Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10830-y

A clinically annotated multi-omic organoid resource with matched tumour samples from 256 patients across 5 cancers maps gene dependencies, reveals subtype-specific vulnerabilities and uncovers treatment-driven changes, expanding mechanistic insight and models for precision oncology.

Nature, Published online: 08 July 2026; doi:10.1038/s41586-026-10755-6

The ARP2/3 complex works together with actomyosin in an oscillatory program at the soma to govern neuronal polarization.