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A single archaeon couples long-chain fatty acid oxidation to methanogenesis

Nature, Published online: 21 October 2026; doi:10.1038/s41586-026-11207-x

Methanoglobus dolicholipophagus AA-75 is a thermophilic archaeon isolated from a Chinese petroleum reservoir that converts methanol into methane, carbon dioxide and acetate, and uses saturated and unsaturated fatty acids to produce methane.
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Engineered TYK2 dependence enables myeloid-selective IL-10 receptor agonism

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11176-1

A tetravalent nanobody-based myeloid-selective IL-10 receptor agonist recapitulates IL-10’s potent suppression of monocytes, macrophages and dendritic cells while avoiding stimulation of T cells.
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