❌

Reading view

↗️

Structure of the pre-initiation complex explains CMGE biogenesis

✇Nature
By: Thomas Pühringer · Berta Canal · Giacomo Palm · Agata Butryn · Emma C. Couves · Oliver Willhoft · Jacob S. Lewis · John F. X. Diffley · Alessandro Costa

Nature, Published online: 17 June 2026; doi:10.1038/s41586-026-10657-7

Cryo-electron microscopy and biochemical reconstitution experiments in yeast provide insight into the assembly of the CMGE complex, a helicase that establishes bidirectional DNA replication in eukaryotic cells, and elucidate the role of the firing factor Sld2.
  •  
  • ↗️
❌