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Proximity-guided graph learning reveals tumour-associated proximity antigens

Nature, Published online: 09 September 2026; doi:10.1038/s41586-026-11003-7

A proximity-mapping atlas defines tumour-associated proximity antigens, revealing disease-associated membrane spatial communities, and identifies EGFR–CDCP1 as a co-target pair that enhances tumour killing by multispecific therapeutics.
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A tumour-derived organoid biobank maps cancer gene dependencies

Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10830-y

A clinically annotated multi-omic organoid resource with matched tumour samples from 256 patients across 5 cancers maps gene dependencies, reveals subtype-specific vulnerabilities and uncovers treatment-driven changes, expanding mechanistic insight and models for precision oncology.
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