Nature, Published online: 05 August 2026; doi:10.1038/s41586-026-10830-y

A clinically annotated multi-omic organoid resource with matched tumour samples from 256 patients across 5 cancers maps gene dependencies, reveals subtype-specific vulnerabilities and uncovers treatment-driven changes, expanding mechanistic insight and models for precision oncology.

Nature, Published online: 01 July 2026; doi:10.1038/s41586-026-10621-5

This Perspective examines the challenges and opportunities of genomic sequencing across multiple clinical applications, including genetic therapies, and calls for the establishment of new, centralized reference standards to improve consistency and accuracy in the field of precision medicine.