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De novo design of cysteine proteases

Nature

By: Hojae Choi · Magnus S. Bauer · Brian Coventry · Preetham Venkatesh · Anqi Chen · Donghyo Kim · Asim K. Bera · Alex Kang · Hannah Nguyen · Shayan Sadre · Justin Decarreau · Emily Joyce · Bhanumathi Shankaran · Tuscan Rock Thompson · Gabriel Greenstein · Kieran Didi · Lars L. Schaaf · Jacob Merle Gershon · Alexander F. Shida · Gyu Rie Lee · Donald Hilvert · Samuel J. Pellock · David Baker

14 October 2026 at 01:00

Nature, Published online: 14 October 2026; doi:10.1038/s41586-026-11143-w

De novo-designed enzymes use an activated cysteine nucleophile to hydrolyse polypeptide backbones in a sequence-dependent manner.

Author Correction: De novo design of quasisymmetric two-component protein cages

Nature

By: Shunzhi Wang · Ying Xie · David Chmielewski · Connor Weidle · Tong Shu · Green Ahn · Ryan D. Kibler · Cindy Hernandez · Wei Chen · David Camilo Duran · Ann Carr · Asim K. Bera · Sangmin Lee · Justin Decarreau · Alex Kang · Evans Brackenbrough · Emily Joyce · Kejia Wu · Andrew J. Borst · Andrew Favor · Buwei Huang · Frank DiMaio · Liam J. Holt · David Baker

9 June 2026 at 01:00

Nature, Published online: 09 June 2026; doi:10.1038/s41586-026-10763-6

Author Correction: De novo design of quasisymmetric two-component protein cages