu · Lin Zeng

8 June 2026 at 00:00

Energy Environ. Sci., 2026, Advance Article
DOI: 10.1039/D6EE02664H, Paper

Ling Wang, Jinpeng Guan, Na Li, Jing Li, Zhaoyu Wang, Jin Yin, Yi-Lin Liu, Maolin Yu, Yongbiao Mu, Zetao Chen, Yuwei Li, Jianxiong Xu, Lin Zeng
A molecularly engineered dual-network eutectogel regulates Zn²⁺ transport, water activity, and polyiodide chemistry, enabling long-life, wide-temperature, and stable high-loading Zn–I₂ batteries.
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