❌

Reading view

Computational design of metalloproteases

By: Anqi Chen · Kejia Wu · Hojae Choi · Preetham Venkatesh · Samuel J. Pellock · Nikita Hanikel · Hojeong shin · Declan Evans · Kieran Didi · Lars L. Schaaf · Cristina Díaz-Perlas · Brian Coventry · Donghyo Kim · Seth M. Woodbury · Pengfei Ji · Shingo Honda · Asim K. Bera · Hannah Nguyen · Alex Kang · Yanqing Wang · Xinting Li · Stacey Gerben · Lemuel Chang · Xiao Yan · Benjamí Oller-Salvia · Anthony A. Hyman · Donald Hilvert · David Baker

14 October 2026 at 01:00

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11167-2

RFdiffusion methods are used to de novo design proteins with water-activating zinc-based active sites adjacent to a peptide substrate binding pocket, yielding highly active, programmable proteases with potential applications in therapeutics, biotechnology and bioremediation.

Author Correction: De novo design of quasisymmetric two-component protein cages

Nature

By: Shunzhi Wang · Ying Xie · David Chmielewski · Connor Weidle · Tong Shu · Green Ahn · Ryan D. Kibler · Cindy Hernandez · Wei Chen · David Camilo Duran · Ann Carr · Asim K. Bera · Sangmin Lee · Justin Decarreau · Alex Kang · Evans Brackenbrough · Emily Joyce · Kejia Wu · Andrew J. Borst · Andrew Favor · Buwei Huang · Frank DiMaio · Liam J. Holt · David Baker

9 June 2026 at 01:00

Nature, Published online: 09 June 2026; doi:10.1038/s41586-026-10763-6

Author Correction: De novo design of quasisymmetric two-component protein cages